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Submitted
Synthesis, cellular evaluation and mechanism-of-action of piperlongumine analogsAdams, DJ, Dai M., Pellegrino G., Wagner BK, Stern AM, Shamji AF, and Schreiber SL, (Submitted) Read More / View Supplemental Materials
2015
Genome Engineering Using CRISPR-Cas9 System.Cong, L., and Zhang F. Methods in molecular biology (Clifton, N.J.), 2015/01/01, Volume 1239, p.197-217, (2015) Read More / View Supplemental Materials
Abstract
2014
De novo CNVs in bipolar affective disorder and schizophrenia.Georgieva, L., Rees E., Moran JL, Chambert KD, Milanova V., Craddock N., Purcell S., Sklar P., McCarroll S., Holmans P., O'Donovan MC, Owen MJ, and Kirov G. Human molecular genetics, 2014/12/15, Volume 23, Issue 24, p.6677-83, (2014) Read More / View Supplemental Materials
Abstract
A comparative encyclopedia of DNA elements in the mouse genome.Yue, F., Cheng Y., Breschi A., Vierstra J., Wu W., Ryba T., Sandstrom R., Ma Z., Davis C., Pope BD, Shen Y., Pervouchine DD, Djebali S., Thurman RE, Kaul R., Rynes E., Kirilusha A., Marinov GK, Williams BA, Trout D., et al. Nature, 2014/11/20, Volume 515, Issue 7527, p.355-64, (2014) Read More / View Supplemental Materials
Abstract
Functional implications of a psychiatric risk variant within CACNA1C in induced human neurons.Yoshimizu, T., Pan JQ, Mungenast AE, Madison JM, Su S., Ketterman J., Ongur D., McPhie D., Cohen B., Perlis R., and Tsai LH Molecular psychiatry, 2014/11/18, (2014) Read More / View Supplemental Materials
Abstract
Novel loci associated with usual sleep duration: the CHARGE Consortium Genome-Wide Association Study.Gottlieb, DJ, Hek K., Chen TH, Watson NF, Eiriksdottir G., Byrne EM, Cornelis M., Warby SC, Bandinelli S., Cherkas L., Evans DS, Grabe HJ, Lahti J., Li M., Lehtimäki T., Lumley T., Marciante KD, Pérusse L., Psaty BM, Robbins J., et al. Molecular psychiatry, 2014/11/18, (2014) Read More / View Supplemental Materials
The draft genome sequence of the ferret (Mustela putorius furo) facilitates study of human respiratory disease.Peng, X., Alföldi J., Gori K., Eisfeld AJ, Tyler SR, Tisoncik-Go J., Brawand D., Law GL, Skunca N., Hatta M., Gasper DJ, Kelly SM, Chang J., Thomas MJ, Johnson J., Berlin AM, Lara M., Russell P., Swofford R., Turner-Maier J., et al. Nature biotechnology, 2014/11/17, (2014) Read More / View Supplemental Materials
Abstract
Long-term persistence and development of induced pancreatic beta cells generated by lineage conversion of acinar cells.Li, W., Cavelti-Weder C., Zhang Y., Clement K., Donovan S., Gonzalez G., Zhu J., Stemann M., Xu K., Hashimoto T., Yamada T., Nakanishi M., Zhang Y., Zeng S., Gifford D., Meissner A., Weir G., and Zhou Q. Nature biotechnology, 2014/11/17, (2014) Read More / View Supplemental Materials
Abstract
Rapid neurogenesis through transcriptional activation in human stem cells.Busskamp, V., Lewis NE, Guye P., Ng AH, Shipman SL, Byrne SM, Sanjana NE, Murn J., Li Y., Li S., Stadler M., Weiss R., and Church GM Molecular systems biology, 2014/11/17, Volume 10, Issue 11, p.760, (2014) Read More / View Supplemental Materials
Abstract
A recurrent de novo mutation in KCNC1 causes progressive myoclonus epilepsy.Muona, M., Berkovic SF, Dibbens LM, Oliver KL, Maljevic S., Bayly MA, Joensuu T., Canafoglia L., Franceschetti S., Michelucci R., Markkinen S., Heron SE, Hildebrand MS, Andermann E., Andermann F., Gambardella A., Tinuper P., Licchetta L., Scheffer IE, Criscuolo C., et al. Nature genetics, 2014/11/17, (2014) Read More / View Supplemental Materials
Abstract
Association of Sickle Cell Trait With Chronic Kidney Disease and Albuminuria in African Americans.Naik, RP, Derebail VK, Grams ME, Franceschini N., Auer PL, Peloso GM, Young BA, Lettre G., Peralta CA, Katz R., Hyacinth HI, Quarells RC, Grove ML, Bick AG, Fontanillas P., Rich SS, Smith JD, Boerwinkle E., Rosamond WD, Ito K., et al. JAMA, 2014/11/13, (2014) Read More / View Supplemental Materials
Abstract
Mental health: depression needs large human-genetics studies.Hyman, S. Nature, 2014/11/13, Volume 515, Issue 7526, p.189-91, (2014) Read More / View Supplemental Materials
Subclonal mutations in SETBP1 confer a poor prognosis in juvenile myelomonocytic leukemia.Stieglitz, E., Troup CB, Gelston LC, Haliburton J., Chow ED, Yu KB, Akutagawa J., Taylor-Weiner AN, Liu YL, Wang YD, Beckman K., Emanuel PD, Braun BS, Abate A., Gerbing RB, Alonzo TA, and Loh M. L. Blood, 2014/11/13, (2014) Read More / View Supplemental Materials
Abstract
Synaptic, transcriptional and chromatin genes disrupted in autism.De Rubeis, S., He X., Goldberg AP, Poultney CS, Samocha K., Ercument Cicek A., Kou Y., Liu L., Fromer M., Walker S., Singh T., Klei L., Kosmicki J., Fu SC, Aleksic B., Biscaldi M., Bolton PF, Brownfeld JM, Cai J., Campbell NG, et al. Nature, 2014/11/13, Volume 515, Issue 7526, p.209-15, (2014) Read More / View Supplemental Materials
Abstract
Unencapsulated Streptococcus pneumoniae from conjunctivitis encode variant traits and belong to a distinct phylogenetic cluster.Valentino, MD, McGuire AM, Rosch JW, Bispo PJ, Burnham C., Sanfilippo CM, Carter RA, Zegans ME, Beall B., Earl AM, Tuomanen EI, Morris TW, Haas W., and Gilmore MS Nature communications, 2014/11/12, Volume 5, p.5411, (2014) Read More / View Supplemental Materials
Abstract
FASTKD2 is associated with memory and hippocampal structure in older adults.Ramanan, VK, Nho K., Shen L., Risacher SL, Kim S., McDonald BC, Farlow MR, Foroud TM, Gao S., Soininen H., Kłoszewska I., Mecocci P., Tsolaki M., Vellas B., Lovestone S., Aisen PS, Petersen RC, Jack CR Jr, Shaw LM, Trojanowski JQ, et al. Molecular psychiatry, 2014/11/11, (2014) Read More / View Supplemental Materials
Abstract
Leveraging population admixture to characterize the heritability of complex traits.Zaitlen, N., Pasaniuc B., Sankararaman S., Bhatia G., Zhang J., Gusev A., Young T., Tandon A., Pollack S., Vilhjálmsson BJ, Assimes TL, Berndt SI, Blot WJ, Chanock S., Franceschini N., Goodman PG, He J., Hennis AJ, Hsing A., Ingles SA, et al. Nature genetics, 2014/11/10, (2014) Read More / View Supplemental Materials
Abstract
Variation at HLA-DRB1 is associated with resistance to enteric fever.Dunstan, SJ, Hue NT, Han B., Li Z., Tram TT, Sim KS, Parry CM, Chinh NT, Vinh H., Lan NP, Thieu NT, Vinh PV, Koirala S., Dongol S., Arjyal A., Karkey A., Shilpakar O., Dolecek C., Foo JN, Phuong LT, et al. Nature genetics, 2014/11/10, (2014) Read More / View Supplemental Materials
Abstract
Genome-Level Determination of Plasmodium falciparum Blood Stage Targets of Malarial Clinical Immunity in the Peruvian Amazon.Torres, KJ, Castrillon CE, Moss EL, Saito M., Tenorio R., Molina DM, Davies H., Neafsey DE, Felgner P., Vinetz JM, and Gamboa D. The Journal of infectious diseases, 2014/11/07, (2014) Read More / View Supplemental Materials
Abstract
Magnetic Resonance Detection of Individual Proton Spins Using Quantum Reporters.Sushkov, AO, Lovchinsky I., Chisholm N., Walsworth RL, Park H., and Lukin MD Physical review letters, 2014/11/07, Volume 113, Issue 19, p.197601, (2014) Read More / View Supplemental Materials
Abstract
Controlling the survival of human pluripotent stem cells by small molecule-based targeting of topoisomerase II alpha.Ben-David, U., Cowell IG, Austin CA, and Benvenisty N. Stem cells (Dayton, Ohio), 2014/11/06, (2014) Read More / View Supplemental Materials
Abstract
Association of Low-Density Lipoprotein Cholesterol-Related Genetic Variants With Aortic Valve Calcium and Incident Aortic Stenosis.Smith, JG, Luk K., Schulz CA, Engert JC, Do R., Hindy G., Rukh G., Dufresne L., Almgren P., Owens DS, Harris TB, Peloso GM, Kerr KF, Wong Q., Smith AV, Budoff MJ, Rotter JI, Cupples LA, Rich S., Kathiresan S., et al. JAMA, 2014/11/05, Volume 312, Issue 17, p.1764-1771, (2014) Read More / View Supplemental Materials
Abstract
No evidence for rare recessive and compound heterozygous disruptive variants in schizophrenia.Ruderfer, DM, Lim ET, Genovese G., Moran JL, Hultman CM, Sullivan PF, McCarroll SA, Holmans P., Sklar P., and Purcell SM European journal of human genetics : EJHG, 2014/11/05, (2014) Read More / View Supplemental Materials
Abstract
Optimization of transcription factor binding map accuracy utilizing knockout-mouse models.Krebs, W., Schmidt SV, Goren A., De Nardo D., Labzin L., Bovier A., Ulas T., Theis H., Kraut M., Latz E., Beyer M., and Schultze JL Nucleic acids research, 2014/11/05, (2014) Read More / View Supplemental Materials
Abstract
Evolution of invasion in a diverse set of fusobacterium species.Manson McGuire, A., Cochrane K., Griggs AD, Haas BJ, Abeel T., Zeng Q., Nice JB, MacDonald H., Birren BW, Berger BW, Allen-Vercoe E., and Earl AM mBio, 2014/11/04, Volume 5, Issue 6, (2014) Read More / View Supplemental Materials
Abstract
Molecular profiling of endometrial carcinoma precursor, primary and metastatic lesions suggests different targets for treatment in obese compared to non-obese patients.Berg, A., Hoivik EA, Mjøs S., Holst F., Werner HM, Tangen IL, Taylor-Weiner A., Gibson WJ, Kusonmano K., Wik E., Trovik J., Halle MK, Oyan AM, Kalland KH, Cherniack AD, Beroukhim R., Stefansson I., Mills GB, Krakstad C., and Salvesen HB Oncotarget, 2014/11/04, (2014) Read More / View Supplemental Materials
Abstract
Association of Brain DNA Methylation in SORL1, ABCA7, HLA-DRB5, SLC24A4, and BIN1 With Pathological Diagnosis of Alzheimer Disease.Yu, L., Chibnik LB, Srivastava GP, Pochet N., Yang J., Xu J., Kozubek J., Obholzer N., Leurgans SE, Schneider JA, Meissner A., De Jager PL, and Bennett DA JAMA neurology, 2014/11/03, (2014) Read More / View Supplemental Materials
Abstract
Immune characterization of P. falciparum parasites with a shared genetic signature in a region of decreasing transmission.Bei, AK, Diouf A., Miura K., Larremore DB, Ribacke U., Tullo G., Moss EL, Neafsey DE, Daniels RF, Zeituni AE, Nosamiefan I., Volkman SK, Ahouidi AD, Ndiaye D., Dieye T., Mboup S., Buckee CO, Long CA, and Wirth DF Infection and immunity, 2014/11/03, (2014) Read More / View Supplemental Materials
Abstract
Pathways targeted by anti-diabetes drugs are enriched for multiple genes associated with type 2 diabetes risk.Segrè, AV, Wei N., DIAGRAM Consortium, investigators MAGIC, Altshuler D., and Florez JC Diabetes, 2014/11/03, (2014) Read More / View Supplemental Materials
Abstract
Coverage recommendations for methylation analysis by whole-genome bisulfite sequencing.Ziller, MJ, Hansen KD, Meissner A., and Aryee MJ Nature methods, 2014/11/02, (2014) Read More / View Supplemental Materials
Abstract
24-hour rhythms of DNA methylation and their relation with rhythms of RNA expression in the human dorsolateral prefrontal cortex.Lim, AS, Srivastava GP, Yu L., Chibnik LB, Xu J., Buchman AS, Schneider JA, Myers AJ, Bennett DA, and De Jager PL PLoS genetics, 2014/11/01, Volume 10, Issue 11, p.e1004792, (2014) Read More / View Supplemental Materials
Abstract
Cell type-specific plasticity of striatal projection neurons in parkinsonism and L-DOPA-induced dyskinesia.Fieblinger, T., Graves SM, Sebel LE, Alcacer C., Plotkin JL, Gertler TS, Chan CS, Heiman M., Greengard P., Cenci MA, and Surmeier DJ Nature communications, 2014/10/31, Volume 5, p.5316, (2014) Read More / View Supplemental Materials
Abstract
Wildlife disease. Recent introduction of a chytrid fungus endangers Western Palearctic salamanders.Martel, A., Blooi M., Adriaensen C., Van Rooij P., Beukema W., Fisher MC, Farrer RA, Schmidt BR, Tobler U., Goka K., Lips KR, Muletz C., Zamudio KR, Bosch J., Lötters S., Wombwell E., Garner TW, Cunningham AA, Spitzen-van der Sluijs A., Salvidio S., et al. Science (New York, N.Y.), 2014/10/31, Volume 346, Issue 6209, p.630-1, (2014) Read More / View Supplemental Materials
Abstract
Genetic and epigenetic fine mapping of causal autoimmune disease variants.Farh, KK, Marson A., Zhu J., Kleinewietfeld M., Housley WJ, Beik S., Shoresh N., Whitton H., Ryan RJ, Shishkin AA, Hatan M., Carrasco-Alfonso MJ, Mayer D., Luckey CJ, Patsopoulos NA, De Jager PL, Kuchroo VK, Epstein CB, Daly M. J., Hafler DA, et al. Nature, 2014/10/29, (2014) Read More / View Supplemental Materials
Abstract
Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis.Benyamin, B., Esko T., Ried JS, Radhakrishnan A., Vermeulen SH, Traglia M., Gögele M., Anderson D., Broer L., Podmore C., Luan J., Kutalik Z., Sanna S., van der Meer P., Tanaka T., Wang F., Westra HJ, Franke L., Mihailov E., Milani L., et al. Nature communications, 2014/10/29, Volume 5, p.4926, (2014) Read More / View Supplemental Materials
Abstract
Genetic background of extreme violent behavior.Tiihonen, J., Rautiainen MR, Ollila HM, Repo-Tiihonen E., Virkkunen M., Palotie A., Pietiläinen O., Kristiansson K., Joukamaa M., Lauerma H., Saarela J., Tyni S., Vartiainen H., Paananen J., Goldman D., and Paunio T. Molecular psychiatry, 2014/10/28, (2014) Read More / View Supplemental Materials
Abstract
Pilicide ec240 Disrupts Virulence Circuits in Uropathogenic Escherichia coli.Greene, SE, Pinkner JS, Chorell E., Dodson KW, Shaffer CL, Conover MS, Livny J., Hadjifrangiskou M., Almqvist F., and Hultgren SJ mBio, 2014/10/28, Volume 5, Issue 6, (2014) Read More / View Supplemental Materials
Abstract
Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors.Tan, L., Wang J., Tanizaki J., Huang Z., Aref AR, Rusan M., Zhu SJ, Zhang Y., Ercan D., Liao RG, Capelletti M., Zhou W., Hur W., Kim N., Sim T., Gaudet S., Barbie DA, Yeh JR, Yun CH, Hammerman PS, et al. Proceedings of the National Academy of Sciences of the United States of America, 2014/10/27, (2014) Read More / View Supplemental Materials
Abstract
RNF43 is frequently mutated in colorectal and endometrial cancers.Giannakis, M., Hodis E., Jasmine Mu X., Yamauchi M., Rosenbluh J., Cibulskis K., Saksena G., Lawrence MS, Qian ZR, Nishihara R., Allen EM, Hahn WC, Gabriel SB, Lander E. S., Getz G., Ogino S., Fuchs CS, and Garraway LA Nature genetics, 2014/10/26, (2014) Read More / View Supplemental Materials
Abstract
Genome sequence of a 45,000-year-old modern human from western Siberia.Fu, Q., Li H., Moorjani P., Jay F., Slepchenko SM, Bondarev AA, Johnson PL, Aximu-Petri A., Prüfer K., de Filippo C., Meyer M., Zwyns N., Salazar-García DC, Kuzmin YV, Keates SG, Kosintsev PA, Razhev DI, Richards MP, Peristov NV, Lachmann M., et al. Nature, 2014/10/23, Volume 514, Issue 7523, p.445-9, (2014) Read More / View Supplemental Materials
Abstract
Hydroxamic Acid-Based Histone Deacetylase (HDAC) Inhibitors Can Mediate Neuroprotection Independent of HDAC Inhibition.Sleiman, SF, Olson DE, Bourassa MW, Karuppagounder SS, Zhang YL, Gale J., Wagner FF, Basso M., Coppola G., Pinto JT, Holson EB, and Ratan RR The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014/10/22, Volume 34, Issue 43, p.14328-37, (2014) Read More / View Supplemental Materials
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Autism spectrum disorder severity reflects the average contribution of de novo and familial influences.Robinson, EB, Samocha KE, Kosmicki JA, McGrath L., Neale BM, Perlis RH, and Daly M. J. Proceedings of the National Academy of Sciences of the United States of America, 2014/10/21, Volume 111, Issue 42, p.15161-5, (2014) Read More / View Supplemental Materials
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CHD8 regulates neurodevelopmental pathways associated with autism spectrum disorder in neural progenitors.Sugathan, A., Biagioli M., Golzio C., Erdin S., Blumenthal I., Manavalan P., Ragavendran A., Brand H., Lucente D., Miles J., Sheridan SD, Stortchevoi A., Kellis M., Haggarty SJ, Katsanis N., Gusella JF, and Talkowski ME Proceedings of the National Academy of Sciences of the United States of America, 2014/10/21, Volume 111, Issue 42, p.E4468-77, (2014) Read More / View Supplemental Materials
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Clonal outbreak of Plasmodium falciparum in eastern Panama.Obaldia N, 3rd, Baro NK, Calzada JE, Santamaria AM, Daniels R., Wong W., Chang HH, Hamilton EJ, Arevalo-Herrera M., Herrera S., Wirth DF, Hartl DL, Marti M., and Volkman SK The Journal of infectious diseases, 2014/10/21, (2014) Read More / View Supplemental Materials
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Diversity-Oriented Synthesis probe targets Plasmodium falciparum cytochrome b ubiquinone reduction site and synergizes with oxidation site inhibitors.Lukens, AK, Heidebrecht RW Jr, Mulrooney C., Beaudoin JA, Comer E., Duvall JR, Fitzgerald ME, Masi D., Galinsky K., Scherer CA, Palmer M., Munoz B., Foley M., Schreiber SL, Wiegand RC, and Wirth DF The Journal of infectious diseases, 2014/10/21, (2014) Read More / View Supplemental Materials
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Origin in Acinetobacter guillouiae and Dissemination of the Aminoglycoside-Modifying Enzyme Aph(3')-VI.Yoon, EJ, Goussard S., Touchon M., Krizova L., Cerqueira G., Murphy C., Lambert T., Grillot-Courvalin C., Nemec A., and Courvalin P. mBio, 2014/10/21, Volume 5, Issue 5, (2014) Read More / View Supplemental Materials
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Comprehensive variation discovery in single human genomes.Weisenfeld, NI, Yin S., Sharpe T., Lau B., Hegarty R., Holmes L., Sogoloff B., Tabbaa D., Williams L., Russ C., Nusbaum C., Lander E. S., Maccallum I., and Jaffe DB Nature genetics, 2014/10/19, (2014) Read More / View Supplemental Materials
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In vivo interrogation of gene function in the mammalian brain using CRISPR-Cas9.Swiech, L., Heidenreich M., Banerjee A., Habib N., Li Y., Trombetta J., Sur M., and Zhang F. Nature biotechnology, 2014/10/19, (2014) Read More / View Supplemental Materials
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An unbiased approach to identify endogenous substrates of "histone" deacetylase 8.Olson, DE, Udeshi ND, Wolfson NA, Pitcairn CA, Sullivan ED, Jaffe JD, Svinkina T., Natoli T., Lu X., Paulk J., McCarren P., Wagner FF, Barker D., Howe E., Lazzaro F., Gale JP, Zhang YL, Subramanian A., Fierke CA, Carr SA, et al. ACS chemical biology, 2014/10/17, Volume 9, Issue 10, p.2210-6, (2014) Read More / View Supplemental Materials
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Malawi polyomavirus is a prevalent human virus that interacts with known tumor suppressors.Berrios, C., Jung J., Primi B., Wang M., Pedamallu C., Duke F., Marcelus C., Cheng J., Garcea RL, Meyerson M., DeCaprio JA, and the TEDDY Study Group Journal of virology, 2014/10/15, (2014) Read More / View Supplemental Materials
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Identification of a Multipotent Self-Renewing Stromal Progenitor Population during Mammalian Kidney Organogenesis.Kobayashi, A., Mugford JW, Krautzberger AM, Naiman N., Liao J., and McMahon AP Stem cell reports, 2014/10/14, Volume 3, Issue 4, p.650-62, (2014) Read More / View Supplemental Materials
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Characterization of HPV and host genome interactions in primary head and neck cancers.Parfenov, M., Pedamallu CS, Gehlenborg N., Freeman SS, Danilova L., Bristow CA, Lee S., Hadjipanayis AG, Ivanova EV, Wilkerson MD, Protopopov A., Yang L., Seth S., Song X., Tang J., Ren X., Zhang J., Pantazi A., Santoso N., Xu AW, et al. Proceedings of the National Academy of Sciences of the United States of America, 2014/10/13, (2014) Read More / View Supplemental Materials
Abstract
The Genomic Diversification of the Whole Acinetobacter Genus: Origins, Mechanisms, and Consequences.Touchon, M., Cury J., Yoon EJ, Krizova L., Cerqueira GC, Murphy C., Feldgarden M., Wortman J., Clermont D., Lambert T., Grillot-Courvalin C., Nemec A., Courvalin P., and Rocha EP Genome biology and evolution, 2014/10/13, (2014) Read More / View Supplemental Materials
Abstract
SNPsnap: a web-based tool for identification and annotation of matched SNPs.Pers, TH, Timshel P., and Hirschhorn JN Bioinformatics (Oxford, England), 2014/10/13, (2014) Read More / View Supplemental Materials
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Gluten sensitivity and relationship to psychiatric symptoms in people with schizophrenia.Jackson, J., Eaton W., Cascella N., Fasano A., Santora D., Sullivan K., Feldman S., Raley H., McMahon RP, Carpenter WT Jr, Demyanovich H., and Kelly DL Schizophrenia research, 2014/10/10, (2014) Read More / View Supplemental Materials
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Advancing the microbiome research community.Huttenhower, C., Knight R., Brown CT, Caporaso JG, Clemente JC, Gevers D., Franzosa EA, Kelley ST, Knights D., Ley RE, Mahurkar A., Ravel J., Scientists for Advancement of Microbiome Research, and White O. Cell, 2014/10/09, Volume 159, Issue 2, p.227-30, (2014) Read More / View Supplemental Materials
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Dnase2a Deficiency Uncovers Lysosomal Clearance of Damaged Nuclear DNA via Autophagy.Lan, YY, Londoño D., Bouley R., Rooney MS, and Hacohen N. Cell reports, 2014/10/09, Volume 9, Issue 1, p.180-92, (2014) Read More / View Supplemental Materials
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Genetic variation in the HLA region is associated with susceptibility to herpes zoster.Crosslin, DR, Carrell DS, Burt A., Kim DS, Underwood JG, Hanna DS, Comstock BA, Baldwin E., de Andrade M., Kullo IJ, Tromp G., Kuivaniemi H., Borthwick KM, McCarty CA, Peissig PL, Doheny KF, Pugh E., Kho A., Pacheco J., Hayes MG, et al. Genes and immunity, 2014/10/09, (2014) Read More / View Supplemental Materials
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Response and acquired resistance to everolimus in anaplastic thyroid cancer.Wagle, N., Grabiner BC, Van Allen EM, Amin-Mansour A., Taylor-Weiner A., Rosenberg M., Gray N., Barletta JA, Guo Y., Swanson SJ, Ruan DT, Hanna GJ, Haddad RI, Getz G., Kwiatkowski DJ, Carter SL, Sabatini DM, Jänne PA, Garraway LA, and Lorch JH The New England journal of medicine, 2014/10/09, Volume 371, Issue 15, p.1426-33, (2014) Read More / View Supplemental Materials
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Genome-wide Enrichment Analysis between Endometriosis and Obesity-related Traits Reveals Novel Susceptibility Loci.Rahmioglu, N., Macgregor S., Drong AW, Hedman AK, Harris HR, Randall JC, Prokopenko I., The International EndoGene Consortium(IEC), The GIANT Consortium, Nyholt DR, Morris AP, Montgomery GW, Missmer SA, Lindgren CM, Zondervan KT, and The International EndoGene Consortium IEC Human molecular genetics, 2014/10/08, (2014) Read More / View Supplemental Materials
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An exact arithmetic toolbox for a consistent and reproducible structural analysis of metabolic network models.Chindelevitch, L., Trigg J., Regev A., and Berger B. Nature communications, 2014/10/07, Volume 5, p.4893, (2014) Read More / View Supplemental Materials
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Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption.The Coffee and Caffeine Genetics, Consortium, Cornelis MC, Byrne EM, Esko T., Nalls MA, Ganna A., Paynter N., Monda KL, Amin N., Fischer K., Renstrom F., Ngwa JS, Huikari V., Cavadino A., Nolte IM, Teumer A., Yu K., Marques-Vidal P., Rawal R., Manichaikul A., et al. Molecular psychiatry, 2014/10/07, (2014) Read More / View Supplemental Materials
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Identification of Orai1 Channel Inhibitors by Using Minimal Functional Domains to Screen Small Molecule Microarrays.Sadaghiani, AM, Lee SM, Odegaard JI, Leveson-Gower DB, McPherson OM, Novick P., Kim MR, Koehler AN, Negrin R., Dolmetsch RE, and Park CY Chemistry & biology, 2014/10/07, (2014) Read More / View Supplemental Materials
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Investigating the possible causal association of smoking with depression and anxiety using Mendelian randomisation meta-analysis: the CARTA consortium.Taylor, AE, Fluharty ME, Bjørngaard JH, Gabrielsen ME, Skorpen F., Marioni RE, Campbell A., Engmann J., Mirza SS, Loukola A., Laatikainen T., Partonen T., Kaakinen M., Ducci F., Cavadino A., Husemoen LL, Ahluwalia TS, Jacobsen RK, Skaaby T., Ebstrup JF, et al. BMJ open, 2014/10/07, Volume 4, Issue 10, p.e006141, (2014) Read More / View Supplemental Materials
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Defining the role of common variation in the genomic and biological architecture of adult human height.Wood, AR, Esko T., Yang J., Vedantam S., Pers TH, Gustafsson S., Chu AY, Estrada K., Luan J., Kutalik Z., Amin N., Buchkovich ML, Croteau-Chonka DC, Day FR, Duan Y., Fall T., Fehrmann R., Ferreira T., Jackson AU, Karjalainen J., et al. Nature genetics, 2014/10/05, (2014) Read More / View Supplemental Materials
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CompMap: a reference-based compression program to speed up read mapping to related reference sequences.Zhu, Z., Li L., Zhang Y., Yang Y., and Yang X. Bioinformatics (Oxford, England), 2014/10/04, (2014) Read More / View Supplemental Materials
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Distinct effects of concomitant Jak2V617F expression and Tet2 loss in mice combine to promote disease progression in myeloproliferative neoplasms.Chen, E., Schneider RK, Breyfogle LJ, Rosen EA, Poveromo L., Elf S., Ko A., Brumme K., LeVine R., Ebert BL, and Mullally A. Blood, 2014/10/03, (2014) Read More / View Supplemental Materials
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A novel common variant in DCST2 is associated with length in early life and height in adulthood.van der Valk, RJ, Kreiner-Møller E., Kooijman MN, Guxens M., Stergiakouli E., Sääf A., Bradfield JP, Geller F., Hayes MG, Cousminer DL, Körner A., Thiering E., Curtin JA, Myhre R., Huikari V., Joro R., Kerkhof M., Warrington NM, Pitkänen N., Ntalla I., et al. Human molecular genetics, 2014/10/03, (2014) Read More / View Supplemental Materials
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Prostate cancer. Ubiquitylome analysis identifies dysregulation of effector substrates in SPOP-mutant prostate cancer.Theurillat, JP, Udeshi ND, Errington WJ, Svinkina T., Baca SC, Pop M., Wild PJ, Blattner M., Groner AC, Rubin MA, Moch H., Privé GG, Carr SA, and Garraway LA Science (New York, N.Y.), 2014/10/03, Volume 346, Issue 6205, p.85-9, (2014) Read More / View Supplemental Materials
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Ascertainment bias causes false signal of anticipation in genetic prion disease.Minikel, EV, Zerr I., Collins SJ, Ponto C., Boyd A., Klug G., Karch A., Kenny J., Collinge J., Takada LT, Forner S., Fong JC, Mead S., and Geschwind MD American journal of human genetics, 2014/10/02, Volume 95, Issue 4, p.371-82, (2014) Read More / View Supplemental Materials
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Cryptic and complex chromosomal aberrations in early-onset neuropsychiatric disorders.Brand, H., Pillalamarri V., Collins RL, Eggert S., O'Dushlaine C., Braaten EB, Stone MR, Chambert K., Doty ND, Hanscom C., Rosenfeld JA, Ditmars H., Blais J., Mills R., Lee C., Gusella JF, McCarroll S., Smoller JW, Talkowski ME, and Doyle AE American journal of human genetics, 2014/10/02, Volume 95, Issue 4, p.454-61, (2014) Read More / View Supplemental Materials
Abstract
Hemani et al. reply.Hemani, G., Shakhbazov K., Westra HJ, Esko T., Henders AK, McRae AF, Yang J., Gibson G., Martin NG, Metspalu A., Franke L., Montgomery GW, Visscher PM, and Powell JE Nature, 2014/10/02, Volume 514, Issue 7520, p.E5-6, (2014) Read More / View Supplemental Materials
Abnormal dosage of ultraconserved elements is highly disfavored in healthy cells but not cancer cells.McCole, RB, Fonseka CY, Koren A., and Wu CT PLoS genetics, 2014/10/01, Volume 10, Issue 10, p.e1004646, (2014) Read More / View Supplemental Materials
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Attention-deficit/hyperactivity disorder polygenic risk scores predict attention problems in a population-based sample of children.Groen-Blokhuis, MM, Middeldorp CM, Kan KJ, Abdellaoui A., van Beijsterveldt CE, Ehli EA, Davies GE, Scheet PA, Xiao X., Hudziak JJ, Hottenga JJ, Psychiatric Genomics Consortium ADHD Working Group, Neale BM, and Boomsma DI Journal of the American Academy of Child and Adolescent Psychiatry, 2014/10/01, Volume 53, Issue 10, p.1123-1129.e6, (2014) Read More / View Supplemental Materials
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Autophagy Controls BCG-Induced Trained Immunity and the Response to Intravesical BCG Therapy for Bladder Cancer.Buffen, K., Oosting M., Quintin J., Ng A., Kleinnijenhuis J., Kumar V., van de Vosse E., Wijmenga C., van Crevel R., Oosterwijk E., Grotenhuis AJ, Vermeulen SH, Kiemeney LA, van de Veerdonk FL, Chamilos G., Xavier RJ, van der Meer JW, Netea MG, and Joosten LA PLoS pathogens, 2014/10/01, Volume 10, Issue 10, p.e1004485, (2014) Read More / View Supplemental Materials
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Functional Analysis of SPECC1L in Craniofacial Development and Oblique Facial Cleft Pathogenesis.Gfrerer, L., Shubinets V., Hoyos T., Kong Y., Nguyen C., Pietschmann P., Morton CC, Maas RL, and Liao EC Plastic and reconstructive surgery, 2014/10/01, Volume 134, Issue 4, p.748-59, (2014) Read More / View Supplemental Materials
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Genetic Studies of Major Depressive Disorder: Why Are There No Genome-wide Association Study Findings and What Can We Do About It?Levinson, DF, Mostafavi S., Milaneschi Y., Rivera M., Ripke S., Wray NR, and Sullivan PF Biological psychiatry, 2014/10/01, Volume 76, Issue 7, p.510-2, (2014) Read More / View Supplemental Materials
Pulmonary macrophage transplantation therapy.Suzuki, T., Arumugam P., Sakagami T., Lachmann N., Chalk C., Sallese A., Abe S., Trapnell C., Carey B., Moritz T., Malik P., Lutzko C., Wood RE, and Trapnell BC Nature, 2014/10/01, (2014) Read More / View Supplemental Materials
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Therapeutic Strategies to Inhibit MYC.McKeown, MR, and Bradner JE Cold Spring Harbor perspectives in medicine, 2014/10/01, Volume 4, Issue 10, (2014) Read More / View Supplemental Materials
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Does poor health predict moving, move quality, and desire to move?: A study examining neighborhood selection in US adolescents and adults.Dunn, EC, Winning A., Zaika N., and Subramanian SV Health & place, 2014/09/30, Volume 30C, p.154-164, (2014) Read More / View Supplemental Materials
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Expanding the Phenotype Associated With the NEFL Mutation: Neuromuscular Disease in a Family With Overlapping Myopathic and Neurogenic Findings.Agrawal, PB, Joshi M., Marinakis NS, Schmitz-Abe K., Ciarlini PD, Sargent JC, Markianos K., De Girolami U., Chad DA, and Beggs AH JAMA neurology, 2014/09/29, (2014) Read More / View Supplemental Materials
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A breast cancer stem cell niche supported by juxtacrine signalling from monocytes and macrophages.Lu, H., Clauser KR, Tam WL, Fröse J., Ye X., Eaton EN, Reinhardt F., Donnenberg VS, Bhargava R., Carr SA, and Weinberg R. A. Nature cell biology, 2014/09/28, (2014) Read More / View Supplemental Materials
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Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development.Mayers, JR, Wu C., Clish CB, Kraft P., Torrence ME, Fiske BP, Yuan C., Bao Y., Townsend MK, Tworoger SS, Davidson SM, Papagiannakopoulos T., Yang A., Dayton TL, Ogino S., Stampfer MJ, Giovannucci EL, Qian ZR, Rubinson DA, Ma J., et al. Nature medicine, 2014/09/28, (2014) Read More / View Supplemental Materials
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Comparative RNA-Seq based dissection of the regulatory networks and environmental stimuli underlying Vibrio parahaemolyticus gene expression during infection.Livny, J., Zhou X., Mandlik A., Hubbard T., Davis BM, and Waldor MK Nucleic acids research, 2014/09/27, (2014) Read More / View Supplemental Materials
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Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity.Saeed, S., Quintin J., Kerstens HH, Rao NA, Aghajanirefah A., Matarese F., Cheng SC, Ratter J., Berentsen K., van der Ent MA, Sharifi N., Janssen-Megens EM, Ter Huurne M., Mandoli A., van Schaik T., Ng A., Burden F., Downes K., Frontini M., Kumar V., et al. Science (New York, N.Y.), 2014/09/26, Volume 345, Issue 6204, p.1251086, (2014) Read More / View Supplemental Materials
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mTOR- and HIF-1α-mediated aerobic glycolysis as metabolic basis for trained immunity.Cheng, SC, Quintin J., Cramer RA, Shepardson KM, Saeed S., Kumar V., Giamarellos-Bourboulis EJ, Martens JH, Rao NA, Aghajanirefah A., Manjeri GR, Li Y., Ifrim DC, Arts RJ, van der Meer BM, Deen PM, Logie C., O'Neill LA, Willems P., van de Veerdonk FL, et al. Science (New York, N.Y.), 2014/09/26, Volume 345, Issue 6204, p.1250684, (2014) Read More / View Supplemental Materials
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Angiomatous meningiomas have a distinct genetic profile with multiple chromosomal polysomies including polysomy of chromosome 5.Abedalthagafi, MS, Merrill PH, Bi WL, Jones RT, Listewnik ML, Ramkissoon SH, Thorner AR, Dunn IF, Beroukhim R., Alexander BM, Brastianos PK, Francis JM, Folkerth RD, Ligon KL, Van Hummelen P., Ligon AH, and Santagata S. Oncotarget, 2014/09/25, (2014) Read More / View Supplemental Materials
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Genome-Wide Association Study of Intracranial Aneurysm Identifies a New Association on Chromosome 7.Foroud, T., Lai D., Koller D., Van't Hof F., Kurki MI, Anderson CS, Brown RD Jr, Connolly ES, Eriksson JG, Flaherty M., Fornage M., von Und Zu Fraunberg M., Gaál EI, Laakso A., Hernesniemi J., Huston J., Jääskeläinen JE, Kiemeney LA, Kivisaari R., Kleindorfer D., et al. Stroke; a journal of cerebral circulation, 2014/09/25, (2014) Read More / View Supplemental Materials
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RNA-RNA Interactions Enable Specific Targeting of Noncoding RNAs to Nascent Pre-mRNAs and Chromatin Sites.Engreitz, JM, Sirokman K., McDonel P., Shishkin AA, Surka C., Russell P., Grossman SR, Chow AY, Guttman M., and Lander E. S. Cell, 2014/09/25, Volume 159, Issue 1, p.188-99, (2014) Read More / View Supplemental Materials
Abstract
CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling.Platt, RJ, Chen S., Zhou Y., Yim MJ, Swiech L., Kempton HR, Dahlman JE, Parnas O., Eisenhaure TM, Jovanovic M., Graham DB, Jhunjhunwala S., Heidenreich M., Xavier RJ, Langer R., Anderson DG, Hacohen N., Regev A., Feng G., Sharp PA, et al. Cell, 2014/09/24, (2014) Read More / View Supplemental Materials
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HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials.Swerdlow, DI, Preiss D., Kuchenbaecker KB, Holmes MV, Engmann JE, Shah T., Sofat R., Stender S., Johnson PC, Scott RA, Leusink M., Verweij N., Sharp SJ, Guo Y., Giambartolomei C., Chung C., Peasey A., Amuzu A., Li K., Palmen J., et al. Lancet, 2014/09/24, (2014) Read More / View Supplemental Materials
Abstract
The Sestrins Interact with GATOR2 to Negatively Regulate the Amino-Acid-Sensing Pathway Upstream of mTORC1.Chantranupong, L., Wolfson RL, Orozco JM, Saxton RA, Scaria SM, Bar-Peled L., Spooner E., Isasa M., Gygi SP, and Sabatini DM Cell reports, 2014/09/24, (2014) Read More / View Supplemental Materials
Abstract
Small molecules facilitate rapid and synchronous iPSC generation.Bar-Nur, O., Brumbaugh J., Verheul C., Apostolou E., Pruteanu-Malinici I., Walsh RM, Ramaswamy S., and Hochedlinger K. Nature methods, 2014/09/24, (2014) Read More / View Supplemental Materials
Abstract
Exploring the genetics of irritable bowel syndrome: a GWA study in the general population and replication in multinational case-control cohorts.Ek, WE, Reznichenko A., Ripke S., Niesler B., Zucchelli M., Rivera NV, Schmidt PT, Pedersen NL, Magnusson P., Talley NJ, Holliday EG, Houghton L., Gazouli M., Karamanolis G., Rappold G., Burwinkel B., Surowy H., Rafter J., Assadi G., Li L., et al. Gut, 2014/09/23, (2014) Read More / View Supplemental Materials
Abstract
Transmembrane adaptor protein PAG/CBP is involved in both positive and negative regulation of mast cell signaling.Draberova, L., Bugajev V., Potuckova L., Halova I., Bambouskova M., Polakovicova I., Xavier RJ, Seed B., and Draber P. Molecular and cellular biology, 2014/09/22, (2014) Read More / View Supplemental Materials
Abstract
Sequence-specific antimicrobials using efficiently delivered RNA-guided nucleases.Citorik, RJ, Mimee M., and Lu TK Nature biotechnology, 2014/09/21, (2014) Read More / View Supplemental Materials
Abstract
Ancient human genomes suggest three ancestral populations for present-day Europeans.Lazaridis, I., Patterson N., Mittnik A., Renaud G., Mallick S., Kirsanow K., Sudmant PH, Schraiber JG, Castellano S., Lipson M., Berger B., Economou C., Bollongino R., Fu Q., Bos KI, Nordenfelt S., Li H., de Filippo C., Prüfer K., Sawyer S., et al. Nature, 2014/09/18, Volume 513, Issue 7518, p.409-13, (2014) Read More / View Supplemental Materials
Abstract
Genome Sequence of the Microsporidian Species Nematocida sp1 Strain ERTm6 (ATCC PRA-372).Bakowski, MA, Priest M., Young S., Cuomo CA, and Troemel ER Genome announcements, 2014/09/18, Volume 2, Issue 5, (2014) Read More / View Supplemental Materials
Abstract
Proteogenomic characterization of human colon and rectal cancer.Zhang, B., Wang J., Wang X., Zhu J., Liu Q., Shi Z., Chambers MC, Zimmerman LJ, Shaddox KF, Kim S., Davies SR, Wang S., Wang P., Kinsinger CR, Rivers RC, Rodriguez H., Townsend RR, Ellis MJ, Carr SA, Tabb DL, et al. Nature, 2014/09/18, Volume 513, Issue 7518, p.382-7, (2014) Read More / View Supplemental Materials
Abstract
Genome-wide Scan of 29,141 African Americans Finds No Evidence of Directional Selection since Admixture.Bhatia, G., Tandon A., Patterson N., Aldrich MC, Ambrosone CB, Amos C., Bandera EV, Berndt SI, Bernstein L., Blot WJ, Bock CH, Caporaso N., Casey G., Deming SL, Diver WR, Gapstur SM, Gillanders EM, Harris CC, Henderson BE, Ingles SA, et al. American journal of human genetics, 2014/09/17, (2014) Read More / View Supplemental Materials
Abstract
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