Multiple Myeloma Genomics Portal (MMGP)
The Multiple Myeloma Genomics Portal is a part of the Multiple Myeloma Genomics Initiative, a collaboration of The Multiple Myeloma Research Consortium, The Broad Institute of MIT and Harvard, and the Translational Genomics Research Institute (TGen). Funding is provided by the Multiple Myeloma Research Foundation. Development of the portal and data curation was performed by the portal team of the Broad Institute and Dana Farber Cancer Center.
The Multiple Myeloma Genomics Portal (MMGP) has been made available to provide access to and limited analysis of the MMGP portal data sets. These include the MMRC funded reference aCGH and gene expression data and additional public multiple myeloma datasets.
The MMGP will be updated with new features such as additional data and analysis tools as they become available.
News / Events
May 20, 2013: The server issues have been resolved. Differential expression, GSEA and sample browsing are once again working normally
May 20, 2013: Due to a change in some servers the MMGP depends on the Differential Expression, GSEA and sample browsing features are currently not working. We are trying to resolve the issue as quickly as possible to bring the portal back to full capability
Feb 6, 2013: New visualizations of the mutations are now available. Select the Browse/Mutations menu item or view them on the pages for individual genes and samples.
Jan 24, 2013: The MMGP portal has been updated with performance improvements and changes to better support users of the InternetExplorer browser.
Jan 23, 2013: The MMGP will be down between 6-9am EST Thursday Jan 24th for maintenance and upgrades.
Jan 22, 2013: GENE-E, a tool for visualizing and analyzing gene expresison data has been added to the analyses available on the MMGP.
Dec 7, 2012: MMGP Downtime: The MMGP may be unavailable all day (EST) on December 15th due to electrical work at the Broad Institute.
Please register for full access to the data and analyses tools MMGP provides.
Terms of Access Register
Tutorials / Manuals
Tutorials, analysis descriptions and other documentation is available at:
HELP > DOCUMENTS
Frequently Altered Genes
clouds summarizing genes frequently altered in the datasets of this
portal are available in the
Mutation tag cloud
Latest advances and current challenges in the treatment of multiple myeloma., Mahindra A et al., Nat Rev Clin Oncol. , 2012
Drug response in a genetically engineered mouse model of multiple myeloma is predictive of clinical efficacy., Chesi M et al., Blood, 2012
Prediction of cytogenetic abnormalities with gene expression profiles., Zhou Y et al., Blood, 2012
What you can do on this portal
Search for information
Enter a keyword to search for genes, news items and publications. Search
results for a gene include links to annotations and analyses.
Browse, analyze and download
studies and data sets.
BROWSE > DATA
The portal provides the
following analysis tools:
Integrative Genomics Viewer (IGV)
Visualize a data set in the Integrative Genomics Viewer (IGV), a high-performance
visualization tool for interactive exploration of large integrated data sets.
Differential Expression Analysis
Find genes that are significantly differentially expressed between two user-defined classes
of samples from an expression data set available on this portal.
View the top 20 genes in a data set that are co-expressed with a gene of interest.
Gene Set Enrichment Analysis (GSEA)
Find pathway gene sets correlated with a gene of interest. Domain
experts curate the pathway gene sets based on data from several online pathway databases.
Create your own sample sets based on a
large number of available criteria and use them in differential expression analysis.
CREATE SAMPLE SETS