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Submitted
Synthesis, cellular evaluation and mechanism-of-action of piperlongumine analogsAdams, DJ, Dai M., Pellegrino G., Wagner BK, Stern AM, Shamji AF, and Schreiber SL, (Submitted) Read More / View Supplemental Materials
2014
Small-molecule screening identifies inhibition of salt-inducible kinases as a therapeutic strategy to enhance immunoregulatory functions of dendritic cells.Sundberg, TB, Choi HG, Song JH, Russell CN, Hussain MM, Graham DB, Khor B., Gagnon J., O'Connell DJ, Narayan K., Dančík V., Perez JR, Reinecker HC, Gray NS, Schreiber SL, Xavier RJ, and Shamji AF Proceedings of the National Academy of Sciences of the United States of America, 2014/08/11, (2014) Read More / View Supplemental Materials
Abstract
Toward performance-diverse small-molecule libraries for cell-based phenotypic screening using multiplexed high-dimensional profiling.Wawer, MJ, Li K., Gustafsdottir SM, Ljosa V., Bodycombe NE, Marton MA, Sokolnicki KL, Bray MA, Kemp MM, Winchester E., Taylor B., Grant GB, Hon CS, Duvall JR, Wilson JA, Bittker JA, Dančík V., Narayan R., Subramanian A., Winckler W., et al. Proceedings of the National Academy of Sciences of the United States of America, 2014/07/14, (2014) Read More / View Supplemental Materials
Abstract
Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense.Lassen, KG, Kuballa P., Conway KL, Patel KK, Becker CE, Peloquin JM, Villablanca EJ, Norman JM, Liu TC, Heath RJ, Becker ML, Fagbami L., Horn H., Mercer J., Yilmaz OH, Jaffe JD, Shamji AF, Bhan AK, Carr SA, Daly M. J., et al. Proceedings of the National Academy of Sciences of the United States of America, 2014/05/12, (2014) Read More / View Supplemental Materials
Abstract
Automated Structure-Activity Relationship Mining: Connecting Chemical Structure to Biological Profiles.Wawer, MJ, Jaramillo DE, Dančik V., Fass DM, Haggarty SJ, Shamji AF, Wagner BK, Schreiber SL, and Clemons PA Journal of biomolecular screening, 2014/04/07, (2014) Read More / View Supplemental Materials
Abstract
Connecting Small Molecules with Similar Assay Performance Profiles Leads to New Biological Hypotheses.Dancík, V., Carrel H., Bodycombe NE, Seiler KP, Fomina-Yadlin D., Kubicek ST, Hartwell K., Shamji AF, Wagner BK, and Clemons PA Journal of biomolecular screening, 2014/01/24, (2014) Read More / View Supplemental Materials
Abstract
Regulation of Ferroptotic Cancer Cell Death by GPX4.Yang, WS, Sriramaratnam R., Welsch ME, Shimada K., Skouta R., Viswanathan VS, Cheah JH, Clemons PA, Shamji AF, Clish CB, Brown LM, Girotti AW, Cornish VW, Schreiber SL, and Stockwell BR Cell, 2014/01/16, Volume 156, Issue 1-2, p.317-31, (2014) Read More / View Supplemental Materials
Abstract
2013
Multiplex cytological profiling assay to measure diverse cellular States.Gustafsdottir, SM, Ljosa V., Sokolnicki KL, Anthony Wilson J., Walpita D., Kemp MM, Petri Seiler K., Carrel HA, Golub T. R., Schreiber SL, Clemons PA, Carpenter AE, and Shamji AF PloS one, 2013/12/02, Volume 8, Issue 12, p.e80999, (2013) Read More / View Supplemental Materials
Abstract
Niche-based screening identifies small-molecule inhibitors of leukemia stem cells.Hartwell, KA, Miller PG, Mukherjee S., Kahn AR, Stewart AL, Logan DJ, Negri JM, Duvet M., Järås M., Puram R., Dancik V., Al-Shahrour F., Kindler T., Tothova Z., Chattopadhyay S., Hasaka T., Narayan R., Dai M., Huang C., Shterental S., et al. Nature chemical biology, 2013/12/01, Volume 9, Issue 12, p.840-8, (2013) Read More / View Supplemental Materials
Abstract
An interactive resource to identify cancer genetic and lineage dependencies targeted by small molecules.Basu, A., Bodycombe NE, Cheah JH, Price EV, Liu K., Schaefer GI, Ebright RY, Stewart ML, Ito D., Wang S., Bracha AL, Liefeld T., Wawer M., Gilbert JC, Wilson AJ, Stransky N., Kryukov GV, Dancik V., Barretina J., Garraway LA, et al. Cell, 2013/08/29, Volume 154, Issue 5, p.1151-61, (2013) Read More / View Supplemental Materials
Abstract
Atg16l1 is Required for Autophagy in Intestinal Epithelial Cells and Protection of Mice from Salmonella Infection.Conway, KL, Kuballa P., Song JH, Patel KK, Castoreno AB, Yilmaz OH, Jijon HB, Zhang M., Aldrich LN, Villablanca EJ, Peloquin JM, Goel G., Lee IA, Mizoguchi E., Shi HN, Bhan AK, Shaw SY, Schreiber SL, Virgin HW, Shamji AF, et al. Gastroenterology, 2013/08/21, (2013) Read More / View Supplemental Materials
Abstract
Gossypol and an HMT G9a inhibitor act in synergy to induce cell death in pancreatic cancer cells.Yuan, Y., Tang AJ, Castoreno AB, Kuo SY, Wang Q., Kuballa P., Xavier R., Shamji AF, Schreiber SL, and Wagner BK Cell death & disease, 2013/06/27, Volume 4, p.e690, (2013) Read More / View Supplemental Materials
Abstract
Discovery of Small-Molecule Enhancers of Reactive Oxygen Species That are Nontoxic or Cause Genotype-Selective Cell Death.Adams, DJ, Boskovic ZV, Theriault JR, Wang AJ, Stern AM, Wagner BK, Shamji AF, and Schreiber SL ACS chemical biology, 2013/03/25, (2013) Read More / View Supplemental Materials
Abstract
2012
Synthesis, cellular evaluation, and mechanism of action of piperlongumine analogs.Adams, DJ, Dai M., Pellegrino G., Wagner BK, Stern AM, Shamji AF, and Schreiber SL Proceedings of the National Academy of Sciences of the United States of America, 2012/09/18, Volume 109, Issue 38, p.15115-20, (2012) Read More / View Supplemental Materials
Abstract
A Small-Molecule Probe of the Histone Methyltransferase G9a Induces Cellular Senescence in Pancreatic Adenocarcinoma.Yuan, Y., Wang Q., Paulk J., Kubicek S., Kemp MM, Adams DJ, Shamji AF, Wagner BK, and Schreiber SL ACS chemical biology, 2012/04/30, (2012) Read More / View Supplemental Materials
Abstract
Chromatin-targeting small molecules cause class-specific transcriptional changes in pancreatic endocrine cells.Kubicek, S., Gilbert JC, Fomina-Yadlin D., Gitlin AD, Yuan Y., Wagner FF, Holson EB, Luo T., Lewis TA, Taylor B., Gupta S., Shamji AF, Wagner BK, Clemons PA, and Schreiber SL Proceedings of the National Academy of Sciences of the United States of America, 2012/04/03, Volume 109, Issue 14, p.5364-9, (2012) Read More / View Supplemental Materials
Abstract
2011
Selective killing of cancer cells by a small molecule targeting the stress response to ROS.Raj, L., Ide T., Gurkar AU, Foley M., Schenone M., Li X., Tolliday NJ, Golub T. R., Carr SA, Shamji AF, Stern AM, Mandinova A., Schreiber SL, and Lee SW Nature, 2011/07/13, Volume 475, Issue 7355, p.231-4, (2011) Read More / View Supplemental Materials
Abstract
2010
Small molecules of different origins have distinct distributions of structural complexity that correlate with protein-binding profiles.Clemons, PA, Bodycombe NE, Carrinski HA, Wilson JA, Shamji AF, Wagner BK, Koehler AN, and Schreiber SL Proceedings of the National Academy of Sciences of the United States of America, 2010/11/02, Volume 107, Issue 44, p.18787-92, (2010) Read More / View Supplemental Materials
Abstract
Towards patient-based cancer therapeutics.Cancer Target Discovery and Development, Network, Schreiber SL, Shamji AF, Clemons PA, Hon C., Koehler AN, Munoz B., Palmer M., Stern AM, Wagner BK, Powers S., Lowe SW, Guo X., Krasnitz A., Sawey ET, Sordella R., Stein L., Trotman LC, Califano A., Dalla-Favera R., et al. Nature biotechnology, 2010/09/01, Volume 28, Issue 9, p.904-6, (2010) Read More / View Supplemental Materials
2004
Rpd3p relocation mediates a transcriptional response to rapamycin in yeast.Humphrey, EL, Shamji AF, Bernstein BE, and Schreiber SL Chemistry & biology, 2004/03/01, Volume 11, Issue 3, p.295-9, (2004) Read More / View Supplemental Materials
Abstract
2003
Discovery of an inhibitor of a transcription factor using small molecule microarrays and diversity-oriented synthesis.Koehler, AN, Shamji AF, and Schreiber SL Journal of the American Chemical Society, 2003/07/16, Volume 125, Issue 28, p.8420-1, (2003) Read More / View Supplemental Materials
Abstract
  • Showing 1-21 of 21 Results