Gene Set: FAELT_B_CLL_WITH_VH3_21_DN

Standard name FAELT_B_CLL_WITH_VH3_21_DN
Systematic name M7218
Brief description Genes changed in samples from B-CLL (B-cell chronic lymphocytic leukemia) using the immunoglobulin heavy chain VH3-21 gene.
Full description or abstract The usage of the immunoglobulin (Ig) V(H)3-21 gene is associated with poor prognosis in B-cell chronic lymphocytic leukemia (B-CLL) despite V(H) gene mutation status. Many V(H)3-21+ patients also display restricted heavy- and light-chain Ig gene rearrangements, implying a role of antigen selection in disease development. To explore the specific phenotypic/genotypic features among V(H)3-21+ B-CLLs, we compared gene expression patterns in 15 V(H)3-21+ and 24 non-V(H)3-21 patients (11 with unmutated and 13 with mutated V(H) genes) using Affymetrix microarray analysis (approximately 12,500 genes). A distinct expression profile was identified for V(H)3-21+ patients in contrast to the Ig-unmutated and -mutated groups. By applying different algorithms, the data enabled an efficient class discrimination of the V(H)3-21+ subset based on 27 or 57 genes. A set of genes was sorted out which, using different analytical methods, consistently gave a distinction between V(H)3-21+ and non-V(H)3-21 samples. Several of these genes are involved in regulation of DNA replication/cell-cycle control, transcription and protein kinase activity, which may render the V(H)3-21+ cells with a higher proliferative drive. However, no clear evidence of increased B-cell receptor signaling was found in the V(H)3-21+ group. Altogether, our identification of a specific V(H)3-21 profile may provide insights into the pathogenesis of the V(H)3-21+ subgroup.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 15817677   Authors: F?lt S,Merup M,Tobin G,Thunberg U,Gahrton G,Rosenquist R,Wennborg A
Exact source Table 1S
Related gene sets (show additional gene sets from the source publication)
External links  
Organism Homo sapiens
Contributed by Kevin Vogelsang (Broad Institute)
Source platform HG_U95Av2
Dataset references  
Download gene set format: grp | text | gmt | gmx | xml
Compute overlaps C1: positional gene sets
C2: curated gene sets
      CGP: chemical and genetic perturbations
      CP: canonical pathways
            CP:BIOCARTA: BioCarta gene sets
            CP:KEGG: KEGG gene sets
            CP:REACTOME: Reactome gene sets
C3: motif gene sets
      MIR: microRNA targets
      TFT: transcription factor targets
C4: computational gene sets
      CGN: cancer gene neighborhoods
      CM: cancer modules
C5: GO gene sets
      BP: GO biological process
      CC: GO cellular component
      MF: GO molecular function
Compendia expression profiles Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 49 genes
Gene families Categorize these 49 genes by gene family
Show members (show 50 members mapped to 49 genes)
Version history 3.0: Renamed from FALT_BCLL_DN