Gene set: DAC_IFN_BLADDER_UP

Standard name DAC_IFN_BLADDER_UP
Brief description Interferon-regulated genes upregulated by DAC treatment in T24 bladder carcinoma cells
Full description or abstract AB - Hypermethylation of the promoters of cancer-related genes is often associated with their inactivation during tumorigenesis. Several preclinical and clinical trials have been developed to use DNA methylation inhibitors such as 5-aza-2'-deoxycytidine (5-Aza-CdR) in attempts to reactivate silenced genes in human cancers. We used high-density oligonucleotide gene expression microarrays to examine the effects of 5-Aza-CdR treatment on human fibroblast cells (LD419) and a human bladder tumor cell line (T24). Data obtained 8 days after recovery from 5-Aza-CdR treatment showed that more genes were induced in tumorigenic cells (61 genes induced >or=4-fold) than nontumorigenic cells (34 genes induced >or= 4-fold). Approximately 60% of induced genes did not have CpG islands within their 5' regions suggesting that some genes activated by 5-Aza-CdR may not result from the direct inhibition of promoter methylation. Interestingly a high percentage of genes activated in both cell types belonged to the IFN signaling pathway confirming data from other tumor cell types.
Collection C2: curated gene sets
CGP: chemical and genetic perturbations
Source publication Pubmed 11861364 Authors: Liang G,Gonzales FA,Jones PA,Orntoft TF,Thykjaer T
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Organism Human
Contributed by L2L John Newman (Washington University)
Source Platform GENE_SYMBOL
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Annotate by computing overlaps C1: positional gene sets
C2: curated gene sets
      CGP: chemical and genetic perturbations
      CP: canonical pathways
C3: motif gene sets
      MIR: microRNA targets
      TFT: transcription factor targets
C4: computational gene sets
      CM: cancer modules
      CGN: cancer gene neighborhoods
C5: GO gene sets
      CC: GO cellular component
      BP: GO biological process
      MF: GO molecular function
Compendia expression profiles Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
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