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Submitted
Synthesis, cellular evaluation and mechanism-of-action of piperlongumine analogsAdams, DJ, Dai M., Pellegrino G., Wagner BK, Stern AM, Shamji AF, and Schreiber SL, (Submitted) Read More / View Supplemental Materials
2014
Hydroxamic Acid-Based Histone Deacetylase (HDAC) Inhibitors Can Mediate Neuroprotection Independent of HDAC Inhibition.Sleiman, SF, Olson DE, Bourassa MW, Karuppagounder SS, Zhang YL, Gale J., Wagner FF, Basso M., Coppola G., Pinto JT, Holson EB, and Ratan RR The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014/10/22, Volume 34, Issue 43, p.14328-37, (2014) Read More / View Supplemental Materials
Abstract
Autism spectrum disorder severity reflects the average contribution of de novo and familial influences.Robinson, EB, Samocha KE, Kosmicki JA, McGrath L., Neale BM, Perlis RH, and Daly M. J. Proceedings of the National Academy of Sciences of the United States of America, 2014/10/21, Volume 111, Issue 42, p.15161-5, (2014) Read More / View Supplemental Materials
Abstract
CHD8 regulates neurodevelopmental pathways associated with autism spectrum disorder in neural progenitors.Sugathan, A., Biagioli M., Golzio C., Erdin S., Blumenthal I., Manavalan P., Ragavendran A., Brand H., Lucente D., Miles J., Sheridan SD, Stortchevoi A., Kellis M., Haggarty SJ, Katsanis N., Gusella JF, and Talkowski ME Proceedings of the National Academy of Sciences of the United States of America, 2014/10/21, Volume 111, Issue 42, p.E4468-77, (2014) Read More / View Supplemental Materials
Abstract
Clonal outbreak of Plasmodium falciparum in eastern Panama.Obaldia N, 3rd, Baro NK, Calzada JE, Santamaria AM, Daniels R., Wong W., Chang HH, Hamilton EJ, Arevalo-Herrera M., Herrera S., Wirth DF, Hartl DL, Marti M., and Volkman SK The Journal of infectious diseases, 2014/10/21, (2014) Read More / View Supplemental Materials
Abstract
Diversity-Oriented Synthesis probe targets Plasmodium falciparum cytochrome b ubiquinone reduction site and synergizes with oxidation site inhibitors.Lukens, AK, Heidebrecht RW Jr, Mulrooney C., Beaudoin JA, Comer E., Duvall JR, Fitzgerald ME, Masi D., Galinsky K., Scherer CA, Palmer M., Munoz B., Foley M., Schreiber SL, Wiegand RC, and Wirth DF The Journal of infectious diseases, 2014/10/21, (2014) Read More / View Supplemental Materials
Abstract
Origin in Acinetobacter guillouiae and Dissemination of the Aminoglycoside-Modifying Enzyme Aph(3')-VI.Yoon, EJ, Goussard S., Touchon M., Krizova L., Cerqueira G., Murphy C., Lambert T., Grillot-Courvalin C., Nemec A., and Courvalin P. mBio, 2014/10/21, Volume 5, Issue 5, (2014) Read More / View Supplemental Materials
Abstract
Comprehensive variation discovery in single human genomes.Weisenfeld, NI, Yin S., Sharpe T., Lau B., Hegarty R., Holmes L., Sogoloff B., Tabbaa D., Williams L., Russ C., Nusbaum C., Lander E. S., Maccallum I., and Jaffe DB Nature genetics, 2014/10/19, (2014) Read More / View Supplemental Materials
Abstract
In vivo interrogation of gene function in the mammalian brain using CRISPR-Cas9.Swiech, L., Heidenreich M., Banerjee A., Habib N., Li Y., Trombetta J., Sur M., and Zhang F. Nature biotechnology, 2014/10/19, (2014) Read More / View Supplemental Materials
Abstract
An unbiased approach to identify endogenous substrates of "histone" deacetylase 8.Olson, DE, Udeshi ND, Wolfson NA, Pitcairn CA, Sullivan ED, Jaffe JD, Svinkina T., Natoli T., Lu X., Paulk J., McCarren P., Wagner FF, Barker D., Howe E., Lazzaro F., Gale JP, Zhang YL, Subramanian A., Fierke CA, Carr SA, et al. ACS chemical biology, 2014/10/17, Volume 9, Issue 10, p.2210-6, (2014) Read More / View Supplemental Materials
Abstract
Malawi polyomavirus is a prevalent human virus that interacts with known tumor suppressors.Berrios, C., Jung J., Primi B., Wang M., Pedamallu C., Duke F., Marcelus C., Cheng J., Garcea RL, Meyerson M., DeCaprio JA, and the TEDDY Study Group Journal of virology, 2014/10/15, (2014) Read More / View Supplemental Materials
Abstract
Characterization of HPV and host genome interactions in primary head and neck cancers.Parfenov, M., Pedamallu CS, Gehlenborg N., Freeman SS, Danilova L., Bristow CA, Lee S., Hadjipanayis AG, Ivanova EV, Wilkerson MD, Protopopov A., Yang L., Seth S., Song X., Tang J., Ren X., Zhang J., Pantazi A., Santoso N., Xu AW, et al. Proceedings of the National Academy of Sciences of the United States of America, 2014/10/13, (2014) Read More / View Supplemental Materials
Abstract
The Genomic Diversification of the Whole Acinetobacter Genus: Origins, Mechanisms, and Consequences.Touchon, M., Cury J., Yoon EJ, Krizova L., Cerqueira GC, Murphy C., Feldgarden M., Wortman J., Clermont D., Lambert T., Grillot-Courvalin C., Nemec A., Courvalin P., and Rocha EP Genome biology and evolution, 2014/10/13, (2014) Read More / View Supplemental Materials
Abstract
SNPsnap: a web-based tool for identification and annotation of matched SNPs.Pers, TH, Timshel P., and Hirschhorn JN Bioinformatics (Oxford, England), 2014/10/13, (2014) Read More / View Supplemental Materials
Abstract
Gluten sensitivity and relationship to psychiatric symptoms in people with schizophrenia.Jackson, J., Eaton W., Cascella N., Fasano A., Santora D., Sullivan K., Feldman S., Raley H., McMahon RP, Carpenter WT Jr, Demyanovich H., and Kelly DL Schizophrenia research, 2014/10/10, (2014) Read More / View Supplemental Materials
Abstract
Advancing the microbiome research community.Huttenhower, C., Knight R., Brown CT, Caporaso JG, Clemente JC, Gevers D., Franzosa EA, Kelley ST, Knights D., Ley RE, Mahurkar A., Ravel J., Scientists for Advancement of Microbiome Research, and White O. Cell, 2014/10/09, Volume 159, Issue 2, p.227-30, (2014) Read More / View Supplemental Materials
Abstract
Dnase2a Deficiency Uncovers Lysosomal Clearance of Damaged Nuclear DNA via Autophagy.Lan, YY, Londoño D., Bouley R., Rooney MS, and Hacohen N. Cell reports, 2014/10/09, Volume 9, Issue 1, p.180-92, (2014) Read More / View Supplemental Materials
Abstract
Genetic variation in the HLA region is associated with susceptibility to herpes zoster.Crosslin, DR, Carrell DS, Burt A., Kim DS, Underwood JG, Hanna DS, Comstock BA, Baldwin E., de Andrade M., Kullo IJ, Tromp G., Kuivaniemi H., Borthwick KM, McCarty CA, Peissig PL, Doheny KF, Pugh E., Kho A., Pacheco J., Hayes MG, et al. Genes and immunity, 2014/10/09, (2014) Read More / View Supplemental Materials
Abstract
Response and acquired resistance to everolimus in anaplastic thyroid cancer.Wagle, N., Grabiner BC, Van Allen EM, Amin-Mansour A., Taylor-Weiner A., Rosenberg M., Gray N., Barletta JA, Guo Y., Swanson SJ, Ruan DT, Hanna GJ, Haddad RI, Getz G., Kwiatkowski DJ, Carter SL, Sabatini DM, Jänne PA, Garraway LA, and Lorch JH The New England journal of medicine, 2014/10/09, Volume 371, Issue 15, p.1426-33, (2014) Read More / View Supplemental Materials
Abstract
Genome-wide Enrichment Analysis between Endometriosis and Obesity-related Traits Reveals Novel Susceptibility Loci.Rahmioglu, N., Macgregor S., Drong AW, Hedman AK, Harris HR, Randall JC, Prokopenko I., The International EndoGene Consortium(IEC), The GIANT Consortium, Nyholt DR, Morris AP, Montgomery GW, Missmer SA, Lindgren CM, Zondervan KT, and The International EndoGene Consortium IEC Human molecular genetics, 2014/10/08, (2014) Read More / View Supplemental Materials
Abstract
An exact arithmetic toolbox for a consistent and reproducible structural analysis of metabolic network models.Chindelevitch, L., Trigg J., Regev A., and Berger B. Nature communications, 2014/10/07, Volume 5, p.4893, (2014) Read More / View Supplemental Materials
Abstract
Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption.The Coffee and Caffeine Genetics, Consortium, Cornelis MC, Byrne EM, Esko T., Nalls MA, Ganna A., Paynter N., Monda KL, Amin N., Fischer K., Renstrom F., Ngwa JS, Huikari V., Cavadino A., Nolte IM, Teumer A., Yu K., Marques-Vidal P., Rawal R., Manichaikul A., et al. Molecular psychiatry, 2014/10/07, (2014) Read More / View Supplemental Materials
Abstract
Identification of Orai1 Channel Inhibitors by Using Minimal Functional Domains to Screen Small Molecule Microarrays.Sadaghiani, AM, Lee SM, Odegaard JI, Leveson-Gower DB, McPherson OM, Novick P., Kim MR, Koehler AN, Negrin R., Dolmetsch RE, and Park CY Chemistry & biology, 2014/10/07, (2014) Read More / View Supplemental Materials
Abstract
Investigating the possible causal association of smoking with depression and anxiety using Mendelian randomisation meta-analysis: the CARTA consortium.Taylor, AE, Fluharty ME, Bjørngaard JH, Gabrielsen ME, Skorpen F., Marioni RE, Campbell A., Engmann J., Mirza SS, Loukola A., Laatikainen T., Partonen T., Kaakinen M., Ducci F., Cavadino A., Husemoen LL, Ahluwalia TS, Jacobsen RK, Skaaby T., Ebstrup JF, et al. BMJ open, 2014/10/07, Volume 4, Issue 10, p.e006141, (2014) Read More / View Supplemental Materials
Abstract
Defining the role of common variation in the genomic and biological architecture of adult human height.Wood, AR, Esko T., Yang J., Vedantam S., Pers TH, Gustafsson S., Chu AY, Estrada K., Luan J., Kutalik Z., Amin N., Buchkovich ML, Croteau-Chonka DC, Day FR, Duan Y., Fall T., Fehrmann R., Ferreira T., Jackson AU, Karjalainen J., et al. Nature genetics, 2014/10/05, (2014) Read More / View Supplemental Materials
Abstract
CompMap: a reference-based compression program to speed up read mapping to related reference sequences.Zhu, Z., Li L., Zhang Y., Yang Y., and Yang X. Bioinformatics (Oxford, England), 2014/10/04, (2014) Read More / View Supplemental Materials
Abstract
Distinct effects of concomitant Jak2V617F expression and Tet2 loss in mice combine to promote disease progression in myeloproliferative neoplasms.Chen, E., Schneider RK, Breyfogle LJ, Rosen EA, Poveromo L., Elf S., Ko A., Brumme K., LeVine R., Ebert BL, and Mullally A. Blood, 2014/10/03, (2014) Read More / View Supplemental Materials
Abstract
A novel common variant in DCST2 is associated with length in early life and height in adulthood.van der Valk, RJ, Kreiner-Møller E., Kooijman MN, Guxens M., Stergiakouli E., Sääf A., Bradfield JP, Geller F., Hayes MG, Cousminer DL, Körner A., Thiering E., Curtin JA, Myhre R., Huikari V., Joro R., Kerkhof M., Warrington NM, Pitkänen N., Ntalla I., et al. Human molecular genetics, 2014/10/03, (2014) Read More / View Supplemental Materials
Abstract
Prostate cancer. Ubiquitylome analysis identifies dysregulation of effector substrates in SPOP-mutant prostate cancer.Theurillat, JP, Udeshi ND, Errington WJ, Svinkina T., Baca SC, Pop M., Wild PJ, Blattner M., Groner AC, Rubin MA, Moch H., Privé GG, Carr SA, and Garraway LA Science (New York, N.Y.), 2014/10/03, Volume 346, Issue 6205, p.85-9, (2014) Read More / View Supplemental Materials
Abstract
Ascertainment bias causes false signal of anticipation in genetic prion disease.Minikel, EV, Zerr I., Collins SJ, Ponto C., Boyd A., Klug G., Karch A., Kenny J., Collinge J., Takada LT, Forner S., Fong JC, Mead S., and Geschwind MD American journal of human genetics, 2014/10/02, Volume 95, Issue 4, p.371-82, (2014) Read More / View Supplemental Materials
Abstract
Cryptic and complex chromosomal aberrations in early-onset neuropsychiatric disorders.Brand, H., Pillalamarri V., Collins RL, Eggert S., O'Dushlaine C., Braaten EB, Stone MR, Chambert K., Doty ND, Hanscom C., Rosenfeld JA, Ditmars H., Blais J., Mills R., Lee C., Gusella JF, McCarroll S., Smoller JW, Talkowski ME, and Doyle AE American journal of human genetics, 2014/10/02, Volume 95, Issue 4, p.454-61, (2014) Read More / View Supplemental Materials
Abstract
Hemani et al. reply.Hemani, G., Shakhbazov K., Westra HJ, Esko T., Henders AK, McRae AF, Yang J., Gibson G., Martin NG, Metspalu A., Franke L., Montgomery GW, Visscher PM, and Powell JE Nature, 2014/10/02, Volume 514, Issue 7520, p.E5-6, (2014) Read More / View Supplemental Materials
Abnormal Dosage of Ultraconserved Elements Is Highly Disfavored in Healthy Cells but Not Cancer Cells.McCole, RB, Fonseka CY, Koren A., and Wu CT PLoS genetics, 2014/10/01, Volume 10, Issue 10, p.e1004646, (2014) Read More / View Supplemental Materials
Abstract
Attention-deficit/hyperactivity disorder polygenic risk scores predict attention problems in a population-based sample of children.Groen-Blokhuis, MM, Middeldorp CM, Kan KJ, Abdellaoui A., van Beijsterveldt CE, Ehli EA, Davies GE, Scheet PA, Xiao X., Hudziak JJ, Hottenga JJ, Psychiatric Genomics Consortium ADHD Working Group, Neale BM, and Boomsma DI Journal of the American Academy of Child and Adolescent Psychiatry, 2014/10/01, Volume 53, Issue 10, p.1123-1129.e6, (2014) Read More / View Supplemental Materials
Abstract
Genetic Studies of Major Depressive Disorder: Why Are There No Genome-wide Association Study Findings and What Can We Do About It?Levinson, DF, Mostafavi S., Milaneschi Y., Rivera M., Ripke S., Wray NR, and Sullivan PF Biological psychiatry, 2014/10/01, Volume 76, Issue 7, p.510-2, (2014) Read More / View Supplemental Materials
Pulmonary macrophage transplantation therapy.Suzuki, T., Arumugam P., Sakagami T., Lachmann N., Chalk C., Sallese A., Abe S., Trapnell C., Carey B., Moritz T., Malik P., Lutzko C., Wood RE, and Trapnell BC Nature, 2014/10/01, (2014) Read More / View Supplemental Materials
Abstract
Therapeutic Strategies to Inhibit MYC.McKeown, MR, and Bradner JE Cold Spring Harbor perspectives in medicine, 2014/10/01, Volume 4, Issue 10, (2014) Read More / View Supplemental Materials
Abstract
Does poor health predict moving, move quality, and desire to move?: A study examining neighborhood selection in US adolescents and adults.Dunn, EC, Winning A., Zaika N., and Subramanian SV Health & place, 2014/09/30, Volume 30C, p.154-164, (2014) Read More / View Supplemental Materials
Abstract
Expanding the Phenotype Associated With the NEFL Mutation: Neuromuscular Disease in a Family With Overlapping Myopathic and Neurogenic Findings.Agrawal, PB, Joshi M., Marinakis NS, Schmitz-Abe K., Ciarlini PD, Sargent JC, Markianos K., De Girolami U., Chad DA, and Beggs AH JAMA neurology, 2014/09/29, (2014) Read More / View Supplemental Materials
Abstract
A breast cancer stem cell niche supported by juxtacrine signalling from monocytes and macrophages.Lu, H., Clauser KR, Tam WL, Fröse J., Ye X., Eaton EN, Reinhardt F., Donnenberg VS, Bhargava R., Carr SA, and Weinberg R. A. Nature cell biology, 2014/09/28, (2014) Read More / View Supplemental Materials
Abstract
Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development.Mayers, JR, Wu C., Clish CB, Kraft P., Torrence ME, Fiske BP, Yuan C., Bao Y., Townsend MK, Tworoger SS, Davidson SM, Papagiannakopoulos T., Yang A., Dayton TL, Ogino S., Stampfer MJ, Giovannucci EL, Qian ZR, Rubinson DA, Ma J., et al. Nature medicine, 2014/09/28, (2014) Read More / View Supplemental Materials
Abstract
Comparative RNA-Seq based dissection of the regulatory networks and environmental stimuli underlying Vibrio parahaemolyticus gene expression during infection.Livny, J., Zhou X., Mandlik A., Hubbard T., Davis BM, and Waldor MK Nucleic acids research, 2014/09/27, (2014) Read More / View Supplemental Materials
Abstract
Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity.Saeed, S., Quintin J., Kerstens HH, Rao NA, Aghajanirefah A., Matarese F., Cheng SC, Ratter J., Berentsen K., van der Ent MA, Sharifi N., Janssen-Megens EM, Ter Huurne M., Mandoli A., van Schaik T., Ng A., Burden F., Downes K., Frontini M., Kumar V., et al. Science (New York, N.Y.), 2014/09/26, Volume 345, Issue 6204, p.1251086, (2014) Read More / View Supplemental Materials
Abstract
mTOR- and HIF-1α-mediated aerobic glycolysis as metabolic basis for trained immunity.Cheng, SC, Quintin J., Cramer RA, Shepardson KM, Saeed S., Kumar V., Giamarellos-Bourboulis EJ, Martens JH, Rao NA, Aghajanirefah A., Manjeri GR, Li Y., Ifrim DC, Arts RJ, van der Meer BM, Deen PM, Logie C., O'Neill LA, Willems P., van de Veerdonk FL, et al. Science (New York, N.Y.), 2014/09/26, Volume 345, Issue 6204, p.1250684, (2014) Read More / View Supplemental Materials
Abstract
Genome-Wide Association Study of Intracranial Aneurysm Identifies a New Association on Chromosome 7.Foroud, T., Lai D., Koller D., Van't Hof F., Kurki MI, Anderson CS, Brown RD Jr, Connolly ES, Eriksson JG, Flaherty M., Fornage M., von Und Zu Fraunberg M., Gaál EI, Laakso A., Hernesniemi J., Huston J., Jääskeläinen JE, Kiemeney LA, Kivisaari R., Kleindorfer D., et al. Stroke; a journal of cerebral circulation, 2014/09/25, (2014) Read More / View Supplemental Materials
Abstract
RNA-RNA Interactions Enable Specific Targeting of Noncoding RNAs to Nascent Pre-mRNAs and Chromatin Sites.Engreitz, JM, Sirokman K., McDonel P., Shishkin AA, Surka C., Russell P., Grossman SR, Chow AY, Guttman M., and Lander E. S. Cell, 2014/09/25, Volume 159, Issue 1, p.188-99, (2014) Read More / View Supplemental Materials
Abstract
CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling.Platt, RJ, Chen S., Zhou Y., Yim MJ, Swiech L., Kempton HR, Dahlman JE, Parnas O., Eisenhaure TM, Jovanovic M., Graham DB, Jhunjhunwala S., Heidenreich M., Xavier RJ, Langer R., Anderson DG, Hacohen N., Regev A., Feng G., Sharp PA, et al. Cell, 2014/09/24, (2014) Read More / View Supplemental Materials
Abstract
HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials.Swerdlow, DI, Preiss D., Kuchenbaecker KB, Holmes MV, Engmann JE, Shah T., Sofat R., Stender S., Johnson PC, Scott RA, Leusink M., Verweij N., Sharp SJ, Guo Y., Giambartolomei C., Chung C., Peasey A., Amuzu A., Li K., Palmen J., et al. Lancet, 2014/09/24, (2014) Read More / View Supplemental Materials
Abstract
The Sestrins Interact with GATOR2 to Negatively Regulate the Amino-Acid-Sensing Pathway Upstream of mTORC1.Chantranupong, L., Wolfson RL, Orozco JM, Saxton RA, Scaria SM, Bar-Peled L., Spooner E., Isasa M., Gygi SP, and Sabatini DM Cell reports, 2014/09/24, (2014) Read More / View Supplemental Materials
Abstract
Small molecules facilitate rapid and synchronous iPSC generation.Bar-Nur, O., Brumbaugh J., Verheul C., Apostolou E., Pruteanu-Malinici I., Walsh RM, Ramaswamy S., and Hochedlinger K. Nature methods, 2014/09/24, (2014) Read More / View Supplemental Materials
Abstract
Exploring the genetics of irritable bowel syndrome: a GWA study in the general population and replication in multinational case-control cohorts.Ek, WE, Reznichenko A., Ripke S., Niesler B., Zucchelli M., Rivera NV, Schmidt PT, Pedersen NL, Magnusson P., Talley NJ, Holliday EG, Houghton L., Gazouli M., Karamanolis G., Rappold G., Burwinkel B., Surowy H., Rafter J., Assadi G., Li L., et al. Gut, 2014/09/23, (2014) Read More / View Supplemental Materials
Abstract
Transmembrane adaptor protein PAG/CBP is involved in both positive and negative regulation of mast cell signaling.Draberova, L., Bugajev V., Potuckova L., Halova I., Bambouskova M., Polakovicova I., Xavier RJ, Seed B., and Draber P. Molecular and cellular biology, 2014/09/22, (2014) Read More / View Supplemental Materials
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Sequence-specific antimicrobials using efficiently delivered RNA-guided nucleases.Citorik, RJ, Mimee M., and Lu TK Nature biotechnology, 2014/09/21, (2014) Read More / View Supplemental Materials
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Ancient human genomes suggest three ancestral populations for present-day Europeans.Lazaridis, I., Patterson N., Mittnik A., Renaud G., Mallick S., Kirsanow K., Sudmant PH, Schraiber JG, Castellano S., Lipson M., Berger B., Economou C., Bollongino R., Fu Q., Bos KI, Nordenfelt S., Li H., de Filippo C., Prüfer K., Sawyer S., et al. Nature, 2014/09/18, Volume 513, Issue 7518, p.409-13, (2014) Read More / View Supplemental Materials
Abstract
Genome Sequence of the Microsporidian Species Nematocida sp1 Strain ERTm6 (ATCC PRA-372).Bakowski, MA, Priest M., Young S., Cuomo CA, and Troemel ER Genome announcements, 2014/09/18, Volume 2, Issue 5, (2014) Read More / View Supplemental Materials
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Proteogenomic characterization of human colon and rectal cancer.Zhang, B., Wang J., Wang X., Zhu J., Liu Q., Shi Z., Chambers MC, Zimmerman LJ, Shaddox KF, Kim S., Davies SR, Wang S., Wang P., Kinsinger CR, Rivers RC, Rodriguez H., Townsend RR, Ellis MJ, Carr SA, Tabb DL, et al. Nature, 2014/09/18, Volume 513, Issue 7518, p.382-7, (2014) Read More / View Supplemental Materials
Abstract
Genome-wide Scan of 29,141 African Americans Finds No Evidence of Directional Selection since Admixture.Bhatia, G., Tandon A., Patterson N., Aldrich MC, Ambrosone CB, Amos C., Bandera EV, Berndt SI, Bernstein L., Blot WJ, Bock CH, Caporaso N., Casey G., Deming SL, Diver WR, Gapstur SM, Gillanders EM, Harris CC, Henderson BE, Ingles SA, et al. American journal of human genetics, 2014/09/17, (2014) Read More / View Supplemental Materials
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Role of Casein Kinase 1A1 in the Biology and Targeted Therapy of del(5q) MDS.Schneider, RK, Ademà V., Heckl D., Järås M., Mallo M., Lord AM, Chu LP, McConkey ME, Kramann R., Mullally A., Bejar R., Solé F., and Ebert BL Cancer cell, 2014/09/17, (2014) Read More / View Supplemental Materials
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Pipeline for illumination correction of images for high-throughput microscopy.Singh, S., Bray MA, Jones TR, and Carpenter AE Journal of microscopy, 2014/09/16, (2014) Read More / View Supplemental Materials
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Sporulation during growth in a gut isolate of Bacillus subtilis.Serra, CR, Earl AM, Barbosa TM, Kolter R., and Henriques AO Journal of bacteriology, 2014/09/15, (2014) Read More / View Supplemental Materials
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TET2 mutations predict response to hypomethylating agents in myelodysplastic syndrome patients. Blood, 2014/09/15, (2014) Read More / View Supplemental Materials
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Nanoparticle vesicle encoding for imaging and tracking cell populations.Rees, P., Wills JW, Brown MR, Tonkin J., Holton MD, Hondow N., Brown AP, Brydson R., Millar V., Carpenter AE, and Summers HD Nature methods, 2014/09/14, (2014) Read More / View Supplemental Materials
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Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak.Gire, SK, Goba A., Andersen KG, Sealfon RS, Park DJ, Kanneh L., Jalloh S., Momoh M., Fullah M., Dudas G., Wohl S., Moses LM, Yozwiak NL, Winnicki S., Matranga CB, Malboeuf CM, Qu J., Gladden AD, Schaffner SF, Yang X., et al. Science (New York, N.Y.), 2014/09/12, Volume 345, Issue 6202, p.1369-72, (2014) Read More / View Supplemental Materials
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Intersection of population variation and autoimmunity genetics in human T cell activation.Ye, CJ, Feng T., Kwon HK, Raj T., Wilson MT, Asinovski N., McCabe C., Lee MH, Frohlich I., Paik HI, Zaitlen N., Hacohen N., Stranger B., De Jager P., Mathis D., Regev A., and Benoist C. Science (New York, N.Y.), 2014/09/12, Volume 345, Issue 6202, p.1254665, (2014) Read More / View Supplemental Materials
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RNA Function. RNA and dynamic nuclear organization.Rinn, J., and Guttman M. Science (New York, N.Y.), 2014/09/12, Volume 345, Issue 6202, p.1240-1, (2014) Read More / View Supplemental Materials
Small-molecule control of cytokine function: new opportunities for treating immune disorders.Sundberg, TB, Xavier RJ, Schreiber SL, and Shamji AF Current opinion in chemical biology, 2014/09/12, Volume 23C, p.23-30, (2014) Read More / View Supplemental Materials
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Cell-state-specific metabolic dependency in hematopoiesis and leukemogenesis.Wang, YH, Israelsen WJ, Lee D., Yu VW, Jeanson NT, Clish CB, Cantley LC, Vander Heiden MG, and Scadden DT Cell, 2014/09/11, Volume 158, Issue 6, p.1309-23, (2014) Read More / View Supplemental Materials
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Draft genome sequences of six enterohepatic helicobacter species isolated from humans and one from rhesus macaques.Shen, Z., Sheh A., Young SK, Abouelliel A., Ward DV, Earl AM, and Fox JG Genome announcements, 2014/09/11, Volume 2, Issue 5, (2014) Read More / View Supplemental Materials
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Effect of phosphodiesterase inhibition on insulin resistance in obese individuals.Ho, JE, Arora P., Walford GA, Ghorbani A., Guanaga DP, Dhakal BP, Nathan DI, Buys ES, Florez JC, Newton-Cheh C., Lewis GD, and Wang TJ Journal of the American Heart Association, 2014/09/11, Volume 3, Issue 5, (2014) Read More / View Supplemental Materials
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Gibbon genome and the fast karyotype evolution of small apes.Carbone, L., Harris RA, Gnerre S., Veeramah KR, Lorente-Galdos B., Huddleston J., Meyer TJ, Herrero J., Roos C., Aken B., Anaclerio F., Archidiacono N., Baker C., Barrell D., Batzer MA, Beal K., Blancher A., Bohrson CL, Brameier M., Campbell MS, et al. Nature, 2014/09/11, Volume 513, Issue 7517, p.195-201, (2014) Read More / View Supplemental Materials
Abstract
Transcriptome-wide Mapping Reveals Widespread Dynamic-Regulated Pseudouridylation of ncRNA and mRNA.Schwartz, S., Bernstein DA, Mumbach MR, Jovanovic M., Herbst RH, León-Ricardo BX, Engreitz JM, Guttman M., Satija R., Lander E. S., Fink G., and Regev A. Cell, 2014/09/10, (2014) Read More / View Supplemental Materials
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The unconscionable gap between what we know and what we do.Hyman, SE Science translational medicine, 2014/09/10, Volume 6, Issue 253, p.253cm9, (2014) Read More / View Supplemental Materials
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Aspirin Should Be Discontinued After Lobar Intracerebral Hemorrhage.Falcone, GJ, and Rosand J. Stroke; a journal of cerebral circulation, 2014/09/09, (2014) Read More / View Supplemental Materials
Evaluation of compounds in primary human islet cell culture.Walpita, D., and Wagner BK Current protocols in chemical biology, 2014/09/09, Volume 6, Issue 3, p.157-68, (2014) Read More / View Supplemental Materials
Abstract
Aneuploidy induces profound changes in gene expression, proliferation and tumorigenicity of human pluripotent stem cells.Ben-David, U., Arad G., Weissbein U., Mandefro B., Maimon A., Golan-Lev T., Narwani K., Clark AT, Andrews PW, Benvenisty N., and Carlos Biancotti J. Nature communications, 2014/09/08, Volume 5, p.4825, (2014) Read More / View Supplemental Materials
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Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.Rietveld, CA, Esko T., Davies G., Pers TH, Turley P., Benyamin B., Chabris CF, Emilsson V., Johnson AD, Lee JJ, de Leeuw C., Marioni RE, Medland SE, Miller MB, Rostapshova O., van der Lee SJ, Vinkhuyzen AA, Amin N., Conley D., Derringer J., et al. Proceedings of the National Academy of Sciences of the United States of America, 2014/09/08, (2014) Read More / View Supplemental Materials
Abstract
Effects of Multiple Genetic Loci on Age at Onset in Late-Onset Alzheimer Disease: A Genome-Wide Association Study.Naj, AC, Jun G., Reitz C., Kunkle BW, Perry W., Park YS, Beecham GW, Rajbhandary RA, Hamilton-Nelson KL, Wang LS, Kauwe JS, Huentelman MJ, Myers AJ, Bird TD, Boeve BF, Baldwin CT, Jarvik GP, Crane PK, Rogaeva E., Barmada MM, et al. JAMA neurology, 2014/09/08, (2014) Read More / View Supplemental Materials
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GWAS of Longevity in CHARGE Consortium Confirms APOE and FOXO3 Candidacy.Broer, L., Buchman AS, Deelen J., Evans DS, Faul JD, Lunetta KL, Sebastiani P., Smith JA, Smith AV, Tanaka T., Yu L., Arnold AM, Aspelund T., Benjamin EJ, De Jager PL, Eirkisdottir G., Evans DA, Garcia ME, Hofman A., Kaplan RC, et al. The journals of gerontology. Series A, Biological sciences and medical sciences, 2014/09/08, (2014) Read More / View Supplemental Materials
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Immunochip SNP array identifies novel genetic variants conferring susceptibility to candidaemia.Kumar, V., Cheng SC, Johnson MD, Smeekens SP, Wojtowicz A., Giamarellos-Bourboulis E., Karjalainen J., Franke L., Withoff S., Plantinga TS, van de Veerdonk FL, van der Meer JW, Joosten LA, Sokol H., Bauer H., Herrmann BG, Bochud PY, Marchetti O., Perfect JR, Xavier RJ, et al. Nature communications, 2014/09/08, Volume 5, p.4675, (2014) Read More / View Supplemental Materials
Abstract
Genome-wide identification and characterization of functional neuronal activity-dependent enhancers.Malik, AN, Vierbuchen T., Hemberg M., Rubin AA, Ling E., Couch CH, Stroud H., Spiegel I., Farh KK, Harmin DA, and Greenberg ME Nature neuroscience, 2014/09/07, (2014) Read More / View Supplemental Materials
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The Glanville fritillary genome retains an ancient karyotype and reveals selective chromosomal fusions in Lepidoptera.Ahola, V., Lehtonen R., Somervuo P., Salmela L., Koskinen P., Rastas P., Välimäki N., Paulin L., Kvist J., Wahlberg N., Tanskanen J., Hornett EA, Ferguson LC, Luo S., Cao Z., de Jong MA, Duplouy A., Smolander OP, Vogel H., McCoy RC, et al. Nature communications, 2014/09/05, Volume 5, p.4737, (2014) Read More / View Supplemental Materials
Abstract
Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles.Goldstein, JI, Fredrik Jarskog L., Hilliard C., Alfirevic A., Duncan L., Fourches D., Huang H., Lek M., Neale BM, Ripke S., Shianna K., Szatkiewicz JP, Tropsha A., van den Oord EJ, Cascorbi I., Dettling M., Gazit E., Goff DC, Holden AL, Kelly DL, et al. Nature communications, 2014/09/04, Volume 5, p.4757, (2014) Read More / View Supplemental Materials
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Association of exome sequences with plasma C-reactive protein levels in >9000 participants.Schick, UM, Auer PL, Bis JC, Lin H., Wei P., Pankratz N., Lange LA, Brody J., Stitziel NO, Kim DS, Carlson CS, Fornage M., Haessler J., Hsu L., Jackson RD, Kooperberg C., Leal SM, Psaty BM, Boerwinkle E., Tracy R., et al. Human molecular genetics, 2014/09/03, (2014) Read More / View Supplemental Materials
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The Genomic Landscape of Pediatric Ewing Sarcoma.Crompton, BD, Stewart C., Taylor-Weiner A., Alexe G., Kurek KC, Calicchio ML, Kiezun A., Carter SL, Shukla SA, Mehta SS, Thorner AR, de Torres C., Lavarino C., Sunol M., McKenna A., Sivachenko A., Cibulskis K., Lawrence MS, Stojanov P., Rosenberg M., et al. Cancer discovery, 2014/09/03, (2014) Read More / View Supplemental Materials
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The genomic substrate for adaptive radiation in African cichlid fish.Brawand, D., Wagner CE, Li YI, Malinsky M., Keller I., Fan S., Simakov O., Ng AY, Lim ZW, Bezault E., Turner-Maier J., Johnson J., Alcazar R., Noh HJ, Russell P., Aken B., Alföldi J., Amemiya C., Azzouzi N., Baroiller JF, et al. Nature, 2014/09/03, (2014) Read More / View Supplemental Materials
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Rational design of highly active sgRNAs for CRISPR-Cas9-mediated gene inactivation.Doench, JG, Hartenian E., Graham DB, Tothova Z., Hegde M., Smith I., Sullender M., Ebert BL, Xavier RJ, and Root DE Nature biotechnology, 2014/09/03, (2014) Read More / View Supplemental Materials
Abstract
Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci.De Jager, PL, Srivastava G., Lunnon K., Burgess J., Schalkwyk LC, Yu L., Eaton ML, Keenan BT, Ernst J., McCabe C., Tang A., Raj T., Replogle J., Brodeur W., Gabriel S., Chai HS, Younkin C., Younkin SG, Zou F., Szyf M., et al. Nature neuroscience, 2014/09/01, Volume 17, Issue 9, p.1156-1163, (2014) Read More / View Supplemental Materials
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Computational pathology: an emerging definition.Louis, DN, Gerber GK, Baron JM, Bry L., Dighe AS, Getz G., Higgins JM, Kuo FC, Lane WJ, Michaelson JS, Le LP, Mermel CH, Gilbertson JR, and Golden JA Archives of pathology & laboratory medicine, 2014/09/01, Volume 138, Issue 9, p.1133-8, (2014) Read More / View Supplemental Materials
De-Differentiation Confers Multidrug Resistance Via Noncanonical PERK-Nrf2 Signaling.Del Vecchio, CA, Feng Y., Sokol ES, Tillman EJ, Sanduja S., Reinhardt F., and Gupta PB PLoS biology, 2014/09/01, Volume 12, Issue 9, p.e1001945, (2014) Read More / View Supplemental Materials
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Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease.Lunnon, K., Smith R., Hannon E., De Jager PL, Srivastava G., Volta M., Troakes C., Al-Sarraj S., Burrage J., Macdonald R., Condliffe D., Harries LW, Katsel P., Haroutunian V., Kaminsky Z., Joachim C., Powell J., Lovestone S., Bennett DA, Schalkwyk LC, et al. Nature neuroscience, 2014/09/01, Volume 17, Issue 9, p.1164-1170, (2014) Read More / View Supplemental Materials
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Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage.Hill, SJ, Rolland T., Adelmant G., Xia X., Owen MS, Dricot A., Zack TI, Sahni N., Jacob Y., Hao T., McKinney KM, Clark AP, Reyon D., Tsai SQ, Joung JK, Beroukhim R., Marto JA, Vidal M., Gaudet S., Hill DE, et al. Genes & development, 2014/09/01, Volume 28, Issue 17, p.1957-75, (2014) Read More / View Supplemental Materials
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Toward a new history and geography of human genes informed by ancient DNA.Pickrell, JK, and Reich D. Trends in genetics : TIG, 2014/09/01, Volume 30, Issue 9, p.377-389, (2014) Read More / View Supplemental Materials
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Rabbit genome analysis reveals a polygenic basis for phenotypic change during domestication.Carneiro, M., Rubin CJ, Di Palma F., Albert FW, Alföldi J., Barrio AM, Pielberg G., Rafati N., Sayyab S., Turner-Maier J., Younis S., Afonso S., Aken B., Alves JM, Barrell D., Bolet G., Boucher S., Burbano HA, Campos R., Chang JL, et al. Science (New York, N.Y.), 2014/08/29, Volume 345, Issue 6200, p.1074-9, (2014) Read More / View Supplemental Materials
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Comparative analysis of metazoan chromatin organization.Ho, JW, Jung YL, Liu T., Alver BH, Lee S., Ikegami K., Sohn KA, Minoda A., Tolstorukov MY, Appert A., Parker SC, Gu T., Kundaje A., Riddle NC, Bishop E., Egelhofer TA, Hu SS, Alekseyenko AA, Rechtsteiner A., Asker D., et al. Nature, 2014/08/28, Volume 512, Issue 7515, p.449-52, (2014) Read More / View Supplemental Materials
Abstract
Dihydropyrimidine accumulation is required for the epithelial-mesenchymal transition.Shaul, YD, Freinkman E., Comb WC, Cantor JR, Tam WL, Thiru P., Kim D., Kanarek N., Pacold ME, Chen WW, Bierie B., Possemato R., Reinhardt F., Weinberg R. A., Yaffe MB, and Sabatini DM Cell, 2014/08/28, Volume 158, Issue 5, p.1094-109, (2014) Read More / View Supplemental Materials
Abstract
Guided visual exploration of genomic stratifications in cancer.Streit, M., Lex A., Gratzl S., Partl C., Schmalstieg D., Pfister H., Park PJ, and Gehlenborg N. Nature methods, 2014/08/28, Volume 11, Issue 9, p.884-5, (2014) Read More / View Supplemental Materials
Multiple Associated Variants Increase the Heritability Explained for Plasma Lipids and Coronary Artery Disease.Tada, H., Won HH, Melander O., Yang J., Peloso GM, and Kathiresan S. Circulation. Cardiovascular genetics, 2014/08/28, (2014) Read More / View Supplemental Materials
Abstract
The Naked Mole Rat Genome Resource: facilitating analyses of cancer and longevity-related adaptations.Keane, M., Craig T., Alföldi J., Berlin AM, Johnson J., Seluanov A., Gorbunova V., Di Palma F., Lindblad-Toh K., Church GM, and de Magalhães JP Bioinformatics (Oxford, England), 2014/08/28, (2014) Read More / View Supplemental Materials
Abstract
Predicting Cancer-Specific Vulnerability via Data-Driven Detection of Synthetic Lethality.Jerby-Arnon, L., Pfetzer N., Waldman YY, McGarry L., James D., Shanks E., Seashore-Ludlow B., Weinstock A., Geiger T., Clemons PA, Gottlieb E., and Ruppin E. Cell, 2014/08/28, Volume 158, Issue 5, p.1199-209, (2014) Read More / View Supplemental Materials
Abstract
Label-free, live optical imaging of reprogrammed bipolar disorder patient-derived cells reveals a functional correlate of lithium responsiveness.Wang, JL, Shamah SM, Sun AX, Waldman ID, Haggarty SJ, and Perlis RH Translational psychiatry, 2014/08/26, Volume 4, p.e428, (2014) Read More / View Supplemental Materials
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