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Synthesis, cellular evaluation and mechanism-of-action of piperlongumine analogsAdams, DJ, Dai M., Pellegrino G., Wagner BK, Stern AM, Shamji AF, and Schreiber SL, (Submitted) Read More / View Supplemental Materials
2014
Breaking Down RET Breakpoints in Lung Adenocarcinoma.Watanabe, H., Brooks AN, and Meyerson M. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2014/05/01, Volume 9, Issue 5, p.590-2, (2014) Read More / View Supplemental Materials
Genomic insights into tuberculosis.Galagan, JE Nature reviews. Genetics, 2014/05/01, Volume 15, Issue 5, p.307-20, (2014) Read More / View Supplemental Materials
Abstract
Regulatory T cells in autoimmune neuroinflammation.Kleinewietfeld, M., and Hafler DA Immunological reviews, 2014/05/01, Volume 259, Issue 1, p.231-44, (2014) Read More / View Supplemental Materials
Abstract
Activity-Dependent p25 Generation Regulates Synaptic Plasticity and Aβ-Induced Cognitive Impairment.Seo, J., Giusti-Rodríguez P., Zhou Y., Rudenko A., Cho S., Ota KT, Park C., Patzke H., Madabhushi R., Pan L., Mungenast AE, Guan JS, Delalle I., and Tsai LH Cell, 2014/04/10, Volume 157, Issue 2, p.486-98, (2014) Read More / View Supplemental Materials
Abstract
Inhibition of ATPIF1 Ameliorates Severe Mitochondrial Respiratory Chain Dysfunction in Mammalian Cells.Chen, WW, Birsoy K., Mihaylova MM, Snitkin H., Stasinski I., Yucel B., Bayraktar EC, Carette JE, Clish CB, Brummelkamp TR, Sabatini DD, and Sabatini DM Cell reports, 2014/04/10, Volume 7, Issue 1, p.27-34, (2014) Read More / View Supplemental Materials
Abstract
Intrinsic membrane hyperexcitability of amyotrophic lateral sclerosis patient-derived motor neurons.Wainger, BJ, Kiskinis E., Mellin C., Wiskow O., Han SS, Sandoe J., Perez NP, Williams LA, Lee S., Boulting G., Berry JD, Brown RH Jr, Cudkowicz ME, Bean BP, Eggan K., and Woolf CJ Cell reports, 2014/04/10, Volume 7, Issue 1, p.1-11, (2014) Read More / View Supplemental Materials
Abstract
Reconstructing and Reprogramming the Tumor-Propagating Potential of Glioblastoma Stem-like Cells.Suvà, ML, Rheinbay E., Gillespie SM, Patel AP, Wakimoto H., Rabkin SD, Riggi N., Chi AS, Cahill DP, Nahed BV, Curry WT, Martuza RL, Rivera MN, Rossetti N., Kasif S., Beik S., Kadri S., Tirosh I., Wortman I., Shalek AK, et al. Cell, 2014/04/09, (2014) Read More / View Supplemental Materials
Abstract
Automated Structure-Activity Relationship Mining: Connecting Chemical Structure to Biological Profiles.Wawer, MJ, Jaramillo DE, Dančik V., Fass DM, Haggarty SJ, Shamji AF, Wagner BK, Schreiber SL, and Clemons PA Journal of biomolecular screening, 2014/04/07, (2014) Read More / View Supplemental Materials
Abstract
Increasing the Content of High-Content Screening: An Overview.Singh, S., Carpenter AE, and Genovesio A. Journal of biomolecular screening, 2014/04/07, (2014) Read More / View Supplemental Materials
Abstract
Fine Mapping Seronegative and Seropositive Rheumatoid Arthritis to Shared and Distinct HLA Alleles by Adjusting for the Effects of Heterogeneity.Han, B., Diogo D., Eyre S., Kallberg H., Zhernakova A., Bowes J., Padyukov L., Okada Y., González-Gay MA, Rantapää-Dahlqvist S., Martin J., Huizinga TW, Plenge RM, Worthington J., Gregersen PK, Klareskog L., de Bakker PI, and Raychaudhuri S. American journal of human genetics, 2014/04/03, Volume 94, Issue 4, p.522-32, (2014) Read More / View Supplemental Materials
Abstract
Meta-analysis of Genome-wide Association Studies Identifies 1q22 as a Susceptibility Locus for Intracerebral Hemorrhage.Woo, D., Falcone GJ, Devan WJ, Brown WM, Biffi A., Howard TD, Anderson CD, Brouwers HB, Valant V., Battey TW, Radmanesh F., Raffeld MR, Baedorf-Kassis S., Deka R., Woo JG, Martin LJ, Haverbusch M., Moomaw CJ, Sun G., Broderick JP, et al. American journal of human genetics, 2014/04/03, Volume 94, Issue 4, p.511-21, (2014) Read More / View Supplemental Materials
Abstract
Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides.Birsoy, K., Possemato R., Lorbeer FK, Bayraktar EC, Thiru P., Yucel B., Wang T., Chen WW, Clish CB, and Sabatini DM Nature, 2014/04/03, Volume 508, Issue 7494, p.108-12, (2014) Read More / View Supplemental Materials
Abstract
Mutations in QARS, Encoding Glutaminyl-tRNA Synthetase, Cause Progressive Microcephaly, Cerebral-Cerebellar Atrophy, and Intractable Seizures.Zhang, X., Ling J., Barcia G., Jing L., Wu J., Barry BJ, Mochida GH, Hill RS, Weimer JM, Stein Q., Poduri A., Partlow JN, Ville D., Dulac O., Yu TW, Lam AT, Servattalab S., Rodriguez J., Boddaert N., Munnich A., et al. American journal of human genetics, 2014/04/03, Volume 94, Issue 4, p.547-58, (2014) Read More / View Supplemental Materials
Abstract
Pathways Disrupted in Human ALS Motor Neurons Identified through Genetic Correction of Mutant SOD1.Kiskinis, E., Sandoe J., Williams LA, Boulting GL, Moccia R., Wainger BJ, Han S., Peng T., Thams S., Mikkilineni S., Mellin C., Merkle FT, Davis-Dusenbery BN, Ziller M., Oakley D., Ichida J., Di Costanzo S., Atwater N., Maeder ML, Goodwin MJ, et al. Cell stem cell, 2014/04/03, (2014) Read More / View Supplemental Materials
Abstract
Perspective: Revealing molecular secrets.Hyman, SE Nature, 2014/04/03, Volume 508, Issue 7494, p.S20, (2014) Read More / View Supplemental Materials
A Central Role for GRB10 in Regulation of Islet Function in Man.Prokopenko, I., Poon W., Mägi R., Prasad B R., Salehi SA, Almgren P., Osmark P., Bouatia-Naji N., Wierup N., Fall T., Stančáková A., Barker A., Lagou V., Osmond C., Xie W., Lahti J., Jackson AU, Cheng YC, Liu J., O'Connell JR, et al. PLoS genetics, 2014/04/01, Volume 10, Issue 4, p.e1004235, (2014) Read More / View Supplemental Materials
Abstract
Current concepts and clinical applications of stroke genetics.Falcone, GJ, Malik R., Dichgans M., and Rosand J. Lancet neurology, 2014/04/01, Volume 13, Issue 4, p.405-418, (2014) Read More / View Supplemental Materials
Abstract
The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells.Trapnell, C., Cacchiarelli D., Grimsby J., Pokharel P., Li S., Morse M., Lennon NJ, Livak KJ, Mikkelsen TS, and Rinn JL Nature biotechnology, 2014/04/01, Volume 32, Issue 4, p.381-6, (2014) Read More / View Supplemental Materials
Abstract
Genetic modifiers and subtypes in schizophrenia: Investigations of age at onset, severity, sex and family history.Bergen, SE, O'Dushlaine CT, Lee PH, Fanous AH, Ruderfer DM, Ripke S., International Schizophrenia Consortium, Swedish Schizophrenia Consortium, Sullivan PF, Smoller JW, Purcell SM, and Corvin A. Schizophrenia research, 2014/04/01, Volume 154, Issue 1-3, p.48-53, (2014) Read More / View Supplemental Materials
Abstract
SOX2 and p63 colocalize at genetic loci in squamous cell carcinomas.Watanabe, H., Ma Q., Peng S., Adelmant G., Swain D., Song W., Fox C., Francis JM, Pedamallu CS, Deluca DS, Brooks AN, Wang S., Que J., Rustgi AK, Wong KK, Ligon KL, Liu XS, Marto JA, Meyerson M., and Bass AJ The Journal of clinical investigation, 2014/04/01, Volume 124, Issue 4, p.1636-45, (2014) Read More / View Supplemental Materials
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Regulation of mTORC1 by amino acids.Bar-Peled, L., and Sabatini DM Trends in cell biology, 2014/03/31, (2014) Read More / View Supplemental Materials
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Activating mTOR Mutations in a Patient with an Extraordinary Response on a Phase I Trial of Everolimus and Pazopanib.Wagle, N., Grabiner BC, Van Allen EM, Hodis E., Jacobus S., Supko JG, Stewart M., Choueiri TK, Gandhi L., Cleary JM, Elfiky AA, Taplin ME, Stack EC, Signoretti S., Loda M., Shapiro GI, Sabatini DM, Lander E. S., Gabriel SB, Kantoff PW, et al. Cancer discovery, 2014/03/27, (2014) Read More / View Supplemental Materials
Abstract
Human CFEOM1 Mutations Attenuate KIF21A Autoinhibition and Cause Oculomotor Axon Stalling.Cheng, L., Desai J., Miranda CJ, Duncan JS, Qiu W., Nugent AA, Kolpak AL, Wu CC, Drokhlyansky E., Delisle MM, Chan WM, Wei Y., Propst F., Reck-Peterson SL, Fritzsch B., and Engle EC Neuron, 2014/03/18, (2014) Read More / View Supplemental Materials
Abstract
Genome Sequencing of SHH Medulloblastoma Predicts Genotype-Related Response to Smoothened Inhibition.Kool, M., Jones DT, Jäger N., Northcott PA, Pugh TJ, Hovestadt V., Piro RM, Esparza LA, Markant SL, Remke M., Milde T., Bourdeaut F., Ryzhova M., Sturm D., Pfaff E., Stark S., Hutter S., Seker-Cin H., Johann P., Bender S., et al. Cancer cell, 2014/03/17, Volume 25, Issue 3, p.393-405, (2014) Read More / View Supplemental Materials
Abstract
Central Precocious Puberty that appears to be sporadic caused by Paternally inherited mutations in the imprinted GENE makorin ring finger 3.Macedo, DB, Abreu AP, Reis AC, Montenegro LR, Dauber A., Beneduzzi D., Cukier P., Silveira LF, Teles MG, Carroll RS, Guerra Junior G., Guaragna Filho G., Gucev Z., Arnhold IJ, de Castro M., Moreira AC, Martinelli CE Jr, Hirschhorn JN, Mendonca BB, Brito VN, et al. The Journal of clinical endocrinology and metabolism, 2014/03/14, p.jc20133126, (2014) Read More / View Supplemental Materials
Abstract
Time for new schizophrenia Rx.Hyman, SE Science (New York, N.Y.), 2014/03/14, Volume 343, Issue 6176, p.1177, (2014) Read More / View Supplemental Materials
Genetic and clonal dissection of murine small cell lung carcinoma progression by genome sequencing.McFadden, DG, Papagiannakopoulos T., Taylor-Weiner A., Stewart C., Carter SL, Cibulskis K., Bhutkar A., McKenna A., Dooley A., Vernon A., Sougnez C., Malstrom S., Heimann M., Park J., Chen F., Farago AF, Dayton T., Shefler E., Gabriel S., Getz G., et al. Cell, 2014/03/13, Volume 156, Issue 6, p.1298-311, (2014) Read More / View Supplemental Materials
Abstract
Microbes, Microbiota, and Colon Cancer.Sears, CL, and Garrett WS Cell host & microbe, 2014/03/12, Volume 15, Issue 3, p.317-328, (2014) Read More / View Supplemental Materials
Abstract
The treatment-naive microbiome in new-onset Crohn's disease.Gevers, D., Kugathasan S., Denson LA, Vázquez-Baeza Y., Van Treuren W., Ren B., Schwager E., Knights D., Song SJ, Yassour M., Morgan XC, Kostic AD, Luo C., González A., McDonald D., Haberman Y., Walters T., Baker S., Rosh J., Stephens M., et al. Cell host & microbe, 2014/03/12, Volume 15, Issue 3, p.382-92, (2014) Read More / View Supplemental Materials
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Extracellular matrix signatures of human mammary carcinoma identify novel metastasis promoters.Naba, A., Clauser KR, Lamar JM, Carr SA, and Hynes R. O. eLife, 2014/03/11, Volume 3, p.e01308, (2014) Read More / View Supplemental Materials
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In Vivo and in vitro dynamics of undifferentiated embryonic cell transcription factor 1.Galonska, C., Smith ZD, and Meissner A. Stem cell reports, 2014/03/11, Volume 2, Issue 3, p.245-52, (2014) Read More / View Supplemental Materials
Abstract
Common genetic variants modulate pathogen-sensing responses in human dendritic cells.Lee, MN, Ye C., Villani AC, Raj T., Li W., Eisenhaure TM, Imboywa SH, Chipendo PI, Ran FA, Slowikowski K., Ward LD, Raddassi K., McCabe C., Lee MH, Frohlich IY, Hafler DA, Kellis M., Raychaudhuri S., Zhang F., Stranger BE, et al. Science (New York, N.Y.), 2014/03/07, Volume 343, Issue 6175, p.1246980, (2014) Read More / View Supplemental Materials
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2013 Victor A. McKusick Leadership Award Introduction: Kurt and Rochelle Hirschhorn.Hirschhorn, JN American journal of human genetics, 2014/03/06, Volume 94, Issue 3, p.334-5, (2014) Read More / View Supplemental Materials
Dietary and Metabolic Control of Stem Cell Function in Physiology and Cancer.Mihaylova, MM, Sabatini DM, and Yilmaz OH Cell stem cell, 2014/03/06, Volume 14, Issue 3, p.292-305, (2014) Read More / View Supplemental Materials
Abstract
An excess of risk-increasing low-frequency variants can be a signal of polygenic inheritance in complex diseases.Chan, Y., Lim ET, Sandholm N., Wang SR, McKnight AJ, Ripke S., DIAGRAM Consortium, GENIE Consortium, GIANT Consortium, IIBDGC Consortium, PGC Consortium, Daly M. J., Neale BM, Salem RM, and Hirschhorn JN American journal of human genetics, 2014/03/06, Volume 94, Issue 3, p.437-52, (2014) Read More / View Supplemental Materials
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Functional and phylogenetic assembly of microbial communities in the human microbiome.Shafquat, A., Joice R., Simmons SL, and Huttenhower C. Trends in microbiology, 2014/03/04, (2014) Read More / View Supplemental Materials
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An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia.Knoechel, B., Roderick JE, Williamson KE, Zhu J., Lohr JG, Cotton MJ, Gillespie SM, Fernandez D., Ku M., Wang H., Piccioni F., Silver SJ, Jain M., Pearson D., Kluk MJ, Ott CJ, Shultz LD, Brehm MA, Greiner DL, Gutierrez A., et al. Nature genetics, 2014/03/02, (2014) Read More / View Supplemental Materials
Abstract
Loss-of-function mutations in SLC30A8 protect against type 2 diabetes.Flannick, J., Thorleifsson G., Beer NL, Jacobs SB, Grarup N., Burtt NP, Mahajan A., Fuchsberger C., Atzmon G., Benediktsson R., Blangero J., Bowden DW, Brandslund I., Brosnan J., Burslem F., Chambers J., Cho YS, Christensen C., Douglas DA, Duggirala R., et al. Nature genetics, 2014/03/02, (2014) Read More / View Supplemental Materials
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The transcription factor BATF operates as an essential differentiation checkpoint in early effector CD8+ T cells.Kurachi, M., Barnitz RA, Yosef N., Odorizzi PM, Diiorio MA, Lemieux ME, Yates K., Godec J., Klatt MG, Regev A., Wherry EJ, and Haining WN Nature immunology, 2014/03/02, (2014) Read More / View Supplemental Materials
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A121: in search of infectious triggers of periodic Fever, aphthous stomatitis, pharyngitis and adenitis syndrome.Freeman, S., Bhatt A., Pedamallu C., King S., Duke F., Jung J., Lawton M., Anderson E., Fuhlbrigge RC, Kenna M., Licameli G., Meyerson M., and Dedeoglu F. Arthritis & rheumatology (Hoboken, N.J.), 2014/03/01, Volume 66 Suppl 11, p.S158, (2014) Read More / View Supplemental Materials
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ARID1B is a specific vulnerability in ARID1A-mutant cancers.Helming, KC, Wang X., Wilson BG, Vazquez F., Haswell JR, Manchester HE, Kim Y., Kryukov GV, Ghandi M., Aguirre AJ, Jagani Z., Wang Z., Garraway LA, Hahn WC, and Roberts CW Nature medicine, 2014/03/01, Volume 20, Issue 3, p.251-4, (2014) Read More / View Supplemental Materials
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Genetic Dissection of Anopheles gambiae Gut Epithelial Responses to Serratia marcescens.Stathopoulos, S., Neafsey DE, Lawniczak MK, Muskavitch MA, and Christophides GK PLoS pathogens, 2014/03/01, Volume 10, Issue 3, p.e1003897, (2014) Read More / View Supplemental Materials
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Lassa Fever in post-conflict sierra leone.Shaffer, JG, Grant DS, Schieffelin JS, Boisen ML, Goba A., Hartnett JN, Levy DC, Yenni RE, Moses LM, Fullah M., Momoh M., Fonnie M., Fonnie R., Kanneh L., Koroma VJ, Kargbo K., Ottomassathien D., Muncy IJ, Jones AB, Illick MM, et al. PLoS neglected tropical diseases, 2014/03/01, Volume 8, Issue 3, p.e2748, (2014) Read More / View Supplemental Materials
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Residual Complexes Containing SMARCA2 (BRM) Underlie the Oncogenic Drive of SMARCA4 (BRG1) Mutation.Wilson, BG, Helming KC, Wang X., Kim Y., Vazquez F., Jagani Z., Hahn WC, and Roberts CW Molecular and cellular biology, 2014/03/01, Volume 34, Issue 6, p.1136-44, (2014) Read More / View Supplemental Materials
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Targeted Peptide Measurements in Biology and Medicine: Best Practices for Mass Spectrometry-based Assay Development Using a Fit-for-Purpose Approach.Carr, SA, Abbatiello SE, Ackermann BL, Borchers C., Domon B., Deutsch EW, Grant RP, Hoofnagle AN, Hüttenhain R., Koomen JM, Liebler DC, Liu T., Maclean B., Mani D., Mansfield E., Neubert H., Paulovich AG, Reiter L., Vitek O., Aebersold R., et al. Molecular & cellular proteomics : MCP, 2014/03/01, Volume 13, Issue 3, p.907-17, (2014) Read More / View Supplemental Materials
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Understanding Th17 cells through systematic genomic analyses.Peters, A., and Yosef N. Current opinion in immunology, 2014/03/01, Volume 28C, p.42-48, (2014) Read More / View Supplemental Materials
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Characterizing the genetic basis of methylome diversity in histologically normal human lung tissue.Shi, J., Marconett CN, Duan J., Hyland PL, Li P., Wang Z., Wheeler W., Zhou B., Campan M., Lee DS, Huang J., Zhou W., Triche T., Amundadottir L., Warner A., Hutchinson A., Chen PH, Chung BS, Pesatori AC, Consonni D., et al. Nature communications, 2014/02/27, Volume 5, p.3365, (2014) Read More / View Supplemental Materials
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Crystal structure of cas9 in complex with guide RNA and target DNA.Nishimasu, H., Ran FA, Hsu PD, Konermann S., Shehata SI, Dohmae N., Ishitani R., Zhang F., and Nureki O. Cell, 2014/02/27, Volume 156, Issue 5, p.935-49, (2014) Read More / View Supplemental Materials
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Genome-Wide Association Study for Circulating Tissue Plasminogen Activator Levels and Functional Follow-Up Implicates Endothelial STXBP5 and STX2.Huang, J., Huffman JE, Yamkauchi M., Trompet S., Asselbergs FW, Sabater-Lleal M., Trégouët DA, Chen WM, Smith NL, Kleber ME, Shin SY, Becker DM, Tang W., Dehghan A., Johnson AD, Truong V., Folkersen L., Yang Q., Oudot-Mellkah T., Buckley BM, et al. Arteriosclerosis, thrombosis, and vascular biology, 2014/02/27, (2014) Read More / View Supplemental Materials
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Genome-Wide Genotyping Demonstrates a Polygenic Risk Score Associated With White Matter Hyperintensity Volume in CADASIL.Opherk, C., Gonik M., Duering M., Malik R., Jouvent E., Hervé D., Adib-Samii P., Bevan S., Pianese L., Silvestri S., Dotti MT, De Stefano N., Liem M., Boon EM, Pescini F., Pachai C., Bracoud L., Müller-Myhsok B., Meitinger T., Rost N., et al. Stroke; a journal of cerebral circulation, 2014/02/27, (2014) Read More / View Supplemental Materials
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Detection and replication of epistasis influencing transcription in humans.Hemani, G., Shakhbazov K., Westra HJ, Esko T., Henders AK, McRae AF, Yang J., Gibson G., Martin NG, Metspalu A., Franke L., Montgomery GW, Visscher PM, and Powell JE Nature, 2014/02/26, (2014) Read More / View Supplemental Materials
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Prostaglandin E2 Regulates Liver versus Pancreas Cell-Fate Decisions and Endodermal Outgrowth.Nissim, S., Sherwood RI, Wucherpfennig J., Saunders D., Harris JM, Esain V., Carroll KJ, Frechette GM, Kim AJ, Hwang KL, Cutting CC, Elledge S., North TE, and Goessling W. Developmental cell, 2014/02/24, Volume 28, Issue 4, p.423-37, (2014) Read More / View Supplemental Materials
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Gene-centric Meta-analysis in 87,736 Individuals of European Ancestry Identifies Multiple Blood-Pressure-Related Loci.Tragante, V., Barnes MR, Ganesh SK, Lanktree MB, Guo W., Franceschini N., Smith EN, Johnson T., Holmes MV, Padmanabhan S., Karczewski KJ, Almoguera B., Barnard J., Baumert J., Chang YP, Elbers CC, Farrall M., Fischer ME, Gaunt TR, Gho JM, et al. American journal of human genetics, 2014/02/19, (2014) Read More / View Supplemental Materials
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The Microbiome in Inflammatory Bowel Diseases: Current Status and the Future Ahead.Kostic, AD, Xavier RJ, and Gevers D. Gastroenterology, 2014/02/18, (2014) Read More / View Supplemental Materials
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Genetic Association Analysis of 300 Genes Identifies a Risk Haplotype in SLC18A2 for Posttraumatic Stress Disorder in two Independent Samples.Solovieff, N., Roberts AL, Ratanatharathorn A., Haloosim M., De Vivo I., King AP, Liberzon I., Aiello A., Uddin M., Wildman DE, Galea S., Smoller JW, Purcell SM, and Koenen KC Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2014/02/14, (2014) Read More / View Supplemental Materials
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Targeting the pancreatic β-cell to treat diabetes.Vetere, A., Choudhary A., Burns SM, and Wagner BK Nature reviews. Drug discovery, 2014/02/14, (2014) Read More / View Supplemental Materials
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De novo mutations in schizophrenia implicate synaptic networks.Fromer, M., Pocklington AJ, Kavanagh DH, Williams HJ, Dwyer S., Gormley P., Georgieva L., Rees E., Palta P., Ruderfer DM, Carrera N., Humphreys I., Johnson JS, Roussos P., Barker DD, Banks E., Milanova V., Grant SG, Hannon E., Rose SA, et al. Nature, 2014/02/13, Volume 506, Issue 7487, p.179-84, (2014) Read More / View Supplemental Materials
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Early Empiric Antibiotic Use in Preterm Infants Is Associated with Lower Bacterial Diversity and Higher Relative Abundance of Enterobacter.Greenwood, C., Morrow AL, Lagomarcino AJ, Altaye M., Taft DH, Yu Z., Newburg DS, Ward DV, and Schibler KR The Journal of pediatrics, 2014/02/13, (2014) Read More / View Supplemental Materials
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A polygenic burden of rare disruptive mutations in schizophrenia.Purcell, SM, Moran JL, Fromer M., Ruderfer D., Solovieff N., Roussos P., O'Dushlaine C., Chambert K., Bergen SE, Kähler A., Duncan L., Stahl E., Genovese G., Fernández E., Collins MO, Komiyama NH, Choudhary JS, Magnusson PK, Banks E., Shakir K., et al. Nature, 2014/02/13, Volume 506, Issue 7487, p.185-90, (2014) Read More / View Supplemental Materials
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Zebrafish models of cerebrovascular disease.Walcott, BP, and Peterson RT Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2014/02/12, (2014) Read More / View Supplemental Materials
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Cohort Profile: Estonian Biobank of the Estonian Genome Center, University of Tartu.Leitsalu, L., Haller T., Esko T., Tammesoo ML, Alavere H., Snieder H., Perola M., Ng PC, Mägi R., Milani L., Fischer K., and Metspalu A. International journal of epidemiology, 2014/02/11, (2014) Read More / View Supplemental Materials
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Identification of Three Molecular and Functional Subtypes in Canine Hemangiosarcoma through Gene Expression Profiling and Progenitor Cell Characterization.Gorden, BH, Kim JH, Sarver AL, Frantz AM, Breen M., Lindblad-Toh K., O'Brien TD, Sharkey LC, Modiano JF, and Dickerson EB The American journal of pathology, 2014/02/11, (2014) Read More / View Supplemental Materials
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Nanog-Independent Reprogramming to iPSCs with Canonical Factors.Carter, AC, Davis-Dusenbery BN, Koszka K., Ichida JK, and Eggan K. Stem cell reports, 2014/02/11, Volume 2, Issue 2, p.119-26, (2014) Read More / View Supplemental Materials
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Polygenic inheritance of paclitaxel-induced sensory peripheral neuropathy driven by axon outgrowth gene sets in CALGB 40101 (Alliance).Chhibber, A., Mefford J., Stahl EA, Pendergrass SA, Baldwin RM, Owzar K., Li M., Winer EP, Hudis CA, Zembutsu H., Kubo M., Nakamura Y., McLeod HL, Ratain MJ, Shulman LN, Ritchie MD, Plenge RM, Witte JS, and Kroetz DL The pharmacogenomics journal, 2014/02/11, (2014) Read More / View Supplemental Materials
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Simplified and Efficient Quantification of Low Abundance Proteins at Very High Multiplex by Targeted Mass Spectrometry.Burgess, MW, Keshishian H., Mani D. R., Gillette MA, and Carr SA Molecular & cellular proteomics : MCP, 2014/02/11, (2014) Read More / View Supplemental Materials
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SYK Is a Critical Regulator of FLT3 in Acute Myeloid Leukemia.Puissant, A., Fenouille N., Alexe G., Pikman Y., Bassil CF, Mehta S., Du J., Kazi JU, Luciano F., Rönnstrand L., Kung AL, Aster J. C., Galinsky I., Stone RM, DeAngelo DJ, Hemann MT, and Stegmaier K. Cancer cell, 2014/02/10, Volume 25, Issue 2, p.226-42, (2014) Read More / View Supplemental Materials
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The antidepressant age.Hyman, SE Nature medicine, 2014/02/06, Volume 20, Issue 2, p.118-9, (2014) Read More / View Supplemental Materials
Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks.Peloso, GM, Auer PL, Bis JC, Voorman A., Morrison AC, Stitziel NO, Brody JA, Khetarpal SA, Crosby JR, Fornage M., Isaacs A., Jakobsdottir J., Feitosa MF, Davies G., Huffman JE, Manichaikul A., Davis B., Lohman K., Joon AY, Smith AV, et al. American journal of human genetics, 2014/02/06, Volume 94, Issue 2, p.223-32, (2014) Read More / View Supplemental Materials
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Building a pipeline to discover and validate novel therapeutic targets and lead compounds for Alzheimer's disease.Bennett, DA, Yu L., and De Jager PL Biochemical pharmacology, 2014/02/06, (2014) Read More / View Supplemental Materials
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Gut microbiome composition and function in experimental colitis during active disease and treatment-induced remission.Rooks, MG, Veiga P., Wardwell-Scott LH, Tickle T., Segata N., Michaud M., Gallini CA, Beal C., van Hylckama-Vlieg JE, Ballal SA, Morgan XC, Glickman JN, Gevers D., Huttenhower C., and Garrett WS The ISME journal, 2014/02/06, (2014) Read More / View Supplemental Materials
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In vivo discovery of immunotherapy targets in the tumour microenvironment.Zhou, P., Shaffer DR, Alvarez Arias DA, Nakazaki Y., Pos W., Torres AJ, Cremasco V., Dougan SK, Cowley GS, Elpek K., Brogdon J., Lamb J., Turley SJ, Ploegh HL, Root DE, Love JC, Dranoff G., Hacohen N., Cantor H., and Wucherpfennig KW Nature, 2014/02/06, Volume 506, Issue 7486, p.52-7, (2014) Read More / View Supplemental Materials
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Whole-Exome Sequencing Identifies Rare and Low-Frequency Coding Variants Associated with LDL Cholesterol.Lange, LA, Hu Y., Zhang H., Xue C., Schmidt EM, Tang ZZ, Bizon C., Lange EM, Smith JD, Turner EH, Jun G., Kang HM, Peloso G., Auer P., Li KP, Flannick J., Zhang J., Fuchsberger C., Gaulton K., Lindgren C., et al. American journal of human genetics, 2014/02/06, Volume 94, Issue 2, p.233-45, (2014) Read More / View Supplemental Materials
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Genetic variation of oxidative phosphorylation genes in stroke and Alzheimer's disease.Biffi, A., Sabuncu MR, Desikan RS, Schmansky N., Salat DH, Rosand J., Anderson CD, and Alzheimer's disease Neuroimaging Initiative(ADNI) Neurobiology of aging, 2014/02/05, (2014) Read More / View Supplemental Materials
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Selective inhibition of histone deacetylase 6 alters the composition of circulating blood cells in a lethal septic model.Zhao, T., Li Y., Liu B., Halaweish I., Mazitschek R., and Alam HB The Journal of surgical research, 2014/02/04, (2014) Read More / View Supplemental Materials
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Extracting data from the muck: deriving biological insight from complex microbial communities and non-model organisms with next generation sequencing.Solomon, KV, Haitjema CH, Thompson DA, and O'Malley MA Current opinion in biotechnology, 2014/02/03, Volume 28C, p.103-110, (2014) Read More / View Supplemental Materials
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Advantages and pitfalls in the application of mixed-model association methods.Yang, J., Zaitlen NA, Goddard ME, Visscher PM, and Price AL Nature genetics, 2014/02/01, Volume 46, Issue 2, p.100-6, (2014) Read More / View Supplemental Materials
Abstract
Analysis of copy number variations at 15 schizophrenia-associated loci.Rees, E., Walters JT, Georgieva L., Isles AR, Chambert KD, Richards AL, Mahoney-Davies G., Legge SE, Moran JL, McCarroll SA, O'Donovan MC, Owen MJ, and Kirov G. The British journal of psychiatry : the journal of mental science, 2014/02/01, Volume 204, Issue 2, p.108-14, (2014) Read More / View Supplemental Materials
Abstract
Biomarker profiling by nuclear magnetic resonance spectroscopy for the prediction of all-cause mortality: an observational study of 17,345 persons.Fischer, K., Kettunen J., Würtz P., Haller T., Havulinna AS, Kangas AJ, Soininen P., Esko T., Tammesoo ML, Mägi R., Smit S., Palotie A., Ripatti S., Salomaa V., Ala-Korpela M., Perola M., and Metspalu A. PLoS medicine, 2014/02/01, Volume 11, Issue 2, p.e1001606, (2014) Read More / View Supplemental Materials
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Canine Hereditary Ataxia in Old English Sheepdogs and Gordon Setters Is Associated with a Defect in the Autophagy Gene Encoding RAB24.Agler, C., Nielsen DM, Urkasemsin G., Singleton A., Tonomura N., Sigurdsson S., Tang R., Linder K., Arepalli S., Hernandez D., Lindblad-Toh K., van de Leemput J., Motsinger-Reif A., O'Brien DP, Bell J., Harris T., Steinberg S., and Olby NJ PLoS genetics, 2014/02/01, Volume 10, Issue 2, p.e1003991, (2014) Read More / View Supplemental Materials
Abstract
Chromosome x-wide association study identifies Loci for fasting insulin and height and evidence for incomplete dosage compensation.Tukiainen, T., Pirinen M., Sarin AP, Ladenvall C., Kettunen J., Lehtimäki T., Lokki ML, Perola M., Sinisalo J., Vlachopoulou E., Eriksson JG, Groop L., Jula A., Järvelin MR, Raitakari OT, Salomaa V., and Ripatti S. PLoS genetics, 2014/02/01, Volume 10, Issue 2, p.e1004127, (2014) Read More / View Supplemental Materials
Abstract
Demonstrating the feasibility of large-scale development of standardized assays to quantify human proteins.Kennedy, JJ, Abbatiello SE, Kim K., Yan P., Whiteaker JR, Lin C., Kim JS, Zhang Y., Wang X., Ivey RG, Zhao L., Min H., Lee Y., Yu MH, Yang EG, Lee C., Wang P., Rodriguez H., Kim Y., Carr SA, et al. Nature methods, 2014/02/01, Volume 11, Issue 2, p.149-55, (2014) Read More / View Supplemental Materials
Abstract
Exome sequencing identifies BRAF mutations in papillary craniopharyngiomas.Brastianos, PK, Taylor-Weiner A., Manley PE, Jones RT, Dias-Santagata D., Thorner AR, Lawrence MS, Rodriguez FJ, Bernardo LA, Schubert L., Sunkavalli A., Shillingford N., Calicchio ML, Lidov HG, Taha H., Martinez-Lage M., Santi M., Storm PB, Lee JY, Palmer JN, et al. Nature genetics, 2014/02/01, Volume 46, Issue 2, p.161-5, (2014) Read More / View Supplemental Materials
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Genomic sequences of a low passage herpes simplex virus 2 clinical isolate and its plaque-purified derivative strain.Colgrove, R., Diaz F., Newman R., Saif S., Shea T., Young S., Henn M., and Knipe DM Virology, 2014/02/01, Volume 450-451, p.140-5, (2014) Read More / View Supplemental Materials
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Identification of Host-Targeted Small Molecules That Restrict Intracellular Mycobacterium tuberculosis Growth.Stanley, SA, Barczak AK, Silvis MR, Luo SS, Sogi K., Vokes M., Bray MA, Carpenter AE, Moore CB, Siddiqi N., Rubin EJ, and Hung DT PLoS pathogens, 2014/02/01, Volume 10, Issue 2, p.e1003946, (2014) Read More / View Supplemental Materials
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The Master Regulator of the Cellular Stress Response (HSF1) Is Critical for Orthopoxvirus Infection.Filone, CM, Caballero IS, Dower K., Mendillo ML, Cowley GS, Santagata S., Rozelle DK, Yen J., Rubins KH, Hacohen N., Root DE, Hensley LE, and Connor J. PLoS pathogens, 2014/02/01, Volume 10, Issue 2, p.e1003904, (2014) Read More / View Supplemental Materials
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Recent discoveries and applications involving small-molecule microarrays.Hong, JA, Neel DV, Wassaf D., Caballero F., and Koehler AN Current opinion in chemical biology, 2014/02/01, Volume 18C, p.21-28, (2014) Read More / View Supplemental Materials
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Topological organization of multichromosomal regions by the long intergenic noncoding RNA Firre.Hacisuleyman, E., Goff LA, Trapnell C., Williams A., Henao-Mejia J., Sun L., McClanahan P., Hendrickson DG, Sauvageau M., Kelley DR, Morse M., Engreitz J., Lander E. S., Guttman M., Lodish HF, Flavell R., Raj A., and Rinn JL Nature structural & molecular biology, 2014/02/01, Volume 21, Issue 2, p.198-206, (2014) Read More / View Supplemental Materials
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The evolution of lncRNA repertoires and expression patterns in tetrapods.Necsulea, A., Soumillon M., Warnefors M., Liechti A., Daish T., Zeller U., Baker JC, Grützner F., and Kaessmann H. Nature, 2014/01/30, Volume 505, Issue 7485, p.635-40, (2014) Read More / View Supplemental Materials
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Analysis of pfhrp2 genetic diversity in Senegal and implications for use of rapid diagnostic tests.Deme, AB, Park DJ, Bei AK, Sarr O., Badiane AS, Gueye Pel H., Ahouidi A., Ndir O., Mboup S., Wirth DF, Ndiaye D., and Volkman SK Malaria journal, 2014/01/29, Volume 13, Issue 1, p.34, (2014) Read More / View Supplemental Materials
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The genomic landscape of Neanderthal ancestry in present-day humans.Sankararaman, S., Mallick S., Dannemann M., Prüfer K., Kelso J., Pääbo S., Patterson N., and Reich D. Nature, 2014/01/29, (2014) Read More / View Supplemental Materials
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Meta'omic Analytic Techniques for Studying the Intestinal Microbiome.Morgan, XC, and Huttenhower C. Gastroenterology, 2014/01/28, (2014) Read More / View Supplemental Materials
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Searching for missing heritability: Designing rare variant association studies.Zuk, O., Schaffner SF, Samocha K., Do R., Hechter E., Kathiresan S., Daly M. J., Neale BM, Sunyaev SR, and Lander E. S. Proceedings of the National Academy of Sciences of the United States of America, 2014/01/28, Volume 111, Issue 4, p.E455-64, (2014) Read More / View Supplemental Materials
Abstract
Oncogenic RIT1 mutations in lung adenocarcinoma.Berger, AH, Imielinski M., Duke F., Wala J., Kaplan N., Shi GX, Andres DA, and Meyerson M. Oncogene, 2014/01/27, (2014) Read More / View Supplemental Materials
Abstract
Derived immune and ancestral pigmentation alleles in a 7,000-year-old Mesolithic European.Olalde, I., Allentoft ME, Sánchez-Quinto F., Santpere G., Chiang CW, Degiorgio M., Prado-Martinez J., Rodríguez JA, Rasmussen S., Quilez J., Ramírez O., Marigorta UM, Fernández-Callejo M., Prada ME, Encinas JM, Nielsen R., Netea MG, Novembre J., Sturm RA, Sabeti P., et al. Nature, 2014/01/26, (2014) Read More / View Supplemental Materials
Abstract
Epigenome-wide association studies without the need for cell-type composition.Zou, J., Lippert C., Heckerman D., Aryee M., and Listgarten J. Nature methods, 2014/01/26, (2014) Read More / View Supplemental Materials
Abstract
Connecting Small Molecules with Similar Assay Performance Profiles Leads to New Biological Hypotheses.Dancík, V., Carrel H., Bodycombe NE, Seiler KP, Fomina-Yadlin D., Kubicek ST, Hartwell K., Shamji AF, Wagner BK, and Clemons PA Journal of biomolecular screening, 2014/01/24, (2014) Read More / View Supplemental Materials
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Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer.Nilsson, R., Jain M., Madhusudhan N., Sheppard NG, Strittmatter L., Kampf C., Huang J., Asplund A., and Mootha VK Nature communications, 2014/01/23, Volume 5, p.3128, (2014) Read More / View Supplemental Materials
Abstract
Translation of branched-chain aminotransferase-1 transcripts is impaired in cells haploinsufficient for ribosomal protein genes.Pereboom, TC, Bondt A., Pallaki P., Klasson T., Goos YJ, Essers PB, Koerkamp MG, Gazda HT, Holstege FC, and Macinnes AW Experimental hematology, 2014/01/23, (2014) Read More / View Supplemental Materials
Abstract
Accuracy of imputation to infer unobserved APOE epsilon alleles in genome-wide genotyping data.Radmanesh, F., Devan WJ, Anderson CD, Rosand J., and Falcone GJ European journal of human genetics : EJHG, 2014/01/22, (2014) Read More / View Supplemental Materials
Abstract
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