News from the Broad

The Broad Institute is committed to open sharing not only of its scientific data and tools, but also information and news about our progress towards achieving our mission. Below are just a few highlights from the Broad scientific community.
  • Broad, Harvard researchers unveil DeCoN, a new resource for neuron transcriptome data

    January 26th, 2015

    Recently in the journal Neuron, researchers reported on a new, high-throughput experimental method that, combined with massively parallel RNA sequencing and robust systems-level analyses, was used to characterize the transcriptome of three neuron populations in the neocortex. The team, which was led by researchers from the Broad Institute and Harvard University’s Department of Stem Cell and Regenerative Biology, have made this transcriptome data available in an intuitive, web-based resource called DeCoN.

  • Researchers find signaling pathway responsible for the generation of slowly proliferating cancer cells

    January 23rd, 2015

    Broad Institute associate member Sridhar Ramaswamy led a study that identified a signaling pathway responsible for the generation of slowly proliferating cancer cells. Because they reproduce at a different rate than other cells that are targeted for treatment, these cancer cells can be hard to eradicate and difficult to detect, and they are thought to be a cause of disease relapse. You can read the study in Molecular Cancer Research, or learn more in the press release from the American Association for Cancer Research.

  • New in vivo method overcomes obstacles to studying CD8+ T cell differentiation

    January 22nd, 2015

    CD8+ T cell differentiation into effector and memory T cells is critical for tumor immunity, pathogen response, and vaccine effectiveness, but to date researchers have not been able to use standard methods to study the factors involved in the process without first extensively manipulating naive T cells ex vivo, making the biology difficult to understand. Broad researchers Nick Haining, Glenn Cowley, David Root, Arlene Sharpe, and colleagues, including first author Jernej Godec of Dana-Farber Cancer Institute, describe overcoming this obstacle in a recent PNAS paper.

  • Researchers find that certain RNA-binding proteins play regulatory role in cancer

    January 20th, 2015

    Christopher Burge and Yarden Katz of the Broad and MIT were co-senior author and co-first author respectively of a recent eLife paper that was featured in Science magazine’s “Science in Other Journals” section. Their team found that Musashi proteins, a family of RNA-binding proteins, play a role in regulating cell state transitions in cancer – particularly in an aggressive form of breast cancer. The study was also covered in MIT News.

  • Study identifies biological mechanisms for schizophrenia, bipolar disorder and depression

    January 20th, 2015
    New research has found that common psychiatric disorders such as schizophrenia, bipolar disorder and major depression share genetic risk factors related to immune function and DNA regulation
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