Scientific Publications

Search by Keyword(s)
Found 20 results

Filters: Author is Mazitschek, R  [Clear All Filters]

Search Results

  • Showing 1-20 of 20 Results
2015
Exploring the 3-piperidin-4-yl-1H-indole scaffold as a novel antimalarial chemotype.Santos, SA, Lukens AK, Coelho L., Nogueira F., Wirth DF, Mazitschek R., Moreira R., and Paulo A. European journal of medicinal chemistry, 2015/07/31, Volume 102, p.320-333, (2015) Read More / View Supplemental Materials
Abstract
Treatment of obesity with celastrol.Liu, J., Lee J., Salazar Hernandez MA, Mazitschek R., and Ozcan U. Cell, 2015/05/21, Volume 161, Issue 5, p.999-1011, (2015) Read More / View Supplemental Materials
Abstract
The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs.Herman, JD, Pepper LR, Cortese JF, Estiu G., Galinsky K., Zuzarte-Luis V., Derbyshire ER, Ribacke U., Lukens AK, Santos SA, Patel V., Clish CB, Sullivan WJ Jr, Zhou H., Bopp SE, Schimmel P., Lindquist S., Clardy J., Mota MM, Keller TL, et al. Science translational medicine, 2015/05/20, Volume 7, Issue 288, p.288ra77, (2015) Read More / View Supplemental Materials
Abstract
Live Cell Multi-Photon Fluorescence Correlation Spectroscopy with an Improved Large Stokes Shift Fluorescent Protein.Guan, Y., Meurer M., Raghavan S., Rebane A., Lindquist JR, Santos S., Kats I., Davidson MW, Mazitschek R., Hughes TE, Drobizhev M., Knop M., and Shah JV Molecular biology of the cell, 2015/04/15, (2015) Read More / View Supplemental Materials
Abstract
Inhibition of histone deacetylase 6 improves long-term survival in a lethal septic model.Li, Y., Zhao T., Liu B., Halaweish I., Mazitschek R., Duan X., and Alam HB The journal of trauma and acute care surgery, 2015/02/01, Volume 78, Issue 2, p.378-85, (2015) Read More / View Supplemental Materials
Abstract
2014
Selective inhibition of histone deacetylase 6 alters the composition of circulating blood cells in a lethal septic model.Zhao, T., Li Y., Liu B., Halaweish I., Mazitschek R., and Alam HB The Journal of surgical research, 2014/02/04, (2014) Read More / View Supplemental Materials
Abstract
A genomic and evolutionary approach reveals non-genetic drug resistance in malaria.Herman, JD, Rice DP, Ribacke U., Silterra J., Deik AA, Moss EL, Broadbent KM, Neafsey DE, Desai MM, Clish CB, Mazitschek R., and Wirth DF Genome biology, 2014/01/01, Volume 15, Issue 11, p.511, (2014) Read More / View Supplemental Materials
Abstract
2012
Crebinostat: A novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity.Fass, DM, Reis SA, Ghosh B., Hennig KM, Joseph NF, Zhao WN, Nieland TJ, Guan JS, Groves Kuhnle CE, Tang W., Barker DD, Mazitschek R., Schreiber SL, Tsai LH, and Haggarty SJ Neuropharmacology, 2012/07/04, (2012) Read More / View Supplemental Materials
Abstract
2011
Identification and validation of tetracyclic benzothiazepines as Plasmodium falciparum cytochrome bc1 inhibitors.Dong, CK, Urgaonkar S., Cortese JF, Gamo FJ, Garcia-Bustos JF, Lafuente MJ, Patel V., Ross L., Coleman BI, Derbyshire ER, Clish CB, Serrano AE, Cromwell M., Barker RH Jr, Dvorin JD, Duraisingh MT, Wirth DF, Clardy J., and Mazitschek R. Chemistry & biology, 2011/12/23, Volume 18, Issue 12, p.1602-10, (2011) Read More / View Supplemental Materials
Abstract
2010
Effect of Inhibiting Histone Deacetylase with Short-Chain Carboxylic Acids and Their Hydroxamic Acid Analogs on Vertebrate Development and Neuronal Chromatin.Fass, DM, Shah R., Ghosh B., Hennig K., Norton S., Zhao WN, Reis SA, Klein PS, Mazitschek R., Maglathlin RL, Lewis TA, and Haggarty SJ ACS medicinal chemistry letters, 2010/10/08, Volume 2, Issue 1, p.39-42, (2010) Read More / View Supplemental Materials
Abstract
A concise silylamine approach to 2-amino-3-hydroxy-indoles with potent in vivo antimalaria activity.Urgaonkar, S., Cortese JF, Barker RH, Cromwell M., Serrano AE, Wirth DF, Clardy J., and Mazitschek R. Organic letters, 2010/09/17, Volume 12, Issue 18, p.3998-4001, (2010) Read More / View Supplemental Materials
Abstract
Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease.Bradner, JE, Mak R., Tanguturi SK, Mazitschek R., Haggarty SJ, Ross K., Chang CY, Bosco J., West N., Morse E., Lin K., Shen JP, Kwiatkowski NP, Gheldof N., Dekker J., DeAngelo DJ, Carr SA, Schreiber SL, Golub T. R., and Ebert BL Proceedings of the National Academy of Sciences of the United States of America, 2010/07/13, Volume 107, Issue 28, p.12617-22, (2010) Read More / View Supplemental Materials
Abstract
Chemical phylogenetics of histone deacetylases.Bradner, JE, West N., Grachan ML, Greenberg EF, Haggarty SJ, Warnow T., and Mazitschek R. Nature chemical biology, 2010/03/01, Volume 6, Issue 3, p.238-243, (2010) Read More / View Supplemental Materials
Abstract
Antiplasmodial activity of piperazine sulfonamides.Martyn, DC, Cortese JF, Tyndall E., Dick J., Mazitschek R., Munoz B., and Clardy J. Bioorganic & medicinal chemistry letters, 2010/01/01, Volume 20, Issue 1, p.218-21, (2010) Read More / View Supplemental Materials
Abstract
Synthesis and antiplasmodial activity of novel 2,4-diaminopyrimidines.Martyn, DC, Nijjar A., Celatka CA, Mazitschek R., Cortese JF, Tyndall E., Liu H., Fitzgerald MM, O'Shea TJ, Danthi S., and Clardy J. Bioorganic & medicinal chemistry letters, 2010/01/01, Volume 20, Issue 1, p.228-31, (2010) Read More / View Supplemental Materials
Abstract
2009
Identification and characterization of small molecule inhibitors of a class I histone deacetylase from Plasmodium falciparum.Patel, V., Mazitschek R., Coleman B., Nguyen C., Urgaonkar S., Cortese J., Barker RH, Greenberg E., Tang W., Bradner JE, Schreiber SL, Duraisingh MT, Wirth DF, and Clardy J. Journal of medicinal chemistry, 2009/04/23, Volume 52, Issue 8, p.2185-7, (2009) Read More / View Supplemental Materials
Abstract
2008
Expression-based screening identifies the combination of histone deacetylase inhibitors and retinoids for neuroblastoma differentiation.Hahn, CK, Ross KN, Warrington IM, Mazitschek R., Kanegai CM, Wright RD, Kung AL, Golub T. R., and Stegmaier K. Proceedings of the National Academy of Sciences of the United States of America, 2008/07/15, Volume 105, Issue 28, p.9751-6, (2008) Read More / View Supplemental Materials
Abstract
Development of a fluorescence polarization based assay for histone deacetylase ligand discovery.Mazitschek, R., Patel V., Wirth DF, and Clardy J. Bioorganic & medicinal chemistry letters, 2008/05/01, Volume 18, Issue 9, p.2809-12, (2008) Read More / View Supplemental Materials
Abstract
2006
A robust small-molecule microarray platform for screening cell lysates.Bradner, JE, McPherson OM, Mazitschek R., Barnes-Seeman D., Shen JP, Dhaliwal J., Stevenson KE, Duffner JL, Park SB, Neuberg DS, Nghiem P., Schreiber SL, and Koehler AN Chemistry & biology, 2006/05/01, Volume 13, Issue 5, p.493-504, (2006) Read More / View Supplemental Materials
Abstract
2005
Synthesis and biological evaluation of novel fumagillin and ovalicin analogues.Mazitschek, R., Huwe A., and Giannis A. Organic & biomolecular chemistry, 2005/06/07, Volume 3, Issue 11, p.2150-4, (2005) Read More / View Supplemental Materials
Abstract
  • Showing 1-20 of 20 Results