News from the Broad

The Broad Institute is committed to open sharing not only of its scientific data and tools, but also information and news about our progress towards achieving our mission. Below are just a few highlights from the Broad scientific community.
  • Broad Institute receives approximately $40 million grant from National Heart, Lung and Blood Institute for whole genome sequencing of 20,000 people

    October 8th, 2015
    NHLBI project will help Broad more than double the number of genomes sequenced annually
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  • Scientists discover new system for human genome editing with potential to increase power and precision of genome engineering

    September 25th, 2015
    CRISPR-Cpf1 system could disrupt both scientific and commercial landscape
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  • DARPA awards $32 million contract to MIT, Broad Institute Foundry to bolster DNA design and manufacturing

    September 24th, 2015
    A facility at the Broad Institute of MIT and Harvard and MIT that aims to achieve the full potential of engineering biology has received a five-year, $32 million contract from the Defense Advanced Research Projects Agency (DARPA).
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  • New approach allows for detection of low-abundance bacterial strains in large metagenomic datasets

    September 24th, 2015

    Singling out microbes in the mountains of metagenomic data from complex samples, such as soil or seawater, is computationally intensive. To address this challenge, a team of researchers from the Broad Institute, led by institute member and senior author Eric Alm, and graduate student and first author Brian Cleary, created a new method – latent strain analysis (LSA) – that separates sequencing reads into biologically informed partitions and enables assembly of individual genomes, including those of bacteria that are relatively low-abundance. The team also showed that LSA is sensitive enough to separate reads from several strains of the same species. Their paper can be found in Nature Biotechnology.

  • Proteomics goes subcellular: Protein labeling technique enables mapping of mitochondrial proteome in live tissues

    September 22nd, 2015

    Working with the Broad Institute’s Proteomics Platform, a team led by Norbert Perrimon of Harvard Medical School and the Broad built a novel proteomic mapping platform that they used in fruit flies. The approach uses a new protein labeling technique that is applied to live tissues, enabling the characterization of organelle proteomes. The team used the technique to map the mitochondrial matrix proteome in Drosophila muscle and then built MitoMax, a database of Drosophila mitochondrial proteins with subcompartmental annotation. Read more in PNAS.