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Synthesis, cellular evaluation and mechanism-of-action of piperlongumine analogsAdams, DJ, Dai M., Pellegrino G., Wagner BK, Stern AM, Shamji AF, and Schreiber SL, (Submitted) Read More / View Supplemental Materials
2015
Haematological malignancies: at the forefront of immunotherapeutic innovation.Bachireddy, P., Burkhardt UE, Rajasagi M., and Wu CJ Nature reviews. Cancer, 2015/04/01, Volume 15, Issue 4, p.201-15, (2015) Read More / View Supplemental Materials
Abstract
A Microbiological Revolution Meets an Ancient Disease: Improving the Management of Tuberculosis with Genomics.Wlodarska, M., Johnston JC, Gardy JL, and Tang P. Clinical microbiology reviews, 2015/04/01, Volume 28, Issue 2, p.523-539, (2015) Read More / View Supplemental Materials
Abstract
Simultaneous measurement of genome-wide transcription elongation speeds and rates of RNA polymerase II transition into active elongation with 4sUDRB-seq.Fuchs, G., Voichek Y., Rabani M., Benjamin S., Gilad S., Amit I., and Oren M. Nature protocols, 2015/04/01, Volume 10, Issue 4, p.605-618, (2015) Read More / View Supplemental Materials
Abstract
Non-crossover gene conversions show strong GC bias and unexpected clustering in humans.Williams, AL, Genovese G., Dyer T., Altemose N., Truax K., Jun G., Patterson N., Myers SR, Curran JE, Duggirala R., Blangero J., Reich D., and Przeworski M. eLife, 2015/03/25, Volume 4, (2015) Read More / View Supplemental Materials
Abstract
Association of a 62 Variant Type 2 Diabetes Genetic Risk Score with Markers of Subclinical Atherosclerosis: A Transethnic, Multicenter Study.Dauriz, M., Porneala BC, Guo X., Bielak LF, Peyser PA, Durant NH, Carnethon MR, Bonadonna RC, Bonora E., Bowden DW, Florez JC, Fornage M., Hivert MF, Jacobs DR Jr, Kabagambe EK, Lewis CE, Murabito JM, Rasmussen-Torvik LJ, Rich SS, Vassy JL, et al. Circulation. Cardiovascular genetics, 2015/03/24, (2015) Read More / View Supplemental Materials
Abstract
Analysing human neural stem cell ontogeny by consecutive isolation of Notch active neural progenitors.Edri, R., Yaffe Y., Ziller MJ, Mutukula N., Volkman R., David E., Jacob-Hirsch J., Malcov H., Levy C., Rechavi G., Gat-Viks I., Meissner A., and Elkabetz Y. Nature communications, 2015/03/23, Volume 6, p.6500, (2015) Read More / View Supplemental Materials
Abstract
Dimethylglycine Deficiency and the Development of Diabetes mellitus.Magnusson, M., Wang TJ, Clish C., Engström G., Nilsson P., Gerszten RE, and Melander O. Diabetes, 2015/03/20, (2015) Read More / View Supplemental Materials
Abstract
Rare Genetic Variants in the CFI Gene are Associated with Advanced Age-Related Macular Degeneration and Commonly Result in Reduced Serum Factor I Levels.Kavanagh, D., Yu Y., Schramm EC, Triebwasser M., Wagner E., Raychaudhuri S., Daly M. J., Atkinson JP, and Seddon JM Human molecular genetics, 2015/03/18, (2015) Read More / View Supplemental Materials
Abstract
CHD2 variants are a risk factor for photosensitivity in epilepsy.Galizia, EC, Myers CT, Leu C., de Kovel CG, Afrikanova T., Cordero-Maldonado ML, Martins TG, Jacmin M., Drury S., Krishna Chinthapalli V., Muhle H., Pendziwiat M., Sander T., Ruppert AK, Møller RS, Thiele H., Krause R., Schubert J., Lehesjoki AE, Nürnberg P., et al. Brain : a journal of neurology, 2015/03/17, (2015) Read More / View Supplemental Materials
Abstract
Contribution of common non-synonymous variants in PCSK1 to body-mass index variation and risk of obesity: a systematic review and meta-analysis with evidence from up to 331,175 individuals.Nead, KT, Li A., Wehner MR, Neupane B., Gustafsson S., Butterworth A., Engert JC, Davis AD, Hegele RA, Miller R., den Hoed M., Khaw KT, Kilpeläinen TO, Wareham N., Edwards TL, Hallmans G., Varga TV, Kardia SL, Smith JA, Zhao W., et al. Human molecular genetics, 2015/03/17, (2015) Read More / View Supplemental Materials
Abstract
A novel Alzheimer disease locus located near the gene encoding tau protein.Jun, G., Ibrahim-Verbaas CA, Vronskaya M., Lambert JC, Chung J., Naj AC, Kunkle BW, Wang LS, Bis JC, Bellenguez C., Harold D., Lunetta KL, Destefano AL, Grenier-Boley B., Sims R., Beecham GW, Smith AV, Chouraki V., Hamilton-Nelson KL, Ikram MA, et al. Molecular psychiatry, 2015/03/17, (2015) Read More / View Supplemental Materials
Abstract
Temporal trends in the incidence and prognosis of aortic stenosis: a nationwide study of the Swedish population.Martinsson, A., Li X., Andersson C., Nilsson J., Smith JG, and Sundquist K. Circulation, 2015/03/17, Volume 131, Issue 11, p.988-94, (2015) Read More / View Supplemental Materials
Abstract
Identification of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase as a novel autophagy regulator by high content shRNA screening.Strohecker, AM, Joshi S., Possemato R., Abraham RT, Sabatini DM, and White E. Oncogene, 2015/03/16, (2015) Read More / View Supplemental Materials
Abstract
Transformation of the intestinal epithelium by the MSI2 RNA-binding protein.Wang, S., Li N., Yousefi M., Nakauka-Ddamba A., Li F., Parada K., Rao S., Minuesa G., Katz Y., Gregory BD, Kharas MG, Yu Z., and Lengner CJ Nature communications, 2015/03/16, Volume 6, p.6517, (2015) Read More / View Supplemental Materials
Abstract
Genome-wide CRISPR Screen in a Mouse Model of Tumor Growth and Metastasis.Chen, S., Sanjana NE, Zheng K., Shalem O., Lee K., Shi X., Scott DA, Song J., Pan JQ, Weissleder R., Lee H., Zhang F., and Sharp PA Cell, 2015/03/12, Volume 160, Issue 6, p.1246-60, (2015) Read More / View Supplemental Materials
Abstract
RB loss in resistant EGFR mutant lung adenocarcinomas that transform to small-cell lung cancer.Niederst, MJ, Sequist LV, Poirier JT, Mermel CH, Lockerman EL, Garcia AR, Katayama R., Costa C., Ross KN, Moran T., Howe E., Fulton LE, Mulvey HE, Bernardo LA, Mohamoud F., Miyoshi N., VanderLaan PA, Costa DB, Jänne PA, Borger DR, et al. Nature communications, 2015/03/11, Volume 6, p.6377, (2015) Read More / View Supplemental Materials
Abstract
Clinical implementation of integrated whole-genome copy number and mutation profiling for glioblastoma.Ramkissoon, SH, Bi WL, Schumacher SE, Ramkissoon LA, Haidar S., Knoff D., Dubuc A., Brown L., Burns M., Cryan JB, Abedalthagafi M., Kang YJ, Schultz N., Reardon DA, Lee EQ, Rinne ML, Norden AD, Nayak L., Ruland S., Doherty LM, et al. Neuro-oncology, 2015/03/09, (2015) Read More / View Supplemental Materials
Abstract
Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers.Onengut-Gumuscu, S., Chen WM, Burren O., Cooper NJ, Quinlan AR, Mychaleckyj JC, Farber E., Bonnie JK, Szpak M., Schofield E., Achuthan P., Guo H., Fortune MD, Stevens H., Walker NM, Ward LD, Kundaje A., Kellis M., Daly M. J., Barrett JC, et al. Nature genetics, 2015/03/09, (2015) Read More / View Supplemental Materials
Abstract
A Functional Landscape of Resistance to ALK Inhibition in Lung Cancer.Wilson, FH, Johannessen CM, Piccioni F., Tamayo P., Kim JW, Van Allen EM, Corsello SM, Capelletti M., Calles A., Butaney M., Sharifnia T., Gabriel SB, Mesirov J. P., Hahn WC, Engelman JA, Meyerson M., Root DE, Jänne PA, and Garraway LA Cancer cell, 2015/03/09, Volume 27, Issue 3, p.397-408, (2015) Read More / View Supplemental Materials
Abstract
Immunogenetics. Dynamic profiling of the protein life cycle in response to pathogens.Jovanovic, M., Rooney MS, Mertins P., Przybylski D., Chevrier N., Satija R., Rodriguez EH, Fields AP, Schwartz S., Raychowdhury R., Mumbach MR, Eisenhaure T., Rabani M., Gennert D., Lu D., Delorey T., Weissman JS, Carr SA, Hacohen N., and Regev A. Science (New York, N.Y.), 2015/03/06, Volume 347, Issue 6226, p.1259038, (2015) Read More / View Supplemental Materials
Abstract
Notch-mediated expansion of cord blood progenitors: maintenance of transcriptional and epigenetic fidelity.Dahlberg, A., Woo S., Delaney C., Boyle P., Gnirke A., Bock C., Bernstein BE, Meissner A., Gottardo R., and Bernstein ID Leukemia, 2015/03/06, (2015) Read More / View Supplemental Materials
2014 curt stern award introduction: mark daly.Palotie, A. American journal of human genetics, 2015/03/05, Volume 96, Issue 3, p.367-8, (2015) Read More / View Supplemental Materials
2014 curt stern award: a tryst with genetics.Daly, M. J. American journal of human genetics, 2015/03/05, Volume 96, Issue 3, p.369-71, (2015) Read More / View Supplemental Materials
Anemia: progress in molecular mechanisms and therapies.Sankaran, VG, and Weiss MJ Nature medicine, 2015/03/05, Volume 21, Issue 3, p.221-230, (2015) Read More / View Supplemental Materials
Abstract
Characterization of large structural genetic mosaicism in human autosomes.Machiela, MJ, Zhou W., Sampson JN, Dean MC, Jacobs KB, Black A., Brinton LA, Chang IS, Chen C., Chen C., Chen K., Cook LS, Crous Bou M., De Vivo I., Doherty J., Friedenreich CM, Gaudet MM, Haiman CA, Hankinson SE, Hartge P., et al. American journal of human genetics, 2015/03/05, Volume 96, Issue 3, p.487-97, (2015) Read More / View Supplemental Materials
Abstract
Remodelling of a homeobox gene cluster by multiple independent gene reunions in Drosophila.Chan, C., Jayasekera S., Kao B., Páramo M., von Grotthuss M., and Ranz JM Nature communications, 2015/03/05, Volume 6, p.6509, (2015) Read More / View Supplemental Materials
Abstract
Characterization of bipolar disorder patient-specific induced pluripotent stem cells from a family reveals neurodevelopmental and mRNA expression abnormalities.Madison, JM, Zhou F., Nigam A., Hussain A., Barker DD, Nehme R., van der Ven K., Hsu J., Wolf P., Fleishman M., O'Dushlaine C., Rose S., Chambert K., Lau FH, Ahfeldt T., Rueckert EH, Sheridan SD, Fass DM, Nemesh J., Mullen TE, et al. Molecular psychiatry, 2015/03/03, (2015) Read More / View Supplemental Materials
Abstract
Single-cell analysis reveals transcriptional heterogeneity of neural progenitors in human cortex.Johnson, MB, Wang PP, Atabay KD, Murphy EA, Doan RN, Hecht JL, and Walsh CA Nature neuroscience, 2015/03/03, (2015) Read More / View Supplemental Materials
Abstract
Highly efficient Cas9-mediated transcriptional programming.Chavez, A., Scheiman J., Vora S., Pruitt BW, Tuttle M., P R Iyer E., Lin S., Kiani S., Guzman CD, Wiegand DJ, Ter-Ovanesyan D., Braff JL, Davidsohn N., Housden BE, Perrimon N., Weiss R., Aach J., Collins JJ, and Church GM Nature methods, 2015/03/02, (2015) Read More / View Supplemental Materials
Abstract
Massive migration from the steppe was a source for Indo-European languages in Europe.Haak, W., Lazaridis I., Patterson N., Rohland N., Mallick S., Llamas B., Brandt G., Nordenfelt S., Harney E., Stewardson K., Fu Q., Mittnik A., Bánffy E., Economou C., Francken M., Friederich S., Pena RG, Hallgren F., Khartanovich V., Khokhlov A., et al. Nature, 2015/03/02, (2015) Read More / View Supplemental Materials
Abstract
Polyploidy can drive rapid adaptation in yeast.Selmecki, AM, Maruvka YE, Richmond PA, Guillet M., Shoresh N., Sorenson AL, De S., Kishony R., Michor F., Dowell R., and Pellman D. Nature, 2015/03/02, (2015) Read More / View Supplemental Materials
Abstract
Simultaneous generation of many RNA-seq libraries in a single reaction.Shishkin, AA, Giannoukos G., Kucukural A., Ciulla D., Busby M., Surka C., Chen J., Bhattacharyya RP, Rudy RF, Patel MM, Novod N., Hung DT, Gnirke A., Garber M., Guttman M., and Livny J. Nature methods, 2015/03/02, (2015) Read More / View Supplemental Materials
Abstract
Antimicrobial-Induced DNA Damage and Genomic Instability in Microbial Pathogens.Shapiro, RS PLoS pathogens, 2015/03/01, Volume 11, Issue 3, p.e1004678, (2015) Read More / View Supplemental Materials
Chromatin regulation at the frontier of synthetic biology.Keung, AJ, Joung JK, Khalil AS, and Collins JJ Nature reviews. Genetics, 2015/03/01, Volume 16, Issue 3, p.159-71, (2015) Read More / View Supplemental Materials
Abstract
Commentary: Insights from across diagnostic boundaries: ADHD in the RDoC era - a commentary on Scerif and Baker ().Doyle, AE Journal of child psychology and psychiatry, and allied disciplines, 2015/03/01, Volume 56, Issue 3, p.274-7, (2015) Read More / View Supplemental Materials
Abstract
Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt.Murn, J., Zarnack K., Yang YJ, Durak O., Murphy EA, Cheloufi S., Gonzalez DM, Teplova M., Curk T., Zuber J., Patel DJ, Ule J., Luscombe NM, Tsai LH, Walsh CA, and Shi Y. Genes & development, 2015/03/01, Volume 29, Issue 5, p.501-12, (2015) Read More / View Supplemental Materials
Abstract
Development of a Single Nucleotide Polymorphism Barcode to Genotype Plasmodium vivax Infections.Baniecki, ML, Faust AL, Schaffner SF, Park DJ, Galinsky K., Daniels RF, Hamilton E., Ferreira MU, Karunaweera ND, Serre D., Zimmerman PA, Sá JM, Wellems TE, Musset L., Legrand E., Melnikov A., Neafsey DE, Volkman SK, Wirth DF, and Sabeti PC PLoS neglected tropical diseases, 2015/03/01, Volume 9, Issue 3, p.e0003539, (2015) Read More / View Supplemental Materials
Abstract
Discovery of novel rhabdoviruses in the blood of healthy individuals from west Africa.Stremlau, MH, Andersen KG, Folarin OA, Grove JN, Odia I., Ehiane PE, Omoniwa O., Omoregie O., Jiang PP, Yozwiak NL, Matranga CB, Yang X., Gire SK, Winnicki S., Tariyal R., Schaffner SF, Okokhere PO, Okogbenin S., Akpede GO, Asogun DA, et al. PLoS neglected tropical diseases, 2015/03/01, Volume 9, Issue 3, p.e0003631, (2015) Read More / View Supplemental Materials
Abstract
A Meta-analysis of Gene Expression Signatures of Blood Pressure and Hypertension.Huan, T., Esko T., Peters MJ, Pilling LC, Schramm K., Schurmann C., Chen BH, Liu C., Joehanes R., Johnson AD, Yao C., Ying SX, Courchesne P., Milani L., Raghavachari N., Wang R., Liu P., Reinmaa E., Dehghan A., Hofman A., et al. PLoS genetics, 2015/03/01, Volume 11, Issue 3, p.e1005035, (2015) Read More / View Supplemental Materials
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Mosquito biology. Evolution of sexual traits influencing vectorial capacity in anopheline mosquitoes.Mitchell, SN, Kakani EG, South A., Howell PI, Waterhouse RM, and Catteruccia F. Science (New York, N.Y.), 2015/02/27, Volume 347, Issue 6225, p.985-8, (2015) Read More / View Supplemental Materials
Abstract
Multiplexed, Quantitative Workflow for Sensitive Biomarker Discovery in Plasma Yields Novel Candidates for Early Myocardial Injury.Keshishian, H., Burgess MW, Gillette MA, Mertins P., Clauser KR, Mani D. R., Kuhn EW, Farrell LA, Gerszten RE, and Carr SA Molecular & cellular proteomics : MCP, 2015/02/27, (2015) Read More / View Supplemental Materials
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Predicting clinical response to anticancer drugs using an ex vivo platform that captures tumour heterogeneity.Majumder, B., Baraneedharan U., Thiyagarajan S., Radhakrishnan P., Narasimhan H., Dhandapani M., Brijwani N., Pinto DD, Prasath A., Shanthappa BU, Thayakumar A., Surendran R., Babu GK, Shenoy AM, Kuriakose MA, Bergthold G., Horowitz P., Loda M., Beroukhim R., Agarwal S., et al. Nature communications, 2015/02/27, Volume 6, p.6169, (2015) Read More / View Supplemental Materials
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A roadmap for interpreting 13C metabolite labeling patterns from cells.Buescher, JM, Antoniewicz MR, Boros LG, Burgess SC, Brunengraber H., Clish CB, DeBerardinis RJ, Feron O., Frezza C., Ghesquiere B., Gottlieb E., Hiller K., Jones RG, Kamphorst JJ, Kibbey RG, Kimmelman AC, Locasale JW, Lunt SY, Maddocks OD, Malloy C., et al. Current opinion in biotechnology, 2015/02/27, Volume 34C, p.189-201, (2015) Read More / View Supplemental Materials
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Data sharing: Make outbreak research open access.Yozwiak, NL, Schaffner SF, and Sabeti PC Nature, 2015/02/26, Volume 518, Issue 7540, p.477-9, (2015) Read More / View Supplemental Materials
Draft Genome Sequence of the Cellulolytic Fungus Chaetomium globosum.Cuomo, CA, Untereiner WA, Ma LJ, Grabherr M., and Birren BW Genome announcements, 2015/02/26, Volume 3, Issue 1, (2015) Read More / View Supplemental Materials
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A genomic data viewer for iPad.Thorvaldsdóttir, H., Robinson JT, Turner D., and Mesirov J. P. Genome biology, 2015/02/26, Volume 16, p.46, (2015) Read More / View Supplemental Materials
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Biogeography of the Intestinal Mucosal and Lumenal Microbiome in the Rhesus Macaque.Yasuda, K., Oh K., Ren B., Tickle TL, Franzosa EA, Wachtman LM, Miller AD, Westmoreland SV, Mansfield KG, Vallender EJ, Miller GM, Rowlett JK, Gevers D., Huttenhower C., and Morgan XC Cell host & microbe, 2015/02/25, (2015) Read More / View Supplemental Materials
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Glucokinase regulatory protein: complexity at the crossroads of triglyceride and glucose metabolism.Raimondo, A., Rees MG, and Gloyn AL Current opinion in lipidology, 2015/02/24, (2015) Read More / View Supplemental Materials
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Searching for a minimal set of behaviors for autism detection through feature selection-based machine learning.Kosmicki, JA, Sochat V., Duda M., and Wall DP Translational psychiatry, 2015/02/24, Volume 5, p.e514, (2015) Read More / View Supplemental Materials
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Age- and Sex-Specific Causal Effects of Adiposity on Cardiovascular Risk Factors.Fall, T., Hägg S., Ploner A., Mägi R., Fischer K., Draisma HH, Sarin AP, Benyamin B., Ladenvall C., Åkerlund M., Kals M., Esko T., Nelson CP, Kaakinen M., Huikari V., Mangino M., Meirhaeghe A., Kristiansson K., Nuotio ML, Kobl M., et al. Diabetes, 2015/02/23, (2015) Read More / View Supplemental Materials
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Oncotator: Cancer Variant Annotation Tool.Ramos, AH, Lichtenstein L., Gupta M., Lawrence MS, Pugh TJ, Saksena G., Meyerson M., and Getz G. Human mutation, 2015/02/23, (2015) Read More / View Supplemental Materials
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BRCA1 Recruitment to Transcriptional Pause Sites Is Required for R-Loop-Driven DNA Damage Repair.Hatchi, E., Skourti-Stathaki K., Ventz S., Pinello L., Yen A., Kamieniarz-Gdula K., Dimitrov S., Pathania S., McKinney KM, Eaton ML, Kellis M., Hill SJ, Parmigiani G., Proudfoot NJ, and Livingston DM Molecular cell, 2015/02/19, Volume 57, Issue 4, p.636-47, (2015) Read More / View Supplemental Materials
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Cell-of-origin chromatin organization shapes the mutational landscape of cancer.Polak, P., Karlić R., Koren A., Thurman R., Sandstrom R., Lawrence MS, Reynolds A., Rynes E., Vlahoviček K., Stamatoyannopoulos JA, and Sunyaev SR Nature, 2015/02/19, Volume 518, Issue 7539, p.360-4, (2015) Read More / View Supplemental Materials
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Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer's disease.Gjoneska, E., Pfenning AR, Mathys H., Quon G., Kundaje A., Tsai LH, and Kellis M. Nature, 2015/02/19, Volume 518, Issue 7539, p.365-9, (2015) Read More / View Supplemental Materials
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Integrative analysis of 111 reference human epigenomes.Roadmap Epigenomics, Consortium, Kundaje A., Meuleman W., Ernst J., Bilenky M., Yen A., Heravi-Moussavi A., Kheradpour P., Zhang Z., Wang J., Ziller MJ, Amin V., Whitaker JW, Schultz MD, Ward LD, Sarkar A., Quon G., Sandstrom RS, Eaton ML, Wu YC, et al. Nature, 2015/02/19, Volume 518, Issue 7539, p.317-30, (2015) Read More / View Supplemental Materials
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Transcription factor binding dynamics during human ES cell differentiation.Tsankov, AM, Gu H., Akopian V., Ziller MJ, Donaghey J., Amit I., Gnirke A., and Meissner A. Nature, 2015/02/19, Volume 518, Issue 7539, p.344-9, (2015) Read More / View Supplemental Materials
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Intermediate DNA methylation is a conserved signature of genome regulation.Elliott, G., Hong C., Xing X., Zhou X., Li D., Coarfa C., Bell RJ, Maire CL, Ligon KL, Sigaroudinia M., Gascard P., Tlsty TD, Harris RA, Schalkwyk LC, Bilenky M., Mill J., Farnham PJ, Kellis M., Marra MA, Milosavljevic A., et al. Nature communications, 2015/02/18, Volume 6, p.6363, (2015) Read More / View Supplemental Materials
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Large-scale imputation of epigenomic datasets for systematic annotation of diverse human tissues.Ernst, J., and Kellis M. Nature biotechnology, 2015/02/18, (2015) Read More / View Supplemental Materials
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Large-scale inter-laboratory study to develop, analytically validate and apply highly multiplexed, quantitative peptide assays to measure cancer-relevant proteins in plasma.Abbatiello, SE, Schilling B., Mani D. R., Zimmerman LJ, Hall SC, Maclean B., Albertolle M., Allen S., Burgess M., Cusack MP, Ghosh M., Hedrick V., Held JM, Inerowicz HD, Jackson A., Keshishian H., Kinsinger CR, Lyssand J., Makowski L., Mesri M., et al. Molecular & cellular proteomics : MCP, 2015/02/18, (2015) Read More / View Supplemental Materials
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Cutting the Gordian Helix - Regulating Genomic Testing in the Era of Precision Medicine.Lander, E. S. The New England journal of medicine, 2015/02/17, (2015) Read More / View Supplemental Materials
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Generation and Characterization of Rat iPSCs.Liao, J., and Cui C. Methods in molecular biology (Clifton, N.J.), 2015/02/17, (2015) Read More / View Supplemental Materials
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Generation of neuropeptidergic hypothalamic neurons from human pluripotent stem cells.Merkle, FT, Maroof A., Wataya T., Sasai Y., Studer L., Eggan K., and Schier AF Development (Cambridge, England), 2015/02/15, Volume 142, Issue 4, p.633-43, (2015) Read More / View Supplemental Materials
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Drug discovery. Tying up a transcription factor.Chen, A., and Koehler AN Science (New York, N.Y.), 2015/02/13, Volume 347, Issue 6223, p.713-4, (2015) Read More / View Supplemental Materials
Expanding the phenotype of GMPPB mutations.Cabrera-Serrano, M., Ghaoui R., Ravenscroft G., Johnsen RD, Davis MR, Corbett A., Reddel S., Sue CM, Liang C., Waddell LB, Kaur S., Lek M., North KN, Macarthur DG, Lamont PJ, Clarke NF, and Laing NG Brain : a journal of neurology, 2015/02/12, (2015) Read More / View Supplemental Materials
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Genetic studies of body mass index yield new insights for obesity biology.Locke, AE, Kahali B., Berndt SI, Justice AE, Pers TH, Day FR, Powell C., Vedantam S., Buchkovich ML, Yang J., Croteau-Chonka DC, Esko T., Fall T., Ferreira T., Gustafsson S., Kutalik Z., Luan J., Mägi R., Randall JC, Winkler TW, et al. Nature, 2015/02/12, Volume 518, Issue 7538, p.197-206, (2015) Read More / View Supplemental Materials
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New genetic loci link adipose and insulin biology to body fat distribution.Shungin, D., Winkler TW, Croteau-Chonka DC, Ferreira T., Locke AE, Mägi R., Strawbridge RJ, Pers TH, Fischer K., Justice AE, Workalemahu T., Wu JM, Buchkovich ML, Heard-Costa NL, Roman TS, Drong AW, Song C., Gustafsson S., Day FR, Esko T., et al. Nature, 2015/02/12, Volume 518, Issue 7538, p.187-96, (2015) Read More / View Supplemental Materials
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Dominance Genetic Variation Contributes Little to the Missing Heritability for Human Complex Traits.Zhu, Z., Bakshi A., Vinkhuyzen AA, Hemani G., Lee SH, Nolte IM, van Vliet-Ostaptchouk JV, Snieder H., The LifeLines Cohort Study, Esko T., Milani L., Mägi R., Metspalu A., Hill WG, Weir BS, Goddard ME, Visscher PM, and Yang J. American journal of human genetics, 2015/02/11, (2015) Read More / View Supplemental Materials
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The Dynamics of the Human Infant Gut Microbiome in Development and in Progression toward Type 1 Diabetes.Kostic, AD, Gevers D., Siljander H., Vatanen T., Hyötyläinen T., Hämäläinen AM, Peet A., Tillmann V., Pöhö P., Mattila I., Lähdesmäki H., Franzosa EA, Vaarala O., de Goffau M., Harmsen H., Ilonen J., Virtanen SM, Clish CB, Orešič M., Huttenhower C., et al. Cell host & microbe, 2015/02/11, Volume 17, Issue 2, p.260-73, (2015) Read More / View Supplemental Materials
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Loss of cyclin-dependent kinase 5 from parvalbumin interneurons leads to hyperinhibition, decreased anxiety, and memory impairment.Rudenko, A., Seo J., Hu J., Su SC, de Anda FC, Durak O., Ericsson M., Carlén M., and Tsai LH The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015/02/11, Volume 35, Issue 6, p.2372-83, (2015) Read More / View Supplemental Materials
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Massively expedited genome-wide heritability analysis (MEGHA).Ge, T., Nichols TE, Lee PH, Holmes AJ, Roffman JL, Buckner RL, Sabuncu MR, and Smoller JW Proceedings of the National Academy of Sciences of the United States of America, 2015/02/09, (2015) Read More / View Supplemental Materials
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Anterior commissural white matter fiber abnormalities in first-episode psychosis: A tractography study.Kikinis, Z., Fitzsimmons J., Dunn C., Vu MA, Makris N., Bouix S., Goldstein JM, Mesholam-Gately RI, Petryshen T., Del Re EC, Wojcik J., Seidman LJ, and Kubicki M. Schizophrenia research, 2015/02/06, (2015) Read More / View Supplemental Materials
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Therapeutic genome editing: prospects and challenges.Cox, DB, Platt RJ, and Zhang F. Nature medicine, 2015/02/05, Volume 21, Issue 2, p.121-131, (2015) Read More / View Supplemental Materials
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16S Community Profiling Identifies Proton Pump Inhibitor Related Differences in Gastric, Lung, and Oropharyngeal Microflora.Rosen, R., Hu L., Amirault J., Khatwa U., Ward DV, and Onderdonk A. The Journal of pediatrics, 2015/02/04, (2015) Read More / View Supplemental Materials
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Human iPSC-Derived Hepatocyte-like Cells Support Plasmodium Liver-Stage Infection In Vitro.Ng, S., Schwartz RE, March S., Galstian A., Gural N., Shan J., Prabhu M., Mota MM, and Bhatia SN Stem cell reports, 2015/02/04, (2015) Read More / View Supplemental Materials
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A Massive Expansion of Effector Genes Underlies Gall-Formation in the Wheat Pest Mayetiola destructor.Zhao, C., Escalante LN, Chen H., Benatti TR, Qu J., Chellapilla S., Waterhouse RM, Wheeler D., Andersson MN, Bao R., Batterton M., Behura SK, Blankenburg KP, Caragea D., Carolan JC, Coyle M., El-Bouhssini M., Francisco L., Friedrich M., Gill N., et al. Current biology : CB, 2015/02/04, (2015) Read More / View Supplemental Materials
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Niche-Based Screening in Multiple Myeloma Identifies a Kinesin-5 Inhibitor with Improved Selectivity over Hematopoietic Progenitors.Chattopadhyay, S., Stewart AL, Mukherjee S., Huang C., Hartwell KA, Miller PG, Subramanian R., Carmody LC, Yusuf RZ, Sykes DB, Paulk J., Vetere A., Vallet S., Santo L., Cirstea DD, Hideshima T., Dančík V., Majireck MM, Hussain MM, Singh S., et al. Cell reports, 2015/02/04, (2015) Read More / View Supplemental Materials
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PTPMT1 Inhibition Lowers Glucose through Succinate Dehydrogenase Phosphorylation.Nath, AK, Ryu JH, Jin YN, Roberts LD, Dejam A., Gerszten RE, and Peterson RT Cell reports, 2015/02/04, (2015) Read More / View Supplemental Materials
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The TMEM106B locus and TDP-43 pathology in older persons without FTLD.Yu, L., De Jager PL, Yang J., Trojanowski JQ, Bennett DA, and Schneider JA Neurology, 2015/02/04, (2015) Read More / View Supplemental Materials
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Boosting bacterial metabolism to combat antibiotic resistance.Bhargava, P., and Collins JJ Cell metabolism, 2015/02/03, Volume 21, Issue 2, p.154-5, (2015) Read More / View Supplemental Materials
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Enabling Consistency in Pluripotent Stem Cell-Derived Products for Research and Development and Clinical Applications Through Material Standards.French, A., Bravery C., Smith J., Chandra A., Archibald P., Gold JD, Artzi N., Kim HW, Barker RW, Meissner A., Wu JC, Knowles JC, Williams D., García-Cardeña G., Sipp D., Oh S., Loring JF, Rao MS, Reeve B., Wall I., et al. Stem cells translational medicine, 2015/02/03, (2015) Read More / View Supplemental Materials
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The evolution of drug resistance in clinical isolates of Candida albicans.Ford, CB, Funt JM, Abbey D., Issi L., Guiducci C., Martinez DA, Delorey T., Li BY, White TC, Cuomo C., Rao RP, Berman J., Thompson DA, and Regev A. eLife, 2015/02/03, Volume 4, (2015) Read More / View Supplemental Materials
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Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53 949).Davies, G., Armstrong N., Bis JC, Bressler J., Chouraki V., Giddaluru S., Hofer E., Ibrahim-Verbaas CA, Kirin M., Lahti J., van der Lee SJ, Le Hellard S., Liu T., Marioni RE, Oldmeadow C., Postmus I., Smith AV, Smith JA, Thalamuthu A., Thomson R., et al. Molecular psychiatry, 2015/02/03, (2015) Read More / View Supplemental Materials
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Whole-genome and multisector exome sequencing of primary and post-treatment glioblastoma reveals patterns of tumor evolution.Im, HK, Zheng S., Amini SS, Virk SM, Mikkelsen T., Brat DJ, Grimsby J., Sougnez C., Muller F., Hu J., Sloan AE, Cohen ML, Van Meir EG, Scarpace L., Laird PW, Weinstein J. N., Lander E. S., Gabriel S., Getz G., Meyerson M., et al. Genome research, 2015/02/03, (2015) Read More / View Supplemental Materials
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Discovery of six new susceptibility loci and analysis of pleiotropic effects in leprosy.Liu, H., Irwanto A., Fu X., Yu G., Yu Y., Sun Y., Wang C., Wang Z., Okada Y., Low H., Li Y., Liany H., Chen M., Bao F., Li J., You J., Zhang Q., Liu J., Chu T., Andiappan AK, et al. Nature genetics, 2015/02/02, (2015) Read More / View Supplemental Materials
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Efficient Bayesian mixed-model analysis increases association power in large cohorts.Loh, PR, Tucker G., Bulik-Sullivan BK, Vilhjálmsson BJ, Finucane HK, Salem RM, Chasman DI, Ridker PM, Neale BM, Berger B., Patterson N., and Price AL Nature genetics, 2015/02/02, (2015) Read More / View Supplemental Materials
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LD Score regression distinguishes confounding from polygenicity in genome-wide association studies.Bulik-Sullivan, BK, Loh PR, Finucane HK, Ripke S., Yang J., Schizophrenia Working Group of the Psychiatric Genomics Consortium, Patterson N., Daly M. J., Price AL, and Neale BM Nature genetics, 2015/02/02, (2015) Read More / View Supplemental Materials
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Message from the ISCB: ISCB Ebola award for important future research on the computational biology of Ebola virus.Karp, PD, Berger B., Kovats D., Lengauer T., Linial M., Sabeti P., Hide W., and Rost B. Bioinformatics (Oxford, England), 2015/02/02, (2015) Read More / View Supplemental Materials
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A split-Cas9 architecture for inducible genome editing and transcription modulation.Zetsche, B., Volz SE, and Zhang F. Nature biotechnology, 2015/02/02, Volume 33, Issue 2, p.139-142, (2015) Read More / View Supplemental Materials
Therapeutic Insights from Genomic Studies of Head and Neck Squamous Cell Carcinomas.Hammerman, PS, Hayes DN, and Grandis JR Cancer discovery, 2015/02/02, (2015) Read More / View Supplemental Materials
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Common and Rare Variants in SCN10A Modulate the Risk of Atrial Fibrillation.Jabbari, J., Olesen MS, Yuan L., Nielsen JB, Liang B., Macri V., Christophersen IE, Nielsen N., Sajadieh A., Ellinor PT, Grunnet M., Haunsø S., Holst AG, Svendsen JH, and Jespersen T. Circulation. Cardiovascular genetics, 2015/02/01, Volume 8, Issue 1, p.64-73, (2015) Read More / View Supplemental Materials
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Functional implications of a psychiatric risk variant within CACNA1C in induced human neurons.Yoshimizu, T., Pan JQ, Mungenast AE, Madison JM, Su S., Ketterman J., Ongur D., McPhie D., Cohen B., Perlis R., and Tsai LH Molecular psychiatry, 2015/02/01, Volume 20, Issue 2, p.162-9, (2015) Read More / View Supplemental Materials
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Genome-wide Association Study Identifies Shared Risk Loci Common to Two Malignancies in Golden Retrievers.Tonomura, N., Elvers I., Thomas R., Megquier K., Turner-Maier J., Howald C., Sarver AL, Swofford R., Frantz AM, Ito D., Mauceli E., Arendt M., Noh HJ, Koltookian M., Biagi T., Fryc S., Williams C., Avery AC, Kim JH, Barber L., et al. PLoS genetics, 2015/02/01, Volume 11, Issue 2, p.e1004922, (2015) Read More / View Supplemental Materials
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Inhibition of histone deacetylase 6 improves long-term survival in a lethal septic model.Li, Y., Zhao T., Liu B., Halaweish I., Mazitschek R., Duan X., and Alam HB The journal of trauma and acute care surgery, 2015/02/01, Volume 78, Issue 2, p.378-85, (2015) Read More / View Supplemental Materials
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Intra-tumor Genetic Heterogeneity and Mortality in Head and Neck Cancer: Analysis of Data from The Cancer Genome Atlas.Mroz, EA, Tward AM, Hammon RJ, Ren Y., and Rocco JW PLoS medicine, 2015/02/01, Volume 12, Issue 2, p.e1001786, (2015) Read More / View Supplemental Materials
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Somatic mutations and atrial fibrillation: the end or just the beginning?Lubitz, SA, and Ellinor PT Circulation. Cardiovascular genetics, 2015/02/01, Volume 8, Issue 1, p.2-3, (2015) Read More / View Supplemental Materials
Systematic Cell-Based Phenotyping of Missense Alleles Empowers Rare Variant Association Studies: A Case for LDLR and Myocardial Infarction.Thormaehlen, AS, Schuberth C., Won HH, Blattmann P., Joggerst-Thomalla B., Theiss S., Asselta R., Duga S., Merlini PA, Ardissino D., Lander E. S., Gabriel S., Rader DJ, Peloso GM, Pepperkok R., Kathiresan S., and Runz H. PLoS genetics, 2015/02/01, Volume 11, Issue 2, p.e1004855, (2015) Read More / View Supplemental Materials
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Top advances in functional genomics and translational biology for 2014.Gupta, RM, Pilbrow AP, and Weeke PE Circulation. Cardiovascular genetics, 2015/02/01, Volume 8, Issue 1, p.207-10, (2015) Read More / View Supplemental Materials
Disease-specific alterations in the enteric virome in inflammatory bowel disease.Norman, JM, Handley SA, Baldridge MT, Droit L., Liu CY, Keller BC, Kambal A., Monaco CL, Zhao G., Fleshner P., Stappenbeck TS, McGovern DP, Keshavarzian A., Mutlu EA, Sauk J., Gevers D., Xavier RJ, Wang D., Parkes M., and Virgin HW Cell, 2015/01/29, Volume 160, Issue 3, p.447-60, (2015) Read More / View Supplemental Materials
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Famine versus feast: understanding the metabolism of tumors in vivo.Mayers, JR, and Vander Heiden MG Trends in biochemical sciences, 2015/01/29, (2015) Read More / View Supplemental Materials
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