News from the Broad

The Broad Institute is committed to open sharing not only of its scientific data and tools, but also information and news about our progress towards achieving our mission. Below are just a few highlights from the Broad scientific community.
  • Study finds no evidence that natural selection has been less effective removing deleterious mutations in Europeans than in West Africans

    January 17th, 2015

    In a recent study published online by Nature Genetics, Broad-affiliated researchers Ron Do, Daniel Balick, Heng Li, Shamil Sunyaev, and David Reich challenged the theory that natural selection has been less effective removing deleterious genetic mutations in non-Africans versus West Africans over the course of human evolution. The team used simulations to show that observed mutation patterns that have been interpreted as evidence supporting the theory are not likely to reflect changes in the effectiveness of selection after the populations diverged, but are instead likely to be driven by other factors of population genetics.

  • Survey shows how tumor types induce and adapt to immune responses

    January 16th, 2015

    Contrary to popular belief, tumors don’t develop undisturbed. They undergo almost constant immune attack — which, as a result, changes their mutational composition. But just how this immune response is initiated and its effect on different tumor types has remained largely unexplored…until now. For the first time, a team of researchers from the Broad — including Mike Rooney, Sachet Shukla, Cathy Wu, Gad Getz, and Nir Hacohen — has performed a systematic survey of how 18 different tumor types induce and adapt to immune responses. Read all about it in Cell.

  • Broad researchers named to Forbes’ “30 Under 30” list

    January 14th, 2015

    For the third consecutive year, Broad Institute researchers have been named to Forbes’ “30 Under 30” list. Among the “young game changers, movers and makers” celebrated for their work in the healthcare field was Alex Bick. Bick, who is also a graduate student at Harvard Medical School, was recognized for his research analyzing genetic data to study disease risk and drug response. In this year’s science category, Patrick Hsu, a scientist from the lab of Broad core member Feng Zhang, was lauded for his work with the CRISPR-Cas9 genome-engineering tool, while Eran Hodis, a graduate student in the Harvard-MIT Division of Health Sciences and Technology, was honored for his role in the discovery of genetic mutations common in cancer.

  • Scientists map the human loop-ome, revealing a new form of genetic regulation

    December 11th, 2014
    Researchers describe the results of a five-year effort to map, in unprecedented detail, how the 2-meter long human genome folds inside the nucleus of a cell.
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  • Disorder in gene-control system is a defining characteristic of cancer, study finds

    December 11th, 2014
    The genetic tumult within cancerous tumors is more than matched by the disorder in one of the mechanisms for switching cells’ genes on and off, scientists at Dana-Farber Cancer Institute and the Broad Institute of MIT and Harvard report in a new study.
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