Scientific Publications

β-Catenin-Driven Cancers Require a YAP1 Transcriptional Complex for Survival and Tumorigenesis.Rosenbluh, J., Nijhawan D., Cox AG, Li X., Neal JT, Schafer EJ, Zack TI, Wang X., Tsherniak A., Schinzel AC, Shao DD, Schumacher SE, Weir BA, Vazquez F., Cowley GS, Root DE, Mesirov J. P., Beroukhim R., Kuo CJ, Goessling W., et al. Cell, 2012/12/21, Volume 151, Issue 7, p.1457-73, (2012) Read More / View Supplemental Materials

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Abstract

Genome variation in Cryptococcus gattii, an emerging pathogen of immunocompetent hosts.D'Souza, CA, Kronstad JW, Taylor G., Warren R., Yuen M., Hu G., Jung WH, Sham A., Kidd SE, Tangen K., Lee N., Zeilmaker T., Sawkins J., McVicker G., Shah S., Gnerre S., Griggs A., Zeng Q., Bartlett K., Li W., et al. mBio, 2012/01/06, Volume 2, Issue 1, p.e00342-10, (2012) Read More / View Supplemental Materials

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Abstract

Amplification of CRKL Induces Transformation and Epidermal Growth Factor Receptor Inhibitor Resistance in Human Non-Small Cell Lung Cancers.Cheung, HW, Du J., Boehm JS, He F., Weir BA, Wang X., Butaney M., Sequist LV, Luo B., Engelman JA, Root DE, Meyerson M., Golub T. R., Jänne PA, and Hahn WC Cancer discovery, 2011/12/01, Volume 1, Issue 7, p.608-25, (2011) Read More / View Supplemental Materials

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Abstract

AAK1 identified as an inhibitor of neuregulin-1/ErbB4-dependent neurotrophic factor signaling using integrative chemical genomics and proteomics.Kuai, L., Ong SE, Madison JM, Wang X., Duvall JR, Lewis TA, Luce CJ, Conner SD, Pearlman DA, Wood JL, Schreiber SL, Carr SA, Scolnick EM, and Haggarty SJ Chemistry & biology, 2011/07/29, Volume 18, Issue 7, p.891-906, (2011) Read More / View Supplemental Materials

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Abstract

A selective inhibitor and probe of the cellular functions of Jumonji C domain-containing histone demethylases.Luo, X., Liu Y., Kubicek S., Myllyharju J., Tumber A., Ng S., Che KH, Podoll J., Heightman TD, Oppermann U., Schreiber SL, and Wang X. Journal of the American Chemical Society, 2011/06/22, Volume 133, Issue 24, p.9451-6, (2011) Read More / View Supplemental Materials

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Abstract

Chemical genetics identifies small-molecule modulators of neuritogenesis involving neuregulin-1/ErbB4 signaling.Kuai, L., Wang X., Madison JM, Schreiber SL, Scolnick EM, and Haggarty SJ ACS chemical neuroscience, 2010/01/28, Volume 1, Issue 4, p.325-342, (2010) Read More / View Supplemental Materials

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Abstract

Syntheses of aminoalcohol-derived macrocycles leading to a small-molecule binder to and inhibitor of Sonic Hedgehog.Peng, LF, Stanton BZ, Maloof N., Wang X., and Schreiber SL Bioorganic & medicinal chemistry letters, 2009/11/15, Volume 19, Issue 22, p.6319-25, (2009) Read More / View Supplemental Materials

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Abstract

Identifying the proteins to which small-molecule probes and drugs bind in cells.Ong, SE, Schenone M., Margolin AA, Li X., Do K., Doud MK, Mani D. R., Kuai L., Wang X., Wood JL, Tolliday NJ, Koehler AN, Marcaurelle LA, Golub T. R., Gould RJ, Schreiber SL, and Carr SA Proceedings of the National Academy of Sciences of the United States of America, 2009/03/24, Volume 106, Issue 12, p.4617-22, (2009) Read More / View Supplemental Materials

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Abstract

A small molecule that binds Hedgehog and blocks its signaling in human cells.Stanton, BZ, Peng LF, Maloof N., Nakai K., Wang X., Duffner JL, Taveras KM, Hyman JM, Lee SW, Koehler AN, Chen JK, Fox JL, Mandinova A., and Schreiber SL Nature chemical biology, 2009/03/01, Volume 5, Issue 3, p.154-6, (2009) Read More / View Supplemental Materials

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Abstract

Diversity synthesis of complex pyridines yields a probe of a neurotrophic signaling pathway.Gray, BL, Wang X., Brown WC, Kuai L., and Schreiber SL Organic letters, 2008/07/03, Volume 10, Issue 13, p.2621-4, (2008) Read More / View Supplemental Materials

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Abstract

Small-molecule reagents for cellular pull-down experiments.Wang, X., Imber BS, and Schreiber SL Bioconjugate chemistry, 2008/03/01, Volume 19, Issue 3, p.585-7, (2008) Read More / View Supplemental Materials

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Abstract