Multiple Myeloma Genomics Portal (MMGP)
 The Multiple Myeloma Genomics Portal is a part of the Multiple Myeloma Genomics Initiative, a collaboration of The Multiple Myeloma Research Consortium, The Broad Institute of MIT and Harvard, and the Translational Genomics Research Institute (TGen). Funding is provided by the Multiple Myeloma Research Foundation. Development of the portal and data curation was performed by the portal team of the Broad Institute and Dana Farber Cancer Center.
The Multiple Myeloma Genomics Portal (MMGP) has been made available to provide access to and limited analysis of the MMGP portal data sets. These include the MMRC funded reference aCGH and gene expression data and additional public multiple myeloma datasets.
The MMGP will be updated with new features such as additional data and analysis tools as they become available.
News / Events
May 24, 2011: The MMGP has been updated and the SampleBrowser is once again fully functional.
May 23, 2011: The sample browser is temporarily broken due to an update of the portal. As a temporary workaround, you can browse the samples as part of the first step of GSEA or ComparativeMarkerSelection. A fix will be released as soon as possible.
Mar 23, 2011: Multiple Myeloma Research Foundation spearheads genome sequencing
more...
Apr 30, 2010: The MMGP Terms of access have been updated. Please review the revised terms of access.
more...
Apr 30, 2010: The MMGP has been updated to version 2.7.4.
Jan 16, 2010: The MMGP has been updated to version 2.3
Dec 7, 2009: Expression and copy number data for the MMRC Reference collection has been updated. It now includes 238 paired samples (from 202 previously)
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New User?
Please register for full access to the data and analyses tools MMGP provides.
Terms of Access Register
Tutorials / Manuals
Tutorials, analysis descriptions and other documentation is available at:
HELP > DOCUMENTS
Publications
 Initial genome sequencing and analysis of multiple myeloma, Michael A. Chapman et al., Nature, 2011
Polycomb Target Genes Are Silenced in Multiple Myeloma, Antonia Kalushkova et al., PLoS one, 2010
Gene expression profiling of plasma cells at myeloma relapse from total therapy 2 predicts subsequent survival., Nair B et al., Blood, 2009
All Publications
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What you can do on this portal
Search for information
Enter a keyword to search for genes, news items and publications. Search
results for a gene include links to annotations and analyses.
Data Sets
 Browse, analyze and download studies and data sets.
BROWSE > DATA
Analysis Tools
 The portal provides the following analysis tools:
Integrative Genomics Viewer (IGV)
Visualize a data set in the Integrative Genomics Viewer (IGV), a high-performance visualization tool for interactive exploration of
large integrated data sets.
Differential Expression Analysis
Find genes that are significantly differentially expressed between two user-defined
classes of samples from an expression data set available on this portal.
Gene co-expression
View the top 20 genes in a data set that are co-expressed with a gene of interest.
Gene Set Enrichment Analysis (GSEA)
Find pathway gene sets correlated with a gene of interest. Domain experts curate the pathway
gene sets based on data from several online pathway databases.
ANALYSIS TOOLS
Sample Sets
Create your own sample sets based on a large number of available criteria and use them in differential expression analysis.
CREATE SAMPLE SETS
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