Overview

Gene Set Enrichment Analysis (GSEA) is a computational method that determines whether an a priori defined set of genes shows statistically
significant, concordant differences between two biological states
(e.g. phenotypes).

From this web site, you can:

What's New

03-Jan-2012:  We now have a CiteULike page where users can browse a list of all citations of the GSEA algorithm.

20-Oct-2011:  We recently submitted a manuscript to Statistical Methods in Medical Research which provides a systematic comparison of the GSEA method with other methods employing a "simpler" t-test assessment of enrichment.

29-Mar-2011: Version 3.7 of this web site has been released. We reviewed and updated the text for improved clarity, and fixed some minor bugs. No changes have been made to the MSigDB data or the GSEA desktop software.

09-Sep-2010: We are pleased to announce the release of version 3.0 of the Molecular Signatures Database (MSigDB). It contains an extensively revised and expanded version of the C2 collection of canonical pathways and literature gene sets. In addition, we have made several enhancements to the GSEA and MSigDB website, and fixed an error in the Compute Overlaps procedure. For further details, see the release notes.

Registration

Please register to download the GSEA software and view the MSigDB gene sets. After registering, you can log in at any time using your email address. Registration is free. Its only purpose is to help us track usage for reports to our funding agencies.

Contributors

GSEA and MSigDB are maintained by the GSEA team with the support of our MSigDB Scientific Advisory Board. Our thanks to our many contributors. Funded by: National Cancer Institute, National Institutes of Health, National Institute of General Medical Sciences.

Citing GSEA

To cite your use of the GSEA software, please reference Subramanian, Tamayo, et al. (2005, PNAS 102, 15545-15550) and Mootha, Lindgren, et al. (2003, Nat Genet 34, 267-273).