Scientific Publications

Synthesis, cellular evaluation and mechanism-of-action of piperlongumine analogsAdams, DJ, Dai M., Pellegrino G., Wagner BK, Stern AM, Shamji AF, and Schreiber SL, (Submitted) Read More / View Supplemental Materials

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Discovery of Small-Molecule Enhancers of Reactive Oxygen Species That are Nontoxic or Cause Genotype-Selective Cell Death.Adams, DJ, Boskovic ZV, Theriault JR, Wang AJ, Stern AM, Wagner BK, Shamji AF, and Schreiber SL ACS chemical biology, 2013/03/25, (2013) Read More / View Supplemental Materials

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Abstract

Synthesis, cellular evaluation, and mechanism of action of piperlongumine analogs.Adams, DJ, Dai M., Pellegrino G., Wagner BK, Stern AM, Shamji AF, and Schreiber SL Proceedings of the National Academy of Sciences of the United States of America, 2012/09/18, Volume 109, Issue 38, p.15115-20, (2012) Read More / View Supplemental Materials

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A Small-Molecule Probe of the Histone Methyltransferase G9a Induces Cellular Senescence in Pancreatic Adenocarcinoma.Yuan, Y., Wang Q., Paulk J., Kubicek S., Kemp MM, Adams DJ, Shamji AF, Wagner BK, and Schreiber SL ACS chemical biology, 2012/04/30, (2012) Read More / View Supplemental Materials

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Chromatin-targeting small molecules cause class-specific transcriptional changes in pancreatic endocrine cells.Kubicek, S., Gilbert JC, Fomina-Yadlin D., Gitlin AD, Yuan Y., Wagner FF, Holson EB, Luo T., Lewis TA, Taylor B., Gupta S., Shamji AF, Wagner BK, Clemons PA, and Schreiber SL Proceedings of the National Academy of Sciences of the United States of America, 2012/04/03, Volume 109, Issue 14, p.5364-9, (2012) Read More / View Supplemental Materials

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Selective killing of cancer cells by a small molecule targeting the stress response to ROS.Raj, L., Ide T., Gurkar AU, Foley M., Schenone M., Li X., Tolliday NJ, Golub T. R., Carr SA, Shamji AF, Stern AM, Mandinova A., Schreiber SL, and Lee SW Nature, 2011/07/13, Volume 475, Issue 7355, p.231-4, (2011) Read More / View Supplemental Materials

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Abstract

Small molecules of different origins have distinct distributions of structural complexity that correlate with protein-binding profiles.Clemons, PA, Bodycombe NE, Carrinski HA, Wilson JA, Shamji AF, Wagner BK, Koehler AN, and Schreiber SL Proceedings of the National Academy of Sciences of the United States of America, 2010/11/02, Volume 107, Issue 44, p.18787-92, (2010) Read More / View Supplemental Materials

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Towards patient-based cancer therapeutics.Cancer Target Discovery and Development, Network, Schreiber SL, Shamji AF, Clemons PA, Hon C., Koehler AN, Munoz B., Palmer M., Stern AM, Wagner BK, Powers S., Lowe SW, Guo X., Krasnitz A., Sawey ET, Sordella R., Stein L., Trotman LC, Califano A., Dalla-Favera R., et al. Nature biotechnology, 2010/09/01, Volume 28, Issue 9, p.904-6, (2010) Read More / View Supplemental Materials

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Rpd3p relocation mediates a transcriptional response to rapamycin in yeast.Humphrey, EL, Shamji AF, Bernstein BE, and Schreiber SL Chemistry & biology, 2004/03/01, Volume 11, Issue 3, p.295-9, (2004) Read More / View Supplemental Materials

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Abstract

Discovery of an inhibitor of a transcription factor using small molecule microarrays and diversity-oriented synthesis.Koehler, AN, Shamji AF, and Schreiber SL Journal of the American Chemical Society, 2003/07/16, Volume 125, Issue 28, p.8420-1, (2003) Read More / View Supplemental Materials

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Abstract