2012 Research Highlights
Uzoamaka Agubokwu, a junior at Lincoln University majoring in biology, studied the effects of insulin-like growth factor II on liver gene expression using Gene Set Enrichment Analysis (GSEA).
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Andrew Baxter, a junior at the University of New Mexico majoring in mathematics, designed an algorithm that differentiates bacterial transcript boundaries in RNA-seq expression data from variations caused by technical artifacts.
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Kayla Berry, a senior at Harvard University with a concentration in chemical and physical biology, spent the summer validating diverse fragments as binders to NFκB1 (p50).
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Rebecca de Frates, a sophomore at the University of Washington in Seattle majoring in Molecular and Cellular Biology, investigated missense variants in voltage-gated calcium channels associated with schizophrenia.
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Leah Escalante, a senior at the University of Wisconsin-Madison majoring in biochemistry, studied the interplay of DNA methylation and chromatin machinery during early embryogenesis.
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David Jaramillo, a sophomore at Harvard concentrating in chemistry and doing a secondary in philosophy, worked on connecting the chemical structure of compounds to biological effects by gene-expression profiling.
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Samuel O.Figueroa Lazú, a sophomore at the University of Puerto Rico-Humacao majoring in chemistry, studied a new class of histone deacetylase inhibitors whose mechanism of action involves the covalent binding of quinone methides.
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Kayla Lee, a senior biology major at Hampton University, mapped and characterized N6-methyladenosine (m6A), an internal base modification found on eukaryotic mRNA.
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Kyle Nakatsuka, a sophomore at Southern Methodist University with a combined major in biology, chemistry, anthropology, and Spanish, investigated linking kinase inhibition to the TMPRSS2-ERG pathway found in prostate cancer.
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Talmo Pereira, a sophomore at the University of Maryland, Baltimore County, majoring in biochemistry and molecular biology, worked on elucidating the neurobiology of the axonal initial segment through different biochemical assays.
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Kedar Perkins, a junior at the University of Maryland, Baltimore County, majoring in chemistry, synthesized small molecule suppressors of cytokine-induced β-cell apoptosis.
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Javier Pineda, a senior at the University of Notre Dame majoring in chemistry and theology, used molecular dynamics simulations and modeling to study the DOT1L and EZH2 methyltransferases, which are involved in cancer.
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Mohammed A. Toure, a freshman at Harvard University concentrating in biomedical engineering, worked on the modulation of c-Myc-mediated transcription with small molecules.
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Cynthia Whittington, a junior at Hampton University majoring in nursing, conducted a project that focused on the ethical dilemmas posed by the use of banked samples for genomic research without proper consent.
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