Gene Set: LEE_LIVER_CANCER_MYC_E2F1_UP

Standard name LEE_LIVER_CANCER_MYC_E2F1_UP
Systematic name M4420
Brief description Genes up-regulated in hepatocellular carcinoma (HCC) from MYC and E2F1 [GeneID=4609] [GeneID=1869] double transgenic mice.
Full description or abstract Genetically modified mice have been extensively used for analyzing the molecular events that occur during tumor development. In many, if not all, cases, however, it is uncertain to what extent the mouse models reproduce features observed in the corresponding human conditions. This is due largely to lack of precise methods for direct and comprehensive comparison at the molecular level of the mouse and human tumors. Here we use global gene expression patterns of 68 hepatocellular carcinomas (HCCs) from seven different mouse models and 91 human HCCs from predefined subclasses to obtain direct comparison of the molecular features of mouse and human HCCs. Gene expression patterns in HCCs from Myc, E2f1 and Myc E2f1 transgenic mice were most similar to those of the better survival group of human HCCs, whereas the expression patterns in HCCs from Myc Tgfa transgenic mice and in diethylnitrosamine-induced mouse HCCs were most similar to those of the poorer survival group of human HCCs. Gene expression patterns in HCCs from Acox1(-/-) mice and in ciprofibrate-induced HCCs were least similar to those observed in human HCCs. We conclude that our approach can effectively identify appropriate mouse models to study human cancers.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 15565109   Authors: Lee JS,Chu IS,Mikaelyan A,Calvisi DF,Heo J,Reddy JK,Thorgeirsson SS
Exact source GSE1897: top 100 up-regulated in Myc/E2f1; convertied to human orthologs
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External links  
Organism Mus musculus
Contributed by Yujin Hoshida (Broad Institute)
Source platform HUMAN_GENE_SYMBOL
Dataset references GSE1897
Download gene set format: grp | text | gmt | gmx | xml
Compute overlaps C1: positional gene sets
C2: curated gene sets
      CGP: chemical and genetic perturbations
      CP: canonical pathways
            CP:BIOCARTA: BioCarta gene sets
            CP:KEGG: KEGG gene sets
            CP:REACTOME: Reactome gene sets
C3: motif gene sets
      MIR: microRNA targets
      TFT: transcription factor targets
C4: computational gene sets
      CGN: cancer gene neighborhoods
      CM: cancer modules
C5: GO gene sets
      BP: GO biological process
      CC: GO cellular component
      MF: GO molecular function
Compendia expression profiles Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
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Show members (show 57 members mapped to 53 genes)
Version history 3.0: Renamed from LEE_MYC_E2F1_UP