Molecular Signatures Database

Overview

The Molecular Signatures Database (MSigDB) is a collection of gene sets for use with GSEA software. From this web site, you can

• Search for gene sets
• Browse gene sets
• View annotations by clicking a gene set name to display its gene set page; for example, AKTPATHWAY
• Download gene sets
• Compute overlaps between your gene set and other gene sets in MSigDB
• Categorize members of a gene set by gene families
• Build an expression signature of the gene set using a compendium of expression profiles

Registration

Please register to download the GSEA software and view the MSigDB gene sets. After registering, you can log in at any time using your email address. Registration is free. Its only purpose is to help us track usage for reports to our funding agencies.

Current Version

GSEA/MSigDB web site v2.0 released December 14 2007
MSigDB database v2.5 updated April 7 2008, Release notes.

Contributors

The MSigDB is maintained by the GSEA team. We welcome and appreciate contributions to this shared resource and encourage users to submit their gene sets to genesets@broadinstitute.org. Our thanks to our many contributors.

Funded by: National Cancer Institute, National Institutes of Health, National Institute of General Medical Sciences.

Collections

The MSigDB gene sets are divided into five major collections:

Citing the MSigDB

To cite your use of the Molecular Signatures Database (MSigDB), please reference Subramanian, Tamayo, et al. (2005, PNAS 102, 15545-15550) and also the source for the gene set as listed on the gene set page.

Contact Us

If you have comments or questions, please contact us: gsea@broadinstitute.org.