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2016
Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints.Koyama, S., Akbay EA, Li YY, Herter-Sprie GS, Buczkowski KA, Richards W. G., Gandhi L., Redig AJ, Rodig SJ, Asahina H., Jones RE, Kulkarni MM, Kuraguchi M., Palakurthi S., Fecci PE, Johnson B. E., Janne PA, Engelman JA, Gangadharan SP, Costa DB, et al. Nature communications, 2016/02/17, Volume 7, p.10501, (2016) Read More / View Supplemental Materials
Abstract
2014
Kinase domain activation of FGFR2 yields high-grade lung adenocarcinoma sensitive to a pan-FGFR inhibitor in a mouse model of NSCLC.Wong, KK, Tchaicha JH, Akbay EA, Altabef A., Mikse OR, Kikuchi E., Rhee K., Liao RG, Bronson RT, Sholl LM, Meyerson M., and Hammerman PS Cancer research, 2014/07/17, (2014) Read More / View Supplemental Materials
Abstract
Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer.Saha, SK, Parachoniak CA, Ghanta KS, Fitamant J., Ross KN, Najem MS, Gurumurthy S., Akbay EA, Sia D., Cornella H., Miltiadous O., Walesky C., Deshpande V., Zhu AX, Hezel AF, Yen KE, Straley KS, Travins J., Popovici-Muller J., Gliser C., et al. Nature, 2014/07/02, (2014) Read More / View Supplemental Materials
Abstract
Loss of Lkb1 and Pten Leads to Lung Squamous Cell Carcinoma with Elevated PD-L1 Expression.Xu, C., Fillmore CM, Koyama S., Wu H., Zhao Y., Chen Z., Herter-Sprie GS, Akbay EA, Tchaicha JH, Altabef A., Reibel JB, Walton Z., Ji H., Watanabe H., Jänne PA, Castrillon DH, Rustgi AK, Bass AJ, Freeman GJ, Padera RF, et al. Cancer cell, 2014/05/12, Volume 25, Issue 5, p.590-604, (2014) Read More / View Supplemental Materials
Abstract
2013
Activation of the PD-1 pathway contributes to immune escape in EGFR-driven lung tumors.Akbay, EA, Koyama S., Carretero J., Altabef A., Tchaicha JH, Christensen CL, Mikse OR, Cherniack AD, Beauchamp EM, Pugh TJ, Wilkerson MD, Fecci PE, Butaney M., Reibel JB, Soucheray M., Cohoon TJ, Janne PA, Meyerson M., Hayes DN, Shapiro GI, et al. Cancer discovery, 2013/09/27, (2013) Read More / View Supplemental Materials
Abstract
  • Showing 1-5 of 5 Results