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Collaboration aims to discover and validate new therapeutic targets and develop novel therapies for inflammatory bowel disease (IBD), a chronic disorder that affects millions worldwide. Image courtesy of Janet Iwasa and Bang Wong
Within an individual patient with multiple myeloma, a single tumor can harbor cells equipped with different mutations or combinations of mutations. These are known as subclonal populations (represented here as different colored cells). Image by Lauren Solomon, Broad Communications/iStockphoto.
Magnification of a cervical adenosquamous carcinoma. Copyright © 2010 by Nephron. Permission to copy, distribute and modify this image has been granted under the terms of the Creative Commons Attribution-Share Alike 3.0 Unported license.
The above map shows relative rates of type 2 diabetes in countries in the Americas. By studying Mexican and Latin American populations, the SIGMA Type 2 Diabetes Consortium uncovered a new genetic risk factor for type 2 diabetes that could account for as much as 20 percent of the populations’ increased prevalence of type 2 diabetes — the origins of which are not well understood. Image adapted by Lauren Solomon, Broad Communications, from International Diabetes Federation (http://www.idf.org/atlasmap/atlasmap)
The CRISPR-Cas9 system causes a precise double strand break in DNA, which leads to a gene being turned off. Researchers have scaled up to turn off genes accurately and efficiently at a genomic scale instead of just one or a few genes at a time. Composite image by Lauren Solomon, Broad Communications. Scissors © iStockphoto.com/ewg3D. Double helix © Can Stock Photo Inc./lhfgraphics.