Vertebrate Genome Biology

The main goal of the Vertebrate Biology Group is threefold: to aid in the annotation and basic understanding of both the structure and function of the human genome (see 29 Mammals Project,) to further inform our understanding of adaptive evolution in all its forms, and to assist in the biological understanding of a variety of biomedically and evolutionarily important vertebrate organisms.

The Vertebrate Biology Group approaches these goals in several ways, both by leveraging the vast amount of data generated from the large number of vertebrate genomes sequenced to date (both at the Broad Institute and elsewhere) and by the coordination of new vertebrate genome sequencing projects. Our group combines two essential components for our endeavors, scientific knowledge and powerful computational expertise.

The Vertebrate Biology Group maintains a variety of collaborations, both within the Broad Institute as well as with a large number of outside research communities. Our collaborations range from work with individual research labs to projects that span multiple other sequencing centers and outside labs. 

Our research is divided across multiple different, ongoing projects, as listed below.  If you have any questions about our group, please don’t hesitate to email us: vertebrategenomes@broadinstitute.org.

For up to date information on all of our release genomes, see here: Current Data Release

Current Projects

Dog genome project
Dog disease mapping project

Software Support/Development

Much of the work done by the VBG requires a large amount of bioinformatic support. Our team has developed a novel set of tools to deal with some of the challenges we've faced in our research. You can read more about these tools (as well as download them for your own applications) via the Broad Institute's software page.


If you have questions, please contact us at: vertebrategenomes@broadinstitute.org