|Gene Relationships Among Implicated Loci
GRAIL takes as input a list of query and/or seed genomic regions; these are presumed to be associated to a phenotype by a genome-wide study. Genes within each genomic region or SNP region are identified. Query regions are scored according to how similar genes within them are to genes in Seed regions; similarity is assessed by published text.
Regions can be entered as either individual SNPs, explicit genomic regions, or gene lists. Enter each in a separate line in the dialog boxes below or in a file for upload. SNPs should be in HapMap and identified with its rs number. Specific regions around the SNPs are defined based on LD properties. Explicit Genomic Regions should be entered as: "ID CHR STARTPOS ENDPOS", where ID is a unique identifier for the region, CHR, STARTPOS, and ENDPOS are the chromosome and region boundaries for the genomic region in base pairs. Gene Lists should be entered as "ID gid GENID1 GENID2...", where ID is a unique identifier for the region, 'gid' is a code word that tells GRAIL that this is a gene list, and GENIDs are Entrez gene identifiers.