Scientific Publications

Search by Keyword(s)
Found 29 results

Filters: Author is Ebert, BL  [Clear All Filters]

Search Results

  • Showing 1-29 of 29 Results
2014
TET2 mutations predict response to hypomethylating agents in myelodysplastic syndrome patients.Bejar, R., Lord A., Stevenson K., Bar-Natan M., Pérez-Ladaga A., Zaneveld J., Wang H., Caughey B., Stojanov P., Getz G., Garcia-Manero G., Kantarjian H., Chen R., Stone RM, Neuberg D., Steensma DP, and Ebert BL Blood, 2014/09/15, (2014) Read More / View Supplemental Materials
Abstract
Rational design of highly active sgRNAs for CRISPR-Cas9-mediated gene inactivation.Doench, JG, Hartenian E., Graham DB, Tothova Z., Hegde M., Smith I., Sullender M., Ebert BL, Xavier RJ, and Root DE Nature biotechnology, 2014/09/03, (2014) Read More / View Supplemental Materials
Abstract
Somatic Mutations Predict Poor Outcome in Patients With Myelodysplastic Syndrome After Hematopoietic Stem-Cell Transplantation.Bejar, R., Stevenson KE, Caughey B., Lindsley RC, Mar BG, Stojanov P., Getz G., Steensma DP, Ritz J., Soiffer R., Antin JH, Alyea E., Armand P., Ho V., Koreth J., Neuberg D., Cutler CS, and Ebert BL Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2014/08/04, (2014) Read More / View Supplemental Materials
Abstract
Generation of mouse models of myeloid malignancy with combinatorial genetic lesions using CRISPR-Cas9 genome editing.Heckl, D., Kowalczyk MS, Yudovich D., Belizaire R., Puram RV, McConkey ME, Thielke A., Aster J. C., Regev A., and Ebert BL Nature biotechnology, 2014/06/22, (2014) Read More / View Supplemental Materials
Abstract
MDS Is a Stem Cell Disorder After All.Jaiswal, S., and Ebert BL Cancer cell, 2014/06/16, Volume 25, Issue 6, p.713-4, (2014) Read More / View Supplemental Materials
Abstract
Integrated genomic analysis illustrates the central role of JAK-STAT pathway activation in myeloproliferative neoplasm pathogenesis.Rampal, R., Al-Shahrour F., Abdel-Wahab O., Patel J., Brunel JP, Mermel CH, Bass AJ, Pretz J., Ahn J., Hricik T., Kilpivaara O., Wadleigh M., Busque L., Gilliland DG, Golub T. R., Ebert BL, and LeVine R. Blood, 2014/04/16, (2014) Read More / View Supplemental Materials
Abstract
Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells.Krönke, J., Udeshi ND, Narla A., Grauman P., Hurst SN, McConkey M., Svinkina T., Heckl D., Comer E., Li X., Ciarlo C., Hartman E., Munshi N., Schenone M., Schreiber SL, Carr SA, and Ebert BL Science (New York, N.Y.), 2014/01/17, Volume 343, Issue 6168, p.301-5, (2014) Read More / View Supplemental Materials
Abstract
Genome-scale CRISPR-Cas9 knockout screening in human cells.Shalem, O., Sanjana NE, Hartenian E., Shi X., Scott DA, Mikkelsen TS, Heckl D., Ebert BL, Root DE, Doench JG, and Zhang F. Science (New York, N.Y.), 2014/01/03, Volume 343, Issue 6166, p.84-7, (2014) Read More / View Supplemental Materials
Abstract
2013
Niche-based screening identifies small-molecule inhibitors of leukemia stem cells.Hartwell, KA, Miller PG, Mukherjee S., Kahn AR, Stewart AL, Logan DJ, Negri JM, Duvet M., Järås M., Puram R., Dancik V., Al-Shahrour F., Kindler T., Tothova Z., Chattopadhyay S., Hasaka T., Narayan R., Dai M., Huang C., Shterental S., et al. Nature chemical biology, 2013/12/01, Volume 9, Issue 12, p.840-8, (2013) Read More / View Supplemental Materials
Abstract
In Vivo RNAi Screening Identifies a Leukemia-Specific Dependence on Integrin Beta 3 Signaling.Miller, PG, Al-Shahrour F., Hartwell KA, Chu LP, Järås M., Puissant A., McConkey ME, Cowley GS, Shterental S., Alexe G., Armstrong SA, Root DE, Scadden DT, Hynes R. O., Mukherjee S., Stegmaier K., and Ebert BL Cancer cell, 2013/06/11, (2013) Read More / View Supplemental Materials
Abstract
2011
Stem cell gene expression programs influence clinical outcome in human leukemia.Eppert, K., Takenaka K., Lechman ER, Waldron L., Nilsson B., van Galen P., Metzeler KH, Poeppl A., Ling V., Beyene J., Canty AJ, Danska JS, Bohlander SK, Buske C., Minden MD, Golub T. R., Jurisica I., Ebert BL, and Dick JE Nature medicine, 2011/08/28, Volume 17, Issue 9, p.1086-93, (2011) Read More / View Supplemental Materials
Abstract
Human tumors instigate granulin-expressing hematopoietic cells that promote malignancy by activating stromal fibroblasts in mice.Elkabets, M., Gifford AM, Scheel C., Nilsson B., Reinhardt F., Bray MA, Carpenter AE, Jirström K., Magnusson K., Ebert BL, Pontén F., Weinberg R. A., and McAllister SS The Journal of clinical investigation, 2011/02/01, Volume 121, Issue 2, p.784-99, (2011) Read More / View Supplemental Materials
Abstract
Densely interconnected transcriptional circuits control cell states in human hematopoiesis.Novershtern, N., Subramanian A., Lawton LN, Mak RH, Haining WN, McConkey ME, Habib N., Yosef N., Chang CY, Shay T., Frampton GM, Drake AC, Leskov I., Nilsson B., Preffer F., Dombkowski D., Evans JW, Liefeld T., Smutko JS, Chen J., et al. Cell, 2011/01/21, Volume 144, Issue 2, p.296-309, (2011) Read More / View Supplemental Materials
Abstract
2010
Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease.Bradner, JE, Mak R., Tanguturi SK, Mazitschek R., Haggarty SJ, Ross K., Chang CY, Bosco J., West N., Morse E., Lin K., Shen JP, Kwiatkowski NP, Gheldof N., Dekker J., DeAngelo DJ, Carr SA, Schreiber SL, Golub T. R., and Ebert BL Proceedings of the National Academy of Sciences of the United States of America, 2010/07/13, Volume 107, Issue 28, p.12617-22, (2010) Read More / View Supplemental Materials
Abstract
The connectivity map links iron regulatory protein-1-mediated inhibition of hypoxia-inducible factor-2a translation to the anti-inflammatory 15-deoxy-delta12,14-prostaglandin J2.Zimmer, M., Lamb J., Ebert BL, Lynch M., Neil C., Schmidt E., Golub T. R., and Iliopoulos O. Cancer research, 2010/04/15, Volume 70, Issue 8, p.3071-9, (2010) Read More / View Supplemental Materials
Abstract
The landscape of somatic copy-number alteration across human cancers.Beroukhim, R., Mermel CH, Porter D., Wei G., Raychaudhuri S., Donovan J., Barretina J., Boehm JS, Dobson J., Urashima M., Mc Henry KT, Pinchback RM, Ligon AH, Cho YJ, Haery L., Greulich H., Reich M., Winckler W., Lawrence MS, Weir BA, et al. Nature, 2010/02/18, Volume 463, Issue 7283, p.899-905, (2010) Read More / View Supplemental Materials
Abstract
2009
Ultrasome: efficient aberration caller for copy number studies of ultra-high resolution.Nilsson, B., Johansson M., Al-Shahrour F., Carpenter AE, and Ebert BL Bioinformatics (Oxford, England), 2009/04/15, Volume 25, Issue 8, p.1078-9, (2009) Read More / View Supplemental Materials
Abstract
2008
Identification of an evolutionarily conserved transcriptional signature of CD8 memory differentiation that is shared by T and B cells.Haining, WN, Ebert BL, Subrmanian A., Wherry EJ, Eichbaum Q., Evans JW, Mak R., Rivoli S., Pretz J., Angelosanto J., Smutko JS, Walker BD, Kaech SM, Ahmed R., Nadler LM, and Golub T. R. Journal of immunology (Baltimore, Md. : 1950), 2008/08/01, Volume 181, Issue 3, p.1859-68, (2008) Read More / View Supplemental Materials
Abstract
MicroRNA-mediated control of cell fate in megakaryocyte-erythrocyte progenitors.Lu, J., Guo S., Ebert BL, Zhang H., Peng X., Bosco J., Pretz J., Schlanger R., Wang JY, Mak RH, Dombkowski DM, Preffer FI, Scadden DT, and Golub T. R. Developmental cell, 2008/06/01, Volume 14, Issue 6, p.843-53, (2008) Read More / View Supplemental Materials
Abstract
An erythroid differentiation signature predicts response to lenalidomide in myelodysplastic syndrome.Ebert, BL, Galili N., Tamayo P., Bosco J., Mak R., Pretz J., Tanguturi S., Ladd-Acosta C., Stone R., Golub T. R., and Raza A. PLoS medicine, 2008/02/01, Volume 5, Issue 2, p.e35, (2008) Read More / View Supplemental Materials
Abstract
Identification of RPS14 as a 5q- syndrome gene by RNA interference screen.Ebert, BL, Pretz J., Bosco J., Chang CY, Tamayo P., Galili N., Raza A., Root DE, Attar E., Ellis SR, and Golub T. R. Nature, 2008/01/17, Volume 451, Issue 7176, p.335-9, (2008) Read More / View Supplemental Materials
Abstract
2007
Identification of driver and passenger mutations of FLT3 by high-throughput DNA sequence analysis and functional assessment of candidate alleles.Fröhling, S., Scholl C., Levine RL, Loriaux M., Boggon TJ, Bernard OA, Berger R., Döhner H., Döhner K., Ebert BL, Teckie S., Golub T. R., Jiang J., Schittenhelm MM, Lee BH, Griffin JD, Stone RM, Heinrich MC, Deininger MW, Druker BJ, et al. Cancer cell, 2007/12/01, Volume 12, Issue 6, p.501-13, (2007) Read More / View Supplemental Materials
Abstract
Metagene projection for cross-platform, cross-species characterization of global transcriptional states.Tamayo, P., Scanfeld D., Ebert BL, Gillette MA, Roberts CW, and Mesirov J. P. Proceedings of the National Academy of Sciences of the United States of America, 2007/04/03, Volume 104, Issue 14, p.5959-64, (2007) Read More / View Supplemental Materials
Abstract
2006
MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia.Pikman, Y., Lee BH, Mercher T., McDowell E., Ebert BL, Gozo M., Cuker A., Wernig G., Moore S., Galinsky I., DeAngelo DJ, Clark JJ, Lee SJ, Golub T. R., Wadleigh M., Gilliland DG, and Levine RL PLoS medicine, 2006/07/01, Volume 3, Issue 7, p.e270, (2006) Read More / View Supplemental Materials
Abstract
2005
Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.Subramanian, A., Tamayo P., Mootha VK, Mukherjee S., Ebert BL, Gillette MA, Paulovich A., Pomeroy SL, Golub T. R., Lander E. S., and Mesirov J. P. Proceedings of the National Academy of Sciences of the United States of America, 2005/10/25, Volume 102, Issue 43, p.15545-50, (2005) Read More / View Supplemental Materials
Abstract
An RNA interference model of RPS19 deficiency in Diamond-Blackfan anemia recapitulates defective hematopoiesis and rescue by dexamethasone: identification of dexamethasone-responsive genes by microarray.Ebert, BL, Lee MM, Pretz JL, Subramanian A., Mak R., Golub T. R., and Sieff CA Blood, 2005/06/15, Volume 105, Issue 12, p.4620-6, (2005) Read More / View Supplemental Materials
Abstract
MicroRNA expression profiles classify human cancers.Lu, J., Getz G., Miska EA, Alvarez-Saavedra E., Lamb J., Peck D., Sweet-Cordero A., Ebert BL, Mak RH, Ferrando AA, Downing J. R., Jacks T., Horvitz HR, and Golub T. R. Nature, 2005/06/09, Volume 435, Issue 7043, p.834-8, (2005) Read More / View Supplemental Materials
Abstract
Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis.Levine, RL, Wadleigh M., Cools J., Ebert BL, Wernig G., Huntly BJ, Boggon TJ, Wlodarska I., Clark JJ, Moore S., Adelsperger J., Koo S., Lee JC, Gabriel S., Mercher T., D'Andrea A., Fröhling S., Döhner K., Marynen P., Vandenberghe P., et al. Cancer cell, 2005/04/01, Volume 7, Issue 4, p.387-97, (2005) Read More / View Supplemental Materials
Abstract
2004
Genomic approaches to hematologic malignancies.Ebert, BL, and Golub T. R. Blood, 2004/08/15, Volume 104, Issue 4, p.923-32, (2004) Read More / View Supplemental Materials
Abstract
  • Showing 1-29 of 29 Results