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2016
Discovery and validation of sub-threshold genome-wide association study loci using epigenomic signatures.Wang, X., Tucker NR, Rizki G., Mills R., Krijger PH, de Wit E., Subramanian V., Bartell E., Nguyen XX, Ye J., Leyton-Mange J., Dolmatova EV, van der Harst P., de Laat W., Ellinor PT, Newton-Cheh C., Milan DJ, Kellis M., and Boyer LA eLife, 2016/05/10, Volume 5, (2016) Read More / View Supplemental Materials
Abstract
Discovery of Genetic Variation on Chromosome 5q22 Associated with Mortality in Heart Failure.Smith, JG, Felix JF, Morrison AC, Kalogeropoulos A., Trompet S., Wilk JB, Gidlöf O., Wang X., Morley M., Mendelson M., Joehanes R., Ligthart S., Shan X., Bis JC, Wang YA, Sjögren M., Ngwa J., Brandimarto J., Stott DJ, Aguilar D., et al. PLoS genetics, 2016/05/01, Volume 12, Issue 5, p.e1006034, (2016) Read More / View Supplemental Materials
Abstract
Computational Reconstruction of NFκB Pathway Interaction Mechanisms during Prostate Cancer.Börnigen, D., Tyekucheva S., Wang X., Rider JR, Lee GS, Mucci LA, Sweeney C., and Huttenhower C. PLoS computational biology, 2016/04/01, Volume 12, Issue 4, p.e1004820, (2016) Read More / View Supplemental Materials
Abstract
18F CFA as a clinically translatable probe for PET imaging of deoxycytidine kinase activity.Kim, W., Le TM, Wei L., Poddar S., Bazzy J., Wang X., Uong NT, Abt ER, Capri JR, Austin WR, Van Valkenburgh JS, Steele D., Gipson RM, Slavik R., Cabebe AE, Taechariyakul T., Yaghoubi SS, Lee JT, Sadeghi S., Lavie A., et al. Proceedings of the National Academy of Sciences of the United States of America, 2016/03/28, (2016) Read More / View Supplemental Materials
Abstract
Integrative analyses reveal a long noncoding RNA-mediated sponge regulatory network in prostate cancer.Du, Z., Sun T., Hacisuleyman E., Fei T., Wang X., Brown M., Rinn JL, Lee MG, Chen Y., Kantoff PW, and Liu XS Nature communications, 2016/03/15, Volume 7, p.10982, (2016) Read More / View Supplemental Materials
Abstract
Twenty-eight genetic loci associated with ST-T wave amplitudes of the electrocardiogram.Verweij, N., Mateo Leach I., Isaacs A., Arking DE, Bis JC, Pers TH, van den Berg ME, Lyytikäinen LP, Barnett P., Wang X., study LifeLines Cohort, Soliman EZ, van Duijn CM, Kähönen M., van Veldhuisen DJ, Kors JA, Raitakari OT, Silva CT, Lehtimäki T., Hillege HL, et al. Human molecular genetics, 2016/03/08, (2016) Read More / View Supplemental Materials
Abstract
Reproducibility of Differential Proteomic Technologies in CPTAC Fractionated Xenografts.Tabb, DL, Wang X., Carr SA, Clauser KR, Mertins P., Chambers MC, Holman JD, Wang J., Zhang B., Zimmerman LJ, Chen X., Gunawardena HP, Davies SR, Ellis MJ, Li S., Townsend RR, Boja ES, Ketchum KA, Kinsinger CR, Mesri M., et al. Journal of proteome research, 2016/03/04, Volume 15, Issue 3, p.691-706, (2016) Read More / View Supplemental Materials
Abstract
CRISPR-Cas9 Targeting of PCSK9 in Human Hepatocytes In Vivo.Wang, X., Raghavan A., Chen T., Qiao L., Zhang Y., Ding Q., and Musunuru K. Arteriosclerosis, thrombosis, and vascular biology, 2016/03/03, (2016) Read More / View Supplemental Materials
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An Analysis of the Sensitivity of Proteogenomic Mapping of Somatic Mutations and Novel Splicing Events in Cancer.Ruggles, KV, Tang Z., Wang X., Grover H., Askenazi M., Teubl J., Cao S., McLellan MD, Clauser KR, Tabb DL, Mertins P., Slebos R., Erdmann-Gilmore P., Li S., Gunawardena HP, Xie L., Liu T., Zhou JY, Sun S., Hoadley KA, et al. Molecular & cellular proteomics : MCP, 2016/03/01, Volume 15, Issue 3, p.1060-71, (2016) Read More / View Supplemental Materials
Abstract
Transancestral fine-mapping of four type 2 diabetes susceptibility loci highlights potential causal regulatory mechanisms.Horikoshi, M., Pasquali L., Wiltshire S., Huyghe JR, Mahajan A., Asimit JL, Ferreira T., Locke AE, Robertson NR, Wang X., Sim X., Fujita H., Hara K., Young R., Zhang W., Choi S., Chen H., Kaur I., Takeuchi F., Fontanillas P., et al. Human molecular genetics, 2016/02/23, (2016) Read More / View Supplemental Materials
Abstract
Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes.Imamura, M., Takahashi A., Yamauchi T., Hara K., Yasuda K., Grarup N., Zhao W., Wang X., Huerta-Chagoya A., Hu C., Moon S., Long J., Kwak SH, Rasheed A., Saxena R., Ma RC, Okada Y., Iwata M., Hosoe J., Shojima N., et al. Nature communications, 2016/01/28, Volume 7, p.10531, (2016) Read More / View Supplemental Materials
Abstract
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).Klionsky, DJ, Abdelmohsen K., Abe A., Abedin MJ, Abeliovich H., Acevedo Arozena A., Adachi H., Adams CM, Adams PD, Adeli K., Adhihetty PJ, Adler SG, Agam G., Agarwal R., Aghi MK, Agnello M., Agostinis P., Aguilar PV, Aguirre-Ghiso J., Airoldi EM, et al. Autophagy, 2016/01/02, Volume 12, Issue 1, p.1-222, (2016) Read More / View Supplemental Materials
2015
Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis.Mancias, JD, Pontano Vaites L., Nissim S., Biancur DE, Kim AJ, Wang X., Liu Y., Goessling W., Kimmelman AC, and Harper JW eLife, 2015/10/05, Volume 4, (2015) Read More / View Supplemental Materials
Abstract
Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation.Kato, N., Loh M., Takeuchi F., Verweij N., Wang X., Zhang W., Kelly TN, Saleheen D., Lehne B., Leach IM, Drong AW, Abbott J., Wahl S., Tan ST, Scott WR, Campanella G., Chadeau-Hyam M., Afzal U., Ahluwalia TS, Bonder MJ, et al. Nature genetics, 2015/09/21, (2015) Read More / View Supplemental Materials
Abstract
Biallelic mutations in SNX14 cause a syndromic form of cerebellar atrophy and lysosome-autophagosome dysfunction.Akizu, N., Cantagrel V., Zaki MS, Al-Gazali L., Wang X., Rosti RO, Dikoglu E., Gelot AB, Rosti B., Vaux KK, Scott EM, Silhavy JL, Schroth J., Copeland B., Schaffer AE, Gordts PL, Esko JD, Buschman MD, Field SJ, Napolitano G., et al. Nature genetics, 2015/04/06, (2015) Read More / View Supplemental Materials
Abstract
DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia.Chen, CW, Koche RP, Sinha AU, Deshpande AJ, Zhu N., Eng R., Doench JG, Xu H., Chu SH, Qi J., Wang X., Delaney C., Bernt KM, Root DE, Hahn WC, Bradner JE, and Armstrong SA Nature medicine, 2015/03/30, (2015) Read More / View Supplemental Materials
Abstract
Integrative analysis of 111 reference human epigenomes.Roadmap Epigenomics, Consortium, Kundaje A., Meuleman W., Ernst J., Bilenky M., Yen A., Heravi-Moussavi A., Kheradpour P., Zhang Z., Wang J., Ziller MJ, Amin V., Whitaker JW, Schultz MD, Ward LD, Sarkar A., Quon G., Sandstrom RS, Eaton ML, Wu YC, et al. Nature, 2015/02/19, Volume 518, Issue 7539, p.317-30, (2015) Read More / View Supplemental Materials
Abstract
2014
Proteogenomic characterization of human colon and rectal cancer.Zhang, B., Wang J., Wang X., Zhu J., Liu Q., Shi Z., Chambers MC, Zimmerman LJ, Shaddox KF, Kim S., Davies SR, Wang S., Wang P., Kinsinger CR, Rivers RC, Rodriguez H., Townsend RR, Ellis MJ, Carr SA, Tabb DL, et al. Nature, 2014/09/18, Volume 513, Issue 7518, p.382-7, (2014) Read More / View Supplemental Materials
Abstract
IRF4 Is a Key Thermogenic Transcriptional Partner of PGC-1α.Kong, X., Banks A., Liu T., Kazak L., Rao RR, Cohen P., Wang X., Yu S., Lo JC, Tseng YH, Cypess AM, Xue R., Kleiner S., Kang S., Spiegelman BM, and Rosen ED Cell, 2014/07/03, Volume 158, Issue 1, p.69-83, (2014) Read More / View Supplemental Materials
Abstract
Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.Arking, DE, Pulit SL, Crotti L., van der Harst P., Munroe PB, Koopmann TT, Sotoodehnia N., Rossin EJ, Morley M., Wang X., Johnson AD, Lundby A., Gudbjartsson DF, Noseworthy PA, Eijgelsheim M., Bradford Y., Tarasov KV, Dörr M., Müller-Nurasyid M., Lahtinen AM, et al. Nature genetics, 2014/06/22, (2014) Read More / View Supplemental Materials
Abstract
Single-cell RNA-seq reveals dynamic paracrine control of cellular variation.Shalek, AK, Satija R., Shuga J., Trombetta JJ, Gennert D., Lu D., Chen P., Gertner RS, Gaublomme JT, Yosef N., Schwartz S., Fowler B., Weaver S., Wang J., Wang X., Ding R., Raychowdhury R., Friedman N., Hacohen N., Park H., et al. Nature, 2014/06/19, Volume 509, Issue 7505, p.363-9, (2014) Read More / View Supplemental Materials
Abstract
KRAS and YAP1 Converge to Regulate EMT and Tumor Survival.Shao, DD, Xue W., Krall EB, Bhutkar A., Piccioni F., Wang X., Schinzel AC, Sood S., Rosenbluh J., Kim JW, Zwang Y., Roberts TM, Root DE, Jacks T., and Hahn WC Cell, 2014/06/17, (2014) Read More / View Supplemental Materials
Abstract
ARID1B is a specific vulnerability in ARID1A-mutant cancers.Helming, KC, Wang X., Wilson BG, Vazquez F., Haswell JR, Manchester HE, Kim Y., Kryukov GV, Ghandi M., Aguirre AJ, Jagani Z., Wang Z., Garraway LA, Hahn WC, and Roberts CW Nature medicine, 2014/03/01, Volume 20, Issue 3, p.251-4, (2014) Read More / View Supplemental Materials
Abstract
Residual Complexes Containing SMARCA2 (BRM) Underlie the Oncogenic Drive of SMARCA4 (BRG1) Mutation.Wilson, BG, Helming KC, Wang X., Kim Y., Vazquez F., Jagani Z., Hahn WC, and Roberts CW Molecular and cellular biology, 2014/03/01, Volume 34, Issue 6, p.1136-44, (2014) Read More / View Supplemental Materials
Abstract
Demonstrating the feasibility of large-scale development of standardized assays to quantify human proteins.Kennedy, JJ, Abbatiello SE, Kim K., Yan P., Whiteaker JR, Lin C., Kim JS, Zhang Y., Wang X., Ivey RG, Zhao L., Min H., Lee Y., Yu MH, Yang EG, Lee C., Wang P., Rodriguez H., Kim Y., Carr SA, et al. Nature methods, 2014/02/01, Volume 11, Issue 2, p.149-55, (2014) Read More / View Supplemental Materials
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2013
Genomic insights into WNT/β-catenin signaling.Rosenbluh, J., Wang X., and Hahn WC Trends in pharmacological sciences, 2013/12/20, (2013) Read More / View Supplemental Materials
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SIRT4 has tumor-suppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism.Jeong, SM, Xiao C., Finley LW, Lahusen T., Souza AL, Pierce K., Li YH, Wang X., Laurent G., German NJ, Xu X., Li C., Wang RH, Lee J., Csibi A., Cerione R., Blenis J., Clish CB, Kimmelman A., Deng CX, et al. Cancer cell, 2013/04/15, Volume 23, Issue 4, p.450-63, (2013) Read More / View Supplemental Materials
Abstract
2012
β-Catenin-Driven Cancers Require a YAP1 Transcriptional Complex for Survival and Tumorigenesis.Rosenbluh, J., Nijhawan D., Cox AG, Li X., Schafer EJ, Zack TI, Wang X., Tsherniak A., Schinzel AC, Shao DD, Schumacher SE, Weir BA, Vazquez F., Cowley GS, Root DE, Mesirov J. P., Beroukhim R., and Hahn WC Cell, 2012/12/21, Volume 151, Issue 7, p.1457-73, (2012) Read More / View Supplemental Materials
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Genome variation in Cryptococcus gattii, an emerging pathogen of immunocompetent hosts.D'Souza, CA, Kronstad JW, Taylor G., Warren R., Yuen M., Hu G., Jung WH, Sham A., Kidd SE, Tangen K., Lee N., Zeilmaker T., Sawkins J., McVicker G., Shah S., Gnerre S., Griggs A., Zeng Q., Bartlett K., Li W., et al. mBio, 2012/01/06, Volume 2, Issue 1, p.e00342-10, (2012) Read More / View Supplemental Materials
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2011
Amplification of CRKL Induces Transformation and Epidermal Growth Factor Receptor Inhibitor Resistance in Human Non-Small Cell Lung Cancers.Cheung, HW, Du J., Boehm JS, He F., Weir BA, Wang X., Butaney M., Sequist LV, Luo B., Engelman JA, Root DE, Meyerson M., Golub T. R., Jänne PA, and Hahn WC Cancer discovery, 2011/12/01, Volume 1, Issue 7, p.608-25, (2011) Read More / View Supplemental Materials
Abstract
AAK1 identified as an inhibitor of neuregulin-1/ErbB4-dependent neurotrophic factor signaling using integrative chemical genomics and proteomics.Kuai, L., Ong SE, Madison JM, Wang X., Duvall JR, Lewis TA, Luce CJ, Conner SD, Pearlman DA, Wood JL, Schreiber SL, Carr SA, Scolnick EM, and Haggarty SJ Chemistry & biology, 2011/07/29, Volume 18, Issue 7, p.891-906, (2011) Read More / View Supplemental Materials
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A selective inhibitor and probe of the cellular functions of Jumonji C domain-containing histone demethylases.Luo, X., Liu Y., Kubicek S., Myllyharju J., Tumber A., Ng S., Che KH, Podoll J., Heightman TD, Oppermann U., Schreiber SL, and Wang X. Journal of the American Chemical Society, 2011/06/22, Volume 133, Issue 24, p.9451-6, (2011) Read More / View Supplemental Materials
Abstract
2010
Chemical genetics identifies small-molecule modulators of neuritogenesis involving neuregulin-1/ErbB4 signaling.Kuai, L., Wang X., Madison JM, Schreiber SL, Scolnick EM, and Haggarty SJ ACS chemical neuroscience, 2010/01/28, Volume 1, Issue 4, p.325-342, (2010) Read More / View Supplemental Materials
Abstract
2009
Syntheses of aminoalcohol-derived macrocycles leading to a small-molecule binder to and inhibitor of Sonic Hedgehog.Peng, LF, Stanton BZ, Maloof N., Wang X., and Schreiber SL Bioorganic & medicinal chemistry letters, 2009/11/15, Volume 19, Issue 22, p.6319-25, (2009) Read More / View Supplemental Materials
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Identifying the proteins to which small-molecule probes and drugs bind in cells.Ong, SE, Schenone M., Margolin AA, Li X., Do K., Doud MK, Mani D. R., Kuai L., Wang X., Wood JL, Tolliday NJ, Koehler AN, Marcaurelle LA, Golub T. R., Gould RJ, Schreiber SL, and Carr SA Proceedings of the National Academy of Sciences of the United States of America, 2009/03/24, Volume 106, Issue 12, p.4617-22, (2009) Read More / View Supplemental Materials
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A small molecule that binds Hedgehog and blocks its signaling in human cells.Stanton, BZ, Peng LF, Maloof N., Nakai K., Wang X., Duffner JL, Taveras KM, Hyman JM, Lee SW, Koehler AN, Chen JK, Fox JL, Mandinova A., and Schreiber SL Nature chemical biology, 2009/03/01, Volume 5, Issue 3, p.154-6, (2009) Read More / View Supplemental Materials
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2008
Diversity synthesis of complex pyridines yields a probe of a neurotrophic signaling pathway.Gray, BL, Wang X., Brown WC, Kuai L., and Schreiber SL Organic letters, 2008/07/03, Volume 10, Issue 13, p.2621-4, (2008) Read More / View Supplemental Materials
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Small-molecule reagents for cellular pull-down experiments.Wang, X., Imber BS, and Schreiber SL Bioconjugate chemistry, 2008/03/01, Volume 19, Issue 3, p.585-7, (2008) Read More / View Supplemental Materials
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  • Showing 1-38 of 38 Results