Matthew Henn

Matthew Henn is a Research Scientist II with the Genome Sequencing and Analysis program at the Broad Institute. Dr. Henn has over 11 years of combined research experience in microbiology and microbial genomics that spans both environmental and infectious disease applications. He joined the Broad in 2004 and is responsible for scientific project development for the Institute's Genome Sequencing Center for Infectious Disease and leads the Broad's viral genomics research efforts.

Dr. Henn has developed many successful large-scale community genome sequencing projects that span several kingdoms of life and has lead the establishment of numerous global genomic consortium including partners from both academia and industry. He is an expert in the development, implementation, and application of various sequencing technologies to the study of viruses and phage and the analysis of these genomic data. Specifically, he has led the Broad's efforts to develop high-throughput sequencing, assembly and annotation pipelines for viruses such as Dengue, HCV, HIV, and WNV, as well as the application of next-generation sequencing technologies to the capture of intra-host viral diversity and the sequencing of unknown phage from environmental samples. In addition, he directs the Broad’s viral bioinformatics efforts which focuses on the development of software tools to enable the analysis of large-scale genomic datasets. These tools include various statistical and visualization packages targeted at identifying significant mutations and regions in the genome under selection as well as web-based general user interfaces for accessing and searching genomic data.

Dr. Henn earned his Ph.D. from the University of California at Berkeley, where he was a NASA Earth Systems Sciences fellow, and trained as an NSF Postdoctoral Fellow in Microbiology at Duke University before joining the Broad.