Gene Set: KEGG_P53_SIGNALING_PATHWAY

Standard name KEGG_P53_SIGNALING_PATHWAY
Systematic name M6370
Brief description p53 signaling pathway
Full description or abstract p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
Collection C2: curated gene sets
      CP:KEGG: KEGG gene sets
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External links http://www.genome.jp/kegg/pathway/hsa/hsa04115.html
Organism Homo sapiens
Contributed by KEGG
Source platform EntrezGeneIds
Dataset references  
Download gene set format: grp | text | gmt | gmx | xml
Compute overlaps C1: positional gene sets
C2: curated gene sets
      CGP: chemical and genetic perturbations
      CP: Canonical pathways
      CP:BIOCARTA: BioCarta gene sets
      CP:KEGG: KEGG gene sets
      CP:REACTOME: Reactome gene sets
C3: motif gene sets
      MIR: microRNA targets
      TFT: transcription factor targets
C4: computational gene sets
      CGN: cancer gene neighborhoods
      CM: cancer modules
C5: GO gene sets
      BP: GO biological process
      CC: GO cellular component
      MF: GO molecular function
C6: oncogenic signatures
C7: immunologic signatures
Compendia expression profiles Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 69 genes
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Show members (show 69 members mapped to 69 genes)
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