Scientific Publications

Search by Keyword(s)
Found 1856 results

Search Results

  • Showing 1-100 of 1856 Results
  • 1
  • 2
  • 3
  • 4
  • 5
  • 6
  • 7...
Submitted
Synthesis, cellular evaluation and mechanism-of-action of piperlongumine analogsAdams, DJ, Dai M., Pellegrino G., Wagner BK, Stern AM, Shamji AF, and Schreiber SL, (Submitted) Read More / View Supplemental Materials
2014
Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci.De Jager, PL, Srivastava G., Lunnon K., Burgess J., Schalkwyk LC, Yu L., Eaton ML, Keenan BT, Ernst J., McCabe C., Tang A., Raj T., Replogle J., Brodeur W., Gabriel S., Chai HS, Younkin C., Younkin SG, Zou F., Szyf M., et al. Nature neuroscience, 2014/09/01, Volume 17, Issue 9, p.1156-1163, (2014) Read More / View Supplemental Materials
Abstract
Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease.Lunnon, K., Smith R., Hannon E., De Jager PL, Srivastava G., Volta M., Troakes C., Al-Sarraj S., Burrage J., Macdonald R., Condliffe D., Harries LW, Katsel P., Haroutunian V., Kaminsky Z., Joachim C., Powell J., Lovestone S., Bennett DA, Schalkwyk LC, et al. Nature neuroscience, 2014/09/01, Volume 17, Issue 9, p.1164-1170, (2014) Read More / View Supplemental Materials
Abstract
Label-free, live optical imaging of reprogrammed bipolar disorder patient-derived cells reveals a functional correlate of lithium responsiveness.Wang, JL, Shamah SM, Sun AX, Waldman ID, Haggarty SJ, and Perlis RH Translational psychiatry, 2014/08/26, Volume 4, p.e428, (2014) Read More / View Supplemental Materials
Abstract
Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes.Majithia, AR, Flannick J., Shahinian P., Guo M., Bray MA, Fontanillas P., Gabriel SB, GoT2D Consortium, NHGRI JHS/FHS Allelic Spectrum Project, SIGMA T2D Consortium, T2D-GENES Consortium, Rosen ED, Altshuler D., and GoT2D Consortium Proceedings of the National Academy of Sciences of the United States of America, 2014/08/25, (2014) Read More / View Supplemental Materials
Abstract
APOE ε variants increase risk of warfarin-related intracerebral hemorrhage.Falcone, GJ, Radmanesh F., Brouwers HB, Battey TW, Devan WJ, Valant V., Raffeld MR, Chitsike LP, Ayres AM, Schwab K., Goldstein JN, Viswanathan A., Greenberg SM, Selim M., Meschia JF, Brown DL, Worrall BB, Silliman SL, Tirschwell DL, Flaherty ML, et al. Neurology, 2014/08/22, (2014) Read More / View Supplemental Materials
Abstract
Cosi2 : An efficient simulator of exact and approximate coalescent with selection.Shlyakhter, I., Sabeti PC, and Schaffner SF Bioinformatics (Oxford, England), 2014/08/22, (2014) Read More / View Supplemental Materials
Abstract
Gabapentin attenuates hyperexcitability in the freeze-lesion model of developmental cortical malformation.Andresen, L., Hampton D., Taylor A., Morel L., Yang Y., Maguire J., and Dulla CG Neurobiology of disease, 2014/08/22, (2014) Read More / View Supplemental Materials
Abstract
ProtocolNavigator: emulation based software for the design, documentation and reproduction biological experiments.Khan, IA, Fraser A., Bray MA, Smith PJ, White NS, Carpenter AE, and Errington RJ Bioinformatics (Oxford, England), 2014/08/22, (2014) Read More / View Supplemental Materials
Abstract
Stem cell therapy. Use of differentiated pluripotent stem cells as replacement therapy for treating disease.Fox, IJ, Daley GQ, Goldman SA, Huard J., Kamp TJ, and Trucco M. Science (New York, N.Y.), 2014/08/22, Volume 345, Issue 6199, p.1247391, (2014) Read More / View Supplemental Materials
Abstract
Multivariate inference of pathway activity in host immunity and response to therapeutics.Goel, G., Conway KL, Jaeger M., Netea MG, and Xavier RJ Nucleic acids research, 2014/08/21, (2014) Read More / View Supplemental Materials
Abstract
PyBamView: a browser based application for viewing short read alignments.Gymrek, M. Bioinformatics (Oxford, England), 2014/08/21, (2014) Read More / View Supplemental Materials
Abstract
Somatic Mutations in Cerebral Cortical Malformations.Jamuar, SS, Lam AT, Kircher M., D'Gama AM, Wang J., Barry BJ, Zhang X., Hill RS, Partlow JN, Rozzo A., Servattalab S., Mehta BK, Topcu M., Amrom D., Andermann E., Dan B., Parrini E., Guerrini R., Scheffer IE, Berkovic SF, et al. The New England journal of medicine, 2014/08/21, Volume 371, Issue 8, p.733-743, (2014) Read More / View Supplemental Materials
Abstract
Single-Cell, Genome-wide Sequencing Identifies Clonal Somatic Copy-Number Variation in the Human Brain.Cai, X., Evrony GD, Lehmann HS, Elhosary PC, Mehta BK, Poduri A., and Walsh CA Cell reports, 2014/08/20, (2014) Read More / View Supplemental Materials
Abstract
The Somatic Genomic Landscape of Chromophobe Renal Cell Carcinoma.Davis, CF, Ricketts CJ, Wang M., Yang L., Cherniack AD, Shen H., Buhay C., Kang H., Kim SC, Fahey CC, Hacker KE, Bhanot G., Gordenin DA, Chu A., Gunaratne PH, Biehl M., Seth S., Kaipparettu BA, Bristow CA, Donehower LA, et al. Cancer cell, 2014/08/20, (2014) Read More / View Supplemental Materials
Abstract
DNA replication timing: Coordinating genome stability with genome regulation on the X chromosome and beyond.Koren, A. BioEssays : news and reviews in molecular, cellular and developmental biology, 2014/08/19, (2014) Read More / View Supplemental Materials
Abstract
Reconstructing Austronesian population history in Island Southeast Asia.Lipson, M., Loh PR, Patterson N., Moorjani P., Ko YC, Stoneking M., Berger B., and Reich D. Nature communications, 2014/08/19, Volume 5, p.4689, (2014) Read More / View Supplemental Materials
Abstract
Genomic instability, driver genes and cell selection: Projections from cancer to stem cells.Ben-David, U. Biochimica et biophysica acta, 2014/08/15, (2014) Read More / View Supplemental Materials
Abstract
Integrating Genetic, Transcriptional, and Functional Analyses to Identify Five Novel Genes for Atrial Fibrillation.Sinner, MF, Tucker NR, Lunetta KL, Ozaki K., Smith JG, Trompet S., Bis JC, Lin H., Chung MK, Nielsen JB, Lubitz SA, Krijthe BP, Magnani JW, Ye J., Gollob MH, Tsunoda T., Müller-Nurasyid M., Lichtner P., Peters A., Dolmatova E., et al. Circulation, 2014/08/14, (2014) Read More / View Supplemental Materials
Abstract
Multiplatform Analysis of 12 Cancer Types Reveals Molecular Classification within and across Tissues of Origin.Hoadley, KA, Yau C., Wolf DM, Cherniack AD, Tamborero D., Ng S., Leiserson MD, Niu B., McLellan MD, Uzunangelov V., Zhang J., Kandoth C., Akbani R., Shen H., Omberg L., Chu A., Margolin AA, Van't Veer LJ, Lopez-Bigas N., Laird PW, et al. Cell, 2014/08/14, Volume 158, Issue 4, p.929-44, (2014) Read More / View Supplemental Materials
Abstract
Twelve-Single Nucleotide Polymorphism Genetic Risk Score Identifies Individuals at Increased Risk for Future Atrial Fibrillation and Stroke.Tada, H., Shiffman D., Smith JG, Sjögren M., Lubitz SA, Ellinor PT, Louie JZ, Catanese JJ, Engström G., Devlin JJ, Kathiresan S., and Melander O. Stroke; a journal of cerebral circulation, 2014/08/14, (2014) Read More / View Supplemental Materials
Abstract
Polyoma Small T Antigen Interacts with YES-Associated Protein (YAP) to Regulate Cell Survival and Differentiation.Hwang, JH, Pores Fernando AT, Faure N., Andrabi S., Hahn WC, Schaffhausen BS, and Roberts TM Journal of virology, 2014/08/13, (2014) Read More / View Supplemental Materials
Abstract
An alteration in ATG16L1 stability in Crohn disease.Lassen, KG, and Xavier RJ Autophagy, 2014/08/12, Volume 10, Issue 10, (2014) Read More / View Supplemental Materials
Abstract
Testing the accuracy of an observation-based classifier for rapid detection of autism risk.Duda, M., Kosmicki JA, and Wall DP Translational psychiatry, 2014/08/12, Volume 4, p.e424, (2014) Read More / View Supplemental Materials
Abstract
Small-molecule screening identifies inhibition of salt-inducible kinases as a therapeutic strategy to enhance immunoregulatory functions of dendritic cells.Sundberg, TB, Choi HG, Song JH, Russell CN, Hussain MM, Graham DB, Khor B., Gagnon J., O'Connell DJ, Narayan K., Dančík V., Perez JR, Reinecker HC, Gray NS, Schreiber SL, Xavier RJ, and Shamji AF Proceedings of the National Academy of Sciences of the United States of America, 2014/08/11, (2014) Read More / View Supplemental Materials
Abstract
An Unbiased Approach To Identify Endogenous Substrates of "Histone" Deacetylase 8.Olson, DE, Udeshi ND, Wolfson NA, Pitcairn CA, Sullivan ED, Jaffe JD, Svinkina T., Natoli T., Lu X., Paulk J., McCarren P., Wagner FF, Barker D., Howe E., Lazzaro F., Gale JP, Zhang YL, Subramanian A., Fierke CA, Carr SA, et al. ACS chemical biology, 2014/08/11, (2014) Read More / View Supplemental Materials
Abstract
Efficient CRISPR-Cas9-mediated genome editing in Plasmodium falciparum.Wagner, JC, Platt RJ, Goldfless SJ, Zhang F., and Niles JC Nature methods, 2014/08/10, (2014) Read More / View Supplemental Materials
Abstract
Genome-wide association analyses identify variants in developmental genes associated with hypospadias.Geller, F., Feenstra B., Carstensen L., Pers TH, van Rooij IA, Körberg IB, Choudhry S., Karjalainen JM, Schnack TH, Hollegaard MV, Feitz WF, Roeleveld N., Hougaard DM, Hirschhorn JN, Franke L., Baskin LS, Nordenskjöld A., van der Zanden LF, and Melbye M. Nature genetics, 2014/08/10, (2014) Read More / View Supplemental Materials
Abstract
Fast construction of FM-index for long sequence reads.Li, H. Bioinformatics (Oxford, England), 2014/08/08, (2014) Read More / View Supplemental Materials
Abstract
Molecular pathogenesis of congenital diaphragmatic hernia revealed by exome sequencing, developmental data, and bioinformatics.Longoni, M., High FA, Russell MK, Kashani A., Tracy AA, Coletti CM, Hila R., Shamia A., Wells J., Ackerman KG, Wilson JM, Bult CJ, Lee C., Lage K., Pober BR, and Donahoe PK Proceedings of the National Academy of Sciences of the United States of America, 2014/08/08, (2014) Read More / View Supplemental Materials
Abstract
Fine mapping major histocompatibility complex associations in psoriasis and its clinical subtypes.Okada, Y., Han B., Tsoi LC, Stuart PE, Ellinghaus E., Tejasvi T., Chandran V., Pellett F., Pollock R., Bowcock AM, Krueger GG, Weichenthal M., Voorhees JJ, Rahman P., Gregersen PK, Franke A., Nair RP, Abecasis GR, Gladman DD, Elder JT, et al. American journal of human genetics, 2014/08/07, Volume 95, Issue 2, p.162-72, (2014) Read More / View Supplemental Materials
Abstract
CRISPR-mediated direct mutation of cancer genes in the mouse liver.Xue, W., Chen S., Yin H., Tammela T., Papagiannakopoulos T., Joshi NS, Cai W., Yang G., Bronson R., Crowley DG, Zhang F., Anderson DG, Sharp PA, and Jacks T. Nature, 2014/08/06, (2014) Read More / View Supplemental Materials
Abstract
Genetic validation of a therapeutic target in a mouse model of ALS.de Boer, AS, Koszka K., Kiskinis E., Suzuki N., Davis-Dusenbery BN, and Eggan K. Science translational medicine, 2014/08/06, Volume 6, Issue 248, p.248ra104, (2014) Read More / View Supplemental Materials
Abstract
Innate immunity pathways regulate the nephropathy gene Apolipoprotein L1.Nichols, B., Jog P., Lee JH, Blackler D., Wilmot M., D'Agati V., Markowitz G., Kopp JB, Alper SL, Pollak MR, and Friedman DJ Kidney international, 2014/08/06, (2014) Read More / View Supplemental Materials
Abstract
A lesson in communication.Dahlman, JE Nature nanotechnology, 2014/08/05, Volume 9, Issue 8, p.656, (2014) Read More / View Supplemental Materials
Microfluidic organs-on-chips.Bhatia, SN, and Ingber DE Nature biotechnology, 2014/08/05, Volume 32, Issue 8, p.760-72, (2014) Read More / View Supplemental Materials
Abstract
Modeling host interactions with hepatitis B virus using primary and induced pluripotent stem cell-derived hepatocellular systems.Shlomai, A., Schwartz RE, Ramanan V., Bhatta A., de Jong YP, Bhatia SN, and Rice CM Proceedings of the National Academy of Sciences of the United States of America, 2014/08/04, (2014) Read More / View Supplemental Materials
Abstract
Somatic Mutations Predict Poor Outcome in Patients With Myelodysplastic Syndrome After Hematopoietic Stem-Cell Transplantation.Bejar, R., Stevenson KE, Caughey B., Lindsley RC, Mar BG, Stojanov P., Getz G., Steensma DP, Ritz J., Soiffer R., Antin JH, Alyea E., Armand P., Ho V., Koreth J., Neuberg D., Cutler CS, and Ebert BL Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2014/08/04, (2014) Read More / View Supplemental Materials
Abstract
A framework for the interpretation of de novo mutation in human disease.Samocha, KE, Robinson EB, Sanders SJ, Stevens C., Sabo A., McGrath LM, Kosmicki JA, Rehnström K., Mallick S., Kirby A., Wall DP, Macarthur DG, Gabriel SB, DePristo M., Purcell SM, Palotie A., Boerwinkle E., Buxbaum JD, Cook EH Jr, Gibbs RA, et al. Nature genetics, 2014/08/03, (2014) Read More / View Supplemental Materials
Abstract
Fungi on the Skin: Dermatophytes and Malassezia.White, TC, Findley K., Dawson TL Jr, Scheynius A., Boekhout T., Cuomo CA, Xu J., and Saunders CW Cold Spring Harbor perspectives in medicine, 2014/08/01, Volume 4, Issue 8, (2014) Read More / View Supplemental Materials
Abstract
A high-throughput, multiplexed assay for superfamily-wide profiling of enzyme activity.Bachovchin, DA, Koblan LW, Wu W., Liu Y., Li Y., Zhao P., Woznica I., Shu Y., Lai JH, Poplawski SE, Kiritsy CP, Healey SE, DiMare M., Sanford DG, Munford RS, Bachovchin WW, and Golub T. R. Nature chemical biology, 2014/08/01, Volume 10, Issue 8, p.656-63, (2014) Read More / View Supplemental Materials
Abstract
Metformin pharmacogenomics: current status and future directions.Pawlyk, AC, Giacomini KM, McKeon C., Shuldiner AR, and Florez JC Diabetes, 2014/08/01, Volume 63, Issue 8, p.2590-9, (2014) Read More / View Supplemental Materials
Abstract
Notch inhibition allows oncogene-independent generation of iPS cells.Ichida, JK, T C W J., Williams LA, Carter AC, Shi Y., Moura MT, Ziller M., Singh S., Amabile G., Bock C., Umezawa A., Rubin LL, Bradner JE, Akutsu H., Meissner A., and Eggan K. Nature chemical biology, 2014/08/01, Volume 10, Issue 8, p.632-9, (2014) Read More / View Supplemental Materials
Abstract
Role of BRAFV600E in the First Preclinical Model of Multifocal Infiltrating Myopericytoma Development and Microenvironment.Sadow, PM, Priolo C., Nanni S., Karreth FA, Duquette M., Martinelli R., Husain A., Clohessy J., Kutzner H., Mentzel T., Carman CV, Farsetti A., Henske EP, Palescandolo E., Macconaill LE, Chung S., Fadda G., Lombardi CP, De Angelis AM, Durante O., et al. Journal of the National Cancer Institute, 2014/08/01, Volume 106, Issue 8, (2014) Read More / View Supplemental Materials
Abstract
Single cell RNA-Seq of hematopoietic stem cells reveals a cell cycle-dependent interplay between aging and differentiation.Kowalczyk, M., Tirosh I., Heckl D., Ebert B., and Regev A. Experimental hematology, 2014/08/01, Volume 42, Issue 8 Suppl, p.S21, (2014) Read More / View Supplemental Materials
The tumour-induced systemic environment as a critical regulator of cancer progression and metastasis.McAllister, SS, and Weinberg R. A. Nature cell biology, 2014/08/01, Volume 16, Issue 8, p.717-27, (2014) Read More / View Supplemental Materials
Abstract
The upside of failure: how regional student groups learn from their mistakes.Mishra, T., Parra RG, and Abeel T. PLoS computational biology, 2014/08/01, Volume 10, Issue 8, p.e1003768, (2014) Read More / View Supplemental Materials
Abstract
DNA methylation dynamics of the human preimplantation embryo.Smith, ZD, Chan MM, Humm KC, Karnik R., Mekhoubad S., Regev A., Eggan K., and Meissner A. Nature, 2014/07/31, Volume 511, Issue 7511, p.611-5, (2014) Read More / View Supplemental Materials
Abstract
Genome Sequence of Fusarium oxysporum f. sp. melonis Strain NRRL 26406, a Fungus Causing Wilt Disease on Melon.Ma, LJ, Shea T., Young S., Zeng Q., and Kistler HC Genome announcements, 2014/07/31, Volume 2, Issue 4, (2014) Read More / View Supplemental Materials
Abstract
Functional variations modulating PRKCA expression and alternative splicing predispose to multiple sclerosis.Paraboschi, EM, Rimoldi V., Soldà G., Tabaglio T., Dall'Osso C., Saba E., Vigliano M., Salviati A., Leone M., Benedetti MD, Fornasari D., Saarela J., De Jager P., Patsopoulos NA, D'Alfonso S., Gemmati D., Duga S., and Asselta R. Human molecular genetics, 2014/07/30, (2014) Read More / View Supplemental Materials
Abstract
Improved vectors and genome-wide libraries for CRISPR screening.Sanjana, NE, Shalem O., and Zhang F. Nature methods, 2014/07/30, Volume 11, Issue 8, p.783-4, (2014) Read More / View Supplemental Materials
Non-cell-autonomous driving of tumour growth supports sub-clonal heterogeneity.Marusyk, A., Tabassum DP, Altrock PM, Almendro V., Michor F., and Polyak K. Nature, 2014/07/30, (2014) Read More / View Supplemental Materials
Abstract
Highly Recombinant VGII Cryptococcus gattii Population Develops Clonal Outbreak Clusters through both Sexual Macroevolution and Asexual Microevolution.Billmyre, RB, Croll D., Li W., Mieczkowski P., Carter DA, Cuomo CA, Kronstad JW, and Heitman J. mBio, 2014/07/29, Volume 5, Issue 4, (2014) Read More / View Supplemental Materials
Abstract
Early remodeling of the neocortex upon episodic memory encoding.Bero, AW, Meng J., Cho S., Shen AH, Canter RG, Ericsson M., and Tsai LH Proceedings of the National Academy of Sciences of the United States of America, 2014/07/28, (2014) Read More / View Supplemental Materials
Abstract
Risk for ACPA-positive rheumatoid arthritis is driven by shared HLA amino acid polymorphisms in Asian and European populations.Okada, Y., Kim K., Han B., Pillai NE, Ong RT, Saw WY, Luo M., Jiang L., Yin J., Bang SY, Lee HS, Brown MA, Bae SC, Xu H., Teo YY, de Bakker PI, and Raychaudhuri S. Human molecular genetics, 2014/07/28, (2014) Read More / View Supplemental Materials
Abstract
Describing the genetic architecture of epilepsy through heritability analysis.Speed, D., O'Brien TJ, Palotie A., Shkura K., Marson AG, Balding DJ, and Johnson MR Brain : a journal of neurology, 2014/07/26, (2014) Read More / View Supplemental Materials
Abstract
Depletion of Rictor, an essential protein component of mTORC2, decreases male lifespan.Lamming, DW, Mihaylova MM, Katajisto P., Baar EL, Yilmaz OH, Hutchins A., Gultekin Y., Gaither R., and Sabatini DM Aging cell, 2014/07/25, (2014) Read More / View Supplemental Materials
Abstract
CC2D1A Regulates Human Intellectual and Social Function as well as NF-κB Signaling Homeostasis.Manzini, MC, Xiong L., Shaheen R., Tambunan DE, Di Costanzo S., Mitisalis V., Tischfield DJ, Cinquino A., Ghaziuddin M., Christian M., Jiang Q., Laurent S., Nanjiani ZA, Rasheed S., Hill RS, Lizarraga SB, Gleason D., Sabbagh D., Salih MA, Alkuraya FS, et al. Cell reports, 2014/07/23, (2014) Read More / View Supplemental Materials
Abstract
De novo CNVs in bipolar affective disorder and schizophrenia.Georgieva, L., Rees E., Moran JL, Chambert KD, Milanova V., Craddock N., Purcell S., Sklar P., McCarroll S., Holmans P., O'Donovan MC, Owen MJ, and Kirov G. Human molecular genetics, 2014/07/23, (2014) Read More / View Supplemental Materials
Abstract
Integrative and comparative genomic analysis of HPV-positive and HPV-negative head and neck squamous cell carcinomas.Seiwert, TY, Zuo Z., Keck MK, Khattri A., Pedamallu CS, Stricker TP, Brown CD, Pugh TJ, Stojanov P., Cho J., Lawrence M., Getz G., Bragelmann J., DeBoer R., Weichselbaum RR, Langerman A., Portugal LD, Blair EA, Stenson KM, Lingen MW, et al. Clinical cancer research : an official journal of the American Association for Cancer Research, 2014/07/23, (2014) Read More / View Supplemental Materials
Abstract
Mechanisms of β-lactam killing and resistance in the context of Mycobacterium tuberculosis.Wivagg, CN, Bhattacharyya RP, and Hung DT The Journal of antibiotics, 2014/07/23, (2014) Read More / View Supplemental Materials
Abstract
Meta-analysis identifies loci affecting levels of the potential osteoarthritis biomarkers sCOMP and uCTX-II with genome wide significance.Ramos, YF, Metrustry S., Arden N., Bay-Jensen AC, Beekman M., de Craen AJ, Cupples LA, Esko T., Evangelou E., Felson DT, Hart DJ, Ioannidis JP, Karsdal M., Kloppenburg M., Lafeber F., Metspalu A., Panoutsopoulou K., Slagboom PE, Spector TD, van Spil EW, et al. Journal of medical genetics, 2014/07/23, (2014) Read More / View Supplemental Materials
Abstract
No association between RORA polymorphisms and PTSD in two independent samples.Guffanti, G., Ashley-Koch AE, Roberts AL, Garrett ME, Solovieff N., Ratanatharathorn A., De Vivo I., Dennis M., Ranu H., Smoller JW, Liu Y., Purcell SM, and Veterans Affairs Mid-Atlantic Mental Illness Research, Education Clinical Center Workgroup, Beckham J., Hauser MA, and Koenen KC Molecular psychiatry, 2014/07/22, (2014) Read More / View Supplemental Materials
Proteogenomic characterization of human colon and rectal cancer.Zhang, B., Wang J., Wang X., Zhu J., Liu Q., Shi Z., Chambers MC, Zimmerman LJ, Shaddox KF, Kim S., Davies SR, Wang S., Wang P., Kinsinger CR, Rivers RC, Rodriguez H., Townsend RR, Ellis MJ, Carr SA, Tabb DL, et al. Nature, 2014/07/20, (2014) Read More / View Supplemental Materials
Abstract
Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.Naba, A., Clauser KR, Whittaker CA, Carr SA, Tanabe KK, and Hynes R. O. BMC cancer, 2014/07/18, Volume 14, p.518, (2014) Read More / View Supplemental Materials
Abstract
Mitochondrial EFTs defects in juvenile-onset Leigh disease, ataxia, neuropathy, and optic atrophy.Ahola, S., Isohanni P., Euro L., Brilhante V., Palotie A., Pihko H., Lönnqvist T., Lehtonen T., Laine J., Tyynismaa H., and Suomalainen A. Neurology, 2014/07/18, (2014) Read More / View Supplemental Materials
Abstract
Insights into secondary metabolism from a global analysis of prokaryotic biosynthetic gene clusters.Cimermancic, P., Medema MH, Claesen J., Kurita K., Wieland Brown LC, Mavrommatis K., Pati A., Godfrey PA, Koehrsen M., Clardy J., Birren BW, Takano E., Sali A., Linington RG, and Fischbach MA Cell, 2014/07/17, Volume 158, Issue 2, p.412-21, (2014) Read More / View Supplemental Materials
Abstract
Kinase domain activation of FGFR2 yields high-grade lung adenocarcinoma sensitive to a pan-FGFR inhibitor in a mouse model of NSCLC.Wong, KK, Tchaicha JH, Akbay EA, Altabef A., Mikse OR, Kikuchi E., Rhee K., Liao RG, Bronson RT, Sholl LM, Meyerson M., and Hammerman PS Cancer research, 2014/07/17, (2014) Read More / View Supplemental Materials
Abstract
Proteomic Mapping of the Human Mitochondrial Intermembrane Space in Live Cells via Ratiometric APEX Tagging.Hung, V., Zou P., Rhee HW, Udeshi ND, Cracan V., Svinkina T., Carr SA, Mootha VK, and Ting AY Molecular cell, 2014/07/17, Volume 55, Issue 2, p.332-41, (2014) Read More / View Supplemental Materials
Abstract
The genetic architecture of pediatric cognitive abilities in the Philadelphia Neurodevelopmental Cohort.Robinson, EB, Kirby A., Ruparel K., Yang J., McGrath L., Anttila V., Neale BM, Merikangas K., Lehner T., Sleiman PM, Daly M. J., Gur R., Gur R., and Hakonarson H. Molecular psychiatry, 2014/07/15, (2014) Read More / View Supplemental Materials
Abstract
Genetic variants in the complement system predisposing to age-related macular degeneration: A review.Schramm, EC, Clark SJ, Triebwasser MP, Raychaudhuri S., Seddon JM, and Atkinson JP Molecular immunology, 2014/07/15, (2014) Read More / View Supplemental Materials
Abstract
Imputation and subset based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33.Wang, Z., Zhu B., Zhang M., Parikh H., Jia J., Chung CC, Sampson JN, Hoskins JW, Hutchinson A., Burdette L., Ibrahim A., Hautman C., Raj PS, Abnet CC, Adjei AA, Ahlbom A., Albanes D., Allen NE, Ambrosone CB, Aldrich M., et al. Human molecular genetics, 2014/07/15, (2014) Read More / View Supplemental Materials
Abstract
Whole-exome imputation of sequence variants identified two novel alleles associated with adult body height in African Americans.Du, M., Auer PL, Jiao S., Haessler J., Altshuler D., Boerwinkle E., Carlson CS, Carty CL, Chen YD, Curtis K., Franceschini N., Hsu L., Jackson R., Lange LA, Lettre G., Monda KL, and National Heart, Lung Blood Institute(NHLBI) GO Exome Sequencing Project, Nickerson DA, Reiner AP, Rich SS, et al. Human molecular genetics, 2014/07/15, (2014) Read More / View Supplemental Materials
Abstract
Effects of Weight Loss, Weight Cycling, and Weight Loss Maintenance on Diabetes Incidence and Change in Cardiometabolic Traits in the Diabetes Prevention Program.Delahanty, LM, Pan Q., Jablonski KA, Aroda VR, Watson KE, Bray GA, Kahn SE, Florez JC, Perreault L., Franks PW, and for the Diabetes Prevention Program Research Group Diabetes care, 2014/07/14, (2014) Read More / View Supplemental Materials
Abstract
Toward performance-diverse small-molecule libraries for cell-based phenotypic screening using multiplexed high-dimensional profiling.Wawer, MJ, Li K., Gustafsdottir SM, Ljosa V., Bodycombe NE, Marton MA, Sokolnicki KL, Bray MA, Kemp MM, Winchester E., Taylor B., Grant GB, Hon CS, Duvall JR, Wilson JA, Bittker JA, Dančík V., Narayan R., Subramanian A., Winckler W., et al. Proceedings of the National Academy of Sciences of the United States of America, 2014/07/14, (2014) Read More / View Supplemental Materials
Abstract
Cancer therapy. Ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility.Yu, M., Bardia A., Aceto N., Bersani F., Madden MW, Donaldson MC, Desai R., Zhu H., Comaills V., Zheng Z., Wittner BS, Stojanov P., Brachtel E., Sgroi D., Kapur R., Shioda T., Ting DT, Ramaswamy S., Getz G., Iafrate AJ, et al. Science (New York, N.Y.), 2014/07/11, Volume 345, Issue 6193, p.216-20, (2014) Read More / View Supplemental Materials
Abstract
Metabolite Markers of Incident CKD Risk.Rhee, EP, and Feldman HI Clinical journal of the American Society of Nephrology : CJASN, 2014/07/10, (2014) Read More / View Supplemental Materials
Rictor/mTORC2 Loss in the Myf5 Lineage Reprograms Brown Fat Metabolism and Protects Mice against Obesity and Metabolic Disease.Hung, CM, Calejman CM, Sanchez-Gurmaches J., Li H., Clish CB, Hettmer S., Wagers AJ, and Guertin DA Cell reports, 2014/07/10, Volume 8, Issue 1, p.256-71, (2014) Read More / View Supplemental Materials
Abstract
Analysis of a Food-Borne Fungal Pathogen Outbreak: Virulence and Genome of a Mucor circinelloides Isolate from Yogurt.Lee, SC, Billmyre RB, Li A., Carson S., Sykes SM, Huh EY, Mieczkowski P., Ko DC, Cuomo CA, and Heitman J. mBio, 2014/07/08, Volume 5, Issue 4, (2014) Read More / View Supplemental Materials
Abstract
Gene co-regulation by Fezf2 selects neurotransmitter identity and connectivity of corticospinal neurons.Lodato, S., Molyneaux BJ, Zuccaro E., Goff LA, Chen HH, Yuan W., Meleski A., Takahashi E., Mahony S., Rinn JL, Gifford DK, and Arlotta P. Nature neuroscience, 2014/07/06, (2014) Read More / View Supplemental Materials
Abstract
Complete Genome Sequences of Bacillus subtilis subsp. subtilis Laboratory Strains JH642 (AG174) and AG1839.Smith, JL, Goldberg JM, and Grossman AD Genome announcements, 2014/07/03, Volume 2, Issue 4, (2014) Read More / View Supplemental Materials
Abstract
Expansion of biological pathways based on evolutionary inference.Li, Y., Calvo SE, Gutman R., Liu JS, and Mootha VK Cell, 2014/07/03, Volume 158, Issue 1, p.213-25, (2014) Read More / View Supplemental Materials
Abstract
How far can mice carry autism research?Hyman, SE Cell, 2014/07/03, Volume 158, Issue 1, p.13-4, (2014) Read More / View Supplemental Materials
Abstract
IRF4 Is a Key Thermogenic Transcriptional Partner of PGC-1α.Kong, X., Banks A., Liu T., Kazak L., Rao RR, Cohen P., Wang X., Yu S., Lo JC, Tseng YH, Cypess AM, Xue R., Kleiner S., Kang S., Spiegelman BM, and Rosen ED Cell, 2014/07/03, Volume 158, Issue 1, p.69-83, (2014) Read More / View Supplemental Materials
Abstract
Loss-of-function mutations in APOC3, triglycerides, and coronary disease.and TG and HDL Working Group of the Exome Sequencing Project, National Heart, Lung Blood Institute, Crosby J., Peloso GM, Auer PL, Crosslin DR, Stitziel NO, Lange LA, Lu Y., Tang ZZ, Zhang H., Hindy G., Masca N., Stirrups K., Kanoni S., Do R., Jun G., Hu Y., Kang HM, Xue C., Goel A., et al. The New England journal of medicine, 2014/07/03, Volume 371, Issue 1, p.22-31, (2014) Read More / View Supplemental Materials
Abstract
Low Incidence of Off-Target Mutations in Individual CRISPR-Cas9 and TALEN Targeted Human Stem Cell Clones Detected by Whole-Genome Sequencing.Veres, A., Gosis BS, Ding Q., Collins R., Ragavendran A., Brand H., Erdin S., Talkowski ME, and Musunuru K. Cell stem cell, 2014/07/03, Volume 15, Issue 1, p.27-30, (2014) Read More / View Supplemental Materials
Abstract
Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer.Saha, SK, Parachoniak CA, Ghanta KS, Fitamant J., Ross KN, Najem MS, Gurumurthy S., Akbay EA, Sia D., Cornella H., Miltiadous O., Walesky C., Deshpande V., Zhu AX, Hezel AF, Yen KE, Straley KS, Travins J., Popovici-Muller J., Gliser C., et al. Nature, 2014/07/02, (2014) Read More / View Supplemental Materials
Abstract
Assessing the clinical utility of cancer genomic and proteomic data across tumor types.Yuan, Y., Van Allen EM, Omberg L., Wagle N., Amin-Mansour A., Sokolov A., Byers LA, Xu Y., Hess KR, Diao L., Han L., Huang X., Lawrence MS, Weinstein J. N., Stuart JM, Mills GB, Garraway LA, Margolin AA, Getz G., and Liang H. Nature biotechnology, 2014/07/01, Volume 32, Issue 7, p.644-52, (2014) Read More / View Supplemental Materials
Abstract
Copy number variation in schizophrenia in Sweden.Szatkiewicz, JP, O'Dushlaine C., Chen G., Chambert K., Moran JL, Neale BM, Fromer M., Ruderfer D., Akterin S., Bergen SE, Kähler A., Magnusson PK, Kim Y., Crowley JJ, Rees E., Kirov G., O'Donovan MC, Owen MJ, Walters J., Scolnick E., et al. Molecular psychiatry, 2014/07/01, Volume 19, Issue 7, p.762-73, (2014) Read More / View Supplemental Materials
Abstract
Defining success in graduate school.Bell, SM, Blumstein J., Brose K., Carroll A., Chang J., Charles J., Haswell ES, Michelitsch M., Owens JC, Patil CK, Smith R., Tupy J., Walsh E., and Ware T. Molecular biology of the cell, 2014/07/01, Volume 25, Issue 13, p.1942-4, (2014) Read More / View Supplemental Materials
Distribution and Medical Impact of Loss-of-Function Variants in the Finnish Founder Population.Lim, ET, Würtz P., Havulinna AS, Palta P., Tukiainen T., Rehnström K., Esko T., Mägi R., Inouye M., Lappalainen T., Chan Y., Salem RM, Lek M., Flannick J., Sim X., Manning A., Ladenvall C., Bumpstead S., Hämäläinen E., Aalto K., et al. PLoS genetics, 2014/07/01, Volume 10, Issue 7, p.e1004494, (2014) Read More / View Supplemental Materials
Abstract
Diverse patterns of genomic targeting by transcriptional regulators in Drosophila melanogaster.Slattery, M., Ma L., Spokony RF, Arthur RK, Kheradpour P., Kundaje A., Nègre N., Crofts A., Ptashkin R., Zieba J., Ostapenko A., Suchy S., Victorsen A., Jameel N., Grundstad AJ, Gao W., Moran JR, Rehm EJ, Grossman RL, Kellis M., et al. Genome research, 2014/07/01, Volume 24, Issue 7, p.1224-35, (2014) Read More / View Supplemental Materials
Abstract
Endometrial Carcinoma Recurrence Score (ECARS) validates to identify aggressive disease and associates with markers of epithelial-mesenchymal transition and PI3K alterations.Wik, E., Trovik J., Kusonmano K., Birkeland E., Raeder MB, Pashtan I., Hoivik EA, Krakstad C., Werner HM, Holst F., Mjøs S., Halle MK, Mannelqvist M., Mauland KK, Oyan AM, Stefansson IM, Petersen K., Simon R., Cherniack AD, Meyerson M., et al. Gynecologic oncology, 2014/07/01, (2014) Read More / View Supplemental Materials
Abstract
Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition.Tang, Y., Gholamin S., Schubert S., Willardson MI, Lee A., Bandopadhayay P., Bergthold G., Masoud S., Nguyen B., Vue N., Balansay B., Yu F., Oh S., Woo P., Chen S., Ponnuswami A., Monje M., Atwood SX, Whitson RJ, Mitra S., et al. Nature medicine, 2014/07/01, Volume 20, Issue 7, p.732-740, (2014) Read More / View Supplemental Materials
Abstract
Evolving Understanding of the CLL Genome.Gruber, M., and Wu CJ Seminars in hematology, 2014/07/01, Volume 51, Issue 3, p.177-87, (2014) Read More / View Supplemental Materials
Abstract
Fast and accurate imputation of summary statistics enhances evidence of functional enrichment.Pasaniuc, B., Zaitlen N., Shi H., Bhatia G., Gusev A., Pickrell J., Hirschhorn J., Strachan DP, Patterson N., and Price AL Bioinformatics (Oxford, England), 2014/07/01, (2014) Read More / View Supplemental Materials
Abstract
Integrative genomics reveals novel molecular pathways and gene networks for coronary artery disease.Mäkinen, VP, Civelek M., Meng Q., Zhang B., Zhu J., Levian C., Huan T., Segrè AV, Ghosh S., Vivar J., Nikpay M., Stewart AF, Nelson CP, Willenborg C., Erdmann J., Blakenberg S., O'Donnell CJ, März W., Laaksonen R., Epstein SE, et al. PLoS genetics, 2014/07/01, Volume 10, Issue 7, p.e1004502, (2014) Read More / View Supplemental Materials
Abstract
Mitosis gives a brief window of opportunity for a change in gene transcription.Halley-Stott, RP, Jullien J., Pasque V., and Gurdon J. PLoS biology, 2014/07/01, Volume 12, Issue 7, p.e1001914, (2014) Read More / View Supplemental Materials
Abstract
Novel Approach Identifies SNPs in SLC2A10 and KCNK9 with Evidence for Parent-of-Origin Effect on Body Mass Index.Hoggart, CJ, Venturini G., Mangino M., Gomez F., Ascari G., Zhao JH, Teumer A., Winkler TW, Tšernikova N., Luan J., Mihailov E., Ehret GB, Zhang W., Lamparter D., Esko T., Macé A., Rüeger S., Bochud PY, Barcella M., Dauvilliers Y., et al. PLoS genetics, 2014/07/01, Volume 10, Issue 7, p.e1004508, (2014) Read More / View Supplemental Materials
Abstract
A Novel MMP12 Locus Is Associated with Large Artery Atherosclerotic Stroke Using a Genome-Wide Age-at-Onset Informed Approach.Traylor, M., Mäkelä KM, Kilarski LL, Holliday EG, Devan WJ, Nalls MA, Wiggins KL, Zhao W., Cheng YC, Achterberg S., Malik R., Sudlow C., Bevan S., Raitoharju E., METASTROKE, International Stroke Genetics Consortium Wellcome Trust Case Consortium(WTCCC2) 2, Oksala N., Thijs V., Lemmens R., Lindgren A., Slowik A., et al. PLoS genetics, 2014/07/01, Volume 10, Issue 7, p.e1004469, (2014) Read More / View Supplemental Materials
Abstract
  • Showing 1-100 of 1856 Results
  • 1
  • 2
  • 3
  • 4
  • 5
  • 6
  • 7...