News from the Broad

The Broad Institute is committed to open sharing not only of its scientific data and tools, but also information and news about our progress towards achieving our mission. Below are just a few highlights from the Broad scientific community.
  • What our gut tells us about the ‘hygiene hypothesis’

    April 27th, 2016
    Study of infants from three European countries reveals connection between microbiome, autoimmune disease
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  • Resisting resistance in tuberculosis

    April 13th, 2016
    Antibiotics do patients no good if the pathogen being targeted is resistant to them. When it comes to tuberculosis, avoiding treatments destined to fail can be lifesaving.
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  • Hunt for noncoding mutations reveals insights into development of red blood cells

    April 12th, 2016

    Chasing mutations in the coding regions of genes associated with disease is one thing; chasing noncoding or regulatory mutations is another. For a study published last week in the Proceedings of the National Academy of Sciences, a team led by Vijay Sankaran, Aoi Wakabayashi, and Jacob Ulirsch of Boston Children’s Hospital, Dana-Farber Cancer Institute, and Broad Institute used CRISPR genome editing to probe rare mutations — all in noncoding DNA — linked to three red blood cell diseases. Their findings reveal new insights into the intricate dance of transcription factors involved in red blood cell development, and provide a framework for studying the functional changes wrought by mutations in noncoding stretches of the genome.

  • Taking on melanoma, one cell at a time

    April 7th, 2016
    In step toward personalized medicine, researchers are using single-cell analysis to unravel cancer’s secrets
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  • Breaking leukemia's rhythm

    April 7th, 2016
    New study finds link between circadian rhythms, AML
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