Welcome to the Jaffe Lab
Cells do stuff when they are stimulated! We are interested in the internal information architecture of cells that allows them to respond to these stimuli. This includes the determination of the scaffolds of protein-protein interactions in cells, the tracing of phosphosignaling routes, and the observation of resulting changes in the epigenome as mediated by these stimuli. We conduct these studies using high-throughput proteomics techniques with an emphasis on reproducibly detecting and quantifying proteins and their modified forms across large numbers of biologically diverse samples, especially in response to challenges by drugs or genetic perturbations. Computational integration of these proteomic data with alternate data streams allows us to map the information architecture inside of cells.
Experimental (Wet) Side
High quality, reproducible data is the backbone of any experiment.
Computational (Dry) Side
A genomic outlook on proteomic data.