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Synthesis, cellular evaluation and mechanism-of-action of piperlongumine analogsAdams, DJ, Dai M., Pellegrino G., Wagner BK, Stern AM, Shamji AF, and Schreiber SL, (Submitted) Read More / View Supplemental Materials
2015
The association between lower educational attainment and depression owing to shared genetic effects? Results in ~25 000 subjects.Peyrot, WJ, Lee SH, Milaneschi Y., Abdellaoui A., Byrne EM, Esko T., de Geus EJ, Hemani G., Hottenga JJ, Kloiber S., Levinson DF, Lucae S., Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium(Corporate Collaborator), Martin NG, Medland SE, Metspalu A., Milani L., Noethen MM, Potash JB, Rietschel M., et al. Molecular psychiatry, 2015/06/01, Volume 20, Issue 6, p.735-43, (2015) Read More / View Supplemental Materials
Abstract
Characterization of bipolar disorder patient-specific induced pluripotent stem cells from a family reveals neurodevelopmental and mRNA expression abnormalities.Madison, JM, Zhou F., Nigam A., Hussain A., Barker DD, Nehme R., van der Ven K., Hsu J., Wolf P., Fleishman M., O'Dushlaine C., Rose S., Chambert K., Lau FH, Ahfeldt T., Rueckert EH, Sheridan SD, Fass DM, Nemesh J., Mullen TE, et al. Molecular psychiatry, 2015/06/01, Volume 20, Issue 6, p.703-17, (2015) Read More / View Supplemental Materials
Abstract
Genetic Risk Score for Essential Hypertension and Risk of Preeclampsia.Smith, CJ, Saftlas AF, Spracklen CN, Triche EW, Bjonnes A., Keating B., Saxena R., Breheny PJ, Dewan AT, Robinson JG, Hoh J., and Ryckman KK American journal of hypertension, 2015/05/23, (2015) Read More / View Supplemental Materials
Abstract
The kinase DYRK1A reciprocally regulates the differentiation of Th17 and regulatory T cells.Khor, B., Gagnon JD, Goel G., Roche MI, Conway KL, Tran K., Aldrich LN, Sundberg TB, Paterson AM, Mordecai S., Dombkowski D., Schirmer M., Tan PH, Bhan AK, Roychoudhuri R., Restifo NP, O'Shea JJ, Medoff BD, Shamji AF, Schreiber SL, et al. eLife, 2015/05/22, Volume 4, (2015) Read More / View Supplemental Materials
Abstract
Explicit Modeling of Ancestry Improves Polygenic Risk Scores and BLUP Prediction.Chen, CY, Han J., Hunter DJ, Kraft P., and Price AL Genetic epidemiology, 2015/05/21, (2015) Read More / View Supplemental Materials
Abstract
Genetics of atrial fibrillation: from families to genomes.Christophersen, IE, and Ellinor PT Journal of human genetics, 2015/05/21, (2015) Read More / View Supplemental Materials
Abstract
Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets.Macosko, EZ, Basu A., Satija R., Nemesh J., Shekhar K., Goldman M., Tirosh I., Bialas AR, Kamitaki N., Martersteck EM, Trombetta JJ, Weitz DA, Sanes JR, Shalek AK, Regev A., and McCarroll SA Cell, 2015/05/21, Volume 161, Issue 5, p.1202-14, (2015) Read More / View Supplemental Materials
Abstract
Integrative clinical genomics of advanced prostate cancer.Robinson, D., Van Allen EM, Wu YM, Schultz N., Lonigro RJ, Mosquera JM, Montgomery B., Taplin ME, Pritchard CC, Attard G., Beltran H., Abida W., Bradley RK, Vinson J., Cao X., Vats P., Kunju LP, Hussain M., Feng FY, Tomlins SA, et al. Cell, 2015/05/21, Volume 161, Issue 5, p.1215-28, (2015) Read More / View Supplemental Materials
Abstract
Shared elements of host-targeting pathways among apicomplexan parasites of differing life styles.Pellé, KG, Jiang RH, Mantel PY, Xiao YP, Hjelmqvist D., Gallego-Lopez GM, Lau AO, Kang BH, Allred DR, and Marti M. Cellular microbiology, 2015/05/21, (2015) Read More / View Supplemental Materials
Abstract
Treatment of obesity with celastrol.Liu, J., Lee J., Salazar Hernandez MA, Mazitschek R., and Ozcan U. Cell, 2015/05/21, Volume 161, Issue 5, p.999-1011, (2015) Read More / View Supplemental Materials
Abstract
Association of DNA methylation in the brain with age in older persons is confounded by common neuropathologies.Yang, J., Yu L., Gaiteri C., Srivastava GP, Chibnik LB, Leurgans SE, Schneider JA, Meissner A., De Jager PL, and Bennett DA The international journal of biochemistry & cell biology, 2015/05/20, (2015) Read More / View Supplemental Materials
Abstract
The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs.Herman, JD, Pepper LR, Cortese JF, Estiu G., Galinsky K., Zuzarte-Luis V., Derbyshire ER, Ribacke U., Lukens AK, Santos SA, Patel V., Clish CB, Sullivan WJ Jr, Zhou H., Bopp SE, Schimmel P., Lindquist S., Clardy J., Mota MM, Keller TL, et al. Science translational medicine, 2015/05/20, Volume 7, Issue 288, p.288ra77, (2015) Read More / View Supplemental Materials
Abstract
Mendelian randomization study of height and risk of colorectal cancer.Thrift, AP, Gong J., Peters U., Chang-Claude J., Rudolph A., Slattery ML, Chan AT, Esko T., Wood AR, Yang J., Vedantam S., Gustafsson S., Pers TH, GIANT Consortium, Baron JA, Bezieau S., Küry S., Ogino S., Berndt SI, Casey G., et al. International journal of epidemiology, 2015/05/20, (2015) Read More / View Supplemental Materials
Abstract
Cervicovaginal bacteria are a major modulator of host inflammatory responses in the female genital tract.Anahtar, MN, Byrne EH, Doherty KE, Bowman BA, Yamamoto HS, Soumillon M., Padavattan N., Ismail N., Moodley A., Sabatini ME, Ghebremichael MS, Nusbaum C., Huttenhower C., Virgin HW, Ndung'u T., Dong KL, Walker BD, Fichorova RN, and Kwon DS Immunity, 2015/05/19, Volume 42, Issue 5, p.965-76, (2015) Read More / View Supplemental Materials
Abstract
Hypoxia drives transient site-specific copy gain and drug-resistant gene expression.Black, JC, Atabakhsh E., Kim J., Biette KM, Van Rechem C., Ladd B., Burrowes PD, Donado C., Mattoo H., Kleinstiver BP, Song B., Andriani G., Joung JK, Iliopoulos O., Montagna C., Pillai S., Getz G., and Whetstine JR Genes & development, 2015/05/15, Volume 29, Issue 10, p.1018-31, (2015) Read More / View Supplemental Materials
Abstract
Genomic signatures of evolutionary transitions from solitary to group living.Kapheim, KM, Pan H., Li C., Salzberg SL, Puiu D., Magoc T., Robertson HM, Hudson ME, Venkat A., Fischman BJ, Hernandez A., Yandell M., Ence D., Holt C., Yocum GD, Kemp WP, Bosch J., Waterhouse RM, Zdobnov EM, Stolle E., et al. Science (New York, N.Y.), 2015/05/14, (2015) Read More / View Supplemental Materials
Abstract
Likelihood Based Complex Trait Association Testing for Arbitrary Depth Sequencing Data.Yan, S., Yuan S., Xu Z., Zhang B., Zhang B., Kang G., Byrnes A., and Li Y. Bioinformatics (Oxford, England), 2015/05/14, (2015) Read More / View Supplemental Materials
Abstract
Association analysis of copy numbers of FC-gamma receptor genes for rheumatoid arthritis and other immune-mediated phenotypes.Franke, L., El Bannoudi H., Jansen DT, Kok K., Trynka G., Diogo D., Swertz M., Fransen K., Knevel R., Gutierrez-Achury J., Ärlestig L., Greenberg JD, Kremer J., Pappas DA, Kanterakis A., Weersma RK, van der Helm-van Mil AH, Guryev V., Rantapää-Dahlqvist S., Gregersen PK, et al. European journal of human genetics : EJHG, 2015/05/13, (2015) Read More / View Supplemental Materials
Abstract
Contrasting host-pathogen interactions and genome evolution in two generalist and specialist microsporidian pathogens of mosquitoes.Desjardins, CA, Sanscrainte ND, Goldberg JM, Heiman D., Young S., Zeng Q., Madhani HD, Becnel JJ, and Cuomo CA Nature communications, 2015/05/13, Volume 6, p.7121, (2015) Read More / View Supplemental Materials
Abstract
Functional inflammatory profiles distinguish myelin-reactive T cells from patients with multiple sclerosis.Cao, Y., Goods BA, Raddassi K., Nepom GT, Kwok WW, Love JC, and Hafler DA Science translational medicine, 2015/05/13, Volume 7, Issue 287, p.287ra74, (2015) Read More / View Supplemental Materials
Abstract
An Integrative View of Microbiome-Host Interactions in Inflammatory Bowel Diseases.Wlodarska, M., Kostic AD, and Xavier RJ Cell host & microbe, 2015/05/13, Volume 17, Issue 5, p.577-591, (2015) Read More / View Supplemental Materials
Abstract
Therapeutic challenges in diabetes prevention: "We have not found the exercise pill".Srinivasan, S., and Florez JC Clinical pharmacology and therapeutics, 2015/05/13, (2015) Read More / View Supplemental Materials
CRISPR germline engineering-the community speaks.Bosley, KS, Botchan M., Bredenoord AL, Carroll D., Charo RA, Charpentier E., Cohen R., Corn J., Doudna J., Feng G., Greely HT, Isasi R., Ji W., Kim JS, Knoppers B., Lanphier E., Li J., Lovell-Badge R., Martin GS, Moreno J., et al. Nature biotechnology, 2015/05/12, Volume 33, Issue 5, p.478-86, (2015) Read More / View Supplemental Materials
Functional profiling in Streptococcus mutans: construction and examination of a genomic collection of gene deletion mutants.Quivey RG, Jr, Grayhack EJ, Faustoferri RC, Hubbard CJ, Baldeck JD, Wolf AS, MacGilvray ME, Rosalen PL, Scott-Anne K., Santiago B., Gopal S., Payne J., and Marquis RE Molecular oral microbiology, 2015/05/12, (2015) Read More / View Supplemental Materials
Abstract
Defining the molecular landscape of ependymomas.Archer, TC, and Pomeroy SL Cancer cell, 2015/05/11, Volume 27, Issue 5, p.613-5, (2015) Read More / View Supplemental Materials
Abstract
Identifying personal microbiomes using metagenomic codes.Franzosa, EA, Huang K., Meadow JF, Gevers D., Lemon KP, Bohannan BJ, and Huttenhower C. Proceedings of the National Academy of Sciences of the United States of America, 2015/05/11, (2015) Read More / View Supplemental Materials
Abstract
The impact of low-frequency and rare variants on lipid levels.Surakka, I., Horikoshi M., Mägi R., Sarin AP, Mahajan A., Lagou V., Marullo L., Ferreira T., Miraglio B., Timonen S., Kettunen J., Pirinen M., Karjalainen J., Thorleifsson G., Hägg S., Hottenga JJ, Isaacs A., Ladenvall C., Beekman M., Esko T., et al. Nature genetics, 2015/05/11, (2015) Read More / View Supplemental Materials
Abstract
Human genomics. Effect of predicted protein-truncating genetic variants on the human transcriptome.Rivas, MA, Pirinen M., Conrad DF, Lek M., Tsang EK, Karczewski KJ, Maller JB, Kukurba KR, Deluca DS, Fromer M., Ferreira PG, Smith KS, Zhang R., Zhao F., Banks E., Poplin R., Ruderfer DM, Purcell SM, Tukiainen T., Minikel EV, et al. Science (New York, N.Y.), 2015/05/08, Volume 348, Issue 6235, p.666-9, (2015) Read More / View Supplemental Materials
Abstract
Human genomics. The human transcriptome across tissues and individuals.Melé, M., Ferreira PG, Reverter F., Deluca DS, Monlong J., Sammeth M., Young TR, Goldmann JM, Pervouchine DD, Sullivan TJ, Johnson R., Segrè AV, Djebali S., Niarchou A., GTEx Consortium, Wright FA, Lappalainen T., Calvo M., Getz G., Dermitzakis ET, et al. Science (New York, N.Y.), 2015/05/08, Volume 348, Issue 6235, p.660-5, (2015) Read More / View Supplemental Materials
Abstract
Malaria. A forward genetic screen identifies erythrocyte CD55 as essential for Plasmodium falciparum invasion.Egan, ES, Jiang RH, Moechtar MA, Barteneva NS, Weekes MP, Nobre LV, Gygi SP, Paulo JA, Frantzreb C., Tani Y., Takahashi J., Watanabe S., Goldberg J., Paul AS, Brugnara C., Root DE, Wiegand RC, Doench JG, and Duraisingh MT Science (New York, N.Y.), 2015/05/08, Volume 348, Issue 6235, p.711-4, (2015) Read More / View Supplemental Materials
Abstract
50 year trends in atrial fibrillation prevalence, incidence, risk factors, and mortality in the Framingham Heart Study: a cohort study.Schnabel, RB, Yin X., Gona P., Larson MG, Beiser AS, McManus DD, Newton-Cheh C., Lubitz SA, Magnani JW, Ellinor PT, Seshadri S., Wolf PA, Vasan RS, Benjamin EJ, and Levy D. Lancet, 2015/05/07, (2015) Read More / View Supplemental Materials
Abstract
A Potential Contributory Role for Ciliary Dysfunction in the 16p11.2 600 kb BP4-BP5 Pathology.Migliavacca, E., Golzio C., Männik K., Blumenthal I., Oh EC, Harewood L., Kosmicki JA, Loviglio MN, Giannuzzi G., Hippolyte L., Maillard AM, Alfaiz AA, 16p11.2 European Consortium, van Haelst MM, Andrieux J., Gusella JF, Daly M. J., Beckmann JS, Jacquemont S., Talkowski ME, et al. American journal of human genetics, 2015/05/07, Volume 96, Issue 5, p.784-96, (2015) Read More / View Supplemental Materials
Abstract
Prospective derivation of a living organoid biobank of colorectal cancer patients.van de Wetering, M., Francies HE, Francis JM, Bounova G., Iorio F., Pronk A., van Houdt W., van Gorp J., Taylor-Weiner A., Kester L., McLaren-Douglas A., Blokker J., Jaksani S., Bartfeld S., Volckman R., van Sluis P., Li VS, Seepo S., Sekhar Pedamallu C., Cibulskis K., et al. Cell, 2015/05/07, Volume 161, Issue 4, p.933-45, (2015) Read More / View Supplemental Materials
Abstract
BFC: correcting Illumina sequencing errors.Li, H. Bioinformatics (Oxford, England), 2015/05/06, (2015) Read More / View Supplemental Materials
Abstract
Brains, Genes, and Primates.Belmonte, JC, Callaway EM, Churchland P., Caddick SJ, Feng G., Homanics GE, Lee KF, Leopold DA, Miller CT, Mitchell JF, Mitalipov S., Moutri AR, Movshon JA, Okano H., Reynolds JH, Ringach D., Sejnowski TJ, Silva AC, Strick PL, Wu J., et al. Neuron, 2015/05/06, Volume 86, Issue 3, p.617-631, (2015) Read More / View Supplemental Materials
Abstract
A Convergent and Essential Interneuron Pathway for Mauthner-Cell-Mediated Escapes.Lacoste, AM, Schoppik D., Robson DN, Haesemeyer M., Portugues R., Li JM, Randlett O., Wee CL, Engert F., and Schier AF Current biology : CB, 2015/05/06, (2015) Read More / View Supplemental Materials
Abstract
Modeling malaria genomics reveals transmission decline and rebound in Senegal.Daniels, RF, Schaffner SF, Wenger EA, Proctor JL, Chang HH, Wong W., Baro N., Ndiaye D., Fall FB, Ndiop M., Ba M., Milner DA Jr, Taylor TE, Neafsey DE, Volkman SK, Eckhoff PA, Hartl DL, and Wirth DF Proceedings of the National Academy of Sciences of the United States of America, 2015/05/04, (2015) Read More / View Supplemental Materials
Abstract
Accounting for experimental noise reveals that mRNA levels, amplified by post-transcriptional processes, largely determine steady-state protein levels in yeast.Csárdi, G., Franks A., Choi DS, Airoldi EM, and Drummond DA PLoS genetics, 2015/05/01, Volume 11, Issue 5, p.e1005206, (2015) Read More / View Supplemental Materials
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Cell Specific eQTL Analysis without Sorting Cells.Westra, HJ, Arends D., Esko T., Peters MJ, Schurmann C., Schramm K., Kettunen J., Yaghootkar H., Fairfax BP, Andiappan AK, Li Y., Fu J., Karjalainen J., Platteel M., Visschedijk M., Weersma RK, Kasela S., Milani L., Tserel L., Peterson P., et al. PLoS genetics, 2015/05/01, Volume 11, Issue 5, p.e1005223, (2015) Read More / View Supplemental Materials
Abstract
Dysregulation of miR-34a links neuronal development to genetic risk factors for bipolar disorder.Bavamian, S., Mellios N., Lalonde J., Fass DM, Wang J., Sheridan SD, Madison JM, Zhou F., Rueckert EH, Barker D., Perlis RH, Sur M., and Haggarty SJ Molecular psychiatry, 2015/05/01, Volume 20, Issue 5, p.573-84, (2015) Read More / View Supplemental Materials
Abstract
Entropic Description of Gas Hydrate Ice-Liquid Equilibrium via Enhanced Sampling of Coexisting Phases.Małolepsza, E., Kim J., and Keyes T. Physical review letters, 2015/05/01, Volume 114, Issue 17, p.170601, (2015) Read More / View Supplemental Materials
Abstract
High-throughput functional genomics using CRISPR-Cas9.Shalem, O., Sanjana NE, and Zhang F. Nature reviews. Genetics, 2015/05/01, Volume 16, Issue 5, p.299-311, (2015) Read More / View Supplemental Materials
Abstract
The histone deacetylase SIRT6 controls embryonic stem cell fate via TET-mediated production of 5-hydroxymethylcytosine.Etchegaray, JP, Chavez L., Huang Y., Ross KN, Choi J., Martinez-Pastor B., Walsh RM, Sommer CA, Lienhard M., Gladden A., Kugel S., Silberman DM, Ramaswamy S., Mostoslavsky G., Hochedlinger K., Goren A., Rao A., and Mostoslavsky R. Nature cell biology, 2015/05/01, Volume 17, Issue 5, p.545-57, (2015) Read More / View Supplemental Materials
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Noncoding RNAs connect genetic risk factors to the neurodevelopmental basis of bipolar disorder.Bavamian, S., Mellios N., Lalonde J., Fass DM, Wang J., Sheridan SD, Madison JM, Zhou F., Rueckert EH, Barker D., Perlis RH, Sur M., and Haggarty SJ Molecular psychiatry, 2015/05/01, Volume 20, Issue 5, p.548, (2015) Read More / View Supplemental Materials
APOE ɛ2 is associated with white matter hyperintensity volume in CADASIL.Gesierich, B., Opherk C., Rosand J., Gonik M., Malik R., Jouvent E., Hervé D., Adib-Samii P., Bevan S., Pianese L., Silvestri S., Dotti MT, De Stefano N., van der Grond J., Boon EM, Pescini F., Rost N., Pantoni L., Lesnik Oberstein SA, Federico A., et al. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2015/04/29, (2015) Read More / View Supplemental Materials
Abstract
Comparing Platforms for Messenger RNA Expression Profiling of Archival Formalin-Fixed, Paraffin-Embedded Tissues.Tyekucheva, S., Martin NE, Stack EC, Wei W., Vathipadiekal V., Waldron L., Fiorentino M., Lis RT, Stampfer MJ, Loda M., Parmigiani G., Mucci LA, and Birrer M. The Journal of molecular diagnostics : JMD, 2015/04/29, (2015) Read More / View Supplemental Materials
Abstract
Efficient CRISPR-Cas9-Mediated Generation of Knockin Human Pluripotent Stem Cells Lacking Undesired Mutations at the Targeted Locus.Merkle, FT, Neuhausser WM, Santos D., Valen E., Gagnon JA, Maas K., Sandoe J., Schier AF, and Eggan K. Cell reports, 2015/04/29, (2015) Read More / View Supplemental Materials
Abstract
Association of HLA-DRB1 haplotypes with rheumatoid arthritis severity, mortality, and treatment response.Viatte, S., Plant D., Han B., Fu B., Yarwood A., Thomson W., Symmons DP, Worthington J., Young A., Hyrich KL, Morgan AW, Wilson AG, Isaacs JD, Raychaudhuri S., and Barton A. JAMA, 2015/04/28, Volume 313, Issue 16, p.1645-56, (2015) Read More / View Supplemental Materials
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CDC20 maintains tumor initiating cells.Xie, Q., Wu Q., Mack SC, Yang K., Kim L., Hubert CG, Flavahan WA, Chu C., Bao S., and Rich JN Oncotarget, 2015/04/28, (2015) Read More / View Supplemental Materials
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A Multivariate Computational Method to Analyze High-Content RNAi Screening Data.Rameseder, J., Krismer K., Dayma Y., Ehrenberger T., Hwang MK, Airoldi EM, Floyd SR, and Yaffe MB Journal of biomolecular screening, 2015/04/27, (2015) Read More / View Supplemental Materials
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Sequencing and beyond: integrating molecular 'omics' for microbial community profiling.Franzosa, EA, Hsu T., Sirota-Madi A., Shafquat A., Abu-Ali G., Morgan XC, and Huttenhower C. Nature reviews. Microbiology, 2015/04/27, (2015) Read More / View Supplemental Materials
Abstract
The Xist lncRNA interacts directly with SHARP to silence transcription through HDAC3.McHugh, CA, Chen CK, Chow A., Surka CF, Tran C., McDonel P., Pandya-Jones A., Blanco M., Burghard C., Moradian A., Sweredoski MJ, Shishkin AA, Su J., Lander E. S., Hess S., Plath K., and Guttman M. Nature, 2015/04/27, (2015) Read More / View Supplemental Materials
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A depauperate immune repertoire precedes evolution of sociality in bees.Barribeau, SM, Sadd BM, du Plessis L., Brown MJ, Buechel SD, Cappelle K., Carolan JC, Christiaens O., Colgan TJ, Erler S., Evans J., Helbing S., Karaus E., Lattorff HM, Marxer M., Meeus I., Näpflin K., Niu J., Schmid-Hempel R., Smagghe G., et al. Genome biology, 2015/04/24, Volume 16, Issue 1, p.83, (2015) Read More / View Supplemental Materials
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The genomes of two key bumblebee species with primitive eusocial organization.Sadd, BM, Barribeau SM, Bloch G., de Graaf DC, Dearden P., Elsik CG, Gadau J., Grimmelikhuijzen CJ, Hasselmann M., Lozier JD, Robertson HM, Smagghe G., Stolle E., Van Vaerenbergh M., Waterhouse RM, Bornberg-Bauer E., Klasberg S., Bennett AK, Câmara F., Guigó R., et al. Genome biology, 2015/04/24, Volume 16, Issue 1, p.76, (2015) Read More / View Supplemental Materials
Abstract
Genome-wide meta-analysis identifies multiple novel associations and ethnic heterogeneity of psoriasis susceptibility.Yin, X., Low HQ, Wang L., Li Y., Ellinghaus E., Han J., Estivill X., Sun L., Zuo X., Shen C., Zhu C., Zhang A., Sanchez F., Padyukov L., Catanese JJ, Krueger GG, Duffin KC, Mucha S., Weichenthal M., Weidinger S., et al. Nature communications, 2015/04/23, Volume 6, p.6916, (2015) Read More / View Supplemental Materials
Abstract
Hydroxamate-Based Histone Deacetylase Inhibitors Can Protect Neurons from Oxidative Stress via a Histone Deacetylase-Independent Catalase-Like Mechanism.Olson, DE, Sleiman SF, Bourassa MW, Wagner FF, Gale JP, Zhang YL, Ratan RR, and Holson EB Chemistry & biology, 2015/04/23, Volume 22, Issue 4, p.439-45, (2015) Read More / View Supplemental Materials
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Long non-coding RNA discovery across the genus anopheles reveals conserved secondary structures within and beyond the Gambiae complex.Jenkins, AM, Waterhouse RM, and Muskavitch MA BMC genomics, 2015/04/23, Volume 16, Issue 1, p.337, (2015) Read More / View Supplemental Materials
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The Psychiatric Genomics Consortium Posttraumatic Stress Disorder Workgroup: Posttraumatic stress disorder enters the age of large-scale genomic collaboration.Logue, MW, Amstadter AB, Baker DG, Duncan L., Koenen KC, Liberzon I., Miller MW, Morey RA, Nievergelt CM, Ressler KJ, Smith AK, Smoller JW, Stein MB, Sumner JA, and Uddin M. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2015/04/23, (2015) Read More / View Supplemental Materials
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Toward the Rational Design of Carbapenem Uptake in Pseudomonas aeruginosa.Isabella, VM, Campbell AJ, Manchester J., Sylvester M., Nayar AS, Ferguson KE, Tommasi R., and Miller AA Chemistry & biology, 2015/04/23, Volume 22, Issue 4, p.535-47, (2015) Read More / View Supplemental Materials
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Widespread macromolecular interaction perturbations in human genetic disorders.Sahni, N., Yi S., Taipale M., Fuxman Bass JI, Coulombe-Huntington J., Yang F., Peng J., Weile J., Karras GI, Wang Y., Kovács IA, Kamburov A., Krykbaeva I., Lam MH, Tucker G., Khurana V., Sharma A., Liu YY, Yachie N., Zhong Q., et al. Cell, 2015/04/23, Volume 161, Issue 3, p.647-60, (2015) Read More / View Supplemental Materials
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Complete Genomes Reveal Signatures of Demographic and Genetic Declines in the Woolly Mammoth.Palkopoulou, E., Mallick S., Skoglund P., Enk J., Rohland N., Li H., Omrak A., Vartanyan S., Poinar H., Götherström A., Reich D., and Dalén L. Current biology : CB, 2015/04/21, (2015) Read More / View Supplemental Materials
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Developing Medicines That Mimic the Natural Successes of the Human Genome: Lessons From NPC1L1, HMGCR, PCSK9, APOC3, and CETP.Kathiresan, S. Journal of the American College of Cardiology, 2015/04/21, Volume 65, Issue 15, p.1562-6, (2015) Read More / View Supplemental Materials
Alternative to the soft-agar assay that permits high-throughput drug and genetic screens for cellular transformation.Rotem, A., Janzer A., Izar B., Ji Z., Doench JG, Garraway LA, and Struhl K. Proceedings of the National Academy of Sciences of the United States of America, 2015/04/20, (2015) Read More / View Supplemental Materials
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DNA replication fidelity in Mycobacterium tuberculosis is mediated by an ancestral prokaryotic proofreader.Rock, JM, Lang UF, Chase MR, Ford CB, Gerrick ER, Gawande R., Coscolla M., Gagneux S., Fortune SM, and Lamers MH Nature genetics, 2015/04/20, (2015) Read More / View Supplemental Materials
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Fine mapping in the MHC region accounts for 18% additional genetic risk for celiac disease.Gutierrez-Achury, J., Zhernakova A., Pulit SL, Trynka G., Hunt KA, Romanos J., Raychaudhuri S., van Heel DA, Wijmenga C., and de Bakker PI Nature genetics, 2015/04/20, (2015) Read More / View Supplemental Materials
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Calibrating genomic and allelic coverage bias in single-cell sequencing.Zhang, CZ, Adalsteinsson VA, Francis J., Cornils H., Jung J., Maire C., Ligon KL, Meyerson M., and Love JC Nature communications, 2015/04/16, Volume 6, p.6822, (2015) Read More / View Supplemental Materials
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Integrative genomic analysis reveals widespread enhancer regulation by p53 in response to DNA damage.Younger, ST, Kenzelmann-Broz D., Jung H., Attardi LD, and Rinn JL Nucleic acids research, 2015/04/16, (2015) Read More / View Supplemental Materials
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Pugh et al. reply.Pugh, TJ, Banerji S., and Meyerson M. Nature, 2015/04/16, Volume 520, Issue 7547, p.E12-4, (2015) Read More / View Supplemental Materials
SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance.Kim, D., Fiske BP, Birsoy K., Freinkman E., Kami K., Possemato RL, Chudnovsky Y., Pacold ME, Chen WW, Cantor JR, Shelton LM, Gui DY, Kwon M., Ramkissoon SH, Ligon KL, Kang SW, Snuderl M., Vander Heiden MG, and Sabatini DM Nature, 2015/04/16, Volume 520, Issue 7547, p.363-7, (2015) Read More / View Supplemental Materials
Abstract
Live Cell Multi-Photon Fluorescence Correlation Spectroscopy with an Improved Large Stokes Shift Fluorescent Protein.Guan, Y., Meurer M., Raghavan S., Rebane A., Lindquist JR, Santos S., Kats I., Davidson MW, Mazitschek R., Hughes TE, Drobizhev M., Knop M., and Shah JV Molecular biology of the cell, 2015/04/15, (2015) Read More / View Supplemental Materials
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Cases of Ebola virus disease predicted to rise from hundreds to thousands per week unless control measures improve.Andersen, KG Evidence-based nursing, 2015/04/14, (2015) Read More / View Supplemental Materials
Mixed Model with Correction for Case-Control Ascertainment Increases Association Power.Hayeck, TJ, Zaitlen NA, Loh PR, Vilhjalmsson B., Pollack S., Gusev A., Yang J., Chen GB, Goddard ME, Visscher PM, Patterson N., and Price AL American journal of human genetics, 2015/04/14, (2015) Read More / View Supplemental Materials
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Distinct metabolomic signatures are associated with longevity in humans.Cheng, S., Larson MG, McCabe EL, Murabito JM, Rhee EP, Ho JE, Jacques PF, Ghorbani A., Magnusson M., Souza AL, Deik AA, Pierce KA, Bullock K., O'Donnell CJ, Melander O., Clish CB, Vasan RS, Gerszten RE, and Wang TJ Nature communications, 2015/04/13, Volume 6, p.6791, (2015) Read More / View Supplemental Materials
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Spatial reconstruction of single-cell gene expression data.Satija, R., Farrell JA, Gennert D., Schier AF, and Regev A. Nature biotechnology, 2015/04/13, (2015) Read More / View Supplemental Materials
Abstract
Discovery of bisamide-heterocycles as inhibitors of scavenger receptor BI (SR-BI)-mediated lipid uptake.Dockendorff, C., Faloon PW, Germain A., Yu M., Youngsaye W., Nag PP, Bennion M., Penman M., Nieland TJ, Dandapani S., Perez JR, Munoz B., Palmer MA, Schreiber SL, and Krieger M. Bioorganic & medicinal chemistry letters, 2015/04/11, (2015) Read More / View Supplemental Materials
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Genome-wide association studies of late-onset cardiovascular disease.Gustav Smith, J., and Newton-Cheh C. Journal of molecular and cellular cardiology, 2015/04/11, (2015) Read More / View Supplemental Materials
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DNA copy number analysis of metastatic urothelial carcinoma with comparison to primary tumors.Bambury, RM, Bhatt AS, Riester M., Pedamallu CS, Duke F., Bellmunt J., Stack EC, Werner L., Park R., Iyer G., Loda M., Kantoff PW, Michor F., Meyerson M., and Rosenberg JE BMC cancer, 2015/04/09, Volume 15, p.242, (2015) Read More / View Supplemental Materials
Abstract
In vivo genome editing using Staphylococcus aureus Cas9.Ran, FA, Cong L., Yan WX, Scott DA, Gootenberg JS, Kriz AJ, Zetsche B., Shalem O., Wu X., Makarova KS, Koonin EV, Sharp PA, and Zhang F. Nature, 2015/04/09, Volume 520, Issue 7546, p.186-91, (2015) Read More / View Supplemental Materials
Abstract
Associations between host gene expression, the mucosal microbiome, and clinical outcome in the pelvic pouch of patients with inflammatory bowel disease.Morgan, XC, Kabakchiev B., Waldron L., Tyler AD, Tickle TL, Milgrom R., Stempak JM, Gevers D., Xavier RJ, Silverberg MS, and Huttenhower C. Genome biology, 2015/04/08, Volume 16, Issue 1, p.67, (2015) Read More / View Supplemental Materials
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Determinants of the CmoB carboxymethyl transferase utilized for selective tRNA wobble modification.Kim, J., Xiao H., Koh J., Wang Y., Bonanno JB, Thomas K., Babbitt PC, Brown S., Lee YS, and Almo SC Nucleic acids research, 2015/04/08, (2015) Read More / View Supplemental Materials
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Genome-wide Analysis of Body Proportion Classifies Height-Associated Variants by Mechanism of Action and Implicates Genes Important for Skeletal Development.Chan, Y., Salem RM, Hsu YH, McMahon G., Pers TH, Vedantam S., Esko T., Guo MH, Lim ET, GIANT Consortium, Franke L., Smith GD, Strachan DP, and Hirschhorn JN American journal of human genetics, 2015/04/08, (2015) Read More / View Supplemental Materials
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Mutations in PYCR2, Encoding Pyrroline-5-Carboxylate Reductase 2, Cause Microcephaly and Hypomyelination.Nakayama, T., Al-Maawali A., El-Quessny M., Rajab A., Khalil S., Stoler JM, Tan WH, Nasir R., Schmitz-Abe K., Hill RS, Partlow JN, Al-Saffar M., Servattalab S., LaCoursiere CM, Tambunan DE, Coulter ME, Elhosary PC, Gorski G., Barkovich AJ, Markianos K., et al. American journal of human genetics, 2015/04/08, (2015) Read More / View Supplemental Materials
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Criteria for biological reproducibility: What does "n" mean?Naegle, K., Gough NR, and Yaffe MB Science signaling, 2015/04/07, Volume 8, Issue 371, p.fs7, (2015) Read More / View Supplemental Materials
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Flavin-containing monooxygenase 3 as a potential player in diabetes-associated atherosclerosis.Miao, J., Ling AV, Manthena PV, Gearing ME, Graham MJ, Crooke RM, Croce KJ, Esquejo RM, Clish CB, Morbid Obesity Study Group, Vicent D., and Biddinger SB Nature communications, 2015/04/07, Volume 6, p.6498, (2015) Read More / View Supplemental Materials
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IGF2BP2/IMP2-Deficient Mice Resist Obesity through Enhanced Translation of Ucp1 mRNA and Other mRNAs Encoding Mitochondrial Proteins.Dai, N., Zhao L., Wrighting D., Krämer D., Majithia A., Wang Y., Cracan V., Borges-Rivera D., Mootha VK, Nahrendorf M., Thorburn DR, Minichiello L., Altshuler D., and Avruch J. Cell metabolism, 2015/04/07, Volume 21, Issue 4, p.609-21, (2015) Read More / View Supplemental Materials
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Reproducibility in science.Yaffe, MB Science signaling, 2015/04/07, Volume 8, Issue 371, p.eg5, (2015) Read More / View Supplemental Materials
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Biallelic mutations in SNX14 cause a syndromic form of cerebellar atrophy and lysosome-autophagosome dysfunction.Akizu, N., Cantagrel V., Zaki MS, Al-Gazali L., Wang X., Rosti RO, Dikoglu E., Gelot AB, Rosti B., Vaux KK, Scott EM, Silhavy JL, Schroth J., Copeland B., Schaffer AE, Gordts PL, Esko JD, Buschman MD, Field SJ, Napolitano G., et al. Nature genetics, 2015/04/06, (2015) Read More / View Supplemental Materials
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The lure of zebrafish in liver research: regulation of hepatic growth in development and regeneration.Cox, AG, and Goessling W. Current opinion in genetics & development, 2015/04/06, Volume 32, p.153-161, (2015) Read More / View Supplemental Materials
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The receptor TREML4 amplifies TLR7-mediated signaling during antiviral responses and autoimmunity.Ramirez-Ortiz, ZG, Prasad A., Griffith JW, Pendergraft WF 3rd, Cowley GS, Root DE, Tai M., Luster AD, El Khoury J., Hacohen N., and Means TK Nature immunology, 2015/04/06, (2015) Read More / View Supplemental Materials
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Cancer and the microbiota.Garrett, WS Science (New York, N.Y.), 2015/04/03, Volume 348, Issue 6230, p.80-6, (2015) Read More / View Supplemental Materials
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Myocardial Infarction-Associated SNP at 6p24 Interferes With MEF2 Binding and Associates With PHACTR1 Expression Levels in Human Coronary Arteries.Beaudoin, M., Gupta RM, Won HH, Lo KS, Do R., Henderson CA, Lavoie-St-Amour C., Langlois S., Rivas D., Lehoux S., Kathiresan S., Tardif JC, Musunuru K., and Lettre G. Arteriosclerosis, thrombosis, and vascular biology, 2015/04/02, (2015) Read More / View Supplemental Materials
Abstract
Association of a brain methylation site with clinical outcomes in depression does not replicate across populations.Uher, R., Ripke S., Müller-Myhsok B., Lewis CM, and Perlis RH The American journal of psychiatry, 2015/04/01, Volume 172, Issue 4, p.395-7, (2015) Read More / View Supplemental Materials
Benzo-fused lactams from a diversity-oriented synthesis (DOS) library as inhibitors of scavenger receptor BI (SR-BI)-mediated lipid uptake.Dockendorff, C., Faloon PW, Pu J., Yu M., Johnston S., Bennion M., Penman M., Nieland TJ, Dandapani S., Perez JR, Munoz B., Palmer MA, Schreiber SL, and Krieger M. Bioorganic & medicinal chemistry letters, 2015/04/01, (2015) Read More / View Supplemental Materials
Abstract
Clinical Acquired Resistance to RAF Inhibitor Combinations in BRAF-Mutant Colorectal Cancer through MAPK Pathway Alterations.Ahronian, LG, Sennott EM, Van Allen EM, Wagle N., Kwak EL, Faris JE, Godfrey JT, Nishimura K., Lynch KD, Mermel CH, Lockerman EL, Kalsy A., Gurski JM Jr, Bahl S., Anderka K., Green LM, Lennon NJ, Huynh TG, Mino-Kenudson M., Getz G., et al. Cancer discovery, 2015/04/01, Volume 5, Issue 4, p.358-67, (2015) Read More / View Supplemental Materials
Abstract
Dynamic epigenetic regulation by menin during pancreatic islet tumor formation.Lin, W., Watanabe H., Peng S., Francis JM, Kaplan N., Pedamallu CS, Ramachandran A., Agoston A., Bass AJ, and Meyerson M. Molecular cancer research : MCR, 2015/04/01, Volume 13, Issue 4, p.689-98, (2015) Read More / View Supplemental Materials
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Frozen Encapsulated Stool in Recurrent Clostridium difficile: Exploring the Role of Pills in the Treatment Hierarchy of Fecal Microbiota Transplant Nonresponders.Stollman, N., Smith M., Giovanelli A., Mendolia G., Burns L., Didyk E., Burgess J., Noh A., Edelstein C., Alm E., and Kassam Z. The American journal of gastroenterology, 2015/04/01, Volume 110, Issue 4, p.600-1, (2015) Read More / View Supplemental Materials
Haematological malignancies: at the forefront of immunotherapeutic innovation.Bachireddy, P., Burkhardt UE, Rajasagi M., and Wu CJ Nature reviews. Cancer, 2015/04/01, Volume 15, Issue 4, p.201-15, (2015) Read More / View Supplemental Materials
Abstract
HDAC3 inhibition improves glycemia and insulin secretion in obese diabetic rats.Lundh, M., Galbo T., Poulsen SS, and Mandrup-Poulsen T. Diabetes, obesity & metabolism, 2015/04/01, (2015) Read More / View Supplemental Materials
Abstract
Loss of PCLO function underlies pontocerebellar hypoplasia type III.Ahmed, MY, Chioza BA, Rajab A., Schmitz-Abe K., Al-Khayat A., Al-Turki S., Baple EL, Patton MA, Al-Memar AY, Hurles ME, Partlow JN, Hill RS, Evrony GD, Servattalab S., Markianos K., Walsh CA, Crosby AH, and Mochida GH Neurology, 2015/04/01, (2015) Read More / View Supplemental Materials
Abstract
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