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Submitted
Synthesis, cellular evaluation and mechanism-of-action of piperlongumine analogsAdams, DJ, Dai M., Pellegrino G., Wagner BK, Stern AM, Shamji AF, and Schreiber SL, (Submitted) Read More / View Supplemental Materials
2014
Automated Structure-Activity Relationship Mining: Connecting Chemical Structure to Biological Profiles.Wawer, MJ, Jaramillo DE, Dančik V., Fass DM, Haggarty SJ, Shamji AF, Wagner BK, Schreiber SL, and Clemons PA Journal of biomolecular screening, 2014/04/07, (2014) Read More / View Supplemental Materials
Abstract
Targeting the pancreatic β-cell to treat diabetes.Vetere, A., Choudhary A., Burns SM, and Wagner BK Nature reviews. Drug discovery, 2014/02/14, (2014) Read More / View Supplemental Materials
Abstract
Connecting Small Molecules with Similar Assay Performance Profiles Leads to New Biological Hypotheses.Dancík, V., Carrel H., Bodycombe NE, Seiler KP, Fomina-Yadlin D., Kubicek ST, Hartwell K., Shamji AF, Wagner BK, and Clemons PA Journal of biomolecular screening, 2014/01/24, (2014) Read More / View Supplemental Materials
Abstract
2013
A Small-Molecule Inducer of PDX1 Expression Identified by High-Throughput Screening.Yuan, Y., Hartland K., Boskovic Z., Wang Y., Walpita D., Lysy PA, Zhong C., Young DW, Kim YK, Tolliday NJ, Sokal EM, Schreiber SL, and Wagner BK Chemistry & biology, 2013/11/23, (2013) Read More / View Supplemental Materials
Abstract
Small-molecule inhibition of inflammatory β-cell death.Lundh, M., Scully SS, Mandrup-Poulsen T., and Wagner BK Diabetes, obesity & metabolism, 2013/09/01, Volume 15 Suppl 3, p.176-84, (2013) Read More / View Supplemental Materials
Abstract
Gossypol and an HMT G9a inhibitor act in synergy to induce cell death in pancreatic cancer cells.Yuan, Y., Tang AJ, Castoreno AB, Kuo SY, Wang Q., Kuballa P., Xavier R., Shamji AF, Schreiber SL, and Wagner BK Cell death & disease, 2013/06/27, Volume 4, p.e690, (2013) Read More / View Supplemental Materials
Abstract
Small-Molecule Inhibitors of Cytokine-Mediated STAT1 Signal Transduction in β-Cells with Improved Aqueous Solubility.Scully, SS, Tang AJ, Lundh M., Mosher CM, Perkins KM, and Wagner BK Journal of medicinal chemistry, 2013/05/23, Volume 56, Issue 10, p.4125-9, (2013) Read More / View Supplemental Materials
Abstract
Target identification and mechanism of action in chemical biology and drug discovery.Schenone, M., Dančík V., Wagner BK, and Clemons PA Nature chemical biology, 2013/04/01, Volume 9, Issue 4, p.232-40, (2013) Read More / View Supplemental Materials
Abstract
Discovery of Small-Molecule Enhancers of Reactive Oxygen Species That are Nontoxic or Cause Genotype-Selective Cell Death.Adams, DJ, Boskovic ZV, Theriault JR, Wang AJ, Stern AM, Wagner BK, Shamji AF, and Schreiber SL ACS chemical biology, 2013/03/25, (2013) Read More / View Supplemental Materials
Abstract
2012
Synthesis, cellular evaluation, and mechanism of action of piperlongumine analogs.Adams, DJ, Dai M., Pellegrino G., Wagner BK, Stern AM, Shamji AF, and Schreiber SL Proceedings of the National Academy of Sciences of the United States of America, 2012/09/18, Volume 109, Issue 38, p.15115-20, (2012) Read More / View Supplemental Materials
Abstract
Inhibition of histone deacetylase 3 protects Beta cells from cytokine-induced apoptosis.Chou, DH, Holson EB, Wagner FF, Tang AJ, Maglathlin RL, Lewis TA, Schreiber SL, and Wagner BK Chemistry & biology, 2012/06/22, Volume 19, Issue 6, p.669-73, (2012) Read More / View Supplemental Materials
Abstract
A Small-Molecule Probe of the Histone Methyltransferase G9a Induces Cellular Senescence in Pancreatic Adenocarcinoma.Yuan, Y., Wang Q., Paulk J., Kubicek S., Kemp MM, Adams DJ, Shamji AF, Wagner BK, and Schreiber SL ACS chemical biology, 2012/04/30, (2012) Read More / View Supplemental Materials
Abstract
Chromatin-targeting small molecules cause class-specific transcriptional changes in pancreatic endocrine cells.Kubicek, S., Gilbert JC, Fomina-Yadlin D., Gitlin AD, Yuan Y., Wagner FF, Holson EB, Luo T., Lewis TA, Taylor B., Gupta S., Shamji AF, Wagner BK, Clemons PA, and Schreiber SL Proceedings of the National Academy of Sciences of the United States of America, 2012/04/03, Volume 109, Issue 14, p.5364-9, (2012) Read More / View Supplemental Materials
Abstract
High-throughput real-time PCR for detection of gene-expression levels.Wagner, BK, and Arany Z. Methods in molecular biology (Clifton, N.J.), 2012/01/09, Volume 486, p.167-75, (2012) Read More / View Supplemental Materials
Abstract
Chemical Methods to Induce Beta-Cell Proliferation.Vetere, A., and Wagner BK International journal of endocrinology, 2012/01/01, Volume 2012, p.925143, (2012) Read More / View Supplemental Materials
Abstract
Correction: GW8510 Increases Insulin Expression in Pancreatic Alpha Cells through Activation of p53 Transcriptional Activity.Fomina-Yadlin, D., Kubicek S., Vetere A., Hu He KH, Schreiber SL, and Wagner BK PloS one, 2012/01/01, Volume 7, Issue 3, (2012) Read More / View Supplemental Materials
Abstract
GW8510 increases insulin expression in pancreatic alpha cells through activation of p53 transcriptional activity.Fomina-Yadlin, D., Kubicek S., Vetere A., He KH, Schreiber SL, and Wagner BK PloS one, 2012/01/01, Volume 7, Issue 1, p.e28808, (2012) Read More / View Supplemental Materials
Abstract
2011
Chemical genomics: probing protein function using small molecules.Wagner, BK, Haggarty SJ, and Clemons PA American journal of pharmacogenomics : genomics-related research in drug development and clinical practice, 2011/12/08, Volume 4, Issue 5, p.313-20, (2011) Read More / View Supplemental Materials
Abstract
A Human Islet Cell Culture System for High-Throughput Screening.Walpita, D., Hasaka T., Spoonamore J., Vetere A., Takane KK, Fomina-Yadlin D., Fiaschi-Taesch N., Shamji A., Clemons PA, Stewart AF, Schreiber SL, and Wagner BK Journal of biomolecular screening, 2011/12/07, (2011) Read More / View Supplemental Materials
Abstract
Synthesis of a novel suppressor of beta-cell apoptosis via diversity-oriented synthesis.Chou, DH, Duvall JR, Gerard B., Liu H., Pandya BA, Suh BC, Forbeck EM, Faloon P., Wagner BK, and Marcaurelle LA ACS medicinal chemistry letters, 2011/09/08, Volume 2, Issue 9, p.698-702, (2011) Read More / View Supplemental Materials
Abstract
Quantifying structure and performance diversity for sets of small molecules comprising small-molecule screening collections.Clemons, PA, Wilson JA, Dančík V., Muller S., Carrinski HA, Wagner BK, Koehler AN, and Schreiber SL Proceedings of the National Academy of Sciences of the United States of America, 2011/04/26, Volume 108, Issue 17, p.6817-22, (2011) Read More / View Supplemental Materials
Abstract
Screening: Low-fat worms on drugs.Wagner, BK Nature chemical biology, 2011/04/01, Volume 7, Issue 4, p.194-5, (2011) Read More / View Supplemental Materials
2010
Grand challenge commentary: Chemical transdifferentiation and regenerative medicine.Wagner, BK Nature chemical biology, 2010/12/01, Volume 6, Issue 12, p.877-9, (2010) Read More / View Supplemental Materials
Abstract
Small molecules of different origins have distinct distributions of structural complexity that correlate with protein-binding profiles.Clemons, PA, Bodycombe NE, Carrinski HA, Wilson JA, Shamji AF, Wagner BK, Koehler AN, and Schreiber SL Proceedings of the National Academy of Sciences of the United States of America, 2010/11/02, Volume 107, Issue 44, p.18787-92, (2010) Read More / View Supplemental Materials
Abstract
Towards patient-based cancer therapeutics.Cancer Target Discovery and Development, Network, Schreiber SL, Shamji AF, Clemons PA, Hon C., Koehler AN, Munoz B., Palmer M., Stern AM, Wagner BK, Powers S., Lowe SW, Guo X., Krasnitz A., Sawey ET, Sordella R., Stein L., Trotman LC, Califano A., Dalla-Favera R., et al. Nature biotechnology, 2010/09/01, Volume 28, Issue 9, p.904-6, (2010) Read More / View Supplemental Materials
Small-molecule inducers of insulin expression in pancreatic alpha-cells.Fomina-Yadlin, D., Kubicek S., Walpita D., Dancik V., Hecksher-Sørensen J., Bittker JA, Sharifnia T., Shamji A., Clemons PA, Wagner BK, and Schreiber SL Proceedings of the National Academy of Sciences of the United States of America, 2010/08/24, Volume 107, Issue 34, p.15099-104, (2010) Read More / View Supplemental Materials
Abstract
Small-Molecule Suppressors of Cytokine-Induced beta-Cell Apoptosis.Chou, DH, Bodycombe NE, Carrinski HA, Lewis TA, Clemons PA, Schreiber SL, and Wagner BK ACS chemical biology, 2010/08/20, Volume 5, Issue 8, p.729-34, (2010) Read More / View Supplemental Materials
Abstract
2009
Connecting synthetic chemistry decisions to cell and genome biology using small-molecule phenotypic profiling.Wagner, BK, and Clemons PA Current opinion in chemical biology, 2009/12/01, Volume 13, Issue 5-6, p.539-48, (2009) Read More / View Supplemental Materials
Abstract
2008
Small-molecule fluorophores to detect cell-state switching in the context of high-throughput screening.Wagner, BK, Carrinski HA, Ahn YH, Kim YK, Gilbert TJ, Fomina DA, Schreiber SL, Chang YT, and Clemons PA Journal of the American Chemical Society, 2008/04/02, Volume 130, Issue 13, p.4208-9, (2008) Read More / View Supplemental Materials
Abstract
Large-scale chemical dissection of mitochondrial function.Wagner, BK, Kitami T., Gilbert TJ, Peck D., Ramanathan A., Schreiber SL, Golub T. R., and Mootha VK Nature biotechnology, 2008/03/01, Volume 26, Issue 3, p.343-51, (2008) Read More / View Supplemental Materials
Abstract
2001
A one-bead, one-stock solution approach to chemical genetics: part 2.Clemons, PA, Koehler AN, Wagner BK, Sprigings TG, Spring DR, King RW, Schreiber SL, and Foley MA Chemistry & biology, 2001/12/01, Volume 8, Issue 12, p.1183-95, (2001) Read More / View Supplemental Materials
Abstract
  • Showing 1-32 of 32 Results