Gene Set: V$CDPCR3HD_01

Standard name V$CDPCR3HD_01
Systematic name M15128
Brief description Genes with promoter regions [-2kb,2kb] around transcription start site containing the motif NATYGATSSS which matches annotation for CUTL1: cut-like 1, CCAAT displacement protein (Drosophila)
Full description or abstract XX
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FA CUTL1
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SY CDP; CCAAT displacement protein; cut homeodomain protein; Cux; cut-like
SY homeodomain protein; Clox.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia;
OC eutheria; primates
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HO cut (Drosophila)
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CL C0006; homeo; 3.1.1.4.1.
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SZ 1505 AA; 164.4 kDa (cDNA), 180-200 kDa (SDS)
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SC SwissProt #P39880
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FT 542 629 PF02376; CUT.
FT 551 610 Cut-repeat 1 (CR1).
FT 551 610 involved in binding to S/MAR-binding factor SATB1
FT [1].
FT 632 653 missing in putative splice variant.
FT 934 1021 PF02376; CUT.
FT 943 1007 Cut-repeat 2 (CR2).
FT 943 1007 involved in binding to S/MAR-binding factor SATB1
FT [1].
FT 1117 1204 PF02376; CUT.
FT 1135 1190 Cut-repeat 3 (CR3).
FT 1244 1306 SM00389; HOX.
FT 1245 1301 homeo domain.
FT 1245 1301 involved in binding to S/MAR-binding factor SATB1
FT [1].
FT 1245 1301 PF00046; homeobox.
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SF the Clox homolog is a splice variant [5];
SF the 3 cut repeats also contribute to DNA-binding, each individual repeat
SF and each combination exhibiting slightly different DNA-binding specificity
SF [4] [2] [5];
SF CR1 exhibits the most restricted resognition pattern [4];
SF KD (CR3-homeo domain) = 0.03 nM, isolated CR3 at least 100-fold lower
SF affinity [2];
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FF repressor [13] [12] [9] [8] [6] [3];
FF may regulate S/MAR-binding factor SATB1 and may be regulated by
FF it via protein-protein interaction [1];
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RN [1]; RE0015021.
RX MEDLINE; 99303784.
RA Liu J., Barnett A., Neufeld E. J., Dudley J. P.
RT Homeoproteins CDP and SATB1interact: potential for tissue-specific
RT regulation
RL Mol. Cell. Biol. 19:4918-4926 (1999).
RN [2]; RE0002973.
RX MEDLINE; 95097984.
RA Harada R., Berube G., Tamplin O. J., Denis-Larose C., Nepveu A.
RT DNA-binding specificity of the cut repeats from the human cut-like protein
RL Mol. Cell. Biol. 15:129-140 (1995).
RN [3]; RE0003999.
RX MEDLINE; 95279415.
RA Lievens P. M., Donady J. J., Tufarelli C., Neufeld E. J.
RT Repressor activity of CCAAT displacement protein in HL-60 myeloid leukemia
RT cells
RL J. Biol. Chem. 270:12745-12750 (1995).
RN [4]; RE0002967.
RX MEDLINE; 94329595.
RA Aufiero B., Neufeld E. J., Orkin S. H.
RT Sequence-specific DNA binding of individual cut repeats of the human CCAAT
RT displacement/ cut homeodomain protein
RL Proc. Natl. Acad. Sci. USA 91:7757-7761 (1994).
RN [5]; RE0002972.
RX MEDLINE; 94131277.
RA Andres V., Chiara M. D., Mahdavi V.
RT A new bipartite DNA-binding domain: cooperative interaction between the cut
RT repeat and homeo domain of the cut homeo proteins
RL Genes Dev. 8:245-257 (1994).
RN [6]; RE0003358.
RX MEDLINE; 94254882.
RA Dufort D., Nepveu A.
RT The human Cut homeodomain protein represses transcription from the c-myc
RT promoter
RL Mol. Cell. Biol. 14:4251-4257 (1994).
RN [7]; RE0005004.
RX MEDLINE; 94124559.
RA Harada R., Dufort D., Denis-Larose C., Nepveu A.
RT Conserved cut repeats in the human cut homeodomain protein function as DNA
RT binding domains
RL J. Biol. Chem. 269:2062-2067 (1994).
RN [8]; RE0005002.
RX MEDLINE; 93250973.
RA Neufeld E. J., Skalnik D. G., Lievens P. M., Orkin S. H.
RT Human CCAAT dis-placement protein is homologous to the Drosophila
RT homeoprotein, cut
RL Nat. Genet. 1:50-55 (1992).
RN [9]; RE0001031.
RX MEDLINE; 91358470.
RA Skalnik D. G., Strauss E. C., Orkin S. H.
RT CCAAT displacement protein as a repressor of the myelomonocytic-specific
RT gp91-phox gene promoter
RL J. Biol. Chem. 266:16736-16744 (1991).
RN [10]; RE0002047.
RX MEDLINE; 89385992.
RA Mantovani R., Superti-Furga G., Gilman J., Ottolenghi S.
RT The deletion of the distal CCAAT box region of the Agamma-globin gene in
RT black HPFH abolishes the binding of the erythroid specific protein NFE3 and
RT of the CCAAT displacement protein
RL Nucleic Acids Res. 17:6681-6691 (1989).
RN [11]; RE0005005.
RX MEDLINE; 89150259.
RA Superti-Furga G., Barberis A., Schaffner G., Busslinger M.
RT The protein CDP, but not CP1, footprints on the CCAAT region of the
RT g-globin gene in unfractionated B-cell extracts
RL Biochim. Biophys. Acta 1007:237-242 (1989).
RN [12]; RE0000346.
RX MEDLINE; 89030605.
RA Superti-Furga G., Barberis A., Schaffner G., Busslinger M.
RT The -117 mutation in Greek HPFH affects the binding of three nuclear
RT factors to the CCAAT region of the gamma-globin gene
RL EMBO J. 7:3099-3107 (1988).
RN [13]; RE0000079.
RX MEDLINE; 87273497.
RA Barberis A., Superti-Furga G., Busslinger M.
RT Mutually Exclusive Interaction of the CCAAT-Binding Factor and of a
RT Displacement Protein with Overlapping Sequences of a Histone Gene Promoter
RL Cell 50:347-359 (1987).
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Collection C3: motif gene sets
      TFT: transcription factor targets
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Organism Homo sapiens
Contributed by Xiaohui Xie (Broad Institute)
Source platform HUMAN_GENE_SYMBOL
Dataset references  
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Compute overlaps C1: positional gene sets
C2: curated gene sets
      CGP: chemical and genetic perturbations
      CP: canonical pathways
            CP:BIOCARTA: BioCarta gene sets
            CP:KEGG: KEGG gene sets
            CP:REACTOME: Reactome gene sets
C3: motif gene sets
      MIR: microRNA targets
      TFT: transcription factor targets
C4: computational gene sets
      CGN: cancer gene neighborhoods
      CM: cancer modules
C5: GO gene sets
      BP: GO biological process
      CC: GO cellular component
      MF: GO molecular function
Compendia expression profiles Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
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