News from the Broad

The Broad Institute is committed to open sharing not only of its scientific data and tools, but also information and news about our progress towards achieving our mission. Below are just a few highlights from the Broad scientific community.
  • International team conducts genomic study of CTLA-4 blockade therapy in metastatic melanoma

    September 16th, 2015

    Monoclonal antibodies that target cytotoxic T lymphocyte–associated antigen-4 (CTLA-4) have shown great clinical benefit in patients with metastatic melanoma, generating a long-term response in 20 percent of treated cases. Last week in the journal Science, an international team that included researchers from the Broad Institute released the largest comprehensive genomic study aimed at identifying the factors that determine response to CTLA-4 blockade therapy in melanoma patients.

  • Broad Institute named as one of two national genome characterization centers

    September 14th, 2015
    Broad Institute and University of Texas MD Anderson Cancer Center in Houston will become the flagship data-production centers for a pioneering five-year project supported by the National Cancer Institute to characterize the genomic changes found in tumors. GCC funding comes via a research subcontract with Leidos Biomedical Research, Inc., operations and technical support contractor for NCI’s Frederick National Laboratory for Cancer...
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  • The wisdom of crowding: Study reveals role of molecular crowding in lipid droplet protein composition

    August 25th, 2015

    Lipid droplets (LDs) are structures that store fat within cells and change size based on energy availability. However, LDs do not function on their own: they require the help of proteins to carry out their metabolic duties. In a recent Developmental Cell paper, researchers from the Broad Institute, Harvard Medical School, and Yale School of Medicine sought to determine what factors influence the composition of such proteins. Results showed that a process known as “molecular crowding” — in which proteins fall off the surface of LDs as they shrink — could be responsible.

  • International research institutes team up to build new schizophrenia patient collections

    August 19th, 2015
    Institute for Molecular Medicine Finland (FIMM) at the University of Helsinki and the Stanley Center for Psychiatric Research at Broad Institute of MIT and Harvard, together with its international partners, are initiating major new sample collections in several regions and countries. The goal is to collect up to 50,000 samples from schizophrenia patients across the globe. The first collection will be established in Finland, where the...
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  • Study sheds light on role of HLA
 gene variants in autoimmune diseases

    August 18th, 2015

    Human leukocyte antigen (HLA) genes encode proteins found on the surface of cells, which help regulate our immune systems. These genes vary tremendously within the population, and such variations can lead to a high risk for, or protection from, autoimmune disorders. In a letter published in Nature Genetics, a team led by Broad researcher Soumya Raychaudhuri and Paul de Bakker of University Medical Center Utrecht (Netherlands) showed evidence that two different versions of certain HLA genes may work together to heighten the risk of autoimmune conditions like rheumatoid arthritis, type 1 diabetes, and celiac disease — potentially explaining differences between individuals with these diseases.