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Synthesis, cellular evaluation and mechanism-of-action of piperlongumine analogsAdams, DJ, Dai M., Pellegrino G., Wagner BK, Stern AM, Shamji AF, and Schreiber SL, (Submitted) Read More / View Supplemental Materials
2016
Analyzing and interpreting genome data at the network level with ConsensusPathDB.Herwig, R., Hardt C., Lienhard M., and Kamburov A. Nature protocols, 2016/10/01, Volume 11, Issue 10, p.1889-907, (2016) Read More / View Supplemental Materials
Abstract
A Genome-Wide Association Meta-Analysis of Attention-Deficit/Hyperactivity Disorder Symptoms in Population-Based Pediatric Cohorts.Middeldorp, CM, Hammerschlag AR, Ouwens KG, Groen-Blokhuis MM, St Pourcain B., Greven CU, Pappa I., Tiesler CM, Ang W., Nolte IM, Vilor-Tejedor N., Bacelis J., Ebejer JL, Zhao H., Davies GE, Ehli EA, Evans DM, Fedko IO, Guxens M., Hottenga JJ, et al. Journal of the American Academy of Child and Adolescent Psychiatry, 2016/10/01, Volume 55, Issue 10, p.896-905.e6, (2016) Read More / View Supplemental Materials
Abstract
High-Throughput Platform for Identifying Molecular Factors Involved in Phenotypic Stabilization of Primary Human Hepatocytes In Vitro.Shan, J., Logan DJ, Root DE, Carpenter AE, and Bhatia SN Journal of biomolecular screening, 2016/10/01, Volume 21, Issue 9, p.897-911, (2016) Read More / View Supplemental Materials
Abstract
Somatic ERCC2 Mutations Are Associated With a Distinct Mutational Signature in Muscle-Invasive Bladder Cancer.Mouw, K., Braunstein LZ, Kim J., Polak P., Getz G., and D'Andrea AD International journal of radiation oncology, biology, physics, 2016/10/01, Volume 96, Issue 2S, p.S54, (2016) Read More / View Supplemental Materials
Erratum to: Comparative genomics and transcriptomics of Pichia pastoris.Love, KR, Shah KA, Whittaker CA, Wu J., Bartlett MC, Ma D., Leeson RL, Priest M., Borowsky J., Young SK, and Love JC BMC genomics, 2016/09/28, Volume 17, Issue 1, p.762, (2016) Read More / View Supplemental Materials
Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.Rosenbluh, J., Mercer J., Shrestha Y., Oliver R., Tamayo P., Doench JG, Tirosh I., Piccioni F., Hartenian E., Horn H., Fagbami L., Root DE, Jaffe J., Lage K., Boehm JS, and Hahn WC Cell systems, 2016/09/28, Volume 3, Issue 3, p.302-316.e4, (2016) Read More / View Supplemental Materials
Abstract
Genome-wide associations for birth weight and correlations with adult disease.Horikoshi, M., Beaumont RN, Day FR, Warrington NM, Kooijman MN, Fernandez-Tajes J., Feenstra B., van Zuydam NR, Gaulton KJ, Grarup N., Bradfield JP, Strachan DP, Li-Gao R., Ahluwalia TS, Kreiner E., Rueedi R., Lyytikäinen LP, Cousminer DL, Wu Y., Thiering E., et al. Nature, 2016/09/28, (2016) Read More / View Supplemental Materials
Abstract
52 Genetic Loci Influencing Myocardial Mass.van der Harst, P., van Setten J., Verweij N., Vogler G., Franke L., Maurano MT, Wang X., Mateo Leach I., Eijgelsheim M., Sotoodehnia N., Hayward C., Sorice R., Meirelles O., Lyytikäinen LP, Polašek O., Tanaka T., Arking DE, Ulivi S., Trompet S., Müller-Nurasyid M., et al. Journal of the American College of Cardiology, 2016/09/27, Volume 68, Issue 13, p.1435-48, (2016) Read More / View Supplemental Materials
Abstract
Emerging roles of p53 and other tumour-suppressor genes in immune regulation.Muñoz-Fontela, C., Mandinova A., Aaronson SA, and Lee SW Nature reviews. Immunology, 2016/09/26, (2016) Read More / View Supplemental Materials
Abstract
Gene expression elucidates functional impact of polygenic risk for schizophrenia.Fromer, M., Roussos P., Sieberts SK, Johnson JS, Kavanagh DH, Perumal TM, Ruderfer DM, Oh EC, Topol A., Shah HR, Klei LL, Kramer R., Pinto D., Gümüş ZH, Cicek AE, Dang KK, Browne A., Lu C., Xie L., Readhead B., et al. Nature neuroscience, 2016/09/26, (2016) Read More / View Supplemental Materials
Abstract
Protein C receptor (PROCR) is a negative regulator of Th17 pathogenicity.Kishi, Y., Kondo T., Xiao S., Yosef N., Gaublomme J., Wu C., Wang C., Chihara N., Regev A., Joller N., and Kuchroo VK The Journal of experimental medicine, 2016/09/26, (2016) Read More / View Supplemental Materials
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Research Into Brain Disorders as an Example of Targeted Science.Hyman, SE, Landis SC, and Leshner AI JAMA, 2016/09/26, (2016) Read More / View Supplemental Materials
Schizophyllum commune has an extensive and functional alternative splicing repertoire.Gehrmann, T., Pelkmans JF, Lugones LG, Wösten HA, Abeel T., and Reinders MJ Scientific reports, 2016/09/23, Volume 6, p.33640, (2016) Read More / View Supplemental Materials
Abstract
Adaptive radiation by waves of gene transfer leads to fine-scale resource partitioning in marine microbes.Hehemann, JH, Arevalo P., Datta MS, Yu X., Corzett CH, Henschel A., Preheim SP, Timberlake S., Alm EJ, and Polz MF Nature communications, 2016/09/22, Volume 7, p.12860, (2016) Read More / View Supplemental Materials
Abstract
Genetic predisposition to elevated levels of C-reactive protein is associated with a decreased risk for preeclampsia.Spracklen, CN, Smith CJ, Saftlas AF, Triche EW, Bjonnes A., Keating BJ, Saxena R., Breheny PJ, Dewan AT, Robinson JG, Hoh J., and Ryckman KK Hypertension in pregnancy, 2016/09/22, p.1-10, (2016) Read More / View Supplemental Materials
Abstract
Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia.Sykes, DB, Kfoury YS, Mercier FE, Wawer MJ, Law JM, Haynes MK, Lewis TA, Schajnovitz A., Jain E., Lee D., Meyer H., Pierce KA, Tolliday NJ, Waller A., Ferrara SJ, Eheim AL, Stoeckigt D., Maxcy KL, Cobert JM, Bachand J., et al. Cell, 2016/09/22, Volume 167, Issue 1, p.171-186.e15, (2016) Read More / View Supplemental Materials
Abstract
LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis.Zheng, J., Erzurumluoglu AM, Elsworth BL, Kemp JP, Howe L., Haycock PC, Hemani G., Tansey K., Laurin C., Early Genetics and Lifecourse Epidemiology(EAGLE) Eczema Consortium, Pourcain BS, Warrington NM, Finucane HK, Price AL, Bulik-Sullivan BK, Anttila V., Paternoster L., Gaunt TR, Evans DM, and Neale BM Bioinformatics (Oxford, England), 2016/09/22, (2016) Read More / View Supplemental Materials
Abstract
A perspective on single cell behavior during infection.Avraham, R., and Hung DT Gut microbes, 2016/09/22, (2016) Read More / View Supplemental Materials
Abstract
Portable, On-Demand Biomolecular Manufacturing.Pardee, K., Slomovic S., Nguyen PQ, Lee JW, Donghia N., Burrill D., Ferrante T., McSorley FR, Furuta Y., Vernet A., Lewandowski M., Boddy CN, Joshi NS, and Collins JJ Cell, 2016/09/22, Volume 167, Issue 1, p.248-259.e12, (2016) Read More / View Supplemental Materials
Abstract
Prescription medication changes following direct-to-consumer personal genomic testing: findings from the Impact of Personal Genomics (PGen) Study.Carere, DA, VanderWeele TJ, Vassy JL, van der Wouden CH, Roberts JS, Kraft P., and Green RC Genetics in medicine : official journal of the American College of Medical Genetics, 2016/09/22, (2016) Read More / View Supplemental Materials
Abstract
Genomic prediction of coronary heart disease.Abraham, G., Havulinna AS, Bhalala OG, Byars SG, De Livera AM, Yetukuri L., Tikkanen E., Perola M., Schunkert H., Sijbrands EJ, Palotie A., Samani NJ, Salomaa V., Ripatti S., and Inouye M. European heart journal, 2016/09/21, (2016) Read More / View Supplemental Materials
Abstract
Increasing Generality and Power of Rare-Variant Tests by Utilizing Extended Pedigrees.Sul, JH, Cade BE, Cho MH, Qiao D., Silverman EK, Redline S., and Sunyaev S. American journal of human genetics, 2016/09/21, (2016) Read More / View Supplemental Materials
Abstract
Mutations in Human Accelerated Regions Disrupt Cognition and Social Behavior.Doan, RN, Bae BI, Cubelos B., Chang C., Hossain AA, Al-Saad S., Mukaddes NM, Oner O., Al-Saffar M., Balkhy S., Gascon GG, Homozygosity Mapping Consortium for Autism, Nieto M., and Walsh CA Cell, 2016/09/21, (2016) Read More / View Supplemental Materials
Abstract
The Simons Genome Diversity Project: 300 genomes from 142 diverse populations.Mallick, S., Li H., Lipson M., Mathieson I., Gymrek M., Racimo F., Zhao M., Chennagiri N., Nordenfelt S., Tandon A., Skoglund P., Lazaridis I., Sankararaman S., Fu Q., Rohland N., Renaud G., Erlich Y., Willems T., Gallo C., Spence JP, et al. Nature, 2016/09/21, (2016) Read More / View Supplemental Materials
Abstract
A Single-Cell Transcriptomic Map of the Human and Mouse Pancreas Reveals Inter- and Intra-cell Population Structure.Baron, M., Veres A., Wolock SL, Faust AL, Gaujoux R., Vetere A., Ryu JH, Wagner BK, Shen-Orr SS, Klein AM, Melton DA, and Yanai I. Cell systems, 2016/09/21, (2016) Read More / View Supplemental Materials
Abstract
The apo-structure of the leucine sensor Sestrin2 is still elusive.Saxton, RA, Knockenhauer KE, Schwartz TU, and Sabatini DM Science signaling, 2016/09/20, Volume 9, Issue 446, p.ra92, (2016) Read More / View Supplemental Materials
Abstract
FTO genotype and weight loss: systematic review and meta-analysis of 9563 individual participant data from eight randomised controlled trials.Livingstone, KM, Celis-Morales C., Papandonatos GD, Erar B., Florez JC, Jablonski KA, Razquin C., Marti A., Heianza Y., Huang T., Sacks FM, Svendstrup M., Sui X., Church TS, Jääskeläinen T., Lindström J., Tuomilehto J., Uusitupa M., Rankinen T., Saris WH, et al. BMJ (Clinical research ed.), 2016/09/20, Volume 354, p.i4707, (2016) Read More / View Supplemental Materials
Abstract
The Genetic Landscape of Renal Complications in Type 1 Diabetes.Sandholm, N., Van Zuydam N., Ahlqvist E., Juliusdottir T., Deshmukh HA, Rayner NW, Di Camillo B., Forsblom C., Fadista J., Ziemek D., Salem RM, Hiraki LT, Pezzolesi M., Trégouët D., Dahlström E., Valo E., Oskolkov N., Ladenvall C., Marcovecchio ML, Cooper J., et al. Journal of the American Society of Nephrology : JASN, 2016/09/19, (2016) Read More / View Supplemental Materials
Abstract
Local microRNA delivery targets Palladin and prevents metastatic breast cancer.Gilam, A., Conde J., Weissglas-Volkov D., Oliva N., Friedman E., Artzi N., and Shomron N. Nature communications, 2016/09/19, Volume 7, p.12868, (2016) Read More / View Supplemental Materials
Abstract
Multiplexed, targeted profiling of single-cell proteomes and transcriptomes in a single reaction.Genshaft, AS, Li S., Gallant CJ, Darmanis S., Prakadan SM, Ziegler CG, Lundberg M., Fredriksson S., Hong J., Regev A., Livak KJ, Landegren U., and Shalek AK Genome biology, 2016/09/19, Volume 17, Issue 1, p.188, (2016) Read More / View Supplemental Materials
Abstract
Regulation of X-linked gene expression during early mouse development by Rlim.Wang, F., Shin J., Shea JM, Yu J., Bošković A., Byron M., Zhu X., Shalek AK, Regev A., Lawrence JB, Torres EM, Zhu LJ, Rando OJ, and Bach I. eLife, 2016/09/19, Volume 5, (2016) Read More / View Supplemental Materials
Abstract
Tolerogenic dendritic cells.Takenaka, MC, and Quintana FJ Seminars in immunopathology, 2016/09/19, (2016) Read More / View Supplemental Materials
Abstract
Bromodomain Inhibitors Correct Bioenergetic Deficiency Caused by Mitochondrial Disease Complex I Mutations.Barrow, JJ, Balsa E., Verdeguer F., Tavares CD, Soustek MS, Hollingsworth LR 4th, Jedrychowski M., Vogel R., Paulo JA, Smeitink J., Gygi SP, Doench J., Root DE, and Puigserver P. Molecular cell, 2016/09/15, (2016) Read More / View Supplemental Materials
Abstract
Guidelines for Large-Scale Sequence-Based Complex Trait Association Studies: Lessons Learned from the NHLBI Exome Sequencing Project.Auer, PL, Reiner AP, Wang G., Kang HM, Abecasis GR, Altshuler D., Bamshad MJ, Nickerson DA, Tracy RP, Rich SS, NHLBI GO Exome Sequencing Project, and Leal SM American journal of human genetics, 2016/09/15, (2016) Read More / View Supplemental Materials
Abstract
Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors.Wagner, FF, Weïwer M., Steinbacher S., Schomburg A., Reinemer P., Gale JP, Campbell AJ, Fisher SL, Zhao WN, Reis SA, Hennig KM, Thomas M., Müller P., Jefson MR, Fass DM, Haggarty SJ, Zhang YL, and Holson EB Bioorganic & medicinal chemistry, 2016/09/15, Volume 24, Issue 18, p.4008-15, (2016) Read More / View Supplemental Materials
Abstract
Metabolites of Glutamate Metabolism Are Associated With Incident Cardiovascular Events in the PREDIMED PREvención con DIeta MEDiterránea (PREDIMED) Trial.Zheng, Y., Hu FB, Ruiz-Canela M., Clish CB, Dennis C., Salas-Salvado J., Hruby A., Liang L., Toledo E., Corella D., Ros E., Fitó M., Gómez-Gracia E., Arós F., Fiol M., Lapetra J., Serra-Majem L., Estruch R., and Martínez-González MA Journal of the American Heart Association, 2016/09/15, Volume 5, Issue 9, (2016) Read More / View Supplemental Materials
Abstract
Permanent inactivation of Huntington's disease mutation by personalized allele-specific CRISPR/Cas9.Shin, JW, Kim KH, Chao MJ, Atwal RS, Gillis T., Macdonald ME, Gusella JF, and Lee JM Human molecular genetics, 2016/09/15, (2016) Read More / View Supplemental Materials
Abstract
High-throughput discovery of novel developmental phenotypes.Dickinson, ME, Flenniken AM, Ji X., Teboul L., Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H., Adissu H., Baker CN, Bower L., Brown JM, Caddle LB, Chiani F., Clary D., Cleak J., Daly M. J., Denegre JM, Doe B., et al. Nature, 2016/09/14, (2016) Read More / View Supplemental Materials
Abstract
Synaptopodin Is a Coincidence Detector of Tyrosine versus Serine/Threonine Phosphorylation for the Modulation of Rho Protein Crosstalk in Podocytes.Buvall, L., Wallentin H., Sieber J., Andreeva S., Choi HY, Mundel P., and Greka A. Journal of the American Society of Nephrology : JASN, 2016/09/14, (2016) Read More / View Supplemental Materials
Abstract
Magnetically Actuated Protease Sensors for in Vivo Tumor Profiling.Schuerle, S., Dudani JS, Christiansen MG, Anikeeva P., and Bhatia SN Nano letters, 2016/09/13, (2016) Read More / View Supplemental Materials
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Peripheral Blood Transcriptomic Signatures of Fasting Glucose and Insulin Concentrations.Chen, BH, Hivert MF, Peters MJ, Pilling LC, Hogan JD, Pham LM, Harries LW, Fox CS, Bandinelli S., Dehghan A., Hernandez DG, Hofman A., Hong J., Joehanes R., Johnson AD, Munson PJ, Rybin DV, Singleton AB, Uitterlinden AG, Ying S., et al. Diabetes, 2016/09/13, (2016) Read More / View Supplemental Materials
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The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals.Ehret, GB, Ferreira T., Chasman DI, Jackson AU, Schmidt EM, Johnson T., Thorleifsson G., Luan J., Donnelly LA, Kanoni S., Petersen AK, Pihur V., Strawbridge RJ, Shungin D., Hughes MF, Meirelles O., Kaakinen M., Bouatia-Naji N., Kristiansson K., Shah S., et al. Nature genetics, 2016/09/12, (2016) Read More / View Supplemental Materials
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Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci.Liu, C., Kraja AT, Smith JA, Brody JA, Franceschini N., Bis JC, Rice K., Morrison AC, Lu Y., Weiss S., Guo X., Palmas W., Martin LW, Chen YI, Surendran P., Drenos F., Cook JP, Auer PL, Chu AY, Giri A., et al. Nature genetics, 2016/09/12, (2016) Read More / View Supplemental Materials
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Physiologic Expression of Sf3b1(K700E) Causes Impaired Erythropoiesis, Aberrant Splicing, and Sensitivity to Therapeutic Spliceosome Modulation.Obeng, EA, Chappell RJ, Seiler M., Chen MC, Campagna DR, Schmidt PJ, Schneider RK, Lord AM, Wang L., Gambe RG, McConkey ME, Ali AM, Raza A., Yu L., Buonamici S., Smith PG, Mullally A., Wu CJ, Fleming MD, and Ebert BL Cancer cell, 2016/09/12, Volume 30, Issue 3, p.404-17, (2016) Read More / View Supplemental Materials
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Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension.Surendran, P., Drenos F., Young R., Warren H., Cook JP, Manning AK, Grarup N., Sim X., Barnes DR, Witkowska K., Staley JR, Tragante V., Tukiainen T., Yaghootkar H., Masca N., Freitag DF, Ferreira T., Giannakopoulou O., Tinker A., Harakalova M., et al. Nature genetics, 2016/09/12, (2016) Read More / View Supplemental Materials
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Targeted Sequencing of Genome Wide Significant Loci Associated with Bone Mineral Density (BMD) Reveals Significant Novel and Rare Variants: The Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Targeted Sequencing Study.Hsu, YH, Li G., Liu CT, Brody JA, Karasik D., Chou WC, Demissie S., Nandakumar K., Zhou Y., Cheng CH, Gill R., Gibbs RA, Muzny D., Santibanez J., Estrada K., Rivadeneira F., Harris T., Gudnason V., Uitterlinden A., Psaty BM, et al. Human molecular genetics, 2016/09/11, (2016) Read More / View Supplemental Materials
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LINC00520 is induced by Src, STAT3, and PI3K and plays a functional role in breast cancer.Henry, WS, Hendrickson DG, Beca F., Glass B., Lindahl-Allen M., He L., Ji Z., Struhl K., Beck AH, Rinn JL, and Toker A. Oncotarget, 2016/09/10, (2016) Read More / View Supplemental Materials
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A Genome-wide CRISPR Death Screen Identifies Genes Essential for Oxidative Phosphorylation.Arroyo, JD, Jourdain AA, Calvo SE, Ballarano CA, Doench JG, Root DE, and Mootha VK Cell metabolism, 2016/09/09, (2016) Read More / View Supplemental Materials
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MicroRNA inhibition fine-tunes and provides robustness to the restriction point switch of the cell cycle.Del Rosario, RC, Damasco JR, and Aguda BD Scientific reports, 2016/09/09, Volume 6, p.32823, (2016) Read More / View Supplemental Materials
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Morphometricity as a measure of the neuroanatomical signature of a trait.Sabuncu, MR, Ge T., Holmes AJ, Smoller JW, Buckner RL, Fischl B., and Alzheimer's Disease Neuroimaging Initiative Proceedings of the National Academy of Sciences of the United States of America, 2016/09/09, (2016) Read More / View Supplemental Materials
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Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers.Mayers, JR, Torrence ME, Danai LV, Papagiannakopoulos T., Davidson SM, Bauer MR, Lau AN, Ji BW, Dixit PD, Hosios AM, Muir A., Chin CR, Freinkman E., Jacks T., Wolpin BM, Vitkup D., and Vander Heiden MG Science (New York, N.Y.), 2016/09/09, Volume 353, Issue 6304, p.1161-5, (2016) Read More / View Supplemental Materials
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A Distinct Gene Module for Dysfunction Uncoupled from Activation in Tumor-Infiltrating T Cells.Singer, M., Wang C., Cong L., Marjanovic ND, Kowalczyk MS, Zhang H., Nyman J., Sakuishi K., Kurtulus S., Gennert D., Xia J., Kwon JY, Nevin J., Herbst RH, Yanai I., Rozenblatt-Rosen O., Kuchroo VK, Regev A., and Anderson AC Cell, 2016/09/08, Volume 166, Issue 6, p.1500-1511.e9, (2016) Read More / View Supplemental Materials
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Diversity-Oriented Synthesis as a Strategy for Fragment Evolution against GSK3β.Wang, Y., Wach JY, Sheehan P., Zhong C., Zhan C., Harris R., Almo SC, Bishop J., Haggarty SJ, Ramek A., Berry KN, O'Herin C., Koehler AN, Hung AW, and Young DW ACS medicinal chemistry letters, 2016/09/08, Volume 7, Issue 9, p.852-6, (2016) Read More / View Supplemental Materials
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Gut Microbiota, Inflammation, and Colorectal Cancer.Brennan, CA, and Garrett WS Annual review of microbiology, 2016/09/08, Volume 70, p.395-411, (2016) Read More / View Supplemental Materials
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The impact of personal genomics on risk perceptions and medical decision-making.Krieger, JL, Murray F., Roberts JS, and Green RC Nature biotechnology, 2016/09/08, Volume 34, Issue 9, p.912-8, (2016) Read More / View Supplemental Materials
Plasma Levels of Fatty Acid-Binding Protein 4, Retinol-Binding Protein 4, High-Molecular-Weight Adiponectin, and Cardiovascular Mortality Among Men With Type 2 Diabetes: A 22-Year Prospective Study.Liu, G., Ding M., Chiuve SE, Rimm EB, Franks PW, Meigs JB, Hu FB, and Sun Q. Arteriosclerosis, thrombosis, and vascular biology, 2016/09/08, (2016) Read More / View Supplemental Materials
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Antimicrobial Chemicals Are Associated with Elevated Antibiotic Resistance Genes in the Indoor Dust Microbiome.Hartmann, EM, Hickey R., Hsu T., Betancourt Román CM, Chen J., Schwager R., Kline J., Brown GZ, Halden RU, Huttenhower C., and Green JL Environmental science & technology, 2016/09/07, (2016) Read More / View Supplemental Materials
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Diversity-oriented synthesis yields novel multistage antimalarial inhibitors.Kato, N., Comer E., Sakata-Kato T., Sharma A., Sharma M., Maetani M., Bastien J., Brancucci NM, Bittker JA, Corey V., Clarke D., Derbyshire ER, Dornan G., Duffy S., Eckley S., Itoe MA, Koolen KM, Lewis TA, Lui PS, Lukens AK, et al. Nature, 2016/09/07, (2016) Read More / View Supplemental Materials
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Evolutionary dynamics of abundant stop codon readthrough.Jungreis, I., Chan CS, Waterhouse RM, Fields G., Lin MF, and Kellis M. Molecular biology and evolution, 2016/09/07, (2016) Read More / View Supplemental Materials
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Recurrent De Novo and Biallelic Variation of ATAD3A, Encoding a Mitochondrial Membrane Protein, Results in Distinct Neurological Syndromes.Harel, T., Yoon WH, Garone C., Gu S., Coban-Akdemir Z., Eldomery MK, Posey JE, Jhangiani SN, Rosenfeld JA, Cho MT, Fox S., Withers M., Brooks SM, Chiang T., Duraine L., Erdin S., Yuan B., Shao Y., Moussallem E., Lamperti C., et al. American journal of human genetics, 2016/09/07, (2016) Read More / View Supplemental Materials
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ATAD2 is an epigenetic reader of newly synthesized histone marks during DNA replication.Koo, SJ, Fernández-Montalván AE, Badock V., Ott CJ, Holton SJ, von Ahsen O., Toedling J., Vittori S., Bradner JE, and Gorjánácz M. Oncotarget, 2016/09/06, (2016) Read More / View Supplemental Materials
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Genome-wide association study of antisocial personality disorder.Rautiainen, MR, Paunio T., Repo-Tiihonen E., Virkkunen M., Ollila HM, Sulkava S., Jolanki O., Palotie A., and Tiihonen J. Translational psychiatry, 2016/09/06, Volume 6, Issue 9, p.e883, (2016) Read More / View Supplemental Materials
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Variation in the molecular clock of primates.Moorjani, P., Amorim CE, Arndt PF, and Przeworski M. Proceedings of the National Academy of Sciences of the United States of America, 2016/09/06, (2016) Read More / View Supplemental Materials
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High-throughput measurement of single-cell growth rates using serial microfluidic mass sensor arrays.Cermak, N., Olcum S., Delgado FF, Wasserman SC, Payer KR, Murakami MA, Knudsen SM, Kimmerling RJ, Stevens MM, Kikuchi Y., Sandikci A., Ogawa M., Agache V., Baléras F., Weinstock DM, and Manalis SR Nature biotechnology, 2016/09/05, (2016) Read More / View Supplemental Materials
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In vivo Ebola virus infection leads to a strong innate response in circulating immune cells.Caballero, IS, Honko AN, Gire SK, Winnicki SM, Melé M., Gerhardinger C., Lin AE, Rinn JL, Sabeti PC, Hensley LE, and Connor JH BMC genomics, 2016/09/05, Volume 17, p.707, (2016) Read More / View Supplemental Materials
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A proposal for validation of antibodies.Uhlen, M., Bandrowski A., Carr S., Edwards A., Ellenberg J., Lundberg E., Rimm DL, Rodriguez H., Hiltke T., Snyder M., and Yamamoto T. Nature methods, 2016/09/05, (2016) Read More / View Supplemental Materials
A Size-Selective Intracellular Delivery Platform.Saung, MT, Sharei A., Adalsteinsson VA, Cho N., Kamath T., Ruiz C., Kirkpatrick J., Patel N., Mino-Kenudson M., Thayer SP, Langer R., Jensen KF, Liss AS, and Love JC Small (Weinheim an der Bergstrasse, Germany), 2016/09/04, (2016) Read More / View Supplemental Materials
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An open-source solution for advanced imaging flow cytometry data analysis using machine learning.Hennig, H., Rees P., Blasi T., Kamentsky L., Hung J., Dao D., Carpenter AE, and Filby A. Methods (San Diego, Calif.), 2016/09/02, (2016) Read More / View Supplemental Materials
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Variants in SLC18A3, vesicular acetylcholine transporter, cause congenital myasthenic syndrome.O'Grady, GL, Verschuuren C., Yuen M., Webster R., Menezes M., Fock JM, Pride N., Best HA, Benavides Damm T., Turner C., Lek M., Engel AG, North KN, Clarke NF, Macarthur DG, Kamsteeg EJ, and Cooper ST Neurology, 2016/09/02, (2016) Read More / View Supplemental Materials
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Accelerating Innovation in Health IT.Rudin, RS, Bates DW, and MacRae C. The New England journal of medicine, 2016/09/01, Volume 375, Issue 9, p.815-7, (2016) Read More / View Supplemental Materials
Cell Painting, a high-content image-based assay for morphological profiling using multiplexed fluorescent dyes.Bray, MA, Singh S., Han H., Davis CT, Borgeson B., Hartland C., Kost-Alimova M., Gustafsdottir SM, Gibson CC, and Carpenter AE Nature protocols, 2016/09/01, Volume 11, Issue 9, p.1757-74, (2016) Read More / View Supplemental Materials
Abstract
Correlating Drug-Target Kinetics and In vivo Pharmacodynamics: Long Residence Time Inhibitors of the FabI Enoyl-ACP Reductase.Daryaee, F., Chang A., Schiebel J., Lu Y., Zhang Z., Kapilashrami K., Walker SG, Kisker C., Sotriffer CA, Fisher SL, and Tonge PJ Chemical science, 2016/09/01, Volume 7, Issue 9, p.5945-5954, (2016) Read More / View Supplemental Materials
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CRISPR/Cas9 gene editing special issue.Doench, JG The FEBS journal, 2016/09/01, Volume 283, Issue 17, p.3160-1, (2016) Read More / View Supplemental Materials
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Erratum to: Type IV collagen drives alveolar epithelial-endothelial association and the morphogenetic movements of septation.Loscertales, M., Nicolaou F., Jeanne M., Longoni M., Gould DB, Sun Y., Maalouf FI, Nagy N., and Donahoe PK BMC biology, 2016/09/01, Volume 14, Issue 1, p.73, (2016) Read More / View Supplemental Materials
A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes.Sidik, SM, Huet D., Ganesan SM, Huynh MH, Wang T., Nasamu AS, Thiru P., Saeij JP, Carruthers VB, Niles JC, and Lourido S. Cell, 2016/09/01, (2016) Read More / View Supplemental Materials
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Massive contribution of transposable elements to mammalian regulatory sequences.Rayan, NA, Del Rosario RC, and Prabhakar S. Seminars in cell & developmental biology, 2016/09/01, Volume 57, p.51-6, (2016) Read More / View Supplemental Materials
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Polycomb and trithorax opposition in development and disease.Poynter, ST, and Kadoch C. Wiley interdisciplinary reviews. Developmental biology, 2016/09/01, (2016) Read More / View Supplemental Materials
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The Rheumatoid Arthritis Risk Variant CCR6DNP Regulates CCR6 via PARP-1.Li, G., Cunin P., Wu D., Diogo D., Yang Y., Okada Y., Plenge RM, and Nigrovic PA PLoS genetics, 2016/09/01, Volume 12, Issue 9, p.e1006292, (2016) Read More / View Supplemental Materials
Abstract
Selenoprotein H is an essential regulator of redox homeostasis that cooperates with p53 in development and tumorigenesis.Cox, AG, Tsomides A., Kim AJ, Saunders D., Hwang KL, Evason KJ, Heidel J., Brown KK, Yuan M., Lien EC, Lee BC, Nissim S., Dickinson B., Chhangawala S., Chang CJ, Asara JM, Houvras Y., Gladyshev VN, and Goessling W. Proceedings of the National Academy of Sciences of the United States of America, 2016/09/01, (2016) Read More / View Supplemental Materials
Abstract
Whole Exome Sequencing in Atrial Fibrillation.Lubitz, SA, Brody JA, Bihlmeyer NA, Roselli C., Weng LC, Christophersen IE, Alonso A., Boerwinkle E., Gibbs RA, Bis JC, NHLBI GO Exome Sequencing Project, Cupples LA, Mohler PJ, Nickerson DA, Muzny D., Perez MV, Psaty BM, Soliman EZ, Sotoodehnia N., Lunetta KL, et al. PLoS genetics, 2016/09/01, Volume 12, Issue 9, p.e1006284, (2016) Read More / View Supplemental Materials
Abstract
Modulating Neuronal Competition Dynamics in the Dentate Gyrus to Rejuvenate Aging Memory Circuits.McAvoy, KM, Scobie KN, Berger S., Russo C., Guo N., Decharatanachart P., Vega-Ramirez H., Miake-Lye S., Whalen M., Nelson M., Bergami M., Bartsch D., Hen R., Berninger B., and Sahay A. Neuron, 2016/08/31, (2016) Read More / View Supplemental Materials
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Normal hematologic parameters and fetal hemoglobin silencing with heterozygous IKZF1 mutations.Abdulhay, N., Fiorini C., Kumánovics A., Sun AA, Hansen-Rejali J., Voelkerding KV, Rosenzweig SD, Hill HR, and Sankaran VG Blood, 2016/08/31, (2016) Read More / View Supplemental Materials
A PGC1α-mediated transcriptional axis suppresses melanoma metastasis.Luo, C., Lim JH, Lee Y., Granter SR, Thomas A., Vazquez F., Widlund HR, and Puigserver P. Nature, 2016/08/31, (2016) Read More / View Supplemental Materials
Abstract
Gene expression profiling at birth characterizing the preterm infant with early onset infection.Hilgendorff, A., Windhorst A., Klein M., Tchatalbachev S., Windemuth-Kieselbach C., Kreuder J., Heckmann M., Gkatzoflia A., Ehrhardt H., Mysliwietz J., Maier M., Izar B., Billion A., Gortner L., Chakraborty T., and Hossain H. Journal of molecular medicine (Berlin, Germany), 2016/08/30, (2016) Read More / View Supplemental Materials
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Mapping rare, deleterious mutations in Factor H: Association with early onset, drusen burden, and lower antigenic levels in familial AMD.Wagner, EK, Raychaudhuri S., Villalonga MB, Java A., Triebwasser MP, Daly M. J., Atkinson JP, and Seddon JM Scientific reports, 2016/08/30, Volume 6, p.31531, (2016) Read More / View Supplemental Materials
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A substrate-driven allosteric switch that enhances PDI catalytic activity.Bekendam, RH, Bendapudi PK, Lin L., Nag PP, Pu J., Kennedy DR, Feldenzer A., Chiu J., Cook KM, Furie B., Huang M., Hogg PJ, and Flaumenhaft R. Nature communications, 2016/08/30, Volume 7, p.12579, (2016) Read More / View Supplemental Materials
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The epigenome in Alzheimer's disease: current state and approaches for a new path to gene discovery and understanding disease mechanism.Klein, HU, Bennett DA, and De Jager PL Acta neuropathologica, 2016/08/29, (2016) Read More / View Supplemental Materials
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ESR1-Amplification-Associated Estrogen Receptor α Activity in Breast Cancer.Holst, F., and Singer CF Trends in endocrinology and metabolism: TEM, 2016/08/29, (2016) Read More / View Supplemental Materials
Fine-mapping, Novel Loci Identification, and SNP Association Transferability in a Genome-Wide Association Study of QRS Duration in African Americans.Evans, DS, Avery CL, Nalls MA, Li G., Barnard J., Smith EN, Tanaka T., Butler AM, Buxbaum SG, Alonso A., Arking DE, Berenson GS, Bis JC, Buyske S., Carty CL, Chen W., Chung MK, Cummings SR, Deo R., Eaton CB, et al. Human molecular genetics, 2016/08/29, (2016) Read More / View Supplemental Materials
Abstract
Genomic analysis of the evolution of fluoroquinolone resistance in Mycobacterium tuberculosis prior to tuberculosis diagnosis.Zhang, D., Gomez JE, Chien JY, Haseley N., Desjardins CA, Earl AM, Hsueh PR, and Hung DT Antimicrobial agents and chemotherapy, 2016/08/29, (2016) Read More / View Supplemental Materials
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Next-generation genotype imputation service and methods.Das, S., Forer L., Schönherr S., Sidore C., Locke AE, Wong AK, Vrieze SI, Chew EY, Levy S., McGue M., Schlessinger D., Stambolian D., Loh PR, Iacono WG, Swaroop A., Scott LJ, Cucca F., Kronenberg F., Boehnke M., Abecasis GR, et al. Nature genetics, 2016/08/29, (2016) Read More / View Supplemental Materials
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A Whole-Blood Transcriptome Meta-Analysis Identifies Gene Expression Signatures of Cigarette Smoking.Huan, T., Joehanes R., Schurmann C., Schramm K., Pilling LC, Peters MJ, Mägi R., DeMeo D., O'Connor GT, Ferrucci L., Teumer A., Homuth G., Biffar R., Völker U., Herder C., Waldenberger M., Peters A., Zeilinger S., Metspalu A., Hofman A., et al. Human molecular genetics, 2016/08/29, (2016) Read More / View Supplemental Materials
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Anti-inflammatory effects of melatonin in multiple sclerosis.Farez, MF, Calandri IL, Correale J., and Quintana FJ BioEssays : news and reviews in molecular, cellular and developmental biology, 2016/08/26, (2016) Read More / View Supplemental Materials
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Discovery of a proteinaceous cellular receptor for a norovirus.Orchard, RC, Wilen CB, Doench JG, Baldridge MT, McCune BT, Lee YC, Lee S., Pruett-Miller SM, Nelson CA, Fremont DH, and Virgin HW Science (New York, N.Y.), 2016/08/26, Volume 353, Issue 6302, p.933-6, (2016) Read More / View Supplemental Materials
Abstract
The hippocampus grows up.Rudenko, A., and Tsai LH Nature neuroscience, 2016/08/26, Volume 19, Issue 9, p.1190-1, (2016) Read More / View Supplemental Materials
Opportunities and challenges in modeling human brain disorders in transgenic primates.Jennings, CG, Landman R., Zhou Y., Sharma J., Hyman J., Movshon JA, Qiu Z., Roberts AC, Roe AW, Wang X., Zhou H., Wang L., Zhang F., Desimone R., and Feng G. Nature neuroscience, 2016/08/26, Volume 19, Issue 9, p.1123-30, (2016) Read More / View Supplemental Materials
Abstract
Absolute Quantification of Matrix Metabolites Reveals the Dynamics of Mitochondrial Metabolism.Chen, WW, Freinkman E., Wang T., Birsoy K., and Sabatini DM Cell, 2016/08/25, Volume 166, Issue 5, p.1324-1337.e11, (2016) Read More / View Supplemental Materials
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Cell-Type-Specific Alternative Splicing Governs Cell Fate in the Developing Cerebral Cortex.Zhang, X., Chen MH, Wu X., Kodani A., Fan J., Doan R., Ozawa M., Ma J., Yoshida N., Reiter JF, Black DL, Kharchenko PV, Sharp PA, and Walsh CA Cell, 2016/08/25, Volume 166, Issue 5, p.1147-1162.e15, (2016) Read More / View Supplemental Materials
Abstract
Comprehensive Classification of Retinal Bipolar Neurons by Single-Cell Transcriptomics.Shekhar, K., Lapan SW, Whitney IE, Tran NM, Macosko EZ, Kowalczyk M., Adiconis X., Levin JZ, Nemesh J., Goldman M., McCarroll SA, Cepko CL, Regev A., and Sanes JR Cell, 2016/08/25, Volume 166, Issue 5, p.1308-1323.e30, (2016) Read More / View Supplemental Materials
Abstract
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