A growing role for beta-catenin in colon cancer

The Wnt/beta-catenin pathway is mutated in virtually all cases of colon cancer, but scientists have not been able to target it with drugs. In this video, Broad Institute senior associate member William Hahn, who is also an associate professor at the Dana--Farber Cancer Institute and Harvard Medical School, describes new work that uses RNAi and dozens of cell lines from the Cancer Cell Line Encyclopedia to reveal previously unknown members of that pathway, opening the door to potential new treatment strategies. Read more about this work in a Broad news story.

Video courtesy of Nick Dua, Broad Communications