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Submitted
Synthesis, cellular evaluation and mechanism-of-action of piperlongumine analogsAdams, DJ, Dai M., Pellegrino G., Wagner BK, Stern AM, Shamji AF, and Schreiber SL, (Submitted) Read More / View Supplemental Materials
2015
Partial uracil-DNA-glycosylase treatment for screening of ancient DNA.Rohland, N., Harney E., Mallick S., Nordenfelt S., and Reich D. Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2015/01/19, Volume 370, Issue 1660, (2015) Read More / View Supplemental Materials
Abstract
Genome Engineering Using CRISPR-Cas9 System.Cong, L., and Zhang F. Methods in molecular biology (Clifton, N.J.), 2015/01/01, Volume 1239, p.197-217, (2015) Read More / View Supplemental Materials
Abstract
2014
Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma.Perry, JA, Kiezun A., Tonzi P., Van Allen EM, Carter SL, Baca SC, Cowley GS, Bhatt AS, Rheinbay E., Pedamallu CS, Helman E., Taylor-Weiner A., McKenna A., Deluca DS, Lawrence MS, Ambrogio L., Sougnez C., Sivachenko A., Walensky LD, Wagle N., et al. Proceedings of the National Academy of Sciences of the United States of America, 2014/12/15, (2014) Read More / View Supplemental Materials
Abstract
Computational Modeling Predicts IL-10 Control of Lesion Sterilization by Balancing Early Host Immunity-Mediated Antimicrobial Responses with Caseation during Mycobacterium tuberculosis Infection.Cilfone, NA, Ford CB, Marino S., Mattila JT, Gideon HP, Flynn JL, Kirschner DE, and Linderman JJ Journal of immunology (Baltimore, Md. : 1950), 2014/12/15, (2014) Read More / View Supplemental Materials
Abstract
De novo CNVs in bipolar affective disorder and schizophrenia.Georgieva, L., Rees E., Moran JL, Chambert KD, Milanova V., Craddock N., Purcell S., Sklar P., McCarroll S., Holmans P., O'Donovan MC, Owen MJ, and Kirov G. Human molecular genetics, 2014/12/15, Volume 23, Issue 24, p.6677-83, (2014) Read More / View Supplemental Materials
Abstract
Dilazep analogues for the study of equilibrative nucleoside transporters 1 and 2 (ENT1 and ENT2).Playa, H., Lewis TA, Ting A., Suh BC, Muñoz B., Matuza R., Passer BJ, Schreiber SL, and Buolamwini JK Bioorganic & medicinal chemistry letters, 2014/12/15, Volume 24, Issue 24, p.5801-4, (2014) Read More / View Supplemental Materials
Abstract
Genetic modifiers of EGFR dependence in non-small cell lung cancer.Sharifnia, T., Rusu V., Piccioni F., Bagul M., Imielinski M., Cherniack AD, Pedamallu CS, Wong B., Wilson FH, Garraway LA, Altshuler D., Golub T. R., Root DE, Subramanian A., and Meyerson M. Proceedings of the National Academy of Sciences of the United States of America, 2014/12/15, (2014) Read More / View Supplemental Materials
Abstract
Identification of nuclear hormone receptor pathways causing insulin resistance by transcriptional and epigenomic analysis.Kang, S., Tsai LT, Zhou Y., Evertts A., Xu S., Griffin MJ, Issner R., Whitton HJ, Garcia BA, Epstein CB, Mikkelsen TS, and Rosen ED Nature cell biology, 2014/12/15, (2014) Read More / View Supplemental Materials
Abstract
Pan-cancer network analysis identifies combinations of rare somatic mutations across pathways and protein complexes.Leiserson, MD, Vandin F., Wu HT, Dobson JR, Eldridge JV, Thomas JL, Papoutsaki A., Kim Y., Niu B., McLellan M., Lawrence MS, Gonzalez-Perez A., Tamborero D., Cheng Y., Ryslik GA, Lopez-Bigas N., Getz G., Ding L., and Raphael BJ Nature genetics, 2014/12/15, (2014) Read More / View Supplemental Materials
Abstract
Core and region-enriched networks of behaviorally regulated genes and the singing genome.Whitney, O., Pfenning AR, Howard JT, Blatti CA, Liu F., Ward JM, Wang R., Audet JN, Kellis M., Mukherjee S., Sinha S., Hartemink AJ, West AE, and Jarvis ED Science (New York, N.Y.), 2014/12/12, Volume 346, Issue 6215, p.1256780, (2014) Read More / View Supplemental Materials
Abstract
Familial aggregation of arthritis-related diseases in seropositive and seronegative rheumatoid arthritis: a register-based case-control study in Sweden.Frisell, T., Hellgren K., Alfredsson L., Raychaudhuri S., Klareskog L., and Askling J. Annals of the rheumatic diseases, 2014/12/12, (2014) Read More / View Supplemental Materials
Abstract
A 3D Map of the Human Genome at Kilobase Resolution Reveals Principles of Chromatin Looping.Rao, SS, Huntley MH, Durand NC, Stamenova EK, Bochkov ID, Robinson JT, Sanborn AL, Machol I., Omer AD, Lander E. S., and Aiden EL Cell, 2014/12/11, (2014) Read More / View Supplemental Materials
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Integrating phenotypic small-molecule profiling and human genetics: the next phase in drug discovery.Johannessen, CM, Clemons PA, and Wagner BK Trends in genetics : TIG, 2014/12/11, (2014) Read More / View Supplemental Materials
Abstract
Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex.Konermann, S., Brigham MD, Trevino AE, Joung J., Abudayyeh OO, Barcena C., Hsu PD, Habib N., Gootenberg JS, Nishimasu H., Nureki O., and Zhang F. Nature, 2014/12/10, (2014) Read More / View Supplemental Materials
Abstract
Genome-wide association study of kidney function decline in individuals of European descent.Gorski, M., Tin A., Garnaas M., McMahon GM, Chu AY, Tayo BO, Pattaro C., Teumer A., Chasman DI, Chalmers J., Hamet P., Tremblay J., Woodward M., Aspelund T., Eiriksdottir G., Gudnason V., Harris TB, Launer LJ, Smith AV, Mitchell BD, et al. Kidney international, 2014/12/10, (2014) Read More / View Supplemental Materials
Abstract
High-Resolution Sequencing and Modeling Identifies Distinct Dynamic RNA Regulatory Strategies.Rabani, M., Raychowdhury R., Jovanovic M., Rooney M., Stumpo DJ, Pauli A., Hacohen N., Schier AF, Blackshear PJ, Friedman N., Amit I., and Regev A. Cell, 2014/12/10, (2014) Read More / View Supplemental Materials
Abstract
Visnagin protects against doxorubicin-induced cardiomyopathy through modulation of mitochondrial malate dehydrogenase.Liu, Y., Asnani A., Zou L., Bentley VL, Yu M., Wang Y., Dellaire G., Sarkar KS, Dai M., Chen HH, Sosnovik DE, Shin JT, Haber DA, Berman JN, Chao W., and Peterson RT Science translational medicine, 2014/12/10, Volume 6, Issue 266, p.266ra170, (2014) Read More / View Supplemental Materials
Abstract
Recommendations From the International Stroke Genetics Consortium, Part 2: Biological Sample Collection and Storage.Battey, TW, Valant V., Kassis SB, Kourkoulis C., Lee C., Anderson CD, Falcone GJ, Jimenez-Conde J., Fernandez-Cadenas I., Pare G., Rundek T., James ML, Lemmens R., Lee TH, Tatlisumak T., Kittner SJ, Lindgren A., Mateen FJ, Berkowitz AL, Holliday EG, et al. Stroke; a journal of cerebral circulation, 2014/12/09, (2014) Read More / View Supplemental Materials
Locally disordered methylation forms the basis of intratumor methylome variation in chronic lymphocytic leukemia.Landau, DA, Clement K., Ziller MJ, Boyle P., Fan J., Gu H., Stevenson K., Sougnez C., Wang L., Li S., Kotliar D., Zhang W., Ghandi M., Garraway L., Fernandes SM, Livak KJ, Gabriel S., Gnirke A., Lander E. S., Brown JR, et al. Cancer cell, 2014/12/08, Volume 26, Issue 6, p.813-25, (2014) Read More / View Supplemental Materials
Abstract
Metabolomics of renal venous plasma from individuals with unilateral renal artery stenosis and essential hypertension.Rhee, EP, Clish CB, Pierce KA, Saad A., Lerman LO, and Textor SC Journal of hypertension, 2014/12/08, (2014) Read More / View Supplemental Materials
Abstract
Mutations in G protein β subunits promote transformation and kinase inhibitor resistance.Yoda, A., Adelmant G., Tamburini J., Chapuy B., Shindoh N., Yoda Y., Weigert O., Kopp N., Wu SC, Kim SS, Liu H., Tivey T., Christie AL, Elpek KG, Card J., Gritsman K., Gotlib J., Deininger MW, Makishima H., Turley SJ, et al. Nature medicine, 2014/12/08, (2014) Read More / View Supplemental Materials
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Improved Gene Tree Error-Correction in the Presence of Horizontal Gene Transfer.Bansal, MS, Wu YC, Alm EJ, and Kellis M. Bioinformatics (Oxford, England), 2014/12/05, (2014) Read More / View Supplemental Materials
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Biallelic Truncating Mutations in FMN2, Encoding the Actin-Regulatory Protein Formin 2, Cause Nonsyndromic Autosomal-Recessive Intellectual Disability.Law, R., Dixon-Salazar T., Jerber J., Cai N., Abbasi AA, Zaki MS, Mittal K., Gabriel SB, Rafiq MA, Khan V., Nguyen M., Ali G., Copeland B., Scott E., Vasli N., Mikhailov A., Khan MN, Andrade DM, Ayaz M., Ansar M., et al. American journal of human genetics, 2014/12/04, Volume 95, Issue 6, p.721-8, (2014) Read More / View Supplemental Materials
Abstract
BioAssay Research Database (BARD): chemical biology and probe-development enabled by structured metadata and result types.Howe, EA, De Souza A., Lahr DL, Chatwin S., Montgomery P., Alexander BR, Nguyen DT, Cruz Y., Stonich DA, Walzer G., Rose JT, Picard SC, Liu Z., Rose JN, Xiang X., Asiedu J., Durkin D., Levine J., Yang JJ, Schürer SC, et al. Nucleic acids research, 2014/12/04, (2014) Read More / View Supplemental Materials
Abstract
Deconstructing transcriptional heterogeneity in pluripotent stem cells.Kumar, RM, Cahan P., Shalek AK, Satija R., DaleyKeyser AJ, Li H., Zhang J., Pardee K., Gennert D., Trombetta JJ, Ferrante TC, Regev A., Daley GQ, and Collins JJ Nature, 2014/12/04, Volume 516, Issue 7529, p.56-61, (2014) Read More / View Supplemental Materials
Abstract
Smoking is associated with mosaic loss of chromosome Y.Dumanski, JP, Rasi C., Lönn M., Davies H., Ingelsson M., Giedraitis V., Lannfelt L., Magnusson PK, Lindgren CM, Morris AP, Cesarini D., Johannesson M., Tiensuu Janson E., Lind L., Pedersen NL, Ingelsson E., and Forsberg LA Science (New York, N.Y.), 2014/12/04, (2014) Read More / View Supplemental Materials
Abstract
Virtual karyotyping reveals greater chromosomal stability in neural cells derived by transdifferentiation than those from stem cells.Weissbein, U., Ben-David U., and Benvenisty N. Cell stem cell, 2014/12/04, Volume 15, Issue 6, p.687-91, (2014) Read More / View Supplemental Materials
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GB virus C co-infections in West African Ebola patients.Lauck, M., Bailey AL, Andersen KG, Goldberg TL, Sabeti PC, and O'Connor DH Journal of virology, 2014/12/03, (2014) Read More / View Supplemental Materials
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Novel loci associated with usual sleep duration: the CHARGE Consortium Genome-Wide Association Study.Gottlieb, DJ, Hek K., Chen TH, Watson NF, Eiriksdottir G., Byrne EM, Cornelis M., Warby SC, Bandinelli S., Cherkas L., Evans DS, Grabe HJ, Lahti J., Li M., Lehtimäki T., Lumley T., Marciante KD, Pérusse L., Psaty BM, Robbins J., et al. Molecular psychiatry, 2014/12/02, (2014) Read More / View Supplemental Materials
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CDK5 is a major regulator of the tumor suppressor DLC1.Tripathi, BK, Qian X., Mertins P., Wang D., Papageorge AG, Carr SA, and Lowy DR The Journal of cell biology, 2014/12/01, (2014) Read More / View Supplemental Materials
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A comparison of non-integrating reprogramming methods.Schlaeger, TM, Daheron L., Brickler TR, Entwisle S., Chan K., Cianci A., DeVine A., Ettenger A., Fitzgerald K., Godfrey M., Gupta D., McPherson J., Malwadkar P., Gupta M., Bell B., Doi A., Jung N., Li X., Lynes MS, Brookes E., et al. Nature biotechnology, 2014/12/01, (2014) Read More / View Supplemental Materials
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Genetics of immune-mediated disorders: from genome-wide association to molecular mechanism.Kumar, V., Wijmenga C., and Xavier RJ Current opinion in immunology, 2014/12/01, Volume 31C, p.51-57, (2014) Read More / View Supplemental Materials
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Genome update of the dimorphic human pathogenic fungi causing paracoccidioidomycosis.Muñoz, JF, Gallo JE, Misas E., Priest M., Imamovic A., Young S., Zeng Q., Clay OK, McEwen JG, and Cuomo CA PLoS neglected tropical diseases, 2014/12/01, Volume 8, Issue 12, p.e3348, (2014) Read More / View Supplemental Materials
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p53 prevents neurodegeneration by regulating synaptic genes.Merlo, P., Frost B., Peng S., Yang YJ, Park PJ, and Feany M. Proceedings of the National Academy of Sciences of the United States of America, 2014/12/01, (2014) Read More / View Supplemental Materials
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Probing small-molecule microarrays with tagged proteins in cell lysates.Pop, MS, Wassaf D., and Koehler AN Current protocols in chemical biology, 2014/12/01, Volume 6, Issue 4, p.209-20, (2014) Read More / View Supplemental Materials
Abstract
Stratification by Smoking Status Reveals an Association of CHRNA5-A3-B4 Genotype with Body Mass Index in Never Smokers.Taylor, AE, Morris RW, Fluharty ME, Bjorngaard JH, Asvold BO, Gabrielsen ME, Campbell A., Marioni R., Kumari M., Hällfors J., Männistö S., Marques-Vidal P., Kaakinen M., Cavadino A., Postmus I., Husemoen LL, Skaaby T., Ahluwalia TS, Treur JL, Willemsen G., et al. PLoS genetics, 2014/12/01, Volume 10, Issue 12, p.e1004799, (2014) Read More / View Supplemental Materials
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A shower of second hit events as the cause of multifocal renal cell carcinoma in Tuberous Sclerosis Complex.Tyburczy, ME, Jozwiak S., Malinowska IA, Chekaluk Y., Pugh TJ, Wu CL, Nussbaum RL, Seepo S., Dzik T., Kotulska K., and Kwiatkowski DJ Human molecular genetics, 2014/11/28, (2014) Read More / View Supplemental Materials
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Extensive introgression in a malaria vector species complex revealed by phylogenomics.Fontaine, MC, Pease JB, Steele A., Waterhouse RM, Neafsey DE, Sharakhov IV, Jiang X., Hall AB, Catteruccia F., Kakani E., Mitchell SN, Wu YC, Smith HA, Love RR, Lawniczak MK, Slotman MA, Emrich SJ, Hahn MW, and Besansky NJ Science (New York, N.Y.), 2014/11/27, (2014) Read More / View Supplemental Materials
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Regulation of Drosophila intestinal stem cell maintenance and differentiation by the transcription factor Escargot.Loza-Coll, MA, Southall TD, Sandall SL, Brand AH, and Jones DL The EMBO journal, 2014/11/27, (2014) Read More / View Supplemental Materials
Abstract
Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes.Jaiswal, S., Fontanillas P., Flannick J., Manning A., Grauman PV, Mar BG, Lindsley RC, Mermel CH, Burtt N., Chavez A., Higgins JM, Moltchanov V., Kuo FC, Kluk MJ, Henderson B., Kinnunen L., Koistinen HA, Ladenvall C., Getz G., Correa A., et al. The New England journal of medicine, 2014/11/26, (2014) Read More / View Supplemental Materials
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Association of Sickle Cell Trait With Chronic Kidney Disease and Albuminuria in African Americans.Naik, RP, Derebail VK, Grams ME, Franceschini N., Auer PL, Peloso GM, Young BA, Lettre G., Peralta CA, Katz R., Hyacinth HI, Quarells RC, Grove ML, Bick AG, Fontanillas P., Rich SS, Smith JD, Boerwinkle E., Rosamond WD, Ito K., et al. JAMA, 2014/11/26, Volume 312, Issue 20, p.2115-2125, (2014) Read More / View Supplemental Materials
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BreaKmer: detection of structural variation in targeted massively parallel sequencing data using kmers.Abo, RP, Ducar M., Garcia EP, Thorner AR, Rojas-Rudilla V., Lin L., Sholl LM, Hahn WC, Meyerson M., Lindeman NI, Van Hummelen P., and Macconaill LE Nucleic acids research, 2014/11/26, (2014) Read More / View Supplemental Materials
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Clonal Hematopoiesis and Blood-Cancer Risk Inferred from Blood DNA Sequence.Genovese, G., Kähler AK, Handsaker RE, Lindberg J., Rose SA, Bakhoum SF, Chambert K., Mick E., Neale BM, Fromer M., Purcell SM, Svantesson O., Landén M., Höglund M., Lehmann S., Gabriel SB, Moran JL, Lander E. S., Sullivan PF, Sklar P., et al. The New England journal of medicine, 2014/11/26, (2014) Read More / View Supplemental Materials
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DNA methylation signatures link prenatal famine exposure to growth and metabolism.Tobi, EW, Goeman JJ, Monajemi R., Gu H., Putter H., Zhang Y., Slieker RC, Stok AP, Thijssen PE, Müller F., van Zwet EW, Bock C., Meissner A., Lumey LH, Eline Slagboom P., and Heijmans BT Nature communications, 2014/11/26, Volume 5, p.5592, (2014) Read More / View Supplemental Materials
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Global Proteome Turnover Analyses of the Yeasts S. cerevisiae and S. pombe.Christiano, R., Nagaraj N., Fröhlich F., and Walther TC Cell reports, 2014/11/26, (2014) Read More / View Supplemental Materials
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Targeted and genome-wide sequencing reveal single nucleotide variations impacting specificity of Cas9 in human stem cells.Yang, L., Grishin D., Wang G., Aach J., Zhang CZ, Chari R., Homsy J., Cai X., Zhao Y., Fan JB, Seidman C., Seidman J., Pu W., and Church G. Nature communications, 2014/11/26, Volume 5, p.5507, (2014) Read More / View Supplemental Materials
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Functional optimization of gene clusters by combinatorial design and assembly.Smanski, MJ, Bhatia S., Zhao D., Park Y., B A Woodruff L., Giannoukos G., Ciulla D., Busby M., Calderon J., Nicol R., Gordon DB, Densmore D., and Voigt CA Nature biotechnology, 2014/11/24, (2014) Read More / View Supplemental Materials
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Measuring missing heritability: Inferring the contribution of common variants.Golan, D., Lander E. S., and Rosset S. Proceedings of the National Academy of Sciences of the United States of America, 2014/11/24, (2014) Read More / View Supplemental Materials
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Modeling pain in vitro using nociceptor neurons reprogrammed from fibroblasts.Wainger, BJ, Buttermore ED, Oliveira JT, Mellin C., Lee S., Saber WA, Wang AJ, Ichida JK, Chiu IM, Barrett L., Huebner EA, Bilgin C., Tsujimoto N., Brenneis C., Kapur K., Rubin LL, Eggan K., and Woolf CJ Nature neuroscience, 2014/11/24, (2014) Read More / View Supplemental Materials
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A Predictive Model of Bifunctional Transcription Factor Signaling during Embryonic Tissue Patterning.Junker, JP, Peterson KA, Nishi Y., Mao J., McMahon AP, and van Oudenaarden A. Developmental cell, 2014/11/24, Volume 31, Issue 4, p.448-60, (2014) Read More / View Supplemental Materials
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In vitro alterations do not reflect a requirement for host cell cycle progression during Plasmodium liver stage infection.Hanson, KK, March S., Ng S., Bhatia S., and Mota MM Eukaryotic cell, 2014/11/21, (2014) Read More / View Supplemental Materials
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A comparative encyclopedia of DNA elements in the mouse genome.Yue, F., Cheng Y., Breschi A., Vierstra J., Wu W., Ryba T., Sandstrom R., Ma Z., Davis C., Pope BD, Shen Y., Pervouchine DD, Djebali S., Thurman RE, Kaul R., Rynes E., Kirilusha A., Marinov GK, Williams BA, Trout D., et al. Nature, 2014/11/20, Volume 515, Issue 7527, p.355-64, (2014) Read More / View Supplemental Materials
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Genetic variation in human DNA replication timing.Koren, A., Handsaker RE, Kamitaki N., Karli R., Ghosh S., Polak P., Eggan K., and McCarroll SA Cell, 2014/11/20, Volume 159, Issue 5, p.1015-26, (2014) Read More / View Supplemental Materials
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iPSC-Derived Dopamine Neurons Reveal Differences between Monozygotic Twins Discordant for Parkinson's Disease.Woodard, CM, Campos BA, Kuo SH, Nirenberg MJ, Nestor MW, Zimmer M., Mosharov EV, Sulzer D., Zhou H., Paull D., Clark L., Schadt EE, Sardi SP, Rubin L., Eggan K., Brock M., Lipnick S., Rao M., Chang S., Li A., et al. Cell reports, 2014/11/20, Volume 9, Issue 4, p.1173-82, (2014) Read More / View Supplemental Materials
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A Negative Feedback Loop of Transcription Factors Specifies Alternative Dendritic Cell Chromatin States.Bornstein, C., Winter D., Barnett-Itzhaki Z., David E., Kadri S., Garber M., and Amit I. Molecular cell, 2014/11/20, (2014) Read More / View Supplemental Materials
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A role for noncoding variation in schizophrenia.Roussos, P., Mitchell AC, Voloudakis G., Fullard JF, Pothula VM, Tsang J., Stahl EA, Georgakopoulos A., Ruderfer DM, Charney A., Okada Y., Siminovitch KA, Worthington J., Padyukov L., Klareskog L., Gregersen PK, Plenge RM, Raychaudhuri S., Fromer M., Purcell SM, et al. Cell reports, 2014/11/20, Volume 9, Issue 4, p.1417-29, (2014) Read More / View Supplemental Materials
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SGK3 Mediates INPP4B-Dependent PI3K Signaling in Breast Cancer.Gasser, JA, Inuzuka H., Lau AW, Wei W., Beroukhim R., and Toker A. Molecular cell, 2014/11/20, Volume 56, Issue 4, p.595-607, (2014) Read More / View Supplemental Materials
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Functional implications of a psychiatric risk variant within CACNA1C in induced human neurons.Yoshimizu, T., Pan JQ, Mungenast AE, Madison JM, Su S., Ketterman J., Ongur D., McPhie D., Cohen B., Perlis R., and Tsai LH Molecular psychiatry, 2014/11/18, (2014) Read More / View Supplemental Materials
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Novel loci associated with usual sleep duration: the CHARGE Consortium Genome-Wide Association Study.Gottlieb, DJ, Hek K., Chen TH, Watson NF, Eiriksdottir G., Byrne EM, Cornelis M., Warby SC, Bandinelli S., Cherkas L., Evans DS, Grabe HJ, Lahti J., Li M., Lehtimäki T., Lumley T., Marciante KD, Pérusse L., Psaty BM, Robbins J., et al. Molecular psychiatry, 2014/11/18, (2014) Read More / View Supplemental Materials
The draft genome sequence of the ferret (Mustela putorius furo) facilitates study of human respiratory disease.Peng, X., Alföldi J., Gori K., Eisfeld AJ, Tyler SR, Tisoncik-Go J., Brawand D., Law GL, Skunca N., Hatta M., Gasper DJ, Kelly SM, Chang J., Thomas MJ, Johnson J., Berlin AM, Lara M., Russell P., Swofford R., Turner-Maier J., et al. Nature biotechnology, 2014/11/17, (2014) Read More / View Supplemental Materials
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Long-term persistence and development of induced pancreatic beta cells generated by lineage conversion of acinar cells.Li, W., Cavelti-Weder C., Zhang Y., Clement K., Donovan S., Gonzalez G., Zhu J., Stemann M., Xu K., Hashimoto T., Yamada T., Nakanishi M., Zhang Y., Zeng S., Gifford D., Meissner A., Weir G., and Zhou Q. Nature biotechnology, 2014/11/17, (2014) Read More / View Supplemental Materials
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Rapid neurogenesis through transcriptional activation in human stem cells.Busskamp, V., Lewis NE, Guye P., Ng AH, Shipman SL, Byrne SM, Sanjana NE, Murn J., Li Y., Li S., Stadler M., Weiss R., and Church GM Molecular systems biology, 2014/11/17, Volume 10, Issue 11, p.760, (2014) Read More / View Supplemental Materials
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A recurrent de novo mutation in KCNC1 causes progressive myoclonus epilepsy.Muona, M., Berkovic SF, Dibbens LM, Oliver KL, Maljevic S., Bayly MA, Joensuu T., Canafoglia L., Franceschetti S., Michelucci R., Markkinen S., Heron SE, Hildebrand MS, Andermann E., Andermann F., Gambardella A., Tinuper P., Licchetta L., Scheffer IE, Criscuolo C., et al. Nature genetics, 2014/11/17, (2014) Read More / View Supplemental Materials
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15 years of zebrafish chemical screening.Rennekamp, AJ, and Peterson RT Current opinion in chemical biology, 2014/11/15, Volume 24C, p.58-70, (2014) Read More / View Supplemental Materials
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Effects of sodium benzoate, a widely used food preservative, on glucose homeostasis and metabolic profiles in humans.Lennerz, BS, Vafai SB, Delaney NF, Clish CB, Deik AA, Pierce KA, Ludwig DS, and Mootha VK Molecular genetics and metabolism, 2014/11/15, (2014) Read More / View Supplemental Materials
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Mental health: depression needs large human-genetics studies.Hyman, S. Nature, 2014/11/13, Volume 515, Issue 7526, p.189-91, (2014) Read More / View Supplemental Materials
Subclonal mutations in SETBP1 confer a poor prognosis in juvenile myelomonocytic leukemia.Stieglitz, E., Troup CB, Gelston LC, Haliburton J., Chow ED, Yu KB, Akutagawa J., Taylor-Weiner AN, Liu YL, Wang YD, Beckman K., Emanuel PD, Braun BS, Abate A., Gerbing RB, Alonzo TA, and Loh M. L. Blood, 2014/11/13, (2014) Read More / View Supplemental Materials
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Synaptic, transcriptional and chromatin genes disrupted in autism.De Rubeis, S., He X., Goldberg AP, Poultney CS, Samocha K., Ercument Cicek A., Kou Y., Liu L., Fromer M., Walker S., Singh T., Klei L., Kosmicki J., Fu SC, Aleksic B., Biscaldi M., Bolton PF, Brownfeld JM, Cai J., Campbell NG, et al. Nature, 2014/11/13, Volume 515, Issue 7526, p.209-15, (2014) Read More / View Supplemental Materials
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Unencapsulated Streptococcus pneumoniae from conjunctivitis encode variant traits and belong to a distinct phylogenetic cluster.Valentino, MD, McGuire AM, Rosch JW, Bispo PJ, Burnham C., Sanfilippo CM, Carter RA, Zegans ME, Beall B., Earl AM, Tuomanen EI, Morris TW, Haas W., and Gilmore MS Nature communications, 2014/11/12, Volume 5, p.5411, (2014) Read More / View Supplemental Materials
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FASTKD2 is associated with memory and hippocampal structure in older adults.Ramanan, VK, Nho K., Shen L., Risacher SL, Kim S., McDonald BC, Farlow MR, Foroud TM, Gao S., Soininen H., Kłoszewska I., Mecocci P., Tsolaki M., Vellas B., Lovestone S., Aisen PS, Petersen RC, Jack CR Jr, Shaw LM, Trojanowski JQ, et al. Molecular psychiatry, 2014/11/11, (2014) Read More / View Supplemental Materials
Abstract
EWS-FLI1 Utilizes Divergent Chromatin Remodeling Mechanisms to Directly Activate or Repress Enhancer Elements in Ewing Sarcoma.Riggi, N., Knoechel B., Gillespie SM, Rheinbay E., Boulay G., Suvà ML, Rossetti NE, Boonseng WE, Oksuz O., Cook EB, Formey A., Patel A., Gymrek M., Thapar V., Deshpande V., Ting DT, Hornicek FJ, Nielsen GP, Stamenkovic I., Aryee MJ, et al. Cancer cell, 2014/11/10, Volume 26, Issue 5, p.668-81, (2014) Read More / View Supplemental Materials
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Leveraging population admixture to characterize the heritability of complex traits.Zaitlen, N., Pasaniuc B., Sankararaman S., Bhatia G., Zhang J., Gusev A., Young T., Tandon A., Pollack S., Vilhjálmsson BJ, Assimes TL, Berndt SI, Blot WJ, Chanock S., Franceschini N., Goodman PG, He J., Hennis AJ, Hsing A., Ingles SA, et al. Nature genetics, 2014/11/10, (2014) Read More / View Supplemental Materials
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Variation at HLA-DRB1 is associated with resistance to enteric fever.Dunstan, SJ, Hue NT, Han B., Li Z., Tram TT, Sim KS, Parry CM, Chinh NT, Vinh H., Lan NP, Thieu NT, Vinh PV, Koirala S., Dongol S., Arjyal A., Karkey A., Shilpakar O., Dolecek C., Foo JN, Phuong LT, et al. Nature genetics, 2014/11/10, (2014) Read More / View Supplemental Materials
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Genome-Level Determination of Plasmodium falciparum Blood Stage Targets of Malarial Clinical Immunity in the Peruvian Amazon.Torres, KJ, Castrillon CE, Moss EL, Saito M., Tenorio R., Molina DM, Davies H., Neafsey DE, Felgner P., Vinetz JM, and Gamboa D. The Journal of infectious diseases, 2014/11/07, (2014) Read More / View Supplemental Materials
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Magnetic resonance detection of individual proton spins using quantum reporters.Sushkov, AO, Lovchinsky I., Chisholm N., Walsworth RL, Park H., and Lukin MD Physical review letters, 2014/11/07, Volume 113, Issue 19, p.197601, (2014) Read More / View Supplemental Materials
Abstract
Building the Connectivity Map of epigenetics: Chromatin profiling by quantitative targeted mass spectrometry.Creech, AL, Taylor JE, Maier VK, Wu X., Feeney CM, Udeshi ND, Peach SE, Boehm JS, Lee JT, Carr SA, and Jaffe JD Methods (San Diego, Calif.), 2014/11/06, (2014) Read More / View Supplemental Materials
Abstract
Changes in Nucleosome Occupancy Associated with Metabolic Alterations in Aged Mammalian Liver.Bochkis, IM, Przybylski D., Chen J., and Regev A. Cell reports, 2014/11/06, Volume 9, Issue 3, p.996-1006, (2014) Read More / View Supplemental Materials
Abstract
Controlling the survival of human pluripotent stem cells by small molecule-based targeting of topoisomerase II alpha.Ben-David, U., Cowell IG, Austin CA, and Benvenisty N. Stem cells (Dayton, Ohio), 2014/11/06, (2014) Read More / View Supplemental Materials
Abstract
A Novel Test for Recessive Contributions to Complex Diseases Implicates Bardet-Biedl Syndrome Gene BBS10 in Idiopathic Type 2 Diabetes and Obesity.Lim, ET, Liu YP, Chan Y., Tiinamaija T., Käräjämäki A., Madsen E., Go-T2D Consortium, Altshuler DM, Raychaudhuri S., Groop L., Flannick J., Hirschhorn JN, Katsanis N., and Daly M. J. American journal of human genetics, 2014/11/06, Volume 95, Issue 5, p.509-20, (2014) Read More / View Supplemental Materials
Abstract
Partitioning Heritability of Regulatory and Cell-Type-Specific Variants across 11 Common Diseases.Gusev, A., Lee SH, Trynka G., Finucane H., Vilhjálmsson BJ, Xu H., Zang C., Ripke S., Bulik-Sullivan B., Stahl E., Schizophrenia Working Group of the Psychiatric Genomics Consortium, SWE-SCZ Consortium, Kähler AK, Hultman CM, Purcell SM, McCarroll SA, Daly M., Pasaniuc B., Sullivan PF, Neale BM, et al. American journal of human genetics, 2014/11/06, Volume 95, Issue 5, p.535-52, (2014) Read More / View Supplemental Materials
Abstract
Association of Low-Density Lipoprotein Cholesterol-Related Genetic Variants With Aortic Valve Calcium and Incident Aortic Stenosis.Smith, JG, Luk K., Schulz CA, Engert JC, Do R., Hindy G., Rukh G., Dufresne L., Almgren P., Owens DS, Harris TB, Peloso GM, Kerr KF, Wong Q., Smith AV, Budoff MJ, Rotter JI, Cupples LA, Rich S., Kathiresan S., et al. JAMA, 2014/11/05, Volume 312, Issue 17, p.1764-1771, (2014) Read More / View Supplemental Materials
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Improving and Accelerating Drug Development for Nervous System Disorders.Pankevich, DE, Altevogt BM, Dunlop J., Gage FH, and Hyman SE Neuron, 2014/11/05, Volume 84, Issue 3, p.546-553, (2014) Read More / View Supplemental Materials
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Medicines for the Mind: Policy-Based "Pull" Incentives for Creating Breakthrough CNS Drugs.Choi, DW, Armitage R., Brady LS, Coetzee T., Fisher W., Hyman S., Pande A., Paul S., Potter W., Roin B., and Sherer T. Neuron, 2014/11/05, Volume 84, Issue 3, p.554-563, (2014) Read More / View Supplemental Materials
Abstract
No evidence for rare recessive and compound heterozygous disruptive variants in schizophrenia.Ruderfer, DM, Lim ET, Genovese G., Moran JL, Hultman CM, Sullivan PF, McCarroll SA, Holmans P., Sklar P., and Purcell SM European journal of human genetics : EJHG, 2014/11/05, (2014) Read More / View Supplemental Materials
Abstract
Optimization of transcription factor binding map accuracy utilizing knockout-mouse models.Krebs, W., Schmidt SV, Goren A., De Nardo D., Labzin L., Bovier A., Ulas T., Theis H., Kraut M., Latz E., Beyer M., and Schultze JL Nucleic acids research, 2014/11/05, (2014) Read More / View Supplemental Materials
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Determining Microbial Products and Identifying Molecular Targets in the Human Microbiome.Joice, R., Yasuda K., Shafquat A., Morgan XC, and Huttenhower C. Cell metabolism, 2014/11/04, Volume 20, Issue 5, p.731-741, (2014) Read More / View Supplemental Materials
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Evolution of invasion in a diverse set of fusobacterium species.Manson McGuire, A., Cochrane K., Griggs AD, Haas BJ, Abeel T., Zeng Q., Nice JB, MacDonald H., Birren BW, Berger BW, Allen-Vercoe E., and Earl AM mBio, 2014/11/04, Volume 5, Issue 6, (2014) Read More / View Supplemental Materials
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Molecular profiling of endometrial carcinoma precursor, primary and metastatic lesions suggests different targets for treatment in obese compared to non-obese patients.Berg, A., Hoivik EA, Mjøs S., Holst F., Werner HM, Tangen IL, Taylor-Weiner A., Gibson WJ, Kusonmano K., Wik E., Trovik J., Halle MK, Oyan AM, Kalland KH, Cherniack AD, Beroukhim R., Stefansson I., Mills GB, Krakstad C., and Salvesen HB Oncotarget, 2014/11/04, (2014) Read More / View Supplemental Materials
Abstract
Association of Brain DNA Methylation in SORL1, ABCA7, HLA-DRB5, SLC24A4, and BIN1 With Pathological Diagnosis of Alzheimer Disease.Yu, L., Chibnik LB, Srivastava GP, Pochet N., Yang J., Xu J., Kozubek J., Obholzer N., Leurgans SE, Schneider JA, Meissner A., De Jager PL, and Bennett DA JAMA neurology, 2014/11/03, (2014) Read More / View Supplemental Materials
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Immune characterization of P. falciparum parasites with a shared genetic signature in a region of decreasing transmission.Bei, AK, Diouf A., Miura K., Larremore DB, Ribacke U., Tullo G., Moss EL, Neafsey DE, Daniels RF, Zeituni AE, Nosamiefan I., Volkman SK, Ahouidi AD, Ndiaye D., Dieye T., Mboup S., Buckee CO, Long CA, and Wirth DF Infection and immunity, 2014/11/03, (2014) Read More / View Supplemental Materials
Abstract
Pathways targeted by anti-diabetes drugs are enriched for multiple genes associated with type 2 diabetes risk.Segrè, AV, Wei N., DIAGRAM Consortium, investigators MAGIC, Altshuler D., and Florez JC Diabetes, 2014/11/03, (2014) Read More / View Supplemental Materials
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Coverage recommendations for methylation analysis by whole-genome bisulfite sequencing.Ziller, MJ, Hansen KD, Meissner A., and Aryee MJ Nature methods, 2014/11/02, (2014) Read More / View Supplemental Materials
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24-hour rhythms of DNA methylation and their relation with rhythms of RNA expression in the human dorsolateral prefrontal cortex.Lim, AS, Srivastava GP, Yu L., Chibnik LB, Xu J., Buchman AS, Schneider JA, Myers AJ, Bennett DA, and De Jager PL PLoS genetics, 2014/11/01, Volume 10, Issue 11, p.e1004792, (2014) Read More / View Supplemental Materials
Abstract
Gray matter myelination of 1555 human brains using partial volume corrected MRI images.Shafee, R., Buckner RL, and Fischl B. NeuroImage, 2014/11/01, (2014) Read More / View Supplemental Materials
Abstract
Utilizing diversity-oriented synthesis in antimicrobial drug discovery.Comer, E., Duvall JR, and duPont Lee M 4th Future medicinal chemistry, 2014/11/01, Volume 6, Issue 17, p.1927-42, (2014) Read More / View Supplemental Materials
Abstract
Cell type-specific plasticity of striatal projection neurons in parkinsonism and L-DOPA-induced dyskinesia.Fieblinger, T., Graves SM, Sebel LE, Alcacer C., Plotkin JL, Gertler TS, Chan CS, Heiman M., Greengard P., Cenci MA, and Surmeier DJ Nature communications, 2014/10/31, Volume 5, p.5316, (2014) Read More / View Supplemental Materials
Abstract
Wildlife disease. Recent introduction of a chytrid fungus endangers Western Palearctic salamanders.Martel, A., Blooi M., Adriaensen C., Van Rooij P., Beukema W., Fisher MC, Farrer RA, Schmidt BR, Tobler U., Goka K., Lips KR, Muletz C., Zamudio KR, Bosch J., Lötters S., Wombwell E., Garner TW, Cunningham AA, Spitzen-van der Sluijs A., Salvidio S., et al. Science (New York, N.Y.), 2014/10/31, Volume 346, Issue 6209, p.630-1, (2014) Read More / View Supplemental Materials
Abstract
Genetic and epigenetic fine mapping of causal autoimmune disease variants.Farh, KK, Marson A., Zhu J., Kleinewietfeld M., Housley WJ, Beik S., Shoresh N., Whitton H., Ryan RJ, Shishkin AA, Hatan M., Carrasco-Alfonso MJ, Mayer D., Luckey CJ, Patsopoulos NA, De Jager PL, Kuchroo VK, Epstein CB, Daly M. J., Hafler DA, et al. Nature, 2014/10/29, (2014) Read More / View Supplemental Materials
Abstract
Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis.Benyamin, B., Esko T., Ried JS, Radhakrishnan A., Vermeulen SH, Traglia M., Gögele M., Anderson D., Broer L., Podmore C., Luan J., Kutalik Z., Sanna S., van der Meer P., Tanaka T., Wang F., Westra HJ, Franke L., Mihailov E., Milani L., et al. Nature communications, 2014/10/29, Volume 5, p.4926, (2014) Read More / View Supplemental Materials
Abstract
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