Gene Set: DISTECHE_ESCAPED_FROM_X_INACTIVATION

Standard name DISTECHE_ESCAPED_FROM_X_INACTIVATION
Systematic name M16091
Brief description Genes that escape X inactivation.
Full description or abstract Although the process of X inactivation in mammalian cells silences the majority of genes on the inactivated X chromosome, some genes escape this chromosome-wide silencing. Genes that escape X inactivation present a unique opportunity to study the process of silencing and the mechanisms that protect some genes from being turned off. In this review, we will discuss evolutionary aspects of escape from X inactivation, in relation to the divergence of the sex chromosomes. Molecular characteristics, expression, and epigenetic modifications of genes that escape will be presented, including their developmental regulation and the implications of chromatin domains along the X chromosome in modeling the escape process.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 12900543   Authors: Disteche CM,Filippova GN,Tsuchiya KD
Exact source Table 1
Related gene sets  
External links  
Organism Homo sapiens
Contributed by Broad Institute
Source platform HUMAN_GENE_SYMBOL
Dataset references  
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Compute overlaps C1: positional gene sets
C2: curated gene sets
      CGP: chemical and genetic perturbations
      CP: canonical pathways
            CP:BIOCARTA: BioCarta gene sets
            CP:KEGG: KEGG gene sets
            CP:REACTOME: Reactome gene sets
C3: motif gene sets
      MIR: microRNA targets
      TFT: transcription factor targets
C4: computational gene sets
      CGN: cancer gene neighborhoods
      CM: cancer modules
C5: GO gene sets
      BP: GO biological process
      CC: GO cellular component
      MF: GO molecular function
Compendia expression profiles Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
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Version history 3.0: Renamed from DISTECHE_XINACTIVATED_GENES