News from the Broad

The Broad Institute is committed to open sharing not only of its scientific data and tools, but also information and news about our progress towards achieving our mission. Below are just a few highlights from the Broad scientific community.
  • New analytical method helps in building largest cancer cell line sensitivity dataset to date

    October 29th, 2015

    Small-molecule-sensitivity profiling of cancer cell lines (CCLs) has emerged as an approach to illuminate the mechanism of action of compounds and to launch the early stage of the discovery of new precision therapies. In a study in Cancer Discovery, a team of scientists from Broad Institute's Center for the Science of Therapeutics — led by researchers Stuart Schreiber, Paul Clemons, and Alykhan Shamji — presents the largest CCL sensitivity dataset to date, and an exciting new analysis method, termed “annotated cluster multi-dimensional enrichment” (ACME), integrating information from multiple CCLs and small molecules.

  • Team studies biology of IBD gene CARD9 by examining protective allele

    October 27th, 2015

    The gene CARD9 codes for a central component of the innate anti-fungal immune response and has recently been associated with risk for several immune-related disorders, including inflammatory bowel disease (IBD). New research from the lab of Broad institute member Ramnik Xavier looks to a rare CARD9 variant, which is strongly protective against IBD, to uncover the basic biology of the gene as well as its regulation. The paper, published this week in Immunity, also offers a potential mechanism for the protective allele.

  • Study finds that antibiotics’ effects on cell metabolism contribute to bacterial demise

    October 22nd, 2015

    Historically, most research on newly identified antibiotics has focused on how they work on their direct targets, but new, high-powered technologies have made it possible to examine their effects system-wide. In a study published this week by Cell Reports, a team led by senior author Jim Collins (of the Broad Institute, MIT, and Harvard University's Wyss Institute) and first author Peter Belenky (of Brown University) observed the metabolome of Escherichia coli (E.

  • International team characterizes three potential alternatives to Cas9

    October 22nd, 2015
    New Cas enzymes shed light on evolution of CRISPR-Cas systems; points the way towards rational design of future genome editing tools
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  • Genomic study sheds light on protective effects of malaria vaccine candidate

    October 21st, 2015
    Evidence of allele-specificity helps explain partial protection of RTS,S/AS01
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