Gene Set Enrichment Analysis (GSEA) is a computational method that determines whether an a priori defined set of genes shows statistically
significant, concordant differences between two biological states
(e.g. phenotypes).

From this web site, you can:

What's New

16-Mar-2015: Version 5.0 of the Molecular Signatures Database (MSigDB) is now available. It includes a new collection (H) of 50 hallmark signatures and a number of other additions and updates. See the release notes MSigDB v5.0 Release Notes for details

10-Jun-2014: In collaboration with the Bader Lab at the University of Toronto, we have added Enrichment Map visualizations as one of the steps in a GSEA analysis. See the GSEA v2.1.0 Release Notes for details.

23-Jan-2014: Version 2.0.14 of the GSEA desktop application is now available, which contains a number of upgrades and bug fixes. See the GSEA v2.0.14 Release Notes for details.

05-Jun-2013: Version 4.0 of the Molecular Signatures Database (MSigDB) is now available, which includes a new gene set collection (C7) of 1,910 immunologic signatures generated as part of the Human Immunology Project Consortium. We also released a newer version (2.0.13) of the GSEA desktop application. There were no changes to the GSEA algorithm.


Please register to download the GSEA software and view the MSigDB gene sets. After registering, you can log in at any time using your email address. Registration is free. Its only purpose is to help us track usage for reports to our funding agencies.


GSEA and MSigDB are maintained by the GSEA team with the support of our MSigDB Scientific Advisory Board. Our thanks to our many contributors. Funded by: National Cancer Institute, National Institutes of Health, National Institute of General Medical Sciences.

Citing GSEA

To cite your use of the GSEA software, please reference Subramanian, Tamayo, et al. (2005, PNAS 102, 15545-15550) and Mootha, Lindgren, et al. (2003, Nat Genet 34, 267-273).