Human Gene Set: BIOCARTA_GH_PATHWAY

For the Mouse gene set with the same name, see BIOCARTA_GH_PATHWAY

Standard name BIOCARTA_GH_PATHWAY
Systematic name M9043
Brief description Growth Hormone Signaling Pathway
Full description or abstract Growth hormone plays a major role in regulating growth during childhood and adolescence and also regulates metabolism. Defects in growth hormone signaling can result in dwarfism and decreases in growth hormone levels with age have been suggested to play a role in the reduced function of some physiological systems. Growth hormone signals a response in cells through the growth hormone receptor, a member of the cytokine receptor gene family. Growth hormone causes the receptor to dimerize, activating the JAK2 protein kinase. The activity of JAK2 mediates many of the downstream responses to growth hormone through phosphorylation of STAT transcription factors, MAP kinases, other kinase cascades and molecules involved in metabolism like IRS-1. Factors like SOCS and SHP-1 appear to play a role in the down regulation of signaling by growth hormone and cytokines.
Collection C2: Curated
      CP: Canonical Pathways
            CP:BIOCARTA: BioCarta Pathways
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External links https://data.broadinstitute.org/gsea-msigdb/msigdb/biocarta/human/h_ghPathway.gif
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Source species Homo sapiens
Contributed by BioCarta
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identifier namespace		 HUMAN_SEQ_ACCESSION
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Version history 7.0: Changed members. Upgraded to final version of Biocarta.

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