Human Gene Set: CHANG_CORE_SERUM_RESPONSE_DN


Standard name CHANG_CORE_SERUM_RESPONSE_DN
Systematic name M5793
Brief description Down-regulated genes in the canonical gene expression signature of the fibroblast core serum response (CSR) defined by the Stanford group.
Full description or abstract Cancer invasion and metastasis have been likened to wound healing gone awry. Despite parallels in cellular behavior between cancer progression and wound healing, the molecular relationships between these two processes and their prognostic implications are unclear. In this study, based on gene expression profiles of fibroblasts from ten anatomic sites, we identify a stereotyped gene expression program in response to serum exposure that appears to reflect the multifaceted role of fibroblasts in wound healing. The genes comprising this fibroblast common serum response are coordinately regulated in many human tumors, allowing us to identify tumors with gene expression signatures suggestive of active wounds. Genes induced in the fibroblast serum-response program are expressed in tumors by the tumor cells themselves, by tumor-associated fibroblasts, or both. The molecular features that define this wound-like phenotype are evident at an early clinical stage, persist during treatment, and predict increased risk of metastasis and death in breast, lung, and gastric carcinomas. Thus, the transcriptional signature of the response of fibroblasts to serum provides a possible link between cancer progression and wound healing, as well as a powerful predictor of the clinical course in several common carcinomas.
Collection ARCHIVED: Archived Founder gene sets that are referenced by current Hallmarks
      C2_NONE: ARCHIVED Curated
            C2_CGP: ARCHIVED Chemical and Genetic Perturbations
Source publication Pubmed 14737219   Authors: Chang HY,Sneddon JB,Alizadeh AA,Sood R,West RB,Montgomery K,Chi JT,van de Rijn M,Botstein D,Brown PO
Exact source CSR_genes.xls: Quiescent=-2
Related gene sets (show 6 additional gene sets from the source publication)

(show 18 gene sets from the same authors)
External links
Filtered by similarity ?
Source species Homo sapiens
Contributed by Arthur Liberzon (MSigDB Team)
Source platform or
identifier namespace
UniGene_ID
Dataset references  
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ?
Compendia expression profiles ?
Advanced query
Gene families ?
Show members (show 233 source identifiers mapped to 0 genes)
Version history  

See MSigDB license terms here. Please note that certain gene sets have special access terms.