Scientific Publications

Search by Keyword(s)
Found 30 results

Filters: Author is Haggarty, SJ  [Clear All Filters]

Search Results

  • Showing 1-30 of 30 Results
2014
CHD8 regulates neurodevelopmental pathways associated with autism spectrum disorder in neural progenitors.Sugathan, A., Biagioli M., Golzio C., Erdin S., Blumenthal I., Manavalan P., Ragavendran A., Brand H., Lucente D., Miles J., Sheridan SD, Stortchevoi A., Kellis M., Haggarty SJ, Katsanis N., Gusella JF, and Talkowski ME Proceedings of the National Academy of Sciences of the United States of America, 2014/10/21, Volume 111, Issue 42, p.E4468-77, (2014) Read More / View Supplemental Materials
Abstract
Label-free, live optical imaging of reprogrammed bipolar disorder patient-derived cells reveals a functional correlate of lithium responsiveness.Wang, JL, Shamah SM, Sun AX, Waldman ID, Haggarty SJ, and Perlis RH Translational psychiatry, 2014/08/26, Volume 4, p.e428, (2014) Read More / View Supplemental Materials
Abstract
Automated Structure-Activity Relationship Mining: Connecting Chemical Structure to Biological Profiles.Wawer, MJ, Jaramillo DE, Dančik V., Fass DM, Haggarty SJ, Shamji AF, Wagner BK, Schreiber SL, and Clemons PA Journal of biomolecular screening, 2014/04/07, (2014) Read More / View Supplemental Materials
Abstract
A polygenic burden of rare disruptive mutations in schizophrenia.Purcell, SM, Moran JL, Fromer M., Ruderfer D., Solovieff N., Roussos P., O'Dushlaine C., Chambert K., Bergen SE, Kähler A., Duncan L., Stahl E., Genovese G., Fernández E., Collins MO, Komiyama NH, Choudhary JS, Magnusson PK, Banks E., Shakir K., et al. Nature, 2014/02/13, Volume 506, Issue 7487, p.185-90, (2014) Read More / View Supplemental Materials
Abstract
Epigenetic Priming of Memory Updating during Reconsolidation to Attenuate Remote Fear Memories.Gräff, J., Joseph NF, Horn ME, Samiei A., Meng J., Seo J., Rei D., Bero AW, Phan TX, Wagner F., Holson E., Xu J., Sun J., Neve RL, Mach RH, Haggarty SJ, and Tsai LH Cell, 2014/01/16, Volume 156, Issue 1-2, p.261-76, (2014) Read More / View Supplemental Materials
Abstract
2013
Epigenetic mechanisms in mood disorders: Targeting neuroplasticity.Fass, DM, Schroeder FA, Perlis RH, and Haggarty SJ Neuroscience, 2013/01/30, (2013) Read More / View Supplemental Materials
Abstract
Design, synthesis, and evaluation of hydroxamic acid-based molecular probes for in vivo imaging of histone deacetylase (HDAC) in brain.Wang, C., Eessalu TE, Barth VN, Mitch CH, Wagner FF, Hong Y., Neelamegam R., Schroeder FA, Holson EB, Haggarty SJ, and Hooker JM American journal of nuclear medicine and molecular imaging, 2013/01/01, Volume 4, Issue 1, p.29-38, (2013) Read More / View Supplemental Materials
Abstract
A selective HDAC 1/2 inhibitor modulates chromatin and gene expression in brain and alters mouse behavior in two mood-related tests.Schroeder, FA, Lewis MC, Fass DM, Wagner FF, Zhang YL, Hennig KM, Gale J., Zhao WN, Reis S., Barker DD, Berry-Scott E., Kim SW, Clore EL, Hooker JM, Holson EB, Haggarty SJ, and Petryshen TL PloS one, 2013/01/01, Volume 8, Issue 8, p.e71323, (2013) Read More / View Supplemental Materials
Abstract
2012
Disruption of a large intergenic noncoding RNA in subjects with neurodevelopmental disabilities.Talkowski, ME, Maussion G., Crapper L., Rosenfeld JA, Blumenthal I., Hanscom C., Chiang C., Lindgren A., Pereira S., Ruderfer D., Diallo AB, Lopez JP, Turecki G., Chen ES, Gigek C., Harris DJ, Lip V., An Y., Biagioli M., Macdonald ME, et al. American journal of human genetics, 2012/12/07, Volume 91, Issue 6, p.1128-34, (2012) Read More / View Supplemental Materials
Abstract
Cis-acting regulation of brain-specific ANK3 gene expression by a genetic variant associated with bipolar disorder.Rueckert, EH, Barker D., Ruderfer D., Bergen SE, O'Dushlaine C., Luce CJ, Sheridan SD, Theriault KM, Chambert K., Moran J., Purcell SM, Madison JM, Haggarty SJ, and Sklar P. Molecular psychiatry, 2012/07/31, (2012) Read More / View Supplemental Materials
Abstract
Crebinostat: A novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity.Fass, DM, Reis SA, Ghosh B., Hennig KM, Joseph NF, Zhao WN, Nieland TJ, Guan JS, Groves Kuhnle CE, Tang W., Barker DD, Mazitschek R., Schreiber SL, Tsai LH, and Haggarty SJ Neuropharmacology, 2012/07/04, (2012) Read More / View Supplemental Materials
Abstract
An epigenetic blockade of cognitive functions in the neurodegenerating brain.Gräff, J., Rei D., Guan JS, Wang WY, Seo J., Hennig KM, Nieland TJ, Fass DM, Kao PF, Kahn M., Su SC, Samiei A., Joseph N., Haggarty SJ, Delalle I., and Tsai LH Nature, 2012/02/29, (2012) Read More / View Supplemental Materials
Abstract
2011
Chemical genomics: probing protein function using small molecules.Wagner, BK, Haggarty SJ, and Clemons PA American journal of pharmacogenomics : genomics-related research in drug development and clinical practice, 2011/12/08, Volume 4, Issue 5, p.313-20, (2011) Read More / View Supplemental Materials
Abstract
The DNA damage mark pH2AX differentiates the cytotoxic effects of small molecule HDAC inhibitors in ovarian cancer cells.Wilson, AJ, Holson E., Wagner F., Zhang YL, Fass DM, Haggarty SJ, Bhaskara S., Hiebert SW, Schreiber SL, and Khabele D. Cancer biology & therapy, 2011/09/15, Volume 12, Issue 6, p.484-93, (2011) Read More / View Supplemental Materials
Abstract
AAK1 identified as an inhibitor of neuregulin-1/ErbB4-dependent neurotrophic factor signaling using integrative chemical genomics and proteomics.Kuai, L., Ong SE, Madison JM, Wang X., Duvall JR, Lewis TA, Luce CJ, Conner SD, Pearlman DA, Wood JL, Schreiber SL, Carr SA, Scolnick EM, and Haggarty SJ Chemistry & biology, 2011/07/29, Volume 18, Issue 7, p.891-906, (2011) Read More / View Supplemental Materials
Abstract
AKT kinase activity is required for lithium to modulate mood-related behaviors in mice.Pan, JQ, Lewis MC, Ketterman JK, Clore EL, Riley M., Richards KR, Berry-Scott E., Liu X., Wagner FF, Holson EB, Neve RL, Biechele TL, Moon RT, Scolnick EM, Petryshen TL, and Haggarty SJ Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2011/06/01, Volume 36, Issue 7, p.1397-411, (2011) Read More / View Supplemental Materials
Abstract
2010
An aldol-based build/couple/pair strategy for the synthesis of medium- and large-sized rings: discovery of macrocyclic histone deacetylase inhibitors.Marcaurelle, LA, Comer E., Dandapani S., Duvall JR, Gerard B., Kesavan S., Lee MD 4th, Liu H., Lowe JT, Marie JC, Mulrooney CA, Pandya BA, Rowley A., Ryba TD, Suh BC, Wei J., Young DW, Akella LB, Ross NT, Zhang YL, et al. Journal of the American Chemical Society, 2010/12/01, Volume 132, Issue 47, p.16962-76, (2010) Read More / View Supplemental Materials
Abstract
Effect of Inhibiting Histone Deacetylase with Short-Chain Carboxylic Acids and Their Hydroxamic Acid Analogs on Vertebrate Development and Neuronal Chromatin.Fass, DM, Shah R., Ghosh B., Hennig K., Norton S., Zhao WN, Reis SA, Klein PS, Mazitschek R., Maglathlin RL, Lewis TA, and Haggarty SJ ACS medicinal chemistry letters, 2010/10/08, Volume 2, Issue 1, p.39-42, (2010) Read More / View Supplemental Materials
Abstract
Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease.Bradner, JE, Mak R., Tanguturi SK, Mazitschek R., Haggarty SJ, Ross K., Chang CY, Bosco J., West N., Morse E., Lin K., Shen JP, Kwiatkowski NP, Gheldof N., Dekker J., DeAngelo DJ, Carr SA, Schreiber SL, Golub T. R., and Ebert BL Proceedings of the National Academy of Sciences of the United States of America, 2010/07/13, Volume 107, Issue 28, p.12617-22, (2010) Read More / View Supplemental Materials
Abstract
Chemical phylogenetics of histone deacetylases.Bradner, JE, West N., Grachan ML, Greenberg EF, Haggarty SJ, Warnow T., and Mazitschek R. Nature chemical biology, 2010/03/01, Volume 6, Issue 3, p.238-243, (2010) Read More / View Supplemental Materials
Abstract
Rapid behavior-based identification of neuroactive small molecules in the zebrafish.Kokel, D., Bryan J., Laggner C., White R., Cheung CY, Mateus R., Healey D., Kim S., Werdich AA, Haggarty SJ, Macrae CA, Shoichet B., and Peterson RT Nature chemical biology, 2010/03/01, Volume 6, Issue 3, p.231-237, (2010) Read More / View Supplemental Materials
Abstract
Chemical genetics identifies small-molecule modulators of neuritogenesis involving neuregulin-1/ErbB4 signaling.Kuai, L., Wang X., Madison JM, Schreiber SL, Scolnick EM, and Haggarty SJ ACS chemical neuroscience, 2010/01/28, Volume 1, Issue 4, p.325-342, (2010) Read More / View Supplemental Materials
Abstract
2009
Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling.Mao, Y., Ge X., Frank CL, Madison JM, Koehler AN, Doud MK, Tassa C., Berry EM, Soda T., Singh KK, Biechele T., Petryshen TL, Moon RT, Haggarty SJ, and Tsai LH Cell, 2009/03/20, Volume 136, Issue 6, p.1017-31, (2009) Read More / View Supplemental Materials
Abstract
2007
Detecting binding interactions using microarrays of natural product extracts.Schmitz, K., Haggarty SJ, McPherson OM, Clardy J., and Koehler AN Journal of the American Chemical Society, 2007/09/19, Volume 129, Issue 37, p.11346-7, (2007) Read More / View Supplemental Materials
2006
The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease.Lamb, J., Crawford ED, Peck D., Modell JW, Blat IC, Wrobel MJ, Lerner J., Brunet JP, Subramanian A., Ross KN, Reich M., Hieronymus H., Wei G., Armstrong SA, Haggarty SJ, Clemons PA, Wei R., Carr SA, Lander E. S., and Golub T. R. Science (New York, N.Y.), 2006/09/29, Volume 313, Issue 5795, p.1929-35, (2006) Read More / View Supplemental Materials
Abstract
Revealing complex traits with small molecules and naturally recombinant yeast strains.Perlstein, EO, Ruderfer DM, Ramachandran G., Haggarty SJ, Kruglyak L., and Schreiber SL Chemistry & biology, 2006/03/01, Volume 13, Issue 3, p.319-27, (2006) Read More / View Supplemental Materials
Abstract
2005
SpectralNET--an application for spectral graph analysis and visualization.Forman, JJ, Clemons PA, Schreiber SL, and Haggarty SJ BMC bioinformatics, 2005/10/19, Volume 6, p.260, (2005) Read More / View Supplemental Materials
Abstract
The principle of complementarity: chemical versus biological space.Haggarty, SJ Current opinion in chemical biology, 2005/06/01, Volume 9, Issue 3, p.296-303, (2005) Read More / View Supplemental Materials
Abstract
2004
Finding new components of the target of rapamycin (TOR) signaling network through chemical genetics and proteome chips.Huang, J., Zhu H., Haggarty SJ, Spring DR, Hwang H., Jin F., Snyder M., and Schreiber SL Proceedings of the National Academy of Sciences of the United States of America, 2004/11/23, Volume 101, Issue 47, p.16594-9, (2004) Read More / View Supplemental Materials
Abstract
Mapping chemical space using molecular descriptors and chemical genetics: deacetylase inhibitors.Haggarty, SJ, Clemons PA, Wong JC, and Schreiber SL Combinatorial chemistry & high throughput screening, 2004/11/01, Volume 7, Issue 7, p.669-76, (2004) Read More / View Supplemental Materials
Abstract
  • Showing 1-30 of 30 Results