News from the Broad

The Broad Institute is committed to open sharing not only of its scientific data and tools, but also information and news about our progress towards achieving our mission. Below are just a few highlights from the Broad scientific community.
  • New methods for leveraging large cohort studies

    February 7th, 2015

    This week, Nature Genetics included papers on two new methods for leveraging large cohort studies. One paper — from the Broad’s Program in Medical and Population Genetics (MPG) and Stanley Center for Psychiatric Research, along with a team of collaborators — shares a powerful new approach for controlling inflation in genome-wide association studies (GWAS). The other — also with contributions from MPG — describes a technique that vastly increases computation speed while simultaneously increasing the statistical power of large data sets.

  • Researchers describe chemical screen for small molecules that overcome stroma-induced drug resistance in multiple myeloma cells

    February 6th, 2015

    Overcoming mechanisms of drug resistance is an ongoing obstacle in developing successful cancer therapeutics. In Cell Reports, researchers from the Broad's Center for the Development of Therapeutics and colleagues describe using multiple myeloma-stroma cell co-cultures to screen for small molecules that overcome stroma-induced drug resistance; notably, they identified a compound that uniquely interacts with a microtubule-bound mitotic protein highly expressed in multiple myeloma cells compared with normal blood cells. These finding illustrate how chemical biology can complement genetics to advance therapeutics discovery.

  • Researchers find link between microbiome, type 1 diabetes

    February 5th, 2015
    Large longitudinal study sees shift in microbiome species diversity prior to onset of disease Updated: February 23, 2015
    Read Full Story
  • GINA, genetic discrimination, and genomic medicine

    February 4th, 2015

    In a New England Journal of Medicine perspective piece, Broad associate member Robert Green and co-authors examine the legacy of the 2008 Genetic Information Nondiscrimination Act (GINA). They note that, while few cases of genetic discrimination have ever been documented, pervasive fears persist about how personal genomic data may be used. This fear, they argue, may be hindering participation in genomic research. A story on their perspective piece can also be found on the Harvard Medical School website.

  • TCGA releases comprehensive genomic characterization of head and neck squamous cell carcinomas

    February 3rd, 2015

    Head and neck squamous cell carcinomas (HNSCCs) affect over 600,000 people annually around the world, many attributable to smoking or human papillomavirus infection. In order to understand the somatic gene mutations and copy number alterations present in these cancers, Broad researchers Andrew Cherniack, Peter Hammerman, Juok Cho, and colleagues as part of The Cancer Genome Atlas Network, profiled 279 HNSCCs. The studies, published in Nature, identified a number of shared and unique sequence alterations that could be further investigated with the goal of preventing and treating these cancers.