2011 Research Highlights
Flor De La Cruz, a sophomore at the Massachusetts Institute of Technology majoring in Chemical Engineering, developed an enzymatic assay to screen for small-molecule activators of glucokinase.
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Alexandra M. de Paz, a senior at the University of Florida majoring in interdisciplinary biomolecular engineering, worked on mapping the DISC1/GSK3β interaction to develop novel chemical probes for GSK3β inhibition as a potential treatment for schizophrenia.
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David Rodriguez Fuentes, a junior majoring in chemical-biological engineering at the Massachusetts Institute of Technology, characterized models of cancer cachexia in terms of their relevance to the pathophysiology of the disease.
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Aurian García-González, a senior at the University of Puerto Rico, Río Piedras majoring in cellular and molecular biology and minoring in math, studied the evolution of regulatory elements involved in the osmotic stress response of seven ascomycete yeasts.
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Nathan Kipniss, a sophomore at the Massachusetts Institute of Technology studying Biological Engineering, studied genes associated with the Hermansky-Pudlak Syndrome for their role in influenza virus entry.
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Wilhemina Koomson, Wilhemina Koomson, a sophomore at Princeton University majoring in molecular biology and neuroscience, quantified β-catenin levels by GSK-3β inhibition in HEK293T cells using ELISA.
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Alessa Moscoso, a rising sophomore at Harvard University concentrating in biomedical engineering, global health and health policy, analyzed exome sequencing to discover Mendelian dyslipidemias in six Dutch families with extreme lipid phenotypes.
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Melony Ochieng, a senior at North Carolina Central University, majoring in pharmaceutical sciences and chemistry, developed a diastereoselective, intramolecular oxa-Michael reaction as a new method to synthesize morpholine-derived fragments.
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Joyce Ohiri, a sophomore at the University of Maryland, Baltimore County, double majoring in biology and interdisciplinary studies-bioethics, worked on targeting ERG in prostate cancer.
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James R. Ortega, a senior from Florida International University, majoring in biological sciences and minoring in chemistry, studied the relationship between gene expression and compound sensitivity in cancer cell lines.
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Javier Pineda, a junior at the University of Notre Dame double majoring in chemistry and theology, designed potential inhibitors of the DOT1L methyltransferase via structure-based optimization of the S-adenosyl methionine cofactor.
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Muska Hassan (ICBP), a junior at University of Massachusetts Amherst majoring in biology, studied the signaling pathways of mutant melanoma that modify sensitivity to PLX4720 in B-RAFV600E mutation.
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