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Synthesis, cellular evaluation and mechanism-of-action of piperlongumine analogsAdams, DJ, Dai M., Pellegrino G., Wagner BK, Stern AM, Shamji AF, and Schreiber SL, (Submitted) Read More / View Supplemental Materials
2016
Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors.Wagner, FF, Weïwer M., Steinbacher S., Schomburg A., Reinemer P., Gale JP, Campbell AJ, Fisher SL, Zhao WN, Reis SA, Hennig KM, Thomas M., Müller P., Jefson MR, Fass DM, Haggarty SJ, Zhang YL, and Holson EB Bioorganic & medicinal chemistry, 2016/09/15, Volume 24, Issue 18, p.4008-15, (2016) Read More / View Supplemental Materials
Abstract
Cell Painting, a high-content image-based assay for morphological profiling using multiplexed fluorescent dyes.Bray, MA, Singh S., Han H., Davis CT, Borgeson B., Hartland C., Kost-Alimova M., Gustafsdottir SM, Gibson CC, and Carpenter AE Nature protocols, 2016/09/01, Volume 11, Issue 9, p.1757-74, (2016) Read More / View Supplemental Materials
Abstract
Correlating Drug-Target Kinetics and In vivo Pharmacodynamics: Long Residence Time Inhibitors of the FabI Enoyl-ACP Reductase.Daryaee, F., Chang A., Schiebel J., Lu Y., Zhang Z., Kapilashrami K., Walker SG, Kisker C., Sotriffer CA, Fisher SL, and Tonge PJ Chemical science, 2016/09/01, Volume 7, Issue 9, p.5945-5954, (2016) Read More / View Supplemental Materials
Abstract
Massive contribution of transposable elements to mammalian regulatory sequences.Rayan, NA, Del Rosario RC, and Prabhakar S. Seminars in cell & developmental biology, 2016/09/01, Volume 57, p.51-6, (2016) Read More / View Supplemental Materials
Abstract
Next-generation genotype imputation service and methods.Das, S., Forer L., Schönherr S., Sidore C., Locke AE, Wong AK, Vrieze SI, Chew EY, Levy S., McGue M., Schlessinger D., Stambolian D., Loh PR, Iacono WG, Swaroop A., Scott LJ, Cucca F., Kronenberg F., Boehnke M., Abecasis GR, et al. Nature genetics, 2016/08/29, (2016) Read More / View Supplemental Materials
Abstract
Anti-inflammatory effects of melatonin in multiple sclerosis.Farez, MF, Calandri IL, Correale J., and Quintana FJ BioEssays : news and reviews in molecular, cellular and developmental biology, 2016/08/26, (2016) Read More / View Supplemental Materials
Abstract
Discovery of a proteinaceous cellular receptor for a norovirus.Orchard, RC, Wilen CB, Doench JG, Baldridge MT, McCune BT, Lee YC, Lee S., Pruett-Miller SM, Nelson CA, Fremont DH, and Virgin HW Science (New York, N.Y.), 2016/08/26, Volume 353, Issue 6302, p.933-6, (2016) Read More / View Supplemental Materials
Abstract
The hippocampus grows up.Rudenko, A., and Tsai LH Nature neuroscience, 2016/08/26, Volume 19, Issue 9, p.1190-1191, (2016) Read More / View Supplemental Materials
Opportunities and challenges in modeling human brain disorders in transgenic primates.Jennings, CG, Landman R., Zhou Y., Sharma J., Hyman J., Movshon JA, Qiu Z., Roberts AC, Roe AW, Wang X., Zhou H., Wang L., Zhang F., Desimone R., and Feng G. Nature neuroscience, 2016/08/26, Volume 19, Issue 9, p.1123-1130, (2016) Read More / View Supplemental Materials
Abstract
Absolute Quantification of Matrix Metabolites Reveals the Dynamics of Mitochondrial Metabolism.Chen, WW, Freinkman E., Wang T., Birsoy K., and Sabatini DM Cell, 2016/08/25, Volume 166, Issue 5, p.1324-1337.e11, (2016) Read More / View Supplemental Materials
Abstract
Cell-Type-Specific Alternative Splicing Governs Cell Fate in the Developing Cerebral Cortex.Zhang, X., Chen MH, Wu X., Kodani A., Fan J., Doan R., Ozawa M., Ma J., Yoshida N., Reiter JF, Black DL, Kharchenko PV, Sharp PA, and Walsh CA Cell, 2016/08/25, Volume 166, Issue 5, p.1147-1162.e15, (2016) Read More / View Supplemental Materials
Abstract
Comprehensive Classification of Retinal Bipolar Neurons by Single-Cell Transcriptomics.Shekhar, K., Lapan SW, Whitney IE, Tran NM, Macosko EZ, Kowalczyk M., Adiconis X., Levin JZ, Nemesh J., Goldman M., McCarroll SA, Cepko CL, Regev A., and Sanes JR Cell, 2016/08/25, Volume 166, Issue 5, p.1308-1323.e30, (2016) Read More / View Supplemental Materials
Abstract
Identification of a Bipolar Disorder Vulnerable Gene CHDH at 3p21.1.Chang, H., Li L., Peng T., Grigoroiu-Serbanescu M., Bergen SE, Landén M., Hultman CM, Forstner AJ, Strohmaier J., Hecker J., Schulze TG, Müller-Myhsok B., Reif A., Mitchell PB, Martin NG, Cichon S., Nöthen MM, Jamain S., Leboyer M., Bellivier F., et al. Molecular neurobiology, 2016/08/25, (2016) Read More / View Supplemental Materials
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Proteomic Analysis of Unbounded Cellular Compartments: Synaptic Clefts.Loh, KH, Stawski PS, Draycott AS, Udeshi ND, Lehrman EK, Wilton DK, Svinkina T., Deerinck TJ, Ellisman MH, Stevens B., Carr SA, and Ting AY Cell, 2016/08/25, Volume 166, Issue 5, p.1295-1307.e21, (2016) Read More / View Supplemental Materials
Abstract
Transitioning from Targeted to Comprehensive Mass Spectrometry Using Genetic Algorithms.Jaffe, JD, Feeney CM, Patel J., Lu X., and Mani D. R. Journal of the American Society for Mass Spectrometry, 2016/08/25, (2016) Read More / View Supplemental Materials
Abstract
Across-cohort QC analyses of GWAS summary statistics from complex traits.Chen, GB, Lee SH, Robinson MR, Trzaskowski M., Zhu ZX, Winkler TW, Day FR, Croteau-Chonka DC, Wood AR, Locke AE, Kutalik Z., Loos RJ, Frayling TM, Hirschhorn JN, Yang J., Wray NR, Genetic Investigation of ANthropometric Traits(GIANT) Consortium, and Visscher PM European journal of human genetics : EJHG, 2016/08/24, (2016) Read More / View Supplemental Materials
Abstract
Development of Light-Activated CRISPR Using Guide RNAs with Photocleavable Protectors.Jain, PK, Ramanan V., Schepers AG, Dalvie NS, Panda A., Fleming HE, and Bhatia SN Angewandte Chemie (International ed. in English), 2016/08/24, (2016) Read More / View Supplemental Materials
Abstract
Polygenic Causes of Congenital Diaphragmatic Hernia Produce Common Lung Pathologies: A Multimodal War on Congenital Diaphragmatic Hernia.Donahoe, PK, Longoni M., and High FA The American journal of pathology, 2016/08/23, (2016) Read More / View Supplemental Materials
Abstract
A reference panel of 64,976 haplotypes for genotype imputation.McCarthy, S., Das S., Kretzschmar W., Delaneau O., Wood AR, Teumer A., Kang HM, Fuchsberger C., Danecek P., Sharp K., Luo Y., Sidore C., Wong AK, Timpson N., Koskinen S., Vrieze S., Scott LJ, Zhang H., Mahajan A., Veldink J., et al. Nature genetics, 2016/08/22, (2016) Read More / View Supplemental Materials
Abstract
West Africa International Centers of Excellence for Malaria Research: Drug Resistance Patterns to Artemether-Lumefantrine in Senegal, Mali, and The Gambia.Dieye, B., Affara M., Sangare L., Joof F., Ndiaye YD, Gomis JF, Ndiaye M., Mbaye A., Diakite M., Sy N., Mbengue B., Deme AB, Daniels R., Ahouidi AD, Dieye T., Abdullahi A., Doumbia S., Ndiaye JL, Diarra A., Ismaela A., et al. The American journal of tropical medicine and hygiene, 2016/08/22, (2016) Read More / View Supplemental Materials
Abstract
Replication of the Association of BDNF and MC4R Variants With Dietary Intake in the Diabetes Prevention Program.McCaffery, JM, Jablonski KA, Franks PW, Delahanty LM, Aroda V., Marrero D., Hamman RF, Horton ES, Dagogo-Jack S., Wylie-Rosett J., Barrett-Connor E., Kitabchi A., Knowler WC, Wing RR, Florez JC, and Diabetes Prevention Program Research Group Psychosomatic medicine, 2016/08/20, (2016) Read More / View Supplemental Materials
Abstract
Migraine genetics: from genome-wide association studies to translational insights.Gormley, P., Winsvold BS, Nyholt DR, Kallela M., Chasman DI, and Palotie A. Genome medicine, 2016/08/19, Volume 8, Issue 1, p.86, (2016) Read More / View Supplemental Materials
Probing the Azaaurone Scaffold against the Hepatic and Erythrocytic Stages of Malaria Parasites.Carrasco, MP, Machado M., Gonçalves L., Sharma M., Gut J., Lukens AK, Wirth DF, André V., Duarte MT, Guedes RC, J V A Dos Santos D., Rosenthal PJ, Mazitschek R., Prudêncio M., and Moreira R. ChemMedChem, 2016/08/19, (2016) Read More / View Supplemental Materials
Abstract
Genome Sequence of Spizellomyces punctatus.Russ, C., Lang BF, Chen Z., Gujja S., Shea T., Zeng Q., Young S., Cuomo CA, and Nusbaum C. Genome announcements, 2016/08/18, Volume 4, Issue 4, (2016) Read More / View Supplemental Materials
Abstract
Point mutations at the catalytic site of PCSK9 inhibit folding, autoprocessing and interaction with the LDL receptor.Garvie, CW, Fraley CV, Elowe NH, Culyba EK, Lemke CT, Hubbard BK, Kaushik VK, and Daniels DS Protein science : a publication of the Protein Society, 2016/08/18, (2016) Read More / View Supplemental Materials
Abstract
Analysis of protein-coding genetic variation in 60,706 humans.Lek, M., Karczewski KJ, Minikel EV, Samocha KE, Banks E., Fennell T., O'Donnell-Luria AH, Ware JS, Hill AJ, Cummings BB, Tukiainen T., Birnbaum DP, Kosmicki JA, Duncan LE, Estrada K., Zhao F., Zou J., Pierce-Hoffman E., Berghout J., Cooper DN, et al. Nature, 2016/08/17, Volume 536, Issue 7616, p.285-91, (2016) Read More / View Supplemental Materials
Abstract
Biallelic Variants in UBA5 Link Dysfunctional UFM1 Ubiquitin-like Modifier Pathway to Severe Infantile-Onset Encephalopathy.Muona, M., Ishimura R., Laari A., Ichimura Y., Linnankivi T., Keski-Filppula R., Herva R., Rantala H., Paetau A., Pöyhönen M., Obata M., Uemura T., Karhu T., Bizen N., Takebayashi H., McKee S., Parker MJ, Akawi N., McRae J., Hurles ME, et al. American journal of human genetics, 2016/08/17, (2016) Read More / View Supplemental Materials
Abstract
Comprehensive Protocols for CRISPR/Cas9-based Gene Editing in Human Pluripotent Stem Cells.Santos, DP, Kiskinis E., Eggan K., and Merkle FT Current protocols in stem cell biology, 2016/08/17, Volume 38, p.5B.6.1-5B.6.60, (2016) Read More / View Supplemental Materials
Abstract
De Novo Mutations in SON Disrupt RNA Splicing of Genes Essential for Brain Development and Metabolism, Causing an Intellectual-Disability Syndrome.Kim, JH, Shinde DN, Reijnders MR, Hauser NS, Belmonte RL, Wilson GR, Bosch DG, Bubulya PA, Shashi V., Petrovski S., Stone JK, Park EY, Veltman JA, Sinnema M., Stumpel CT, Draaisma JM, Nicolai J., University of Washington Center for Mendelian Genomics, Yntema HG, Lindstrom K., et al. American journal of human genetics, 2016/08/17, (2016) Read More / View Supplemental Materials
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Determinants of Power in Gene-Based Burden Testing for Monogenic Disorders.Guo, MH, Dauber A., Lippincott MF, Chan YM, Salem RM, and Hirschhorn JN American journal of human genetics, 2016/08/17, (2016) Read More / View Supplemental Materials
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Genomic complexity of multiple myeloma and its clinical implications.Manier, S., Salem KZ, Park J., Landau DA, Getz G., and Ghobrial IM Nature reviews. Clinical oncology, 2016/08/17, (2016) Read More / View Supplemental Materials
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Patterns of genic intolerance of rare copy number variation in 59,898 human exomes.Ruderfer, DM, Hamamsy T., Lek M., Karczewski KJ, Kavanagh D., Samocha KE, Exome Aggregation Consortium, Daly M. J., Macarthur DG, Fromer M., and Purcell SM Nature genetics, 2016/08/17, (2016) Read More / View Supplemental Materials
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Reassessment of Mendelian gene pathogenicity using 7,855 cardiomyopathy cases and 60,706 reference samples.Walsh, R., Thomson KL, Ware JS, Funke BH, Woodley J., McGuire KJ, Mazzarotto F., Blair E., Seller A., Taylor JC, Minikel EV, Exome Aggregation Consortium, Macarthur DG, Farrall M., Cook SA, and Watkins H. Genetics in medicine : official journal of the American College of Medical Genetics, 2016/08/17, (2016) Read More / View Supplemental Materials
Abstract
Indels, structural variation, and recombination drive genomic diversity in Plasmodium falciparum.Miles, A., Iqbal Z., Vauterin P., Pearson R., Campino S., Theron M., Gould K., Mead D., Drury E., O'Brien J., Ruano Rubio V., MacInnis B., Mwangi J., Samarakoon U., Ranford-Cartwright L., Ferdig M., Hayton K., Su XZ, Wellems T., Rayner J., et al. Genome research, 2016/08/16, (2016) Read More / View Supplemental Materials
Abstract
Lineage-specific and single-cell chromatin accessibility charts human hematopoiesis and leukemia evolution.Corces, MR, Buenrostro JD, Wu B., Greenside PG, Chan SM, Koenig JL, Snyder MP, Pritchard JK, Kundaje A., Greenleaf WJ, Majeti R., and Chang HY Nature genetics, 2016/08/15, (2016) Read More / View Supplemental Materials
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Modulation of long noncoding RNAs by risk SNPs underlying genetic predispositions to prostate cancer.Guo, H., Ahmed M., Zhang F., Yao CQ, Li S., Liang Y., Hua J., Soares F., Sun Y., Langstein J., Li Y., Poon C., Bailey SD, Desai K., Fei T., Li Q., Sendorek DH, Fraser M., Prensner JR, Pugh TJ, et al. Nature genetics, 2016/08/15, (2016) Read More / View Supplemental Materials
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Analysis of cancer genomes reveals basic features of human aging and its role in cancer development.Podolskiy, DI, Lobanov AV, Kryukov GV, and Gladyshev VN Nature communications, 2016/08/12, Volume 7, p.12157, (2016) Read More / View Supplemental Materials
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Challenging Roadblocks to Cancer Cure.Loda, M. Cancer research, 2016/08/12, (2016) Read More / View Supplemental Materials
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Comment on "Mutation rate and genotype variation of Ebola virus from Mali case sequences".Rambaut, A., Dudas G., de Carvalho LM, Park DJ, Yozwiak NL, Holmes EC, and Andersen KG Science (New York, N.Y.), 2016/08/12, Volume 353, Issue 6300, p.658, (2016) Read More / View Supplemental Materials
Abstract
Efficient Routes to a Diverse Array of Amino Alcohol-Derived Chiral Fragments.Haftchenary, S., Nelson SD Jr, Furst L., Dandapani S., Ferrara SJ, Bošković Ž. V., Figueroa Lazú S., Guerrero AM, Serrano JC, Crews DK, Brackeen C., Mowat J., Brumby T., Bauser M., Schreiber SL, and Phillips AJ ACS combinatorial science, 2016/08/12, (2016) Read More / View Supplemental Materials
Abstract
Multifaceted biological insights from a draft genome sequence of the tobacco hornworm moth, Manduca sexta.Kanost, MR, Arrese EL, Cao X., Chen YR, Chellapilla S., Goldsmith MR, Grosse-Wilde E., Heckel DG, Herndon N., Jiang H., Papanicolaou A., Qu J., Soulages JL, Vogel H., Walters J., Waterhouse RM, Ahn SJ, Almeida FC, An C., Aqrawi P., et al. Insect biochemistry and molecular biology, 2016/08/11, (2016) Read More / View Supplemental Materials
Abstract
Fap2 Mediates Fusobacterium nucleatum Colorectal Adenocarcinoma Enrichment by Binding to Tumor-Expressed Gal-GalNAc.Abed, J., Emgård JE, Zamir G., Faroja M., Almogy G., Grenov A., Sol A., Naor R., Pikarsky E., Atlan KA, Mellul A., Chaushu S., Manson AL, Earl AM, Ou N., Brennan CA, Garrett WS, and Bachrach G. Cell host & microbe, 2016/08/10, Volume 20, Issue 2, p.215-25, (2016) Read More / View Supplemental Materials
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HLA-C levels impact natural killer cell subset distribution and function.Sips, M., Liu Q., Draghi M., Ghebremichael M., Berger CT, Suscovich TJ, Sun Y., Walker BD, Carrington M., Altfeld M., Brouckaert P., De Jager PL, and Alter G. Human immunology, 2016/08/10, (2016) Read More / View Supplemental Materials
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In Vivo Characterization of Linc-p21 Reveals Functional cis-Regulatory DNA Elements.Groff, AF, Sanchez-Gomez DB, Soruco MM, Gerhardinger C., Barutcu AR, Li E., Elcavage L., Plana O., Sanchez LV, Lee JC, Sauvageau M., and Rinn JL Cell reports, 2016/08/10, (2016) Read More / View Supplemental Materials
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Loss of Function of GALNT2 Lowers High-Density Lipoproteins in Humans, Nonhuman Primates, and Rodents.Khetarpal, SA, Schjoldager KT, Christoffersen C., Raghavan A., Edmondson AC, Reutter HM, Ahmed B., Ouazzani R., Peloso GM, Vitali C., Zhao W., Somasundara AV, Millar JS, Park Y., Fernando G., Livanov V., Choi S., Noé E., Patel P., Ho SP, et al. Cell metabolism, 2016/08/09, Volume 24, Issue 2, p.234-45, (2016) Read More / View Supplemental Materials
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A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis.Rivas, MA, Graham D., Sulem P., Stevens C., Desch AN, Goyette P., Gudbjartsson D., Jonsdottir I., Thorsteinsdottir U., Degenhardt F., Mucha S., Kurki MI, Li D., D'Amato M., Annese V., Vermeire S., Weersma RK, Halfvarson J., Paavola-Sakki P., Lappalainen M., et al. Nature communications, 2016/08/09, Volume 7, p.12342, (2016) Read More / View Supplemental Materials
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Discovery of a Highly Selective Glycogen Synthase Kinase-3 Inhibitor (PF-04802367) That Modulates Tau Phosphorylation in the Brain: Translation for PET Neuroimaging.Liang, SH, Chen JM, Normandin MD, Chang JS, Chang GC, Taylor CK, Trapa P., Plummer MS, Para KS, Conn EL, Lopresti-Morrow L., Lanyon LF, Cook JM, Richter KE, Nolan CE, Schachter JB, Janat F., Che Y., Shanmugasundaram V., Lefker BA, et al. Angewandte Chemie (International ed. in English), 2016/08/08, Volume 55, Issue 33, p.9601-5, (2016) Read More / View Supplemental Materials
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Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin.Zhou, K., Yee SW, Seiser EL, van Leeuwen N., Tavendale R., Bennett AJ, Groves CJ, Coleman RL, van der Heijden AA, Beulens JW, de Keyser CE, Zaharenko L., Rotroff DM, Out M., Jablonski KA, Chen L., Javorský M., Židzik J., Levin AM, Williams LK, et al. Nature genetics, 2016/08/08, (2016) Read More / View Supplemental Materials
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Delayed seizures after intracerebral haemorrhage.Biffi, A., Rattani A., Anderson CD, Ayres AM, Gurol EM, Greenberg SM, Rosand J., and Viswanathan A. Brain : a journal of neurology, 2016/08/06, (2016) Read More / View Supplemental Materials
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A genomic view of the peopling of the Americas.Skoglund, P., and Reich D. Current opinion in genetics & development, 2016/08/06, Volume 41, p.27-35, (2016) Read More / View Supplemental Materials
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Sibling risk of hospitalization for heart failure - A nationwide study.Lindgren, MP, Smith JG, Li X., Sundquist J., Sundquist K., and Zöller B. International journal of cardiology, 2016/08/06, Volume 223, p.379-384, (2016) Read More / View Supplemental Materials
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Comparative genomics and transcriptomics of Pichia pastoris.Love, KR, Shah KA, Whittaker CA, Wu J., Bartlett MC, Ma D., Leeson RL, Priest M., Borowsky J., Young SK, and Love JC BMC genomics, 2016/08/05, Volume 17, p.550, (2016) Read More / View Supplemental Materials
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Diverse evolutionary roots and mechanistic variations of the CRISPR-Cas systems.Mohanraju, P., Makarova KS, Zetsche B., Zhang F., Koonin EV, and van der Oost J. Science (New York, N.Y.), 2016/08/05, Volume 353, Issue 6299, p.aad5147, (2016) Read More / View Supplemental Materials
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Contribution of a Non-classical HLA Gene, HLA-DOA, to the Risk of Rheumatoid Arthritis.Okada, Y., Suzuki A., Ikari K., Terao C., Kochi Y., Ohmura K., Higasa K., Akiyama M., Ashikawa K., Kanai M., Hirata J., Suita N., Teo YY, Xu H., Bae SC, Takahashi A., Momozawa Y., Matsuda K., Momohara S., Taniguchi A., et al. American journal of human genetics, 2016/08/04, Volume 99, Issue 2, p.366-74, (2016) Read More / View Supplemental Materials
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Understanding human immune function using the resources from the Human Functional Genomics Project.Netea, MG, Joosten LA, Li Y., Kumar V., Oosting M., Smeekens S., Jaeger M., Ter Horst R., Schirmer M., Vlamakis H., Notebaart R., Pavelka N., Aguirre-Gamboa RR, Swertz MA, Tunjungputri RN, van de Heijden W., Franzosa EA, Ng A., Graham D., Lassen K., et al. Nature medicine, 2016/08/04, Volume 22, Issue 8, p.831-3, (2016) Read More / View Supplemental Materials
Whole-Exome Sequencing Identifies Loci Associated with Blood Cell Traits and Reveals a Role for Alternative GFI1B Splice Variants in Human Hematopoiesis.Polfus, LM, Khajuria RK, Schick UM, Pankratz N., Pazoki R., Brody JA, Chen MH, Auer PL, Floyd JS, Huang J., Lange L., van Rooij FJ, Gibbs RA, Metcalf G., Muzny D., Veeraraghavan N., Walter K., Chen L., Yanek L., Becker LC, et al. American journal of human genetics, 2016/08/04, Volume 99, Issue 2, p.481-8, (2016) Read More / View Supplemental Materials
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Genome-wide scans reveal variants at EDAR predominantly affecting hair straightness in Han Chinese and Uyghur populations.Wu, S., Tan J., Yang Y., Peng Q., Zhang M., Li J., Lu D., Liu Y., Lou H., Feng Q., Lu Y., Guan Y., Zhang Z., Jiao Y., Sabeti P., Krutmann J., Tang K., Jin L., Xu S., and Wang S. Human genetics, 2016/08/03, (2016) Read More / View Supplemental Materials
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Genomic Analysis of Viral Outbreaks.Wohl, S., Schaffner SF, and Sabeti PC Annual review of virology, 2016/08/03, (2016) Read More / View Supplemental Materials
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Mechanism of arginine sensing by CASTOR1 upstream of mTORC1.Saxton, RA, Chantranupong L., Knockenhauer KE, Schwartz TU, and Sabatini DM Nature, 2016/08/03, Volume 536, Issue 7615, p.229-233, (2016) Read More / View Supplemental Materials
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Bidirectional Crosstalk Between Patient-Derived Melanoma and Cancer-Associated Fibroblasts Promotes Invasion and Proliferation.Izar, B., Joyce C., Goff S., Cho NL, Shah PM, Sharma G., Li J., Ibrahim N., Gold J., Hodi FS, Garraway LA, Novina CD, Bertagnolli MM, and Yoon CH Pigment cell & melanoma research, 2016/08/02, (2016) Read More / View Supplemental Materials
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Elucidating Combinatorial Chromatin States at Single-Nucleosome Resolution.Sadeh, R., Launer-Wachs R., Wandel H., Rahat A., and Friedman N. Molecular cell, 2016/08/02, (2016) Read More / View Supplemental Materials
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An enzyme in the kynurenine pathway that governs vulnerability to suicidal behavior by regulating excitotoxicity and neuroinflammation.Brundin, L., Sellgren CM, Lim CK, Grit J., Pålsson E., Landén M., Samuelsson M., Lundgren K., Brundin P., Fuchs D., Postolache TT, Traskman-Bendz L., Guillemin GJ, and Erhardt S. Translational psychiatry, 2016/08/02, Volume 6, Issue 8, p.e865, (2016) Read More / View Supplemental Materials
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APOE polymorphisms influence longitudinal lipid trends preceding intracerebral hemorrhage.Phuah, CL, Raffeld MR, Ayres AM, Gurol ME, Viswanathan A., Greenberg SM, Biffi A., Rosand J., and Anderson CD Neurology. Genetics, 2016/08/01, Volume 2, Issue 4, p.e81, (2016) Read More / View Supplemental Materials
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A comparison of the CHARGE-AF and the CHA2DS2-VASc risk scores for prediction of atrial fibrillation in the Framingham Heart Study.Christophersen, IE, Yin X., Larson MG, Lubitz SA, Magnani JW, McManus DD, Ellinor PT, and Benjamin EJ American heart journal, 2016/08/01, Volume 178, p.45-54, (2016) Read More / View Supplemental Materials
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Differential dopaminergic regulation of inwardly rectifying potassium channel mediated subthreshold dynamics in striatal medium spiny neurons.Zhao, B., Zhu J., Dai D., Xing J., He J., Fu Z., Zhang L., Li Z., and Wang W. Neuropharmacology, 2016/08/01, Volume 107, p.396-410, (2016) Read More / View Supplemental Materials
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A highly multiplexed and sensitive RNA-seq protocol for simultaneous analysis of host and pathogen transcriptomes.Avraham, R., Haseley N., Fan A., Bloom-Ackermann Z., Livny J., and Hung DT Nature protocols, 2016/08/01, Volume 11, Issue 8, p.1477-91, (2016) Read More / View Supplemental Materials
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Loss of vhl in the zebrafish pronephros recapitulates early stages of human clear cell renal cell carcinoma.Noonan, HR, Metelo AM, Kamei CN, Peterson RT, Drummond IA, and Iliopoulos O. Disease models & mechanisms, 2016/08/01, Volume 9, Issue 8, p.873-84, (2016) Read More / View Supplemental Materials
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Microfluidic device for the formation of optically excitable, three-dimensional, compartmentalized motor units.Uzel, SG, Platt RJ, Subramanian V., Pearl TM, Rowlands CJ, Chan V., Boyer LA, So PT, and Kamm RD Science advances, 2016/08/01, Volume 2, Issue 8, p.e1501429, (2016) Read More / View Supplemental Materials
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Neoantigens encoded in the cancer genome.Schumacher, TN, and Hacohen N. Current opinion in immunology, 2016/08/01, Volume 41, p.98-103, (2016) Read More / View Supplemental Materials
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Novel Genetic Variants are Associated With Increased Vertebral Volumetric BMD, Reduced Vertebral Fracture Risk, and Increased Expression of SCL1A3 and EPHB2.Nielson, CM, Liu CT, Smith AV, Ackert-Bicknell CL, Reppe S., Johanna J., Wassel C., Register TC, Oei L., Alonso Lopez N., Oei EH, Parimi N., Samelson EJ, Nalls MA, Zmuda J., Lang T., Bouxsein M., Latourelle J., Claussnitzer M., Siggeirsdottir K., et al. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2016/08/01, (2016) Read More / View Supplemental Materials
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A pleiotropic missense variant in SLC39A8 is associated with Crohn's disease and human gut microbiome composition.Li, D., Achkar JP, Haritunians T., Jacobs JP, Hui KY, D'Amato M., Brand S., Radford-Smith G., Halfvarson J., Niess JH, Kugathasan S., Büning C., Schumm LP, Klei L., Ananthakrishnan A., Aumais G., Baidoo L., Dubinsky M., Fiocchi C., Glas J., et al. Gastroenterology, 2016/08/01, (2016) Read More / View Supplemental Materials
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Revealing disease-associated pathways by network integration of untargeted metabolomics.Pirhaji, L., Milani P., Leidl M., Curran T., Avila-Pacheco J., Clish CB, White FM, Saghatelian A., and Fraenkel E. Nature methods, 2016/08/01, (2016) Read More / View Supplemental Materials
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Trans-pQTL study identifies immune crosstalk between Parkinson and Alzheimer loci.Chan, G., White CC, Winn PA, Cimpean M., Replogle JM, Glick LR, Cuerdon NE, Ryan KJ, Johnson KA, Schneider JA, Bennett DA, Chibnik LB, Sperling RA, De Jager PL, and Bradshaw EM Neurology. Genetics, 2016/08/01, Volume 2, Issue 4, p.e90, (2016) Read More / View Supplemental Materials
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Virtual microfluidics for digital quantification and single-cell sequencing.Xu, L., Brito IL, Alm EJ, and Blainey PC Nature methods, 2016/08/01, (2016) Read More / View Supplemental Materials
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Whole Exome Sequencing Identifies TSC1/TSC2 Biallelic Loss as the Primary and Sufficient Driver Event for Renal Angiomyolipoma Development.Giannikou, K., Malinowska IA, Pugh TJ, Yan R., Tseng YY, Oh C., Kim J., Tyburczy ME, Chekaluk Y., Liu Y., Alesi N., Finlay GA, Wu CL, Signoretti S., Meyerson M., Getz G., Boehm JS, Henske EP, and Kwiatkowski DJ PLoS genetics, 2016/08/01, Volume 12, Issue 8, p.e1006242, (2016) Read More / View Supplemental Materials
Abstract
Accelerating global innovation to address antibacterial resistance: introducing CARB-X.Outterson, K., Rex JH, Jinks T., Jackson P., Hallinan J., Karp S., Hung DT, Franceschi F., Merkeley T., Houchens C., Dixon DM, Kurilla MG, Aurigemma R., and Larsen J. Nature reviews. Drug discovery, 2016/07/29, (2016) Read More / View Supplemental Materials
Abstract
Meta-analysis of the DRD5 VNTR in persistent ADHD.Klein, M., Berger S., Hoogman M., Dammers J., Makkinje R., Heister AJ, Galesloot TE, Kiemeney LA, Weber H., Kittel-Schneider S., Lesch KP, Reif A., Ribasés M., Ramos-Quiroga JA, Cormand B., Zayats T., Hegvik TA, Jacobsen KK, Johansson S., Haavik J., et al. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2016/07/29, (2016) Read More / View Supplemental Materials
Abstract
Synthetic biology and microbioreactor platforms for programmable production of biologics at the point-of-care.Perez-Pinera, P., Han N., Cleto S., Cao J., Purcell O., Shah KA, Lee K., Ram R., and Lu TK Nature communications, 2016/07/29, Volume 7, p.12211, (2016) Read More / View Supplemental Materials
Abstract
Calcium intake and colorectal cancer risk: Results from the Nurses' Health Study and Health Professionals Follow-up Study.Zhang, X., Keum N., Wu K., Smith-Warner SA, Ogino S., Chan AT, Fuchs CS, and Giovannucci EL International journal of cancer, 2016/07/28, (2016) Read More / View Supplemental Materials
Abstract
Div-Seq: Single-nucleus RNA-Seq reveals dynamics of rare adult newborn neurons.Habib, N., Li Y., Heidenreich M., Swiech L., Avraham-Davidi I., Trombetta JJ, Hession C., Zhang F., and Regev A. Science (New York, N.Y.), 2016/07/28, (2016) Read More / View Supplemental Materials
Abstract
High-throughput Phenotyping of Lung Cancer Somatic Mutations.Berger, AH, Brooks AN, Wu X., Shrestha Y., Chouinard C., Piccioni F., Bagul M., Kamburov A., Imielinski M., Hogstrom L., Zhu C., Yang X., Pantel S., Sakai R., Watson J., Kaplan N., Campbell JD, Singh S., Root DE, Narayan R., et al. Cancer cell, 2016/07/28, (2016) Read More / View Supplemental Materials
Abstract
Synthesis of sodium polyhydrides at high pressures.Struzhkin, VV, Kim DY, Stavrou E., Muramatsu T., Mao HK, Pickard CJ, Needs RJ, Prakapenka VB, and Goncharov AF Nature communications, 2016/07/28, Volume 7, p.12267, (2016) Read More / View Supplemental Materials
Abstract
Impaired Autophagy in Macrophages Promotes Inflammatory Eye Disease.Santeford, A., Wiley LA, Park S., Bamba S., Nakamura R., Gdoura A., Ferguson TA, Rao PK, Guan JL, Saitoh T., Akira S., Xavier R., Virgin HW, and Apte RS Autophagy, 2016/07/27, (2016) Read More / View Supplemental Materials
Abstract
Regular Aspirin Use Associates with Lower Risk of Colorectal Cancers With Low Numbers of Tumor-infiltrating Lymphocytes.Cao, Y., Nishihara R., Qian ZR, Song M., Mima K., Inamura K., Nowak JA, Drew DA, Lochhead P., Nosho K., Morikawa T., Zhang X., Wu K., Wang M., Garrett WS, Giovannucci EL, Fuchs CS, Chan AT, and Ogino S. Gastroenterology, 2016/07/27, (2016) Read More / View Supplemental Materials
Abstract
Aptamer-Based Proteomic Profiling Reveals Novel Candidate Biomarkers and Pathways in Cardiovascular Disease.Ngo, D., Sinha S., Shen D., Kuhn EW, Keyes MJ, Shi X., Benson MD, O'Sullivan JF, Keshishian H., Farrell LA, Fifer MA, Vasan RS, Sabatine MS, Larson MG, Carr SA, Wang TJ, and Gerszten RE Circulation, 2016/07/26, Volume 134, Issue 4, p.270-85, (2016) Read More / View Supplemental Materials
Abstract
Biomaterials for Metastasis: Bridging the Gap between Basic and Translational Research.Conde, J., Shomron N., and Artzi N. Advanced healthcare materials, 2016/07/26, (2016) Read More / View Supplemental Materials
Abstract
Functional analysis of rare variants found in schizophrenia implicates a critical role for GIT1-PAK3 signaling in neuroplasticity.Kim, MJ, Biag J., Fass DM, Lewis MC, Zhang Q., Fleishman M., Gangwar SP, Machius M., Fromer M., Purcell SM, McCarroll SA, Rudenko G., Premont RT, Scolnick EM, and Haggarty SJ Molecular psychiatry, 2016/07/26, (2016) Read More / View Supplemental Materials
Abstract
The impact of tumor profiling approaches and genomic data strategies for cancer precision medicine.Garofalo, A., Sholl L., Reardon B., Taylor-Weiner A., Amin-Mansour A., Miao D., Liu D., Oliver N., MacConaill L., Ducar M., Rojas-Rudilla V., Giannakis M., Ghazani A., Gray S., Janne P., Garber J., Joffe S., Lindeman N., Wagle N., Garraway LA, et al. Genome medicine, 2016/07/26, Volume 8, Issue 1, p.79, (2016) Read More / View Supplemental Materials
Abstract
Iterative use of nuclear receptor Nr5a2 regulates multiple stages of liver and pancreas development.Nissim, S., Weeksb O., Talbot JC, Hedgepeth JW, Wucherpfennig J., Schatzman-Bone S., Swinburne I., Cortes M., Alexa K., Megason S., North TE, Amacher SL, and Goessling W. Developmental biology, 2016/07/26, (2016) Read More / View Supplemental Materials
Abstract
Microglia contribute to circuit defects in Mecp2 null mice independent of microglia-specific loss of Mecp2 expression.Schafer, DP, Heller CT, Gunner G., Heller M., Gordon C., Hammond T., Wolf Y., Jung S., and Stevens B. eLife, 2016/07/26, Volume 5, (2016) Read More / View Supplemental Materials
Abstract
An exome array study of the plasma metabolome.Rhee, EP, Yang Q., Yu B., Liu X., Cheng S., Deik A., Pierce KA, Bullock K., Ho JE, Levy D., Florez JC, Kathiresan S., Larson MG, Vasan RS, Clish CB, Wang TJ, Boerwinkle E., O'Donnell CJ, and Gerszten RE Nature communications, 2016/07/25, Volume 7, p.12360, (2016) Read More / View Supplemental Materials
Abstract
Genetic risk of extranodal natural killer T-cell lymphoma: a genome-wide association study.Li, Z., Xia Y., Feng LN, Chen JR, Li HM, Cui J., Cai QQ, Sim KS, Nairismägi ML, Laurensia Y., Meah WY, Liu WS, Guo YM, Chen LZ, Feng QS, Pang CP, Chen LJ, Chew SH, Ebstein RP, Foo JN, et al. The Lancet. Oncology, 2016/07/25, (2016) Read More / View Supplemental Materials
Abstract
Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis.van Rheenen, W., Shatunov A., Dekker AM, McLaughlin RL, Diekstra FP, Pulit SL, van der Spek RA, Võsa U., de Jong S., Robinson MR, Yang J., Fogh I., van Doormaal PT, Tazelaar GH, Koppers M., Blokhuis AM, Sproviero W., Jones AR, Kenna KP, van Eijk KR, et al. Nature genetics, 2016/07/25, (2016) Read More / View Supplemental Materials
Abstract
Genomic insights into the origin of farming in the ancient Near East.Lazaridis, I., Nadel D., Rollefson G., Merrett DC, Rohland N., Mallick S., Fernandes D., Novak M., Gamarra B., Sirak K., Connell S., Stewardson K., Harney E., Fu Q., Gonzalez-Fortes G., Jones ER, Roodenberg SA, Lengyel G., Bocquentin F., Gasparian B., et al. Nature, 2016/07/25, (2016) Read More / View Supplemental Materials
Abstract
The importance of serine metabolism in cancer.Mattaini, KR, Sullivan MR, and Vander Heiden MG The Journal of cell biology, 2016/07/25, (2016) Read More / View Supplemental Materials
Abstract
Local triple-combination therapy results in tumour regression and prevents recurrence in a colon cancer model.Conde, J., Oliva N., Zhang Y., and Artzi N. Nature materials, 2016/07/25, (2016) Read More / View Supplemental Materials
Abstract
Microglia: Phagocytosing to Clear, Sculpt, and Eliminate.Hong, S., and Stevens B. Developmental cell, 2016/07/25, Volume 38, Issue 2, p.126-8, (2016) Read More / View Supplemental Materials
Abstract
Multiplexed and scalable super-resolution imaging of three-dimensional protein localization in size-adjustable tissues.Ku, T., Swaney J., Park JY, Albanese A., Murray E., Cho JH, Park YG, Mangena V., Chen J., and Chung K. Nature biotechnology, 2016/07/25, (2016) Read More / View Supplemental Materials
Abstract
Relations of Arterial Stiffness and Brachial Flow-Mediated Dilation With New-Onset Atrial Fibrillation: The Framingham Heart Study.Shaikh, AY, Wang N., Yin X., Larson MG, Vasan RS, Hamburg NM, Magnani JW, Ellinor PT, Lubitz SA, Mitchell GF, Benjamin EJ, and McManus DD Hypertension, 2016/07/25, (2016) Read More / View Supplemental Materials
Abstract
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