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2016
An Isochemogenic Set of Inhibitors To Define the Therapeutic Potential of Histone Deacetylases in β-Cell Protection.Wagner, FF, Lundh M., Kaya T., McCarren P., Zhang YL, Chattopadhyay S., Gale JP, Galbo T., Fisher SL, Meier BC, Vetere A., Richardson S., Morgan NG, Christensen DP, Gilbert TJ, Hooker JM, Leroy M., Walpita D., Mandrup-Poulsen T., Wagner BK, et al. ACS chemical biology, 2016/02/19, Volume 11, Issue 2, p.363-74, (2016) Read More / View Supplemental Materials
Abstract
2014
In vivo imaging of histone deacetylases (HDACs) in the central nervous system and major peripheral organs.Wang, C., Schroeder FA, Wey HY, Borra R., Wagner FF, Reis S., Kim SW, Holson EB, Haggarty SJ, and Hooker JM Journal of medicinal chemistry, 2014/10/09, Volume 57, Issue 19, p.7999-8009, (2014) Read More / View Supplemental Materials
Abstract
Image-guided synthesis reveals potent blood-brain barrier permeable histone deacetylase inhibitors.Seo, YJ, Kang Y., Muench L., Reid A., Caesar S., Jean L., Wagner F., Holson E., Haggarty SJ, Weiss P., King P., Carter P., Volkow ND, Fowler JS, Hooker JM, and Kim SW ACS chemical neuroscience, 2014/07/16, Volume 5, Issue 7, p.588-96, (2014) Read More / View Supplemental Materials
Abstract
2013
Design, synthesis, and evaluation of hydroxamic acid-based molecular probes for in vivo imaging of histone deacetylase (HDAC) in brain.Wang, C., Eessalu TE, Barth VN, Mitch CH, Wagner FF, Hong Y., Neelamegam R., Schroeder FA, Holson EB, Haggarty SJ, and Hooker JM American journal of nuclear medicine and molecular imaging, 2013/01/01, Volume 4, Issue 1, p.29-38, (2013) Read More / View Supplemental Materials
Abstract
A selective HDAC 1/2 inhibitor modulates chromatin and gene expression in brain and alters mouse behavior in two mood-related tests.Schroeder, FA, Lewis MC, Fass DM, Wagner FF, Zhang YL, Hennig KM, Gale J., Zhao WN, Reis S., Barker DD, Berry-Scott E., Kim SW, Clore EL, Hooker JM, Holson EB, Haggarty SJ, and Petryshen TL PloS one, 2013/01/01, Volume 8, Issue 8, p.e71323, (2013) Read More / View Supplemental Materials
Abstract
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