---------------------------------------------------------------- **** GISTIC 2.0 LICENSE AGREEMENT **** ---------------------------------------------------------------- BROAD INSTITUTE SINGLE USER LICENSE AGREEMENT FOR INTERNAL RESEARCH PURPOSES ONLY This Agreement is made between Broad Institute with a principal address at 7 Cambridge Center, Cambridge, MA 02142 ("BROAD") and the subscriber above ("LICENSEE"), and is effective at the date the downloading is completed and proper registration/licensee subscriber information submitted ("EFFECTIVE DATE"). WHEREAS, LICENSEE desires to license the PROGRAM, as defined hereinafter, BROAD wishes to have this PROGRAM utilized in the public interest, subject only to the royalty-free, nonexclusive, nontransferable license rights of the United States Government pursuant to 48 CFR 52.227-14, and WHEREAS, LICENSEE desires to license the PROGRAM and BROAD desires to grant a license on the following terms and conditions. NOW, THEREFORE, in consideration of the promises and covenants made herein, the parties hereto agree as follows: 1. DEFINITIONS 1.1 "BUG FIX(ES)" shall mean LICENSEE-created code that repairs a BROAD identified function of the PROGRAM. 1.2 "PROGRAM" shall mean the second major version of the executable and source code known as "Genomic Identification of Significant Targets In Cancer (GISTIC2)" and related documentation, if any, as they exist on the EFFECTIVE DATE and as can be downloaded from http://www.broadinstitute.org/cancer/pub/GISTIC2 on the EFFECTIVE DATE. 2. LICENSE 2.1 Grant. Subject to the terms of this Agreement, BROAD hereby grants to LICENSEE, solely for a single user and for internal research purposes, a non-exclusive, non-transferable license to: (a) install, execute and display the PROGRAM, only for the single user; (b) create BUG FIXES; and (c) modify the PROGRAM only for the purpose of making the PROGRAM compatible with pre-existing LICENSEE networks, platforms and applications. 2.2 No Sublicensing or Additional Rights. In no event shall LICENSEE sublicense or distribute , in whole or in part, the PROGRAM, modifications, or BUG FIXES, without prior permission from BROAD. LICENSEE agrees not to allow any non-employee of LICENSEE to access, view, or use the PROGRAM, unless such person is an independent contractor performing services on behalf of LICENSEE. LICENSEE agrees not to put the PROGRAM on a network, server, or other similar technology that may be accessed by any individual other than the LICENSEE. 2.3 License Limitations. Nothing in this Agreement shall be construed to confer any rights upon LICENSEE by implication, estoppel, or otherwise to any computer software, trademark, intellectual property, or patent rights of BROAD, the Broad Institute, Inc. (BROAD), or of any other entity, except as expressly granted herein. LICENSEE agrees that the PROGRAM shall be used as the basis of a commercial software or hardware product and that the same shall not be rewritten in another computer language or otherwise adapted to circumvent the need for obtaining a license for use of the PROGRAM other than as specified by this Agreement. 3. CONSIDERATION As consideration for the licenses granted in this Agreement, LICENSEE agrees to provide accurate registration information prior to using the PROGRAM and a written evaluation of the PROGRAM, including a description of its functionality or problems and areas for further improvement in the PROGRAM. LICENSEE hereby automatically grants to BROAD a non-exclusive, royalty-free, irrevocable worldwide license to any BUG FIXES or modifications to the PROGRAM with unlimited rights to sublicense and/or distribute. Such modifications and BUG FIXES shall be provided to BROAD promptly upon their creation. 4. OWNERSHIP OF INTELLECTUAL PROPERTY LICENSEE acknowledges that title to the PROGRAM shall remain with BROAD. To the extent the PROGRAM is marked with a BROAD copyright notice, or notice of attribution to contributors, LICENSEE shall retain such notice on all copies, and on modifications and BUG FIXES where applicable. LICENSEE shall be entitled to establish all proprietary rights for itself in the modifications or BUG FIXES created pursuant to Section 2.1, whether in the nature of trade secrets or copyrights, provided that all such rights are subject to BROAD's copyright and that any copyright registration by LICENSEE gives full attribution to BROAD's copyright. 5. INDEMNIFICATION LICENSEE shall indemnify, defend, and hold harmless BROAD and its respective trustees, officers, faculty, students, employees, affiliated investigators, and agents, and their respective successors, heirs and assigns, ("Indemnitees"), against any liability, damage, loss, or expense (including reasonable attorneys fees and expenses) incurred by or imposed upon any of the Indemnitees in connection with any claims, suits, actions, demands or judgments arising out of any theory of liability (including, without limitation, actions in the form of tort, warranty, or strict liability and regardless of whether such action has any factual basis) pursuant to any right or license granted under this Agreement. 6. NO REPRESENTATIONS OR WARRANTIES THE PROGRAM AND SOURCE FILES ARE DELIVERED "AS IS." BROAD MAKES NO REPRESENTATIONS OR WARRANTIES OF ANY KIND CONCERNING THE PROGRAM OR THE COPYRIGHT, EXPRESS OR IMPLIED, INCLUDING, WITHOUT LIMITATION, WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE, NONINFRINGEMENT, OR THE ABSENCE OF LATENT OR OTHER DEFECTS, WHETHER OR NOT DISCOVERABLE. BROAD EXTENDS NO WARRANTIES OF ANY KIND AS TO PROGRAM CONFORMITY WITH WHATEVER USER MANUALS OR OTHER LITERATURE MAY BE ISSUED FROM TIME TO TIME. IN NO EVENT SHALL BROAD OR ITS RESPECTIVE TRUSTEES, DIRECTORS, OFFICERS, EMPLOYEES, AFFILIATED INVESTIGATORS, AND AFFILIATES BE LIABLE FOR INCIDENTAL OR CONSEQUENTIAL DAMAGES OF ANY KIND, INCLUDING, WITHOUT LIMITATION, ECONOMIC DAMAGES OR INJURY TO PROPERTY AND LOST PROFITS, REGARDLESS OF WHETHER BROAD SHALL BE ADVISED, SHALL HAVE OTHER REASON TO KNOW, OR IN FACT SHALL KNOW OF THE POSSIBILITY OF THE FOREGOING. 7. ASSIGNMENT This Agreement is personal to LICENSEE and any rights or obligations assigned by LICENSEE without the prior written consent of BROAD shall be null and void. 8. MISCELLANEOUS 8.1 Export Control. LICENSEE gives assurance that it will comply with all United States export control laws and regulations controlling the export of the PROGRAM, including, without limitation, all Export Administration Regulations of the United States Department of Commerce. Among other things, these laws and regulations prohibit, or require a license for, the export of certain types of software to specified countries. 8.2 Non-Use Of Name. LICENSEE shall not use any trademark or trade name of BROAD, or any variation, adaptation, or abbreviation, of such marks or trade names, or any names of trustees, officers, faculty, students, employees, or agents of BROAD without the prior written consent of BROAD. 8.3 Termination. LICENSEE shall have the right to terminate this Agreement for any reason upon prior written notice to BROAD. If LICENSEE breaches any provision hereunder, and fails to cure such breach within thirty (30) days, BROAD may terminate this Agreement immediately. Upon termination, LICENSEE shall provide BROAD with written assurance that the original and all copies of the PROGRAM, including partial copies of the PROGRAM in modifications, have been destroyed, except that, upon prior written authorization from BROAD, LICENSEE may retain a copy for archive purposes. 8.4 Survival. The following provisions shall survive the expiration or termination of this Agreement: Articles 1, 5, 6 and Sections 2.2, 2.3, 8.2, 8.4 and 8.5. 8.5 Notice. Any notices under this Agreement shall be in writing, shall specifically refer to this Agreement, and shall be sent by hand, recognized national overnight courier, confirmed facsimile transmission, confirmed electronic mail, or registered or certified mail, postage prepaid, return receipt requested All notices under this Agreement shall be deemed effective upon receipt. 8.6 Amendment And Waiver; Entire Agreement. This Agreement may be amended, supplemented, or otherwise modified only by means of a written instrument signed by all parties. Any waiver of any rights or failure to act in a specific instance shall relate only to such instance and shall not be construed as an agreement to waive any rights or fail to act in any other instance, whether or not similar. This Agreement constitutes the entire agreement among the parties with respect to its subject matter and supersedes prior agreements or understandings between the parties relating to its subject matter. BROAD shall not be bound by any provisions on the face or reverse side of any LICENSEE Purchase Order relating to the PROGRAM, or any LICENSEE attachment to a Purchase Order, that are inconsistent with or in addition to the provisions of this Agreement. 8.7 Binding Effect; Headings. This Agreement shall be binding upon and inure to the benefit of the parties and their respective permitted successors and assigns. All headings are for convenience only and shall not affect the meaning of any provision of this Agreement. 8.8 Governing Law. This Agreement shall be construed, governed, interpreted and applied in accordance with the internal laws of the Commonwealth of Massachusetts, U.S.A., without regard to conflict of laws principles.