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<MSIGDB NAME="BIOCARTA_AKT_PATHWAY" VERSION="" BUILD_DATE="">
    <GENESET SUB_CATEGORY_CODE="CP:BIOCARTA" ORGANISM="Homo sapiens" CATEGORY_CODE="C2" STANDARD_NAME="BIOCARTA_AKT_PATHWAY" SYSTEMATIC_NAME="M15258" HISTORICAL_NAMES="" PMID="" GEOID="" EXACT_SOURCE="" CHIP="EntrezGeneIds" AUTHORS="" CONTRIBUTOR="BioCarta" CONTRIBUTOR_ORG="BioCarta" EXTERNAL_DETAILS_URL="http://www.biocarta.com/pathfiles/h_aktPathway.asp" GENESET_LISTING_URL="http://www.biocarta.com/pathfiles/PathwayProteinList.asp?showPFID=89" DESCRIPTION_BRIEF="AKT Signaling Pathway" DESCRIPTION_FULL="Many cell-surface receptors induce production of second messengers like PIP3, phosphatidylinositol 3,4,5-trisphosphate, that convey signals to the cytoplasm from the cell surface. PIP3 signals activates the kinase PDK1, 3-phosphoinositide-dependent protein kinase-1, which in turn activates the kinase AKT, also known as protein kinase B. Proteins phosphorylated by activated AKT promote cell survival. Phosphorylation of Ikappa-B kinase leads to activation of the transcription factor NF-kB to oppose apoptosis. Bad is a protein in the Bcl-2 gene family that opposes Bcl-2 to induce apoptosis. Phosphorylation of Bad by AKT blocks anti-apoptotic activity to promote cell survival. Similarly, phosphorylation of the protease caspase 9 or forkhead transcription factors by AKT block the induction of apoptosis by these factors. AKT promotes cell survival and opposes apoptosis by a variety of routes." TAGS="" MEMBERS="1147,207,2308,2309,2688,2690,3320,3551,356,4303,4790,4792,5170,5290,5294,5295,5515,572,5970,7533,842,8517" MEMBERS_MAPPING="1147,CHUK,1147|207,AKT1,207|2308,FOXO1,2308|2309,FOXO3,2309|2688,GH1,2688|2690,GHR,2690|3320,HSP90AA1,3320|3551,IKBKB,3551|356,FASLG,356|4303,FOXO4,4303|4790,NFKB1,4790|4792,NFKBIA,4792|5170,PDPK1,5170|5290,PIK3CA,5290|5294,PIK3CG,5294|5295,PIK3R1,5295|5515,PPP2CA,5515|572,BAD,572|5970,RELA,5970|7533,YWHAH,7533|842,CASP9,842|8517,IKBKG,8517" MEMBERS_SYMBOLIZED="AKT1,BAD,CASP9,CHUK,FASLG,FOXO1,FOXO3,FOXO4,GH1,GHR,HSP90AA1,IKBKB,IKBKG,NFKB1,NFKBIA,PDPK1,PIK3CA,PIK3CG,PIK3R1,PPP2CA,RELA,YWHAH" MEMBERS_EZID="1147,207,2308,2309,2688,2690,3320,3551,356,4303,4790,4792,5170,5290,5294,5295,5515,572,5970,7533,842,8517"/>
</MSIGDB>
