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Synthesis, cellular evaluation and mechanism-of-action of piperlongumine analogsAdams, DJ, Dai M., Pellegrino G., Wagner BK, Stern AM, Shamji AF, and Schreiber SL, (Submitted) Read More / View Supplemental Materials
2015
Disentangling the Effects of Colocalizing Genomic Annotations to Functionally Prioritize Non-coding Variants within Complex-Trait Loci.Trynka, G., Westra HJ, Slowikowski K., Hu X., Xu H., Stranger BE, Klein RJ, Han B., and Raychaudhuri S. American journal of human genetics, 2015/07/02, Volume 97, Issue 1, p.139-152, (2015) Read More / View Supplemental Materials
Abstract
From Dish to Bedside: Lessons Learned While Translating Findings from a Stem Cell Model of Disease to a Clinical Trial.McNeish, J., Gardner JP, Wainger BJ, Woolf CJ, and Eggan K. Cell stem cell, 2015/07/02, Volume 17, Issue 1, p.8-10, (2015) Read More / View Supplemental Materials
Abstract
Correction for hwang et Al., polyomavirus small T antigen interacts with yes-associated protein to regulate cell survival and differentiation.Hwang, JH, Pores Fernando AT, Faure N., Andrabi S., Adelmant G., Hahn WC, Marto JA, Schaffhausen BS, and Roberts TM Journal of virology, 2015/07/01, Volume 89, Issue 13, p.6971, (2015) Read More / View Supplemental Materials
Directional dominance on stature and cognition in diverse human populations.Joshi, PK, Esko T., Mattsson H., Eklund N., Gandin I., Nutile T., Jackson AU, Schurmann C., Smith AV, Zhang W., Okada Y., Stančáková A., Faul JD, Zhao W., Bartz TM, Concas MP, Franceschini N., Enroth S., Vitart V., Trompet S., et al. Nature, 2015/07/01, (2015) Read More / View Supplemental Materials
Abstract
Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation.Horikoshi, M., Mӓgi R., van de Bunt M., Surakka I., Sarin AP, Mahajan A., Marullo L., Thorleifsson G., Hӓgg S., Hottenga JJ, Ladenvall C., Ried JS, Winkler TW, Willems SM, Pervjakova N., Esko T., Beekman M., Nelson CP, Willenborg C., Wiltshire S., et al. PLoS genetics, 2015/07/01, Volume 11, Issue 7, p.e1005230, (2015) Read More / View Supplemental Materials
Abstract
An ecosystem of cancer cell line factories to support a cancer dependency map.Boehm, JS, and Golub T. R. Nature reviews. Genetics, 2015/07/01, Volume 16, Issue 7, p.373-4, (2015) Read More / View Supplemental Materials
Abstract
Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS.Krönke, J., Fink EC, Hollenbach PW, MacBeth KJ, Hurst SN, Udeshi ND, Chamberlain PP, Mani D. R., Man HW, Gandhi AK, Svinkina T., Schneider RK, McConkey M., Järås M., Griffiths E., Wetzler M., Bullinger L., Cathers BE, Carr SA, Chopra R., et al. Nature, 2015/07/01, (2015) Read More / View Supplemental Materials
Abstract
Integrated Genomics of Crohn's Disease Risk Variant Identifies a Role for CLEC12A in Antibacterial Autophagy.Begun, J., Lassen KG, Jijon HB, Baxt LA, Goel G., Heath RJ, Ng A., Tam JM, Kuo SY, Villablanca EJ, Fagbami L., Oosting M., Kumar V., Schenone M., Carr SA, Joosten LA, Vyas JM, Daly M. J., Netea MG, Brown GD, et al. Cell reports, 2015/06/30, Volume 11, Issue 12, p.1905-1918, (2015) Read More / View Supplemental Materials
Abstract
The RSK Inhibitor BIX02565 Limits Cardiac Ischemia/Reperfusion Injury.Shi, X., O'Neill MM, MacDonnell S., Brookes PS, Yan C., and Berk BC Journal of cardiovascular pharmacology and therapeutics, 2015/06/30, (2015) Read More / View Supplemental Materials
Abstract
Development of a High-Throughput Functional Screen Using Nanowell-Assisted Cell Patterning.Ozkumur, AY, Goods BA, and Love JC Small (Weinheim an der Bergstrasse, Germany), 2015/06/29, (2015) Read More / View Supplemental Materials
Abstract
Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas.Cancer Genome Atlas Research, Network, Brat DJ, Verhaak RG, Aldape KD, Yung WK, Salama SR, Cooper LA, Rheinbay E., Miller CR, Vitucci M., Morozova O., Robertson AG, Noushmehr H., Laird PW, Cherniack AD, Akbani R., Huse JT, Ciriello G., Poisson LM, Barnholtz-Sloan JS, et al. The New England journal of medicine, 2015/06/25, Volume 372, Issue 26, p.2481-98, (2015) Read More / View Supplemental Materials
Abstract
Rare Coding Variation and Risk of Intracerebral Hemorrhage.Radmanesh, F., Falcone GJ, Anderson CD, McWilliams D., Devan WJ, Brown WM, Battey TW, Ayres AM, Raffeld MR, Schwab K., Sun G., Deka R., Viswanathan A., Goldstein JN, Greenberg SM, Tirschwell DL, Silliman SL, Selim M., Meschia JF, Brown DL, et al. Stroke; a journal of cerebral circulation, 2015/06/25, (2015) Read More / View Supplemental Materials
Abstract
Deficiency of UBE2T, the E2 Ubiquitin Ligase Necessary for FANCD2 and FANCI Ubiquitination, Causes FA-T Subtype of Fanconi Anemia.Rickman, KA, Lach FP, Abhyankar A., Donovan FX, Sanborn EM, Kennedy JA, Sougnez C., Gabriel SB, Elemento O., Chandrasekharappa SC, Schindler D., Auerbach AD, and Smogorzewska A. Cell reports, 2015/06/24, (2015) Read More / View Supplemental Materials
Abstract
Distinct lineages of Ebola virus in Guinea during the 2014 West African epidemic.Simon-Loriere, E., Faye O., Faye O., Koivogui L., Magassouba N., Keita S., Thiberge JM, Diancourt L., Bouchier C., Vandenbogaert M., Caro V., Fall G., Buchmann JP, Matranga CB, Sabeti PC, Manuguerra JC, Holmes EC, and Sall AA Nature, 2015/06/24, (2015) Read More / View Supplemental Materials
Abstract
Linked genetic variants on chromosome 10 control ear morphology and body mass among dog breeds.Webster, MT, Kamgari N., Perloski M., Hoeppner MP, Axelsson E., Hedhammar Å., Pielberg G., and Lindblad-Toh K. BMC genomics, 2015/06/23, Volume 16, p.474, (2015) Read More / View Supplemental Materials
Abstract
Antibiotic efficacy is linked to bacterial cellular respiration.Lobritz, MA, Belenky P., Porter CB, Gutierrez A., Yang JH, Schwarz EG, Dwyer DJ, Khalil AS, and Collins JJ Proceedings of the National Academy of Sciences of the United States of America, 2015/06/22, (2015) Read More / View Supplemental Materials
Abstract
An early modern human from Romania with a recent Neanderthal ancestor.Fu, Q., Hajdinjak M., Moldovan OT, Constantin S., Mallick S., Skoglund P., Patterson N., Rohland N., Lazaridis I., Nickel B., Viola B., Prüfer K., Meyer M., Kelso J., Reich D., and Pääbo S. Nature, 2015/06/22, (2015) Read More / View Supplemental Materials
Abstract
Engineered CRISPR-Cas9 nucleases with altered PAM specificities.Kleinstiver, BP, Prew MS, Tsai SQ, Topkar VV, Nguyen NT, Zheng Z., Gonzales AP, Li Z., Peterson RT, Yeh JJ, Aryee MJ, and Joung JK Nature, 2015/06/22, (2015) Read More / View Supplemental Materials
Abstract
Interactions between amino-acid-defined MHC class II variants and smoking for seropositive rheumatoid arthritis.Kim, K., Jiang X., Cui J., Lu B., Costenbader KH, Sparks JA, Bang SY, Lee HS, Okada Y., Raychaudhuri S., Alfredsson L., Bae SC, Klareskog L., and Karlson EW Arthritis & rheumatology (Hoboken, N.J.), 2015/06/22, (2015) Read More / View Supplemental Materials
Abstract
Structural forms of the human amylase locus and their relationships to SNPs, haplotypes and obesity.Usher, CL, Handsaker RE, Esko T., Tuke MA, Weedon MN, Hastie AR, Cao H., Moon JE, Kashin S., Fuchsberger C., Metspalu A., Pato CN, Pato MT, McCarthy MI, Boehnke M., Altshuler DM, Frayling TM, Hirschhorn JN, and McCarroll SA Nature genetics, 2015/06/22, (2015) Read More / View Supplemental Materials
Abstract
Marrying microfluidics and microwells for parallel, high-throughput single-cell genomics.Wadsworth MH, 2nd, Hughes TK, and Shalek AK Genome biology, 2015/06/20, Volume 16, Issue 1, p.129, (2015) Read More / View Supplemental Materials
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Cooperation for Better Inhibiting.Novoa, EM, and Ribas de Pouplana L. Chemistry & biology, 2015/06/18, Volume 22, Issue 6, p.685-6, (2015) Read More / View Supplemental Materials
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Ebola Virus Epidemiology, Transmission, and Evolution during Seven Months in Sierra Leone.Park, DJ, Dudas G., Wohl S., Goba A., Whitmer SL, Andersen KG, Sealfon RS, Ladner JT, Kugelman JR, Matranga CB, Winnicki SM, Qu J., Gire SK, Gladden-Young A., Jalloh S., Nosamiefan D., Yozwiak NL, Moses LM, Jiang PP, Lin AE, et al. Cell, 2015/06/18, Volume 161, Issue 7, p.1516-26, (2015) Read More / View Supplemental Materials
Abstract
Single Amino Acid Variation Underlies Species-Specific Sensitivity to Amphibian Skin-Derived Opioid-like Peptides.Vardy, E., Sassano MF, Rennekamp AJ, Kroeze WK, Mosier PD, Westkaemper RB, Stevens CW, Katritch V., Stevens RC, Peterson RT, and Roth BL Chemistry & biology, 2015/06/18, Volume 22, Issue 6, p.764-75, (2015) Read More / View Supplemental Materials
Abstract
miRNA-embedded shRNAs for lineage-specific BCL11A knockdown and hemoglobin F induction.Guda, S., Brendel C., Renella R., Du P., Bauer DE, Canver MC, Grenier JK, Grimson AW, Kamran SC, Thornton J., De Boer H., Root DE, Milsom MD, Orkin SH, Gregory RI, and Williams DA Molecular therapy : the journal of the American Society of Gene Therapy, 2015/06/17, (2015) Read More / View Supplemental Materials
Abstract
Paired-Duplication Signatures Mark Cryptic Inversions and Other Complex Structural Variation.Brand, H., Collins RL, Hanscom C., Rosenfeld JA, Pillalamarri V., Stone MR, Kelley F., Mason T., Margolin L., Eggert S., Mitchell E., Hodge JC, Gusella JF, Sanders SJ, and Talkowski ME American journal of human genetics, 2015/06/17, (2015) Read More / View Supplemental Materials
Abstract
Phenotypic assays identify azoramide as a small-molecule modulator of the unfolded protein response with antidiabetic activity.Fu, S., Yalcin A., Lee GY, Li P., Fan J., Arruda AP, Pers BM, Yilmaz M., Eguchi K., and Hotamisligil GS Science translational medicine, 2015/06/17, Volume 7, Issue 292, p.292ra98, (2015) Read More / View Supplemental Materials
Abstract
Functionally Distinct Subsets of Lineage-Biased Multipotent Progenitors Control Blood Production in Normal and Regenerative Conditions.Pietras, EM, Reynaud D., Kang YA, Carlin D., Calero-Nieto FJ, Leavitt AD, Stuart JM, Göttgens B., and Passegué E. Cell stem cell, 2015/06/16, (2015) Read More / View Supplemental Materials
Abstract
Global and local ancestry in African-Americans: Implications for Alzheimer's disease risk.Hohman, TJ, Cooke-Bailey JN, Reitz C., Jun G., Naj A., Beecham GW, Liu Z., Carney RM, Vance JM, Cuccaro ML, Rajbhandary R., Vardarajan BN, Wang LS, Valladares O., Lin CF, Larson EB, Graff-Radford NR, Evans D., De Jager PL, Crane PK, et al. Alzheimer's & dementia : the journal of the Alzheimer's Association, 2015/06/16, (2015) Read More / View Supplemental Materials
Abstract
The MicroRNA-132 and MicroRNA-212 Cluster Regulates Hematopoietic Stem Cell Maintenance and Survival with Age by Buffering FOXO3 Expression.Mehta, A., Zhao JL, Sinha N., Marinov GK, Mann M., Kowalczyk MS, Galimidi RP, Du X., Erikci E., Regev A., Chowdhury K., and Baltimore D. Immunity, 2015/06/16, Volume 42, Issue 6, p.1021-32, (2015) Read More / View Supplemental Materials
Abstract
Sex and parasites: genomic and transcriptomic analysis of Microbotryum lychnidis-dioicae, the biotrophic and plant-castrating anther smut fungus.Perlin, MH, Amselem J., Fontanillas E., Toh SS, Chen Z., Goldberg J., Duplessis S., Henrissat B., Young S., Zeng Q., Aguileta G., Petit E., Badouin H., Andrews J., Razeeq D., Gabaldón T., Quesneville H., Giraud T., Hood ME, Schultz DJ, et al. BMC genomics, 2015/06/16, Volume 16, Issue 1, p.461, (2015) Read More / View Supplemental Materials
Abstract
Somatic Cell Fusions Reveal Extensive Heterogeneity in Basal-like Breast Cancer.Su, Y., Subedee A., Bloushtain-Qimron N., Savova V., Krzystanek M., Li L., Marusyk A., Tabassum DP, Zak A., Flacker MJ, Li M., Lin JJ, Sukumar S., Suzuki H., Long H., Szallasi Z., Gimelbrant A., Maruyama R., and Polyak K. Cell reports, 2015/06/16, Volume 11, Issue 10, p.1549-63, (2015) Read More / View Supplemental Materials
Abstract
In silico phenotyping via co-training for improved phenotype prediction from genotype.Roqueiro, D., Witteveen MJ, Anttila V., Terwindt GM, van den Maagdenberg AM, and Borgwardt K. Bioinformatics (Oxford, England), 2015/06/15, Volume 31, Issue 12, p.i303-i310, (2015) Read More / View Supplemental Materials
Abstract
Strand-specific RNA sequencing in Plasmodium falciparum malaria identifies developmentally regulated long non-coding RNA and circular RNA.Broadbent, KM, Broadbent JC, Ribacke U., Wirth D., Rinn JL, and Sabeti PC BMC genomics, 2015/06/13, Volume 16, p.454, (2015) Read More / View Supplemental Materials
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Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels.Draisma, HH, Pool R., Kobl M., Jansen R., Petersen AK, Vaarhorst AA, Yet I., Haller T., Demirkan A., Esko T., Zhu G., Böhringer S., Beekman M., van Klinken JB, Römisch-Margl W., Prehn C., Adamski J., de Craen AJ, van Leeuwen EM, Amin N., et al. Nature communications, 2015/06/12, Volume 6, p.7208, (2015) Read More / View Supplemental Materials
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Protect researchers from harassment.Hyman, SE, and Goldberg ME Science (New York, N.Y.), 2015/06/12, Volume 348, Issue 6240, p.1216-7, (2015) Read More / View Supplemental Materials
Genetic variants associated with autoimmunity drive NFκB signaling and responses to inflammatory stimuli.Housley, WJ, Fernandez SD, Vera K., Murikinati SR, Grutzendler J., Cuerdon N., Glick L., De Jager PL, Mitrovic M., Cotsapas C., and Hafler DA Science translational medicine, 2015/06/10, Volume 7, Issue 291, p.291ra93, (2015) Read More / View Supplemental Materials
Abstract
Light-weight reference-based compression of FASTQ data.Zhang, Y., Li L., Yang Y., Yang X., He S., and Zhu Z. BMC bioinformatics, 2015/06/09, Volume 16, Issue 1, p.188, (2015) Read More / View Supplemental Materials
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Reply to Letter.Replogle, JM, and De Jager PL Annals of neurology, 2015/06/09, (2015) Read More / View Supplemental Materials
Host lysozyme-mediated lysis of Lactococcus lactis facilitates delivery of colitis-attenuating superoxide dismutase to inflamed colons.Ballal, SA, Veiga P., Fenn K., Michaud M., Kim JH, Gallini CA, Glickman JN, Quéré G., Garault P., Béal C., Derrien M., Courtin P., Kulakauskas S., Chapot-Chartier MP, van Hylckama Vlieg J., and Garrett WS Proceedings of the National Academy of Sciences of the United States of America, 2015/06/08, (2015) Read More / View Supplemental Materials
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Inference of transcriptional regulation in cancers.Jiang, P., Freedman ML, Liu JS, and Liu XS Proceedings of the National Academy of Sciences of the United States of America, 2015/06/08, (2015) Read More / View Supplemental Materials
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Accurate and Fast Multiple-Testing Correction in eQTL Studies.Sul, JH, Raj T., de Jong S., de Bakker PI, Raychaudhuri S., Ophoff RA, Stranger BE, Eskin E., and Han B. American journal of human genetics, 2015/06/04, Volume 96, Issue 6, p.857-68, (2015) Read More / View Supplemental Materials
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Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes.Schreiber, SL, Kotz JD, Li M., Aubé J., Austin CP, Reed JC, Rosen H., White EL, Sklar LA, Lindsley CW, Alexander BR, Bittker JA, Clemons PA, De Souza A., Foley MA, Palmer M., Shamji AF, Wawer MJ, McManus O., Wu M., et al. Cell, 2015/06/04, Volume 161, Issue 6, p.1252-1265, (2015) Read More / View Supplemental Materials
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Breakpoint mapping by whole genome sequencing identifies PTH2R gene disruption in a patient with midline craniosynostosis and a de novo balanced chromosomal rearrangement.Kim, J., Won HH, Kim Y., Choi JR, Yu N., and Lee KA Journal of medical genetics, 2015/06/04, (2015) Read More / View Supplemental Materials
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Activity-Induced DNA Breaks Govern the Expression of Neuronal Early-Response Genes.Madabhushi, R., Gao F., Pfenning AR, Pan L., Yamakawa S., Seo J., Rueda R., Phan TX, Yamakawa H., Pao PC, Stott RT, Gjoneska E., Nott A., Cho S., Kellis M., and Tsai LH Cell, 2015/06/03, (2015) Read More / View Supplemental Materials
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Brave New Genome.Lander, E. S. The New England journal of medicine, 2015/06/03, (2015) Read More / View Supplemental Materials
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Genetic variants primarily associated with type 2 diabetes are related to coronary artery disease risk.Jansen, H., Loley C., Lieb W., Pencina MJ, Nelson CP, Kathiresan S., Peloso GM, Voight BF, Reilly MP, Assimes TL, Boerwinkle E., Hengstenberg C., Laaksonen R., McPherson R., Roberts R., Thorsteinsdottir U., Peters A., Gieger C., Rawal R., Thompson JR, et al. Atherosclerosis, 2015/06/03, Volume 241, Issue 2, p.419-426, (2015) Read More / View Supplemental Materials
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Novel Findings from CNVs Implicate Inhibitory and Excitatory Signaling Complexes in Schizophrenia.Pocklington, AJ, Rees E., Walters JT, Han J., Kavanagh DH, Chambert KD, Holmans P., Moran JL, McCarroll SA, Kirov G., O'Donovan MC, and Owen MJ Neuron, 2015/06/03, Volume 86, Issue 5, p.1203-14, (2015) Read More / View Supplemental Materials
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CRISPR/Cas9 cleavage of viral DNA efficiently suppresses hepatitis B virus.Ramanan, V., Shlomai A., Cox DB, Schwartz RE, Michailidis E., Bhatta A., Scott DA, Zhang F., Rice CM, and Bhatia SN Scientific reports, 2015/06/02, Volume 5, p.10833, (2015) Read More / View Supplemental Materials
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African Ancestry Analysis and Admixture Genetic Mapping for Proliferative Diabetic Retinopathy in African Americans.Tandon, A., Chen CJ, Penman A., Hancock H., James M., Husain D., Andreoli C., Li X., Kuo JZ, Idowu O., Riche D., Papavasilieou E., Brauner S., Smith SO, Hoadley S., Richardson C., Kieser T., Vazquez V., Chi C., Fernandez M., et al. Investigative ophthalmology & visual science, 2015/06/01, Volume 56, Issue 6, p.3999-4005, (2015) Read More / View Supplemental Materials
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Alzheimer's loci: epigenetic associations and interaction with genetic factors.Chibnik, LB, Yu L., Eaton ML, Srivastava G., Schneider JA, Kellis M., Bennett DA, and De Jager PL Annals of clinical and translational neurology, 2015/06/01, Volume 2, Issue 6, p.636-47, (2015) Read More / View Supplemental Materials
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The association between lower educational attainment and depression owing to shared genetic effects? Results in ~25 000 subjects.Peyrot, WJ, Lee SH, Milaneschi Y., Abdellaoui A., Byrne EM, Esko T., de Geus EJ, Hemani G., Hottenga JJ, Kloiber S., Levinson DF, Lucae S., Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium(Corporate Collaborator), Martin NG, Medland SE, Metspalu A., Milani L., Noethen MM, Potash JB, Rietschel M., et al. Molecular psychiatry, 2015/06/01, Volume 20, Issue 6, p.735-43, (2015) Read More / View Supplemental Materials
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Characterization of bipolar disorder patient-specific induced pluripotent stem cells from a family reveals neurodevelopmental and mRNA expression abnormalities.Madison, JM, Zhou F., Nigam A., Hussain A., Barker DD, Nehme R., van der Ven K., Hsu J., Wolf P., Fleishman M., O'Dushlaine C., Rose S., Chambert K., Lau FH, Ahfeldt T., Rueckert EH, Sheridan SD, Fass DM, Nemesh J., Mullen TE, et al. Molecular psychiatry, 2015/06/01, Volume 20, Issue 6, p.703-17, (2015) Read More / View Supplemental Materials
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Genetic absence of PD-1 promotes accumulation of terminally differentiated exhausted CD8+ T cells.Odorizzi, PM, Pauken KE, Paley MA, Sharpe A., and Wherry EJ The Journal of experimental medicine, 2015/06/01, (2015) Read More / View Supplemental Materials
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Genomic Variants and Variations in Malformations of Cortical Development.Jamuar, SS, and Walsh CA Pediatric clinics of North America, 2015/06/01, Volume 62, Issue 3, p.571-585, (2015) Read More / View Supplemental Materials
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Multiple Changes of Gene Expression and Function Reveal Genomic and Phenotypic Complexity in SLE-like Disease.Wilbe, M., Kozyrev SV, Farias FH, Bremer HD, Hedlund A., Pielberg GR, Seppälä EH, Gustafson U., Lohi H., Carlborg Ö., Andersson G., Hansson-Hamlin H., and Lindblad-Toh K. PLoS genetics, 2015/06/01, Volume 11, Issue 6, p.e1005248, (2015) Read More / View Supplemental Materials
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Multiplexable, locus-specific targeting of long RNAs with CRISPR-Display.Shechner, DM, Hacisuleyman E., Younger ST, and Rinn JL Nature methods, 2015/06/01, (2015) Read More / View Supplemental Materials
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Spatiotemporal expression and transcriptional perturbations by long noncoding RNAs in the mouse brain.Goff, LA, Groff AF, Sauvageau M., Trayes-Gibson Z., Sanchez-Gomez DB, Morse M., Martin RD, Elcavage LE, Liapis SC, Gonzalez-Celeiro M., Plana O., Li E., Gerhardinger C., Tomassy GS, Arlotta P., and Rinn JL Proceedings of the National Academy of Sciences of the United States of America, 2015/06/01, (2015) Read More / View Supplemental Materials
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Controlling for conservation in genome-wide DNA methylation studies.Singer, M., and Pachter L. BMC genomics, 2015/05/30, Volume 16, p.420, (2015) Read More / View Supplemental Materials
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Functional genome-wide siRNA screen identifies KIAA0586 as mutated in Joubert syndrome.Roosing, S., Hofree M., Kim S., Scott E., Copeland B., Romani M., Silhavy JL, Rosti RO, Schroth J., Mazza T., Miccinilli E., Zaki MS, Swoboda KJ, Milisa-Drautz J., Dobyns WB, Mikati M., İncecik F., Azam M., Borgatti R., Romaniello R., et al. eLife, 2015/05/30, Volume 4, (2015) Read More / View Supplemental Materials
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Genome-wide association study of toxic metals and trace elements reveals novel associations.Ng, E., Lind M., Lindgren C., Ingelsson E., Mahajan A., Morris A., and Lind L. Human molecular genetics, 2015/05/29, (2015) Read More / View Supplemental Materials
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Recent pathogenetic advances in ANCA-associated vasculitis.Pendergraft WF, 3rd, and Nachman PH Presse medicale (Paris, France : 1983), 2015/05/29, (2015) Read More / View Supplemental Materials
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Adiposity as a cause of cardiovascular disease: a Mendelian randomization study.Hägg, S., Fall T., Ploner A., Mägi R., Fischer K., Draisma HH, Kals M., de Vries PS, Dehghan A., Willems SM, Sarin AP, Kristiansson K., Nuotio ML, Havulinna AS, de Bruijn RF, Ikram MA, Kuningas M., Stricker BH, Franco OH, Benyamin B., et al. International journal of epidemiology, 2015/05/27, (2015) Read More / View Supplemental Materials
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Chromothripsis from DNA damage in micronuclei.Zhang, CZ, Spektor A., Cornils H., Francis JM, Jackson EK, Liu S., Meyerson M., and Pellman D. Nature, 2015/05/27, (2015) Read More / View Supplemental Materials
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Genome Sequencing and Analysis of Geographically Diverse Clinical Isolates of Herpes Simplex Virus 2.Newman, RM, Lamers SL, Weiner B., Ray SC, Colgrove RC, Diaz F., Jing L., Wang K., Saif S., Young S., Henn M., Laeyendecker O., Tobian AA, Cohen JI, Koelle DM, Quinn TC, and Knipe DM Journal of virology, 2015/05/27, (2015) Read More / View Supplemental Materials
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Global Diversity Within and Between Human Herpes Virus 1 and 2 Glycoproteins.Lamers, SL, Newman R., Laeyendecker O., Tobian AA, Colgrove RC, Ray SC, Koelle DM, Cohen J., Knipe DM, and Quinn TC Journal of virology, 2015/05/27, (2015) Read More / View Supplemental Materials
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Programmable probiotics for detection of cancer in urine.Danino, T., Prindle A., Kwong GA, Skalak M., Li H., Allen K., Hasty J., and Bhatia SN Science translational medicine, 2015/05/27, Volume 7, Issue 289, p.289ra84, (2015) Read More / View Supplemental Materials
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Web-based phenotyping for Tourette Syndrome: Reliability of common co-morbid diagnoses.Darrow, SM, Illmann C., Gauvin C., Osiecki L., Egan CA, Greenberg E., Eckfield M., Hirschtritt ME, Pauls DL, Batterson JR, Berlin CM, Malaty IA, Woods DW, Scharf JM, and Mathews CA Psychiatry research, 2015/05/27, (2015) Read More / View Supplemental Materials
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Innovation in metabolomics to improve personalized healthcare.Cacciatore, S., and Loda M. Annals of the New York Academy of Sciences, 2015/05/26, (2015) Read More / View Supplemental Materials
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Variants in ELL2 influencing immunoglobulin levels associate with multiple myeloma.Swaminathan, B., Thorleifsson G., Jöud M., Ali M., Johnsson E., Ajore R., Sulem P., Halvarsson BM, Eyjolfsson G., Haraldsdottir V., Hultman C., Ingelsson E., Kristinsson SY, Kähler AK, Lenhoff S., Masson G., Mellqvist UH, Månsson R., Nelander S., Olafsson I., et al. Nature communications, 2015/05/26, Volume 6, p.7213, (2015) Read More / View Supplemental Materials
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Inactivating mutations in MFSD2A, required for omega-3 fatty acid transport in brain, cause a lethal microcephaly syndrome.Guemez-Gamboa, A., Nguyen LN, Yang H., Zaki MS, Kara M., Ben-Omran T., Akizu N., Rosti RO, Rosti B., Scott E., Schroth J., Copeland B., Vaux KK, Cazenave-Gassiot A., Quek DQ, Wong BH, Tan BC, Wenk MR, Gunel M., Gabriel S., et al. Nature genetics, 2015/05/25, (2015) Read More / View Supplemental Materials
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Metabolic control of type 1 regulatory T cell differentiation by AHR and HIF1-α.Mascanfroni, ID, Takenaka MC, Yeste A., Patel B., Wu Y., Kenison JE, Siddiqui S., Basso AS, Otterbein LE, Pardoll DM, Pan F., Priel A., Clish CB, Robson SC, and Quintana FJ Nature medicine, 2015/05/25, (2015) Read More / View Supplemental Materials
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The schizophrenia risk gene product miR-137 alters presynaptic plasticity.Siegert, S., Seo J., Kwon EJ, Rudenko A., Cho S., Wang W., Flood Z., Martorell AJ, Ericsson M., Mungenast AE, and Tsai LH Nature neuroscience, 2015/05/25, (2015) Read More / View Supplemental Materials
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Genetic Risk Score for Essential Hypertension and Risk of Preeclampsia.Smith, CJ, Saftlas AF, Spracklen CN, Triche EW, Bjonnes A., Keating B., Saxena R., Breheny PJ, Dewan AT, Robinson JG, Hoh J., and Ryckman KK American journal of hypertension, 2015/05/23, (2015) Read More / View Supplemental Materials
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MERFISHing for spatial context.Shalek, AK, and Satija R. Trends in immunology, 2015/05/23, (2015) Read More / View Supplemental Materials
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The kinase DYRK1A reciprocally regulates the differentiation of Th17 and regulatory T cells.Khor, B., Gagnon JD, Goel G., Roche MI, Conway KL, Tran K., Aldrich LN, Sundberg TB, Paterson AM, Mordecai S., Dombkowski D., Schirmer M., Tan PH, Bhan AK, Roychoudhuri R., Restifo NP, O'Shea JJ, Medoff BD, Shamji AF, Schreiber SL, et al. eLife, 2015/05/22, Volume 4, (2015) Read More / View Supplemental Materials
Abstract
Association of DNA methylation in the brain with age in older persons is confounded by common neuropathologies.Yang, J., Yu L., Gaiteri C., Srivastava GP, Chibnik LB, Leurgans SE, Schneider JA, Meissner A., De Jager PL, and Bennett DA The international journal of biochemistry & cell biology, 2015/05/21, (2015) Read More / View Supplemental Materials
Abstract
Explicit Modeling of Ancestry Improves Polygenic Risk Scores and BLUP Prediction.Chen, CY, Han J., Hunter DJ, Kraft P., and Price AL Genetic epidemiology, 2015/05/21, (2015) Read More / View Supplemental Materials
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Genetics of atrial fibrillation: from families to genomes.Christophersen, IE, and Ellinor PT Journal of human genetics, 2015/05/21, (2015) Read More / View Supplemental Materials
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Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets.Macosko, EZ, Basu A., Satija R., Nemesh J., Shekhar K., Goldman M., Tirosh I., Bialas AR, Kamitaki N., Martersteck EM, Trombetta JJ, Weitz DA, Sanes JR, Shalek AK, Regev A., and McCarroll SA Cell, 2015/05/21, Volume 161, Issue 5, p.1202-14, (2015) Read More / View Supplemental Materials
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Integrative clinical genomics of advanced prostate cancer.Robinson, D., Van Allen EM, Wu YM, Schultz N., Lonigro RJ, Mosquera JM, Montgomery B., Taplin ME, Pritchard CC, Attard G., Beltran H., Abida W., Bradley RK, Vinson J., Cao X., Vats P., Kunju LP, Hussain M., Feng FY, Tomlins SA, et al. Cell, 2015/05/21, Volume 161, Issue 5, p.1215-28, (2015) Read More / View Supplemental Materials
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Shared elements of host-targeting pathways among apicomplexan parasites of differing life styles.Pellé, KG, Jiang RH, Mantel PY, Xiao YP, Hjelmqvist D., Gallego-Lopez GM, Lau AO, Kang BH, Allred DR, and Marti M. Cellular microbiology, 2015/05/21, (2015) Read More / View Supplemental Materials
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Treatment of obesity with celastrol.Liu, J., Lee J., Salazar Hernandez MA, Mazitschek R., and Ozcan U. Cell, 2015/05/21, Volume 161, Issue 5, p.999-1011, (2015) Read More / View Supplemental Materials
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Ancient Wolf Genome Reveals an Early Divergence of Domestic Dog Ancestors and Admixture into High-Latitude Breeds.Skoglund, P., Ersmark E., Palkopoulou E., and Dalén L. Current biology : CB, 2015/05/20, (2015) Read More / View Supplemental Materials
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The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs.Herman, JD, Pepper LR, Cortese JF, Estiu G., Galinsky K., Zuzarte-Luis V., Derbyshire ER, Ribacke U., Lukens AK, Santos SA, Patel V., Clish CB, Sullivan WJ Jr, Zhou H., Bopp SE, Schimmel P., Lindquist S., Clardy J., Mota MM, Keller TL, et al. Science translational medicine, 2015/05/20, Volume 7, Issue 288, p.288ra77, (2015) Read More / View Supplemental Materials
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Mendelian randomization study of height and risk of colorectal cancer.Thrift, AP, Gong J., Peters U., Chang-Claude J., Rudolph A., Slattery ML, Chan AT, Esko T., Wood AR, Yang J., Vedantam S., Gustafsson S., Pers TH, GIANT Consortium, Baron JA, Bezieau S., Küry S., Ogino S., Berndt SI, Casey G., et al. International journal of epidemiology, 2015/05/20, (2015) Read More / View Supplemental Materials
Abstract
Cervicovaginal bacteria are a major modulator of host inflammatory responses in the female genital tract.Anahtar, MN, Byrne EH, Doherty KE, Bowman BA, Yamamoto HS, Soumillon M., Padavattan N., Ismail N., Moodley A., Sabatini ME, Ghebremichael MS, Nusbaum C., Huttenhower C., Virgin HW, Ndung'u T., Dong KL, Walker BD, Fichorova RN, and Kwon DS Immunity, 2015/05/19, Volume 42, Issue 5, p.965-76, (2015) Read More / View Supplemental Materials
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Hypoxia drives transient site-specific copy gain and drug-resistant gene expression.Black, JC, Atabakhsh E., Kim J., Biette KM, Van Rechem C., Ladd B., Burrowes PD, Donado C., Mattoo H., Kleinstiver BP, Song B., Andriani G., Joung JK, Iliopoulos O., Montagna C., Pillai S., Getz G., and Whetstine JR Genes & development, 2015/05/15, Volume 29, Issue 10, p.1018-31, (2015) Read More / View Supplemental Materials
Abstract
Genomic signatures of evolutionary transitions from solitary to group living.Kapheim, KM, Pan H., Li C., Salzberg SL, Puiu D., Magoc T., Robertson HM, Hudson ME, Venkat A., Fischman BJ, Hernandez A., Yandell M., Ence D., Holt C., Yocum GD, Kemp WP, Bosch J., Waterhouse RM, Zdobnov EM, Stolle E., et al. Science (New York, N.Y.), 2015/05/14, (2015) Read More / View Supplemental Materials
Abstract
Likelihood Based Complex Trait Association Testing for Arbitrary Depth Sequencing Data.Yan, S., Yuan S., Xu Z., Zhang B., Zhang B., Kang G., Byrnes A., and Li Y. Bioinformatics (Oxford, England), 2015/05/14, (2015) Read More / View Supplemental Materials
Abstract
Association analysis of copy numbers of FC-gamma receptor genes for rheumatoid arthritis and other immune-mediated phenotypes.Franke, L., El Bannoudi H., Jansen DT, Kok K., Trynka G., Diogo D., Swertz M., Fransen K., Knevel R., Gutierrez-Achury J., Ärlestig L., Greenberg JD, Kremer J., Pappas DA, Kanterakis A., Weersma RK, van der Helm-van Mil AH, Guryev V., Rantapää-Dahlqvist S., Gregersen PK, et al. European journal of human genetics : EJHG, 2015/05/13, (2015) Read More / View Supplemental Materials
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Contrasting host-pathogen interactions and genome evolution in two generalist and specialist microsporidian pathogens of mosquitoes.Desjardins, CA, Sanscrainte ND, Goldberg JM, Heiman D., Young S., Zeng Q., Madhani HD, Becnel JJ, and Cuomo CA Nature communications, 2015/05/13, Volume 6, p.7121, (2015) Read More / View Supplemental Materials
Abstract
Functional inflammatory profiles distinguish myelin-reactive T cells from patients with multiple sclerosis.Cao, Y., Goods BA, Raddassi K., Nepom GT, Kwok WW, Love JC, and Hafler DA Science translational medicine, 2015/05/13, Volume 7, Issue 287, p.287ra74, (2015) Read More / View Supplemental Materials
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An Integrative View of Microbiome-Host Interactions in Inflammatory Bowel Diseases.Wlodarska, M., Kostic AD, and Xavier RJ Cell host & microbe, 2015/05/13, Volume 17, Issue 5, p.577-591, (2015) Read More / View Supplemental Materials
Abstract
Non-helical DNA Triplex Forms a Unique Aptamer Scaffold for High Affinity Recognition of Nerve Growth Factor.Jarvis, TC, Davies DR, Hisaminato A., Resnicow DI, Gupta S., Waugh SM, Nagabukuro A., Wadatsu T., Hishigaki H., Gawande B., Zhang C., Wolk SK, Mayfield WS, Nakaishi Y., Burgin AB, Stewart LJ, Edwards TE, Gelinas AD, Schneider DJ, and Janjic N. Structure (London, England : 1993), 2015/05/13, (2015) Read More / View Supplemental Materials
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Therapeutic challenges in diabetes prevention: "We have not found the exercise pill".Srinivasan, S., and Florez JC Clinical pharmacology and therapeutics, 2015/05/13, (2015) Read More / View Supplemental Materials
CRISPR germline engineering-the community speaks.Bosley, KS, Botchan M., Bredenoord AL, Carroll D., Charo RA, Charpentier E., Cohen R., Corn J., Doudna J., Feng G., Greely HT, Isasi R., Ji W., Kim JS, Knoppers B., Lanphier E., Li J., Lovell-Badge R., Martin GS, Moreno J., et al. Nature biotechnology, 2015/05/12, Volume 33, Issue 5, p.478-86, (2015) Read More / View Supplemental Materials
Functional profiling in Streptococcus mutans: construction and examination of a genomic collection of gene deletion mutants.Quivey RG, Jr, Grayhack EJ, Faustoferri RC, Hubbard CJ, Baldeck JD, Wolf AS, MacGilvray ME, Rosalen PL, Scott-Anne K., Santiago B., Gopal S., Payne J., and Marquis RE Molecular oral microbiology, 2015/05/12, (2015) Read More / View Supplemental Materials
Abstract
Defining the molecular landscape of ependymomas.Archer, TC, and Pomeroy SL Cancer cell, 2015/05/11, Volume 27, Issue 5, p.613-5, (2015) Read More / View Supplemental Materials
Abstract
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