Overview

Gene Set Enrichment Analysis (GSEA) is a computational method that determines whether an a priori defined set of genes shows statistically
significant, concordant differences between two biological states
(e.g. phenotypes).

From this web site, you can:

What's New

23-Jan-2014: Version 2.0.14 of the GSEA desktop application is now available, which contains a number of upgrades and bug fixes. See the GSEA v2.0.14 Release Notes for details.

05-Jun-2013: Version 4.0 of the Molecular Signatures Database (MSigDB) is now available, which includes a new gene set collection (C7) of 1,910 immunologic signatures generated as part of the Human Immunology Project Consortium. We also released a newer version (2.0.13) of the GSEA desktop application. There were no changes to the GSEA algorithm.

Registration

Please register to download the GSEA software and view the MSigDB gene sets. After registering, you can log in at any time using your email address. Registration is free. Its only purpose is to help us track usage for reports to our funding agencies.

Contributors

GSEA and MSigDB are maintained by the GSEA team with the support of our MSigDB Scientific Advisory Board. Our thanks to our many contributors. Funded by: National Cancer Institute, National Institutes of Health, National Institute of General Medical Sciences.

Citing GSEA

To cite your use of the GSEA software, please reference Subramanian, Tamayo, et al. (2005, PNAS 102, 15545-15550) and Mootha, Lindgren, et al. (2003, Nat Genet 34, 267-273).