News from the Broad

The Broad Institute is committed to open sharing not only of its scientific data and tools, but also information and news about our progress towards achieving our mission. Below are just a few highlights from the Broad scientific community.
  • New HDAC inhibitor toolkit helps reveal potential therapy to protect pancreatic β-cells from effects of diabetes

    February 2nd, 2016

    Histone deacetylase inhibitors (HDACi) hold therapeutic potential for many diverse diseases, including psychiatric disease and diabetes. But so far, most HDACi were found to inhibit more than one histone deacetylase, a characteristic that can decrease efficacy and contribute to side effects. In work published in ACS Chemical Biology, researchers Edward Holson and Florence Wagner of the Broad’s Stanley Center for Psychiatric Research, and colleagues present a toolkit of highly potent and differentially selective HDACi, which they developed to understand the role of histone deacetylases in cognition. The paper also reports the results of a collaboration with Bridget Wagner of Broad’s Center for the Science of Therapeutics, who used the toolkit to reveal that the isoform selective inhibition of HDAC3 by BRD3308 protects pancreatic beta cells from the effects of diabetes.

  • First glimpse of schizophrenia’s genetic roots shines light on a developmental process gone awry

    January 26th, 2016
    Groundbreaking work is the result of analytical ingenuity, fortuitous collaborations, and catalytic philanthropic funding
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  • Genetic study provides first-ever insight into biological origin of schizophrenia

    January 26th, 2016
    Landmark analysis reveals excessive “pruning” of connections between neurons in brain predisposes to schizophrenia
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  • Compendium of immune signatures to improve Gene Set Enrichment Analysis

    January 26th, 2016

    Researchers Nick Haining and Jernej Godec of Dana-Farber Cancer Institute, Harvard Medical School, and Broad Institute collaborated with Broad and UC San Francisco computational biologists to build a collection of gene signatures from different immune cell types and perturbations. The collection, called ImmuneSigDB, includes almost 5,000 new gene sets and has been added to MSigDB. The additions are expected to greatly improve the use of Gene Set Enrichment Analysis for immunological studies; in a paper published by the journal Immunity, the team uses the collection to identify species-specific and shared aspects of the biology of the immune response to sepsis between mice and humans.

  • Broad Institute Genomic Services partners with Takeda Pharmaceuticals to offer genomic insight into the recently approved therapeutic NINLARO® (ixazomib)

    January 22nd, 2016
    Broad Institute Genomic Services has partnered with Takeda Pharmaceutical Company Limited to perform genomic analysis on patient samples from a Phase 3 clinical trial of NINLARO® (ixazomib), an oral proteasome inhibitor that was recently approved by the U.S. Food and Drug Administration (FDA), indicated in combination with lenalidomide and dexamethasone, for the treatment of patients with multiple myeloma who have received at least one...
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