News from the Broad

The Broad Institute is committed to open sharing not only of its scientific data and tools, but also information and news about our progress towards achieving our mission. Below are just a few highlights from the Broad scientific community.
  • Feng Zhang receives 2016 Canada Gairdner International Award

    March 22nd, 2016
    Broad/MIT scientist among five honored as pioneers of CRISPR-Cas9 system
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  • Researchers publish system-wide analysis of T-cell response in zebrafish

    March 15th, 2016

    A study led by Francisco Quintana of Brigham and Women’s Hospital and the Broad Institute used zebrafish as a model to examine T-cell receptors (TCRs) and their response to foreign and native antigens. The team found that a general pool of “public” TCRs capable of dealing with diverse antigen threats dominate the T-cell response in zebrafish. It’s possible that these TCR “first-responders” buy time, giving the immune system a short window during which it can develop more specialized, “private” TCRs. 

  • Toward a complete genetic picture of heart disease

    March 3rd, 2016
    Broad researchers implicate two more genes in the lipoprotein lipase pathway and provide robust evidence that lowering triglyceride levels through this pathway can lower the risk of coronary artery disease
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  • Research uncovers widespread evidence that RNA interactions play role in regulating chromatin states

    March 1st, 2016

    Recent evidence has suggested that interaction with RNA can regulate the activity and localization of chromatin-associated proteins, but it’s not known whether this is a widespread mechanism underlying chromatin states and gene regulation. As part of the ENCODE initiative, researchers from Harvard University and the Broad Institute used a scalable protocol for cataloguing RNA–protein interactions—including those on and around chromatin—to uncover many examples of RNA binding that suggest that RNA does indeed play an important roles in creating and/or maintaining chromatin states. The data provide a powerful, novel resource that can help dissect the interplay of RNA and epigenetic regulation across diverse chromatin regulatory complexes.

  • Illuminating the broad spectrum of disease

    February 29th, 2016
    PRISM efficiently tests drug compounds in multiple cell lines simultaneously, accelerating discovery of targeted therapies in the service of precision medicine
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