News from the Broad

The Broad Institute is committed to open sharing not only of its scientific data and tools, but also information and news about our progress towards achieving our mission. Below are just a few highlights from the Broad scientific community.
  • TCGA releases comprehensive genomic characterization of head and neck squamous cell carcinomas

    February 3rd, 2015

    Head and neck squamous cell carcinomas (HNSCCs) affect over 600,000 people annually around the world, many attributable to smoking or human papillomavirus infection. In order to understand the somatic gene mutations and copy number alterations present in these cancers, Broad researchers Andrew Cherniack, Peter Hammerman, Juok Cho, and colleagues as part of The Cancer Genome Atlas Network, profiled 279 HNSCCs. The studies, published in Nature, identified a number of shared and unique sequence alterations that could be further investigated with the goal of preventing and treating these cancers.

  • Variety show

    January 31st, 2015
    New techniques reveal “extreme” gene copy range
    Read Full Story
  • A new tool to DEPICT and predict

    January 29th, 2015

    Finding the causal genes at disease- and trait-associated loci is key to revealing biological insights from genome-wide association studies.

  • Broad, Harvard researchers unveil DeCoN, a new resource for neuron transcriptome data

    January 26th, 2015

    Recently in the journal Neuron, researchers reported on a new, high-throughput experimental method that, combined with massively parallel RNA sequencing and robust systems-level analyses, was used to characterize the transcriptome of three neuron populations in the neocortex. The team, which was led by researchers from the Broad Institute and Harvard University’s Department of Stem Cell and Regenerative Biology, have made this transcriptome data available in an intuitive, web-based resource called DeCoN.

  • Researchers find signaling pathway responsible for the generation of slowly proliferating cancer cells

    January 23rd, 2015

    Broad Institute associate member Sridhar Ramaswamy led a study that identified a signaling pathway responsible for the generation of slowly proliferating cancer cells. Because they reproduce at a different rate than other cells that are targeted for treatment, these cancer cells can be hard to eradicate and difficult to detect, and they are thought to be a cause of disease relapse. You can read the study in Molecular Cancer Research, or learn more in the press release from the American Association for Cancer Research.