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Submitted
Synthesis, cellular evaluation and mechanism-of-action of piperlongumine analogsAdams, DJ, Dai M., Pellegrino G., Wagner BK, Stern AM, Shamji AF, and Schreiber SL, (Submitted) Read More / View Supplemental Materials
2015
Gender Disparity and Mutation Burden in Metastatic Melanoma.Gupta, S., Artomov M., Goggins W., Daly M., and Tsao H. Journal of the National Cancer Institute, 2015/11/01, Volume 107, Issue 11, (2015) Read More / View Supplemental Materials
Abstract
Epidemiologic Investigation of a Cluster of Neuroinvasive Bacillus cereus Infections in 5 Patients With Acute Myelogenous Leukemia.Rhee, C., Klompas M., Tamburini FB, Fremin BJ, Chea N., Epstein L., Halpin AL, Guh A., Gallen R., Coulliette A., Gee J., Hsieh C., Desjardins CA, Pedamullu CS, DeAngelo DJ, Manzo VE, Folkerth RD, Milner DA Jr, Pecora N., Osborne M., et al. Open forum infectious diseases, 2015/09/01, Volume 2, Issue 3, p.ofv096, (2015) Read More / View Supplemental Materials
Abstract
The molecular era of the mitochondrial calcium uniporter.Kamer, KJ, and Mootha VK Nature reviews. Molecular cell biology, 2015/09/01, Volume 16, Issue 9, p.545-53, (2015) Read More / View Supplemental Materials
Abstract
Fusobacterium nucleatum in colorectal carcinoma tissue and patient prognosis.Mima, K., Nishihara R., Qian ZR, Cao Y., Sukawa Y., Nowak JA, Yang J., Dou R., Masugi Y., Song M., Kostic AD, Giannakis M., Bullman S., Milner DA, Baba H., Giovannucci EL, Garraway LA, Freeman GJ, Dranoff G., Garrett WS, et al. Gut, 2015/08/26, (2015) Read More / View Supplemental Materials
Abstract
Comparative genomics of Fusarium oxysporum f. sp. melonis reveals the secreted protein recognized by the Fom-2 resistance gene in melon.Schmidt, SM, Lukasiewicz J., Farrer R., van Dam P., Bertoldo C., and Rep M. The New phytologist, 2015/08/25, (2015) Read More / View Supplemental Materials
Abstract
Genetic association analyses highlight biological pathways underlying mitral valve prolapse.Dina, C., Bouatia-Naji N., Tucker N., Delling FN, Toomer K., Durst R., Perrocheau M., Fernandez-Friera L., Solis J., investigators PROMESA, Le Tourneau T., Chen MH, Probst V., Bosse Y., Pibarot P., Zelenika D., Lathrop M., Hercberg S., Roussel R., Benjamin EJ, et al. Nature genetics, 2015/08/24, (2015) Read More / View Supplemental Materials
Abstract
In situ single-cell analysis identifies heterogeneity for PIK3CA mutation and HER2 amplification in HER2-positive breast cancer.Janiszewska, M., Liu L., Almendro V., Kuang Y., Paweletz C., Sakr RA, Weigelt B., Hanker AB, Chandarlapaty S., King TA, Reis-Filho JS, Arteaga CL, Park SY, Michor F., and Polyak K. Nature genetics, 2015/08/24, (2015) Read More / View Supplemental Materials
Abstract
A direct fate exclusion mechanism by Sonic hedgehog-regulated transcriptional repressors.Nishi, Y., Zhang X., Jeong J., Peterson KA, Vedenko A., Bulyk ML, Hide WA, and McMahon AP Development (Cambridge, England), 2015/08/20, (2015) Read More / View Supplemental Materials
Abstract
Mutations in PIGY: expanding the phenotype of inherited glycosylphosphatidylinositol (GPI) deficiencies.Ilkovski, B., Pagnamenta AT, O'Grady GL, Kinoshita T., Howard MF, Lek M., Thomas B., Turner A., Christodoulou J., Sillence D., Knight SJ, Popitsch N., Keays DA, Anzilotti C., Goriely A., Waddell LB, Brilot F., North KN, Kanzawa N., Macarthur DG, et al. Human molecular genetics, 2015/08/20, (2015) Read More / View Supplemental Materials
Abstract
Disruption of the Rag-Ragulator Complex by c17orf59 Inhibits mTORC1.Schweitzer, LD, Comb WC, Bar-Peled L., and Sabatini DM Cell reports, 2015/08/19, (2015) Read More / View Supplemental Materials
Abstract
FTO Obesity Variant Circuitry and Adipocyte Browning in Humans.Claussnitzer, M., Dankel SN, Kim KH, Quon G., Meuleman W., Haugen C., Glunk V., Sousa IS, Beaudry JL, Puviindran V., Abdennur NA, Liu J., Svensson PA, Hsu YH, Drucker DJ, Mellgren G., Hui CC, Hauner H., and Kellis M. The New England journal of medicine, 2015/08/19, (2015) Read More / View Supplemental Materials
Abstract
PRC2 Is Required to Maintain Expression of the Maternal Gtl2-Rian-Mirg Locus by Preventing De Novo DNA Methylation in Mouse Embryonic Stem Cells.Das, PP, Hendrix DA, Apostolou E., Buchner AH, Canver MC, Beyaz S., Ljuboja D., Kuintzle R., Kim W., Karnik R., Shao Z., Xie H., Xu J., De Los Angeles A., Zhang Y., Choe J., Jun DL, Shen X., Gregory RI, Daley GQ, et al. Cell reports, 2015/08/19, (2015) Read More / View Supplemental Materials
Abstract
Association studies of genomic variants with treatment response to risperidone, clozapine, quetiapine and chlorpromazine in the Chinese Han population.Xu, Q., Wu X., Li M., Huang H., Minica C., Yi Z., Wang G., Shen L., Xing Q., Shi Y., He L., and Qin S. The pharmacogenomics journal, 2015/08/18, (2015) Read More / View Supplemental Materials
Abstract
Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations.Hayes, MG, Urbanek M., Ehrmann DA, Armstrong LL, Lee JY, Sisk R., Karaderi T., Barber TM, McCarthy MI, Franks S., Lindgren CM, Welt CK, Diamanti-Kandarakis E., Panidis D., Goodarzi MO, Azziz R., Zhang Y., James RG, Olivier M., Kissebah AH, et al. Nature communications, 2015/08/18, Volume 6, p.7502, (2015) Read More / View Supplemental Materials
Abstract
New data and an old puzzle: the negative association between schizophrenia and rheumatoid arthritis.Lee, SH, Byrne EM, Hultman CM, Kähler A., Vinkhuyzen AA, Ripke S., Andreassen OA, Frisell T., Gusev A., Hu X., Karlsson R., Mantzioris VX, McGrath JJ, Mehta D., Stahl EA, Zhao Q., Kendler KS, Sullivan PF, Price AL, O'Donovan M., et al. International journal of epidemiology, 2015/08/18, (2015) Read More / View Supplemental Materials
Abstract
Systematic chromatin state comparison of epigenomes associated with diverse properties including sex and tissue type.Yen, A., and Kellis M. Nature communications, 2015/08/18, Volume 6, p.7973, (2015) Read More / View Supplemental Materials
Abstract
Clinical Effects of Phosphodiesterase 3A Mutations in Inherited Hypertension With Brachydactyly.Toka, O., Tank J., Schächterle C., Aydin A., Maass PG, Elitok S., Bartels-Klein E., Hollfinger I., Lindschau C., Mai K., Boschmann M., Rahn G., Movsesian MA, Müller T., Doescher A., Gnoth S., Mühl A., Toka HR, Wefeld-Neuenfeld Y., Utz W., et al. Hypertension, 2015/08/17, (2015) Read More / View Supplemental Materials
Abstract
Structure and mechanism of activity-based inhibition of the EGF receptor by Mig6.Park, E., Kim N., Ficarro SB, Zhang Y., Lee BI, Cho A., Kim K., Park AK, Park WY, Murray B., Meyerson M., Beroukhim R., Marto JA, Cho J., and Eck MJ Nature structural & molecular biology, 2015/08/17, (2015) Read More / View Supplemental Materials
Abstract
Doxycycline: new tricks for an old drug.Barbie, DA, and Kennedy BK Oncotarget, 2015/08/14, Volume 6, Issue 23, p.19336-7, (2015) Read More / View Supplemental Materials
Clinical Sequencing Uncovers Origins and Evolution of Lassa Virus.Andersen, KG, Shapiro BJ, Matranga CB, Sealfon R., Lin AE, Moses LM, Folarin OA, Goba A., Odia I., Ehiane PE, Momoh M., England EM, Winnicki S., Branco LM, Gire SK, Phelan E., Tariyal R., Tewhey R., Omoniwa O., Fullah M., et al. Cell, 2015/08/13, Volume 162, Issue 4, p.738-50, (2015) Read More / View Supplemental Materials
Abstract
Individual intestinal symbionts induce a distinct population of RORγ+ regulatory T cells.Sefik, E., Geva-Zatorsky N., Oh S., Konnikova L., Zemmour D., McGuire AM, Burzyn D., Ortiz-Lopez A., Lobera M., Yang J., Ghosh S., Earl A., Snapper SB, Jupp R., Kasper D., Mathis D., and Benoist C. Science (New York, N.Y.), 2015/08/13, (2015) Read More / View Supplemental Materials
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Korean Atrial Fibrillation (AF) Network: Genetic Variants for AF Do Not Predict Ablation Success.Choi, EK, Park JH, Lee JY, Nam CM, Hwang MK, Uhm JS, Joung B., Ko YG, Lee MH, Lubitz SA, Ellinor PT, and Pak HN Journal of the American Heart Association, 2015/08/13, Volume 4, Issue 8, (2015) Read More / View Supplemental Materials
Abstract
GWAS of longitudinal amyloid accumulation on 18F-florbetapir PET in Alzheimer's disease implicates microglial activation gene IL1RAP.Ramanan, VK, Risacher SL, Nho K., Kim S., Shen L., McDonald BC, Yoder KK, Hutchins GD, West JD, Tallman EF, Gao S., Foroud TM, Farlow MR, De Jager PL, Bennett DA, Aisen PS, Petersen RC, Jack CR Jr, Toga AW, Green RC, et al. Brain : a journal of neurology, 2015/08/11, (2015) Read More / View Supplemental Materials
Abstract
Heavier smoking may lead to a relative increase in waist circumference: evidence for a causal relationship from a Mendelian randomisation meta-analysis. The CARTA consortium.Morris, RW, Taylor AE, Fluharty ME, Bjørngaard JH, Åsvold BO, Elvestad Gabrielsen M., Campbell A., Marioni R., Kumari M., Korhonen T., Männistö S., Marques-Vidal P., Kaakinen M., Cavadino A., Postmus I., Husemoen LL, Skaaby T., Ahluwalia TV, Treur JL, Willemsen G., et al. BMJ open, 2015/08/11, Volume 5, Issue 8, p.e008808, (2015) Read More / View Supplemental Materials
Abstract
Adaptive evolution of malaria parasites in French Guiana: Reversal of chloroquine resistance by acquisition of a mutation in pfcrt.Pelleau, S., Moss EL, Dhingra SK, Volney B., Casteras J., Gabryszewski SJ, Volkman SK, Wirth DF, Legrand E., Fidock DA, Neafsey DE, and Musset L. Proceedings of the National Academy of Sciences of the United States of America, 2015/08/10, (2015) Read More / View Supplemental Materials
Abstract
An APOBEC3A hypermutation signature is distinguishable from the signature of background mutagenesis by APOBEC3B in human cancers.Chan, K., Roberts SA, Klimczak LJ, Sterling JF, Saini N., Malc EP, Kim J., Kwiatkowski DJ, Fargo DC, Mieczkowski PA, Getz G., and Gordenin DA Nature genetics, 2015/08/10, (2015) Read More / View Supplemental Materials
Abstract
Malaria Molecular Epidemiology: Lessons from the International Centers of Excellence for Malaria Research Network.Escalante, AA, Ferreira MU, Vinetz JM, Volkman SK, Cui L., Gamboa D., Krogstad DJ, Barry AE, Carlton JM, van Eijk AM, Pradhan K., Mueller I., Greenhouse B., Pacheco MA, Vallejo AF, Herrera S., and Felger I. The American journal of tropical medicine and hygiene, 2015/08/10, (2015) Read More / View Supplemental Materials
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Population Genetics, Evolutionary Genomics, and Genome-Wide Studies of Malaria: A View Across the International Centers of Excellence for Malaria Research.Carlton, JM, Volkman SK, Uplekar S., Hupalo DN, Pereira Alves JM, Cui L., Donnelly M., Roos DS, Harb OS, Acosta M., Read A., Ribolla PE, Singh OP, Valecha N., Wassmer SC, Ferreira M., and Escalante AA The American journal of tropical medicine and hygiene, 2015/08/10, (2015) Read More / View Supplemental Materials
Abstract
Widespread non-additive and interaction effects within HLA loci modulate the risk of autoimmune diseases.Lenz, TL, Deutsch AJ, Han B., Hu X., Okada Y., Eyre S., Knapp M., Zhernakova A., Huizinga TW, Abecasis G., Becker J., Boeckxstaens GE, Chen WM, Franke A., Gladman DD, Gockel I., Gutierrez-Achury J., Martin J., Nair RP, Nöthen MM, et al. Nature genetics, 2015/08/10, (2015) Read More / View Supplemental Materials
Abstract
Genetic predisposition to weight loss & regain with lifestyle intervention: analyses from the Diabetes Prevention Program & the Look AHEAD randomized controlled trials.Papandonatos, GD, Pan Q., Pajewski NM, Delahanty LM, Peter I., Erar B., Ahmad S., Harden M., Chen L., Fontanillas P., GIANT Consortium, Wagenknecht LE, Kahn SE, Wing RR, Jablonski KA, Huggins GS, Knowler WC, Florez JC, McCaffery JM, Franks PW, et al. Diabetes, 2015/08/07, (2015) Read More / View Supplemental Materials
Abstract
A Dominant Mutation in Human RAD51 Reveals Its Function in DNA Interstrand Crosslink Repair Independent of Homologous Recombination.Wang, AT, Kim T., Wagner JE, Conti BA, Lach FP, Huang AL, Molina H., Sanborn EM, Zierhut H., Cornes BK, Abhyankar A., Sougnez C., Gabriel SB, Auerbach AD, Kowalczykowski SC, and Smogorzewska A. Molecular cell, 2015/08/06, Volume 59, Issue 3, p.478-90, (2015) Read More / View Supplemental Materials
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Global diversity, population stratification, and selection of human copy number variation.Sudmant, PH, Mallick S., Nelson BJ, Hormozdiari F., Krumm N., Huddleston J., Coe BP, Baker C., Nordenfelt S., Bamshad M., Jorde LB, Posukh OL, Sahakyan H., Watkins WS, Yepiskoposyan L., Abdullah MS, Bravi CM, Capelli C., Hervig T., Wee JT, et al. Science (New York, N.Y.), 2015/08/06, (2015) Read More / View Supplemental Materials
Abstract
Rheumatoid factor is associated with the distribution of hand joint destruction in rheumatoid arthritis.Terao, C., Yamakawa N., Yano K., Markusse IM, Ikari K., Yoshida S., Furu M., Hashimoto M., Ito H., Fujii T., Ohmura K., Murakami K., Takahashi M., Hamaguchi M., Tabara Y., Taniguchi A., Momohara S., Raychaudhuri S., Allaart CF, Yamanaka H., et al. Arthritis & rheumatology (Hoboken, N.J.), 2015/08/05, (2015) Read More / View Supplemental Materials
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Dynamics of Tumor Heterogeneity Derived from Clonal Karyotypic Evolution.Laughney, AM, Elizalde S., Genovese G., and Bakhoum SF Cell reports, 2015/08/04, Volume 12, Issue 5, p.809-820, (2015) Read More / View Supplemental Materials
Abstract
Hypoxia-Mediated Increases in l-2-hydroxyglutarate Coordinate the Metabolic Response to Reductive Stress.Oldham, WM, Clish CB, Yang Y., and Loscalzo J. Cell metabolism, 2015/08/04, Volume 22, Issue 2, p.291-303, (2015) Read More / View Supplemental Materials
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Organization of the Mammalian Metabolome according to Organ Function, Lineage Specialization, and Longevity.Ma, S., Yim SH, Lee SG, Kim EB, Lee SR, Chang KT, Buffenstein R., Lewis KN, Park TJ, Miller RA, Clish CB, and Gladyshev VN Cell metabolism, 2015/08/04, Volume 22, Issue 2, p.332-43, (2015) Read More / View Supplemental Materials
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Preserved DNA Damage Checkpoint Pathway Protects against Complications in Long-Standing Type 1 Diabetes.Bhatt, S., Gupta MK, Khamaisi M., Martinez R., Gritsenko MA, Wagner BK, Guye P., Busskamp V., Shirakawa J., Wu G., Liew CW, Clauss TR, Valdez I., El Ouaamari A., Dirice E., Takatani T., Keenan HA, Smith RD, Church G., Weiss R., et al. Cell metabolism, 2015/08/04, Volume 22, Issue 2, p.239-52, (2015) Read More / View Supplemental Materials
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Rare coding variants and X-linked loci associated with age at menarche.Lunetta, KL, Day FR, Sulem P., Ruth KS, Tung JY, Hinds DA, Esko T., Elks CE, Altmaier E., He C., Huffman JE, Mihailov E., Porcu E., Robino A., Rose LM, Schick UM, Stolk L., Teumer A., Thompson DJ, Traglia M., et al. Nature communications, 2015/08/04, Volume 6, p.7756, (2015) Read More / View Supplemental Materials
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Rare variants in the notch signaling pathway describe a novel type of autosomal recessive Klippel-Feil syndrome.Karaca, E., Yuregir OO, Bozdogan ST, Aslan H., Pehlivan D., Jhangiani SN, Akdemir ZC, Gambin T., Bayram Y., Atik MM, Erdin S., Muzny D., Gibbs RA, Lupski JR, and Baylor-Hopkins Center for Mendelian Genomics American journal of medical genetics. Part A, 2015/08/04, (2015) Read More / View Supplemental Materials
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Automated, high-throughput derivation, characterization and differentiation of induced pluripotent stem cells.Paull, D., Sevilla A., Zhou H., Hahn AK, Im HK, Napolitano C., Tsankov A., Shang L., Krumholz K., Jagadeesan P., Woodard CM, Sun B., Vilboux T., Zimmer M., Forero E., Moroziewicz DN, Martinez H., Malicdan MC, Weiss KA, Vensand LB, et al. Nature methods, 2015/08/03, (2015) Read More / View Supplemental Materials
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Improved canine exome designs, featuring ncRNAs and increased coverage of protein coding genes.Broeckx, BJ, Hitte C., Coopman F., Verhoeven GE, De Keulenaer S., De Meester E., Derrien T., Alfoldi J., Lindblad-Toh K., Bosmans T., Gielen I., Van Bree H., Van Ryssen B., Saunders JH, Van Nieuwerburgh F., and Deforce D. Scientific reports, 2015/08/03, Volume 5, p.12810, (2015) Read More / View Supplemental Materials
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ERBB2 Emerges as a New Target for Colorectal Cancer.Pectasides, E., and Bass AJ Cancer discovery, 2015/08/01, Volume 5, Issue 8, p.799-801, (2015) Read More / View Supplemental Materials
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CELL DEATH. Control of signaling-mediated clearance of apoptotic cells by the tumor suppressor p53.Yoon, KW, Byun S., Kwon E., Hwang SY, Chu K., Hiraki M., Jo SH, Weins A., Hakroush S., Cebulla A., Sykes DB, Greka A., Mundel P., Fisher DE, Mandinova A., and Lee SW Science (New York, N.Y.), 2015/07/31, Volume 349, Issue 6247, p.1261669, (2015) Read More / View Supplemental Materials
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Exploring the 3-piperidin-4-yl-1H-indole scaffold as a novel antimalarial chemotype.Santos, SA, Lukens AK, Coelho L., Nogueira F., Wirth DF, Mazitschek R., Moreira R., and Paulo A. European journal of medicinal chemistry, 2015/07/31, Volume 102, p.320-333, (2015) Read More / View Supplemental Materials
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METABOLISM. S-Nitrosylation links obesity-associated inflammation to endoplasmic reticulum dysfunction.Yang, L., Calay ES, Fan J., Arduini A., Kunz RC, Gygi SP, Yalcin A., Fu S., and Hotamisligil GS Science (New York, N.Y.), 2015/07/31, Volume 349, Issue 6247, p.500-6, (2015) Read More / View Supplemental Materials
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An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis.Birsoy, K., Wang T., Chen WW, Freinkman E., Abu-Remaileh M., and Sabatini DM Cell, 2015/07/30, Volume 162, Issue 3, p.540-51, (2015) Read More / View Supplemental Materials
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A Genome-wide CRISPR Screen in Primary Immune Cells to Dissect Regulatory Networks.Parnas, O., Jovanovic M., Eisenhaure TM, Herbst RH, Dixit A., Ye CJ, Przybylski D., Platt RJ, Tirosh I., Sanjana NE, Shalem O., Satija R., Raychowdhury R., Mertins P., Carr SA, Zhang F., Hacohen N., and Regev A. Cell, 2015/07/30, Volume 162, Issue 3, p.675-86, (2015) Read More / View Supplemental Materials
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Growth dynamics of gut microbiota in health and disease inferred from single metagenomic samples.Korem, T., Zeevi D., Suez J., Weinberger A., Avnit-Sagi T., Pompan-Lotan M., Matot E., Jona G., Harmelin A., Cohen N., Sirota-Madi A., Thaiss CA, Pevsner-Fischer M., Sorek R., Xavier R., Elinav E., and Segal E. Science (New York, N.Y.), 2015/07/30, (2015) Read More / View Supplemental Materials
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Ground State Conditions Induce Rapid Reorganization of Core Pluripotency Factor Binding before Global Epigenetic Reprogramming.Galonska, C., Ziller MJ, Karnik R., and Meissner A. Cell stem cell, 2015/07/29, (2015) Read More / View Supplemental Materials
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The Stress-Induced Atf3-Gelsolin Cascade Underlies Dendritic Spine Deficits in Neuronal Models of Tuberous Sclerosis Complex.Nie, D., Chen Z., Ebrahimi-Fakhari D., Di Nardo A., Julich K., Robson VK, Cheng YC, Woolf CJ, Heiman M., and Sahin M. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015/07/29, Volume 35, Issue 30, p.10762-72, (2015) Read More / View Supplemental Materials
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A targeted functional RNAi screen uncovers Glypican 5 as an entry factor for hepatitis B and D viruses.Verrier, ER, Colpitts CC, Bach C., Heydmann L., Weiss A., Renaud M., Durand SC, Habersetzer F., Durantel D., Abou-Jaoudé G., López Ledesma MM, Felmlee DJ, Soumillon M., Croonenborghs T., Pochet N., Nassal M., Schuster C., Brino L., Sureau C., Zeisel MB, et al. Hepatology (Baltimore, Md.), 2015/07/29, (2015) Read More / View Supplemental Materials
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FermiKit: assembly-based variant calling for Illumina resequencing data.Li, H. Bioinformatics (Oxford, England), 2015/07/27, (2015) Read More / View Supplemental Materials
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CXCR3 Polymorphism and Expression Associate with Spontaneous Preterm Birth.Karjalainen, MK, Ojaniemi M., Haapalainen AM, Mahlman M., Salminen A., Huusko JM, Määttä TA, Kaukola T., Anttonen J., Ulvila J., Haataja R., Teramo K., Kingsmore SF, Palotie A., Muglia LJ, Rämet M., and Hallman M. Journal of immunology (Baltimore, Md. : 1950), 2015/07/24, (2015) Read More / View Supplemental Materials
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Multiple cell and population-level interactions with mouse embryonic stem cell heterogeneity.Cannon, D., Corrigan AM, Miermont A., McDonel P., and Chubb JR Development (Cambridge, England), 2015/07/24, (2015) Read More / View Supplemental Materials
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Genotype-specific variation in West Nile virus dispersal in California.Duggal, NK, Reisen WK, Fang Y., Newman RM, Yang X., Ebel GD, and Brault AC Virology, 2015/07/23, Volume 485, p.79-85, (2015) Read More / View Supplemental Materials
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Protein Crowding Is a Determinant of Lipid Droplet Protein Composition.Kory, N., Thiam AR, Farese RV Jr, and Walther TC Developmental cell, 2015/07/22, (2015) Read More / View Supplemental Materials
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Steroid sex hormones, sex hormone binding globulin and diabetes incidence in the Diabetes Prevention Program.Mather, KM, Kim C., Christophi CA, Aroda VR, Knowler WC, Edelstein SE, Florez JC, Labrie F., Kahn SE, Goldberg RB, Barrett-Connor E., and Diabetes Prevention Program Research Group The Journal of clinical endocrinology and metabolism, 2015/07/22, p.jc20152328, (2015) Read More / View Supplemental Materials
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Analysis of exome sequence in 604 trios for recessive genotypes in schizophrenia.Rees, E., Kirov G., Walters JT, Richards AL, Howrigan D., Kavanagh DH, Pocklington AJ, Fromer M., Ruderfer DM, Georgieva L., Carrera N., Gormley P., Palta P., Williams H., Dwyer S., Johnson JS, Roussos P., Barker DD, Banks E., Milanova V., et al. Translational psychiatry, 2015/07/21, Volume 5, p.e607, (2015) Read More / View Supplemental Materials
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Functional genomics identifies negative regulatory nodes controlling phagocyte oxidative burst.Graham, DB, Becker CE, Doan A., Goel G., Villablanca EJ, Knights D., Mok A., Ng AC, Doench JG, Root DE, Clish CB, and Xavier RJ Nature communications, 2015/07/21, Volume 6, p.7838, (2015) Read More / View Supplemental Materials
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Genetic evidence for two founding populations of the Americas.Skoglund, P., Mallick S., Bortolini MC, Chennagiri N., Hünemeier T., Petzl-Erler ML, Salzano FM, Patterson N., and Reich D. Nature, 2015/07/21, (2015) Read More / View Supplemental Materials
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The promise and peril of chemical probes.Arrowsmith, CH, Audia JE, Austin C., Baell J., Bennett J., Blagg J., Bountra C., Brennan PE, Brown PJ, Bunnage ME, Buser-Doepner C., Campbell RM, Carter AJ, Cohen P., Copeland RA, Cravatt B., Dahlin JL, Dhanak D., Edwards AM, Frye SV, et al. Nature chemical biology, 2015/07/21, Volume 11, Issue 8, p.536-41, (2015) Read More / View Supplemental Materials
A genetic basis of variation in eccrine sweat gland and hair follicle density.Kamberov, YG, Karlsson EK, Kamberova GL, Lieberman DE, Sabeti PC, Morgan BA, and Tabin CJ Proceedings of the National Academy of Sciences of the United States of America, 2015/07/20, (2015) Read More / View Supplemental Materials
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Paired exome analysis of Barrett's esophagus and adenocarcinoma.Stachler, MD, Taylor-Weiner A., Peng S., McKenna A., Loda M., Stewart C., Stojanov P., Seepo S., Lawrence MS, Lin J., Chang AC, Gabriel SB, Lander E. S., Beer DG, Getz G., Carter SL, and Bass AJ Nature genetics, 2015/07/20, (2015) Read More / View Supplemental Materials
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Small-molecule enhancers of autophagy modulate cellular disease phenotypes suggested by human genetics.Kuo, SY, Castoreno AB, Aldrich LN, Lassen KG, Goel G., Dančík V., Kuballa P., Latorre I., Conway KL, Sarkar S., Maetzel D., Jaenisch R., Clemons PA, Schreiber SL, Shamji AF, and Xavier RJ Proceedings of the National Academy of Sciences of the United States of America, 2015/07/20, (2015) Read More / View Supplemental Materials
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GenomeConnect: Matchmaking Between Patients, Clinical Laboratories and Researchers to Improve Genomic Knowledge.Kirkpatrick, BE, Riggs ER, Azzariti DR, Miller VR, Ledbetter DH, Miller DT, Rehm H., Martin CL, Faucett WA, and ClinGen Resource Human mutation, 2015/07/16, (2015) Read More / View Supplemental Materials
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Integrative Analyses of Human Reprogramming Reveal Dynamic Nature of Induced Pluripotency.Cacchiarelli, D., Trapnell C., Ziller MJ, Soumillon M., Cesana M., Karnik R., Donaghey J., Smith ZD, Ratanasirintrawoot S., Zhang X., Ho Sui SJ, Wu Z., Akopian V., Gifford CA, Doench J., Rinn JL, Daley GQ, Meissner A., Lander E. S., and Mikkelsen TS Cell, 2015/07/16, Volume 162, Issue 2, p.412-24, (2015) Read More / View Supplemental Materials
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Revisited HLA and non-HLA genetics of Takayasu arteritis-where are we?Terao, C. Journal of human genetics, 2015/07/16, (2015) Read More / View Supplemental Materials
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Body Mass Index, Genetic Susceptibility, and Risk of Complications Among Individuals with Crohn's Disease.Pringle, PL, Stewart KO, Peloquin JM, Sturgeon HC, Nguyen D., Sauk J., Garber JJ, Yajnik V., Ananthakrishnan AN, Chan AT, Xavier RJ, and Khalili H. Inflammatory bowel diseases, 2015/07/15, (2015) Read More / View Supplemental Materials
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Chromerid genomes reveal the evolutionary path from photosynthetic algae to obligate intracellular parasites.Woo, YH, Ansari H., Otto TD, Klinger CM, Kolisko M., Michálek J., Saxena A., Shanmugam D., Tayyrov A., Veluchamy A., Ali S., Bernal A., Del Campo J., Cihlář J., Flegontov P., Gornik SG, Hajdušková E., Horák A., Janouškovec J., Katris NJ, et al. eLife, 2015/07/15, Volume 4, (2015) Read More / View Supplemental Materials
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Extending the phenotypic spectrum of RBFOX1 deletions: Sporadic focal epilepsy.Lal, D., Pernhorst K., Klein KM, Reif P., Tozzi R., Toliat MR, Winterer G., Neubauer B., Nürnberg P., Rosenow F., Becker F., Lerche H., Kunz WS, Kurki MI, Hoffmann P., Becker AJ, Perucca E., Zara F., Sander T., and Weber YG Epilepsia, 2015/07/15, (2015) Read More / View Supplemental Materials
Abstract
CCL2 Promotes Colorectal Carcinogenesis by Enhancing Polymorphonuclear Myeloid-Derived Suppressor Cell Population and Function.Chun, E., Lavoie S., Michaud M., Gallini CA, Kim J., Soucy G., Odze R., Glickman JN, and Garrett WS Cell reports, 2015/07/14, Volume 12, Issue 2, p.244-257, (2015) Read More / View Supplemental Materials
Abstract
Near universal detection of alterations in CTNNB1 and Wnt pathway regulators in desmoid-type fibromatosis by whole-exome sequencing and genomic analysis.Crago, AM, Chmielecki J., Rosenberg M., O'Connor R., Byrne C., Wilder FG, Thorn K., Agius P., Kuk D., Socci ND, Qin LX, Meyerson M., Hameed M., and Singer S. Genes, chromosomes & cancer, 2015/07/14, (2015) Read More / View Supplemental Materials
Abstract
Responding to the challenge of untreatable gonorrhea: ETX0914, a first-in-class agent with a distinct mechanism-of-action against bacterial Type II topoisomerases.Basarab, GS, Kern GH, McNulty J., Mueller JP, Lawrence K., Vishwanathan K., Alm RA, Barvian K., Doig P., Galullo V., Gardner H., Gowravaram M., Huband M., Kimzey A., Morningstar M., Kutschke A., Lahiri SD, Perros M., Singh R., Schuck VJ, et al. Scientific reports, 2015/07/14, Volume 5, p.11827, (2015) Read More / View Supplemental Materials
Abstract
Activity of the Type II JAK2 Inhibitor CHZ868 in B Cell Acute Lymphoblastic Leukemia.Wu, SC, Li LS, Kopp N., Montero J., Chapuy B., Yoda A., Christie AL, Liu H., Christodoulou A., van Bodegom D., van der Zwet J., Layer JV, Tivey T., Lane AA, Ryan JA, Ng SY, DeAngelo DJ, Stone RM, Steensma D., Wadleigh M., et al. Cancer cell, 2015/07/13, Volume 28, Issue 1, p.29-41, (2015) Read More / View Supplemental Materials
Abstract
Additive and interaction effects at three amino acid positions in HLA-DQ and HLA-DR molecules drive type 1 diabetes risk.Hu, X., Deutsch AJ, Lenz TL, Onengut-Gumuscu S., Han B., Chen WM, Howson JM, Todd JA, de Bakker PI, Rich SS, and Raychaudhuri S. Nature genetics, 2015/07/13, (2015) Read More / View Supplemental Materials
Abstract
Role of Autophagy in the Maintenance of Intestinal Homeostasis.Baxt, LA, and Xavier RJ Gastroenterology, 2015/07/10, (2015) Read More / View Supplemental Materials
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Association of Polymerase e-Mutated and Microsatellite-Instable Endometrial Cancers With Neoantigen Load, Number of Tumor-Infiltrating Lymphocytes, and Expression of PD-1 and PD-L1.Howitt, BE, Shukla SA, Sholl LM, Ritterhouse LL, Watkins JC, Rodig S., Stover E., Strickland KC, D'Andrea AD, Wu CJ, Matulonis UA, and Konstantinopoulos PA JAMA oncology, 2015/07/09, (2015) Read More / View Supplemental Materials
Abstract
Data analysis: Create a cloud commons.Stein, LD, Knoppers BM, Campbell P., Getz G., and Korbel JO Nature, 2015/07/09, Volume 523, Issue 7559, p.149-51, (2015) Read More / View Supplemental Materials
Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS.Krönke, J., Fink EC, Hollenbach PW, MacBeth KJ, Hurst SN, Udeshi ND, Chamberlain PP, Mani D. R., Man HW, Gandhi AK, Svinkina T., Schneider RK, McConkey M., Järås M., Griffiths E., Wetzler M., Bullinger L., Cathers BE, Carr SA, Chopra R., et al. Nature, 2015/07/09, Volume 523, Issue 7559, p.183-8, (2015) Read More / View Supplemental Materials
Abstract
Cross-sectional examination of metabolites and metabolic phenotypes in uremia.Kalim, S., Clish CB, Deferio JJ, Ortiz G., Moffet AS, Gerszten RE, Thadhani R., and Rhee EP BMC nephrology, 2015/07/07, Volume 16, p.98, (2015) Read More / View Supplemental Materials
Abstract
Deficiency of UBE2T, the E2 Ubiquitin Ligase Necessary for FANCD2 and FANCI Ubiquitination, Causes FA-T Subtype of Fanconi Anemia.Rickman, KA, Lach FP, Abhyankar A., Donovan FX, Sanborn EM, Kennedy JA, Sougnez C., Gabriel SB, Elemento O., Chandrasekharappa SC, Schindler D., Auerbach AD, and Smogorzewska A. Cell reports, 2015/07/07, Volume 12, Issue 1, p.35-41, (2015) Read More / View Supplemental Materials
Abstract
The Extracellular Matrix: Tools and Insights for the "Omics" Era.Naba, A., Clauser KR, Ding H., Whittaker CA, Carr SA, and Hynes R. O. Matrix biology : journal of the International Society for Matrix Biology, 2015/07/07, (2015) Read More / View Supplemental Materials
Abstract
Quantitative proteomics suggests decrease in the secretogranin-1 cerebrospinal fluid levels during the disease course of multiple sclerosis.Kroksveen, AC, Jaffe JD, Aasebø E., Barsnes H., Bjørlykke Y., Franciotta D., Keshishian H., Myhr KM, Opsahl JA, van Pesch V., Teunissen CE, Torkildsen Ø., Ulvik RJ, Vethe H., Carr SA, and Berven FS Proteomics, 2015/07/07, (2015) Read More / View Supplemental Materials
Abstract
Genome-Scale Protein Microarray Comparison of Human Antibody Responses in Plasmodium vivax Relapse and Reinfection.Chuquiyauri, R., Molina DM, Moss EL, Wang R., Gardner MJ, Brouwer KC, Torres S., Gilman RH, Llanos-Cuentas A., Neafsey DE, Felgner P., Liang X., and Vinetz JM The American journal of tropical medicine and hygiene, 2015/07/06, (2015) Read More / View Supplemental Materials
Abstract
Combined Whole Methylome and Genomewide Association Study Implicates CNTN4 in Alcohol Use.Clark, SL, Aberg KA, Nerella S., Kumar G., McClay JL, Chen W., Xie LY, Harada A., Shabalin AA, Gao G., Bergen SE, Hultman CM, Magnusson PK, Sullivan PF, and van den Oord EJ Alcoholism, clinical and experimental research, 2015/07/04, (2015) Read More / View Supplemental Materials
Abstract
CSER and eMERGE: current and potential state of the display of genetic information in the electronic health record.Shirts, BH, Salama JS, Aronson SJ, Chung WK, Gray SW, Hindorff LA, Jarvik GP, Plon SE, Stoffel EM, Tarczy-Hornoch PZ, Van Allen EM, Weck KE, Chute CG, Freimuth RR, Grundmeier RW, Hartzler AL, Li R., Peissig PL, Peterson JF, Rasmussen LV, et al. Journal of the American Medical Informatics Association : JAMIA, 2015/07/03, (2015) Read More / View Supplemental Materials
Abstract
Biomarkers in multiple sclerosis.Housley, WJ, Pitt D., and Hafler DA Clinical immunology (Orlando, Fla.), 2015/07/02, (2015) Read More / View Supplemental Materials
Abstract
Disentangling the Effects of Colocalizing Genomic Annotations to Functionally Prioritize Non-coding Variants within Complex-Trait Loci.Trynka, G., Westra HJ, Slowikowski K., Hu X., Xu H., Stranger BE, Klein RJ, Han B., and Raychaudhuri S. American journal of human genetics, 2015/07/02, Volume 97, Issue 1, p.139-52, (2015) Read More / View Supplemental Materials
Abstract
From Dish to Bedside: Lessons Learned While Translating Findings from a Stem Cell Model of Disease to a Clinical Trial.McNeish, J., Gardner JP, Wainger BJ, Woolf CJ, and Eggan K. Cell stem cell, 2015/07/02, Volume 17, Issue 1, p.8-10, (2015) Read More / View Supplemental Materials
Abstract
Correction for hwang et Al., polyomavirus small T antigen interacts with yes-associated protein to regulate cell survival and differentiation.Hwang, JH, Pores Fernando AT, Faure N., Andrabi S., Adelmant G., Hahn WC, Marto JA, Schaffhausen BS, and Roberts TM Journal of virology, 2015/07/01, Volume 89, Issue 13, p.6971, (2015) Read More / View Supplemental Materials
CRISPR-Cas9: Prospects and Challenges.Zhang, F. Human gene therapy, 2015/07/01, Volume 26, Issue 7, p.409-10, (2015) Read More / View Supplemental Materials
Directional dominance on stature and cognition in diverse human populations.Joshi, PK, Esko T., Mattsson H., Eklund N., Gandin I., Nutile T., Jackson AU, Schurmann C., Smith AV, Zhang W., Okada Y., Stančáková A., Faul JD, Zhao W., Bartz TM, Concas MP, Franceschini N., Enroth S., Vitart V., Trompet S., et al. Nature, 2015/07/01, (2015) Read More / View Supplemental Materials
Abstract
Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation.Horikoshi, M., Mӓgi R., van de Bunt M., Surakka I., Sarin AP, Mahajan A., Marullo L., Thorleifsson G., Hӓgg S., Hottenga JJ, Ladenvall C., Ried JS, Winkler TW, Willems SM, Pervjakova N., Esko T., Beekman M., Nelson CP, Willenborg C., Wiltshire S., et al. PLoS genetics, 2015/07/01, Volume 11, Issue 7, p.e1005230, (2015) Read More / View Supplemental Materials
Abstract
An ecosystem of cancer cell line factories to support a cancer dependency map.Boehm, JS, and Golub T. R. Nature reviews. Genetics, 2015/07/01, Volume 16, Issue 7, p.373-4, (2015) Read More / View Supplemental Materials
Abstract
Metabolic Rewiring by Oncogenic BRAF V600E Links Ketogenesis Pathway to BRAF-MEK1 Signaling.Kang, HB, Fan J., Lin R., Elf S., Ji Q., Zhao L., Jin L., Seo JH, Shan C., Arbiser JL, Cohen C., Brat D., Miziorko HM, Kim E., Abdel-Wahab O., Merghoub T., Fröhling S., Scholl C., Tamayo P., Barbie DA, et al. Molecular cell, 2015/07/01, (2015) Read More / View Supplemental Materials
Abstract
Integrated Genomics of Crohn's Disease Risk Variant Identifies a Role for CLEC12A in Antibacterial Autophagy.Begun, J., Lassen KG, Jijon HB, Baxt LA, Goel G., Heath RJ, Ng A., Tam JM, Kuo SY, Villablanca EJ, Fagbami L., Oosting M., Kumar V., Schenone M., Carr SA, Joosten LA, Vyas JM, Daly M. J., Netea MG, Brown GD, et al. Cell reports, 2015/06/30, Volume 11, Issue 12, p.1905-1918, (2015) Read More / View Supplemental Materials
Abstract
The RSK Inhibitor BIX02565 Limits Cardiac Ischemia/Reperfusion Injury.Shi, X., O'Neill MM, MacDonnell S., Brookes PS, Yan C., and Berk BC Journal of cardiovascular pharmacology and therapeutics, 2015/06/30, (2015) Read More / View Supplemental Materials
Abstract
Development of a High-Throughput Functional Screen Using Nanowell-Assisted Cell Patterning.Ozkumur, AY, Goods BA, and Love JC Small (Weinheim an der Bergstrasse, Germany), 2015/06/29, (2015) Read More / View Supplemental Materials
Abstract
Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas.Cancer Genome Atlas Research, Network, Brat DJ, Verhaak RG, Aldape KD, Yung WK, Salama SR, Cooper LA, Rheinbay E., Miller CR, Vitucci M., Morozova O., Robertson AG, Noushmehr H., Laird PW, Cherniack AD, Akbani R., Huse JT, Ciriello G., Poisson LM, Barnholtz-Sloan JS, et al. The New England journal of medicine, 2015/06/25, Volume 372, Issue 26, p.2481-98, (2015) Read More / View Supplemental Materials
Abstract
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