News from the Broad

The Broad Institute is committed to open sharing not only of its scientific data and tools, but also information and news about our progress towards achieving our mission. Below are just a few highlights from the Broad scientific community.
  • New MCL1 protein construct solves previously intractable structural biology problem

    May 4th, 2015

    As one of the most commonly altered genes in cancer, MCL1 has been the focus of widespread drug development efforts — but the gene, which encodes a protein that helps keep cells alive, remains an elusive target. A new finding published this week by Broad researchers is expected to catalyze the development of effective MCL1 inhibitors. The team, led by senior author Michael Serrano-Wu, designed a new MCL1 protein construct that provides a robust solution to a previously intractable structural biology problem. Their paper is published online in PLoS One.

  • Better data for the bedside: Broad sequencing gets closer to the clinic

    May 1st, 2015
    CRSP appoints a new clinical director and aims to increase the impact of clinical sequencing services
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  • Study identifies mechanism by which hydroxamate-based HDAC inhibitors protect neurons from oxidative stress

    April 30th, 2015

    The development of histone deacetylase inhibitors to treat a variety of diseases has been somewhat hampered by HDAC-related toxicity concerns. A team from the Stanley Center for Psychiatric Research at Broad Institute, led by the Center’s director of medicinal chemistry Ed Holson and Broad postdoctoral associate David Olson, has discovered a new HDAC-independent mechanism by which some hydroxamate-based HDAC inhibitors protect neurons from oxidative stress, such as during stroke.

  • Fine mapping of MHC region leads to identification of new genetic risk factors for celiac disease

    April 29th, 2015

    In a study published online last week in Nature Genetics, a team led by Broad visiting scientist Paul de Bakker of University Medical Center Utrecht fine mapped the major histocompatibility complex (MHC) – a linked set of genetic loci known to influence the development of celiac disease. The team’s approach turned up five new associated genetic variants that together account for roughly 18% of the genetic risk for the disease. Combined with previously identified risk factors, these genetic loci can now explain up to 48% of celiac disease heritability.

  • Study investigates biological pathways involved in inflammatory response to stress

    April 22nd, 2015

    A recent paper by Broad associate member Gökhan Hotamisligil, first author Takahisa Nakamura of Harvard T.H. Chan School of Public Health and Cincinnati Children’s Hospital Medical Center, and colleagues identifies components of a pathway— including a complex between double-stranded RNA-dependent kinase (PKR) and TAR RNA-binding protein (TRBP)—that integrates metabolic cues, stress signals, translational regulation, and the metabolically driven inflammatory response in obesity-related pathogenesis. These findings uncover a potential link between RNA metabolism and endogenous dsRNA-mediated signaling in the initiation and maintenance of a metabolic inflammatory state and provide potential targets for the treatment of chronic stress-related diseases including obesity-induced metabolic diseases. Their paper can be found online in Cell Reports.