Difference between revisions of "GIANT consortium data files"

From Giant Consortium
Jump to navigation Jump to search
(58 intermediate revisions by the same user not shown)
Line 29: Line 29:
 
If you use these '''waist-hip ratio adjusted for BMI''' data, please cite: [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=20935629 Heid, I.M., Jackson, A.U., Randall, J.C., Winkler, T.W., Qi, L., Steinthorsdottir, V., Thorleifsson, G., Zillikens, M.C., Speliotes, E.K., Magi, R., et al.] (2010). Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet <strong>42</strong>, 949-960.
 
If you use these '''waist-hip ratio adjusted for BMI''' data, please cite: [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=20935629 Heid, I.M., Jackson, A.U., Randall, J.C., Winkler, T.W., Qi, L., Steinthorsdottir, V., Thorleifsson, G., Zillikens, M.C., Speliotes, E.K., Magi, R., et al.] (2010). Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet <strong>42</strong>, 949-960.
  
= GIANT consortium 2012-2013 GWAS Metadata is Available Here for Download =  
+
= GIANT consortium 2012-2015 GWAS Metadata is Available Here for Download =  
  
===2012-2013 Data File Description:===
+
===2012-2015 Data File Description:===
Each file consists of the following information for each SNP and its association to the specified trait based on meta-analysis in the respective publication. Significant digits for the p values, betas and standard errors are limited to two digits to further limit the possibility of identifiability.
+
Each file consists of the following information for each SNP and its association to the specified trait based on meta-analysis in the respective publication. Significant digits for the p values, betas and standard errors are limited to two digits to further limit the possibility of identifiability.  
 
*'''MarkerName''': The [http://www.ncbi.nlm.nih.gov/SNP/ dbSNP] name of the genetic marker
 
*'''MarkerName''': The [http://www.ncbi.nlm.nih.gov/SNP/ dbSNP] name of the genetic marker
*'''Allele1''': The first allele, by definition the trait-increasing allele (hg18 + strand)
+
*'''Allele1''': The first allele (hg19 + strand). Where the regression coefficients (betas) are provided, the first allele is the effect allele.  Where betas are not provided (typically the 2010 data), the first allele is the trait-increasing allele.
*'''Allele2''': The second allele (hg18 + strand)
+
*'''Allele2''': The second allele (hg19 + strand)
 
*'''Freq.Allele1.HapMapCEU''': The allele frequency of Allele1 in the [http://www.hapmap.org HapMap] CEU population
 
*'''Freq.Allele1.HapMapCEU''': The allele frequency of Allele1 in the [http://www.hapmap.org HapMap] CEU population
 
*'''b''': beta
 
*'''b''': beta
 
*'''SE''': standard error
 
*'''SE''': standard error
 
*'''p''': p-value after meta-analysis using regression coefficients (beta and standard error), and after correction for inflation of test statistics using genomic control both at the individual study level and again after meta-analysis
 
*'''p''': p-value after meta-analysis using regression coefficients (beta and standard error), and after correction for inflation of test statistics using genomic control both at the individual study level and again after meta-analysis
*'''N''': Number of observations  
+
*'''N''': Number of observations
 +
 
 +
 
 +
For the Height DEPICT Gene Set Enrichment Analysis file, the columns are as follows:
 +
*'''A''': the ID of the predefined gene set (before reconstitution by DEPICT);
 +
*'''B''': the name of the gene set;
 +
*'''C''': the DEPICT P-value for enrichment;
 +
*'''D''': the false discovery rate for enrichment;
 +
*'''E''': the genes in the gene set that overlap height-associated loci
 +
 
 +
 
 +
==GWAS Anthropometric 2015 BMI==
 +
*[[Media:Men_SNP_gwas_mc_merge_nogc.tbl.uniq.gz|Download BMI Men Only GZIP]]
 +
 
 +
*[[Media:Women_SNP_gwas_mc_merge_nogc.tbl.uniq.gz|Download BMI Women Only GZIP]]
 +
 
 +
*[[Media:SNP_gwas_mc_merge_nogc.tbl.uniq.gz|Download BMI EUR Ancestry GZIP]]
 +
 
 +
*[[Media:All_ancestries_SNP_gwas_mc_merge_nogc.tbl.uniq.gz|Download BMI All Ancestries GZIP]]
 +
 
 +
If you use these '''BMI''' data, please cite: Locke AE, Kahali B, Berndt SI, Justice AE, Pers TH, Day FR, Powell C, Vedantam S, Buchkovich ML, Yang J, Croteau-Chonka DC, Esko T et al. (2015). Genetic studies of body mass index yield new insights for obesity biology. Nature 518, 197-206.
 +
 
 +
==GWAS Anthropometric 2015 Waist==
 +
'''HIP:'''
 +
*[[Media:GIANT_2015_HIP_MALES_EUR.txt.gz| Download HIP Males EUR GZIP]]
 +
*[[Media:GIANT_2015_HIP_MALES_AllAncestries.txt.gz| Download HIP Males All Ancestries GZIP ]]
 +
*[[Media:GIANT_2015_HIP_FEMALES_EUR.txt.gz| Download HIP Females EUR GZIP ]]
 +
*[[Media:GIANT_2015_HIP_FEMALES_AllAncestries.txt.gz| Download HIP Females All Ancestries GZIP ]]
 +
*[[Media:GIANT_2015_HIP_COMBINED_EUR.txt.gz| Download HIP Combined EUR GZIP ]]
 +
*[[Media:GIANT_2015_HIP_COMBINED_AllAncestries.txt.gz| Download HIP Combined All Ancestries GZIP]]
 +
 
 +
'''HIPadjBMI:'''
 +
*[[Media:GIANT_2015_HIPadjBMI_MALES_EUR.txt.gz| Download HIPadjBMI Males EUR GZIP]]
 +
*[[Media:GIANT_2015_HIPadjBMI_MALES_AllAncestries.txt.gz| Download HIPadjBMI Males All Ancestries GZIP]]
 +
*[[Media:GIANT_2015_HIPadjBMI_FEMALES_EUR.txt.gz| Download HIPadjBMI Females EUR GZIP]]
 +
*[[Media:GIANT_2015_HIPadjBMI_FEMALES_AllAncestries.txt.gz| Download HIPadjBMI Females All Ancestries GZIP]]
 +
*[[Media:GIANT_2015_HIPadjBMI_COMBINED_EUR.txt.gz| Download HIPadjBMI Combined EUR GZIP]]
 +
*[[Media:GIANT_2015_HIPadjBMI_COMBINED_AllAncestries.txt.gz| Download HIPadjBMI Combined All Ancestries GZIP]]
 +
 
 +
'''WC:'''
 +
*[[Media:GIANT_2015_WC_MALES_EUR.txt.gz| Download WC Males EUR GZIP]]
 +
*[[Media:GIANT_2015_WC_MALES_AllAncestries.txt.gz| Download WC Males All Ancestries GZIP]]
 +
*[[Media:GIANT_2015_WC_FEMALES_EUR.txt.gz| Download WC Females EUR GZIP]]
 +
*[[Media:GIANT_2015_WC_FEMALES_AllAncestries.txt.gz| Download WC Females All Ancestries GZIP]]
 +
*[[Media:GIANT_2015_WC_COMBINED_EUR.txt.gz| Download WC Combined EUR GZIP]]
 +
*[[Media:GIANT_2015_WC_COMBINED_AllAncestries.txt.gz| Download WC Combined All Ancestries GZIP]]
 +
 
 +
'''WCadjBMI:'''
 +
*[[Media:GIANT_2015_WCadjBMI_MALES_EUR.txt.gz| Download WCadjBMI Males EUR GZIP]]
 +
*[[Media:GIANT_2015_WCadjBMI_MALES_AllAncestries.txt.gz| Download WCadjBMI Males All Ancestries GZIP]]
 +
*[[Media:GIANT_2015_WCadjBMI_FEMALES_EUR.txt.gz| Download WCadjBMI Females EUR GZIP]]
 +
*[[Media:GIANT_2015_WCadjBMI_FEMALES_AllAncestries.txt.gz| Download WCadjBMI Females All Ancestries GZIP]]
 +
*[[Media:GIANT_2015_WCadjBMI_COMBINED_EUR.txt.gz| Download WCadjBMI Combined EUR GZIP]]
 +
*[[Media:GIANT_2015_WCadjBMI_COMBINED_AllAncestries.txt.gz| Download WCadjBMI Combined All Ancestries GZIP]]
 +
 
 +
'''WHR:'''
 +
*[[Media:GIANT_2015_WHR_MALES_EUR.txt.gz| Download WHR Males EUR GZIP]]
 +
*[[Media:GIANT_2015_WHR_MALES_AllAncestries.txt.gz| Download WHR Males All Ancestries GZIP]]
 +
*[[Media:GIANT_2015_WHR_FEMALES_EUR.txt.gz| Download WHR Females EUR GZIP]]
 +
*[[Media:GIANT_2015_WHR_FEMALES_AllAncestries.txt.gz| Download WHR Females All Ancestries GZIP]]
 +
*[[Media:GIANT_2015_WHR_COMBINED_EUR.txt.gz| Download WHR Combined EUR GZIP]]
 +
*[[Media:GIANT_2015_WHR_COMBINED_AllAncestries.txt.gz| Download WHR Combined All Ancestries GZIP]]
 +
 
 +
'''WHRadjBMI:'''
 +
*[[Media:GIANT_2015_WHRadjBMI_MALES_EUR.txt.gz| Download WHRadjBMI Males EUR GZIP]]
 +
*[[Media:GIANT_2015_WHRadjBMI_MALES_AllAncestries.txt.gz| Download WHRadjBMI Males All Ancestries GZIP]]
 +
*[[Media:GIANT_2015_WHRadjBMI_FEMALES_EUR.txt.gz| Download WHRadjBMI Females EUR GZIP]]
 +
*[[Media:GIANT_2015_WHRadjBMI_FEMALES_AllAncestries.txt.gz| Download WHRadjBMI Females All Ancestries GZIP]]
 +
*[[Media:GIANT_2015_WHRadjBMI_COMBINED_EUR.txt.gz| Download WHRadjBMI Combined EUR GZIP]]
 +
*[[Media:GIANT_2015_WHRadjBMI_COMBINED_AllAncestries.txt.gz| Download WHRadjBMI Combined All Ancestries GZIP]]
 +
 
 +
If you use these '''Waist''' data please cite: Shungin D, Winkler TW, Croteau-Chonka DC, Ferreira T, Locke AE, Magi R, Strawbridge R, Pers TH, Fischer K, Justice AE, Workalemahu T, Wu JM, et al. (2015). New genetic loci link adipose and insulin biology to body fat distribution. Nature <strong>518</strong>: 187-196.
 +
 
 +
==GWAS Anthropometric 2014 Height==
 +
 
 +
*[[Media:GIANT_HEIGHT_Wood_et_al_2014_publicrelease_HapMapCeuFreq.txt.gz|Download Height GZIP]]
 +
 +
*[[Media:GIANT_HEIGHT_Wood_et_al_2014_depict_gene_set_enrichment.txt.gz|Download full set of DEPICT gene set enrichment results GZIP]]
 +
 
 +
If you use these '''Height''' data, please cite: [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=25282103 Wood AR, Esko T, Yang J, Vedantam S, Pers TH, Gustafsson S et al.] (2014). Defining the role of common variation in the genomic and biological architecture of adult human height. Nature Genetics <strong>11</strong>:1173-86.
  
 
==Variability in BMI and Height==
 
==Variability in BMI and Height==
Line 48: Line 127:
 
*[[Media:GIANT_Yang2012Nature_publicrelease_HapMapCeuFreq_Height.txt.gz|Download Height GZIP]]
 
*[[Media:GIANT_Yang2012Nature_publicrelease_HapMapCeuFreq_Height.txt.gz|Download Height GZIP]]
  
If you use these '''Body Mass Index''' or '''Heigh'''t data, please cite: [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=22982992 Yang J, Loos RJ, Powell JE, Medland SE, Speliotes EK, Chasman DI, Rose LM, Thorleifsson G, Steinthorsdottir V, Mägi R, et al.] (2012). FTO genotype is associated with phenotypic variability of body mass index. Nature <strong>490</strong>, 267-272.
+
If you use these '''Body Mass Index''' or '''Height''' data, please cite: [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=22982992 Yang J, Loos RJ, Powell JE, Medland SE, Speliotes EK, Chasman DI, Rose LM, Thorleifsson G, Steinthorsdottir V, Mägi R, et al.] (2012). FTO genotype is associated with phenotypic variability of body mass index. Nature <strong>490</strong>:267-272.
  
 
==Sex Stratified Anthropometrics==
 
==Sex Stratified Anthropometrics==
*[[Media:GIANT_Randall2013PlosGenet_stage1_publicrelease_HapMapCeuFreq_BMI_MEN.txt.gz|Download BMI Men GZIP]]
 
*[[Media:GIANT_Randall2013PlosGenet_stage1_publicrelease_HapMapCeuFreq_BMI_WOMEN.txt.gz|Download BMI Women GZIP]]
 
  
*[[Media:GIANT_Randall2013PlosGenet_stage1_publicrelease_HapMapCeuFreq_HEIGHT_MEN.txt.gz|Download HEIGHT Men GZIP]]
+
*[[Media:GIANT_Randall2013PlosGenet_stage1_publicrelease_HapMapCeuFreq_BMI_MEN_N.txt|Download BMI Men]]
*[[Media:GIANT_Randall2013PlosGenet_stage1_publicrelease_HapMapCeuFreq_HEIGHT_WOMEN.txt.gz| Download HEIGHT Women GZIP]]
+
*[[Media:GIANT_Randall2013PlosGenet_stage1_publicrelease_HapMapCeuFreq_BMI_WOMEN_N.txt|Download BMI Women]]
 +
 
 +
*[[Media:GIANT_Randall2013PlosGenet_stage1_publicrelease_HapMapCeuFreq_HEIGHT_MEN_N.txt|Download HEIGHT Men]]
 +
*[[Media:GIANT_Randall2013PlosGenet_stage1_publicrelease_HapMapCeuFreq_HEIGHT_WOMEN_N.txt| Download HEIGHT Women]]
 +
 
 +
*[[Media:GIANT_Randall2013PlosGenet_stage1_publicrelease_HapMapCeuFreq_HIP_MEN_N.txt|Download HIP Men]]
 +
*[[Media:GIANT_Randall2013PlosGenet_stage1_publicrelease_HapMapCeuFreq_HIP_WOMEN_N.txt|Download HIP Women]]
 +
 
 +
*[[Media:GIANT_Randall2013PlosGenet_stage1_publicrelease_HapMapCeuFreq_HIPadjBMI_MEN_N.txt|Download HIPadjBMI Men]]
 +
*[[Media:GIANT_Randall2013PlosGenet_stage1_publicrelease_HapMapCeuFreq_HIPadjBMI_WOMEN_N.txt|Download HIPadjBMI Women]]
 +
 
 +
*[[Media:GIANT_Randall2013PlosGenet_stage1_publicrelease_HapMapCeuFreq_WC_MEN_N.txt|Download WC Men]]
 +
*[[Media:GIANT_Randall2013PlosGenet_stage1_publicrelease_HapMapCeuFreq_WC_WOMEN_N.txt|Download WC Women]]
 +
 
 +
*[[Media:GIANT_Randall2013PlosGenet_stage1_publicrelease_HapMapCeuFreq_WCadjBMI_MEN_N.txt| Download WCadjBMI Men]]
 +
*[[Media:GIANT_Randall2013PlosGenet_stage1_publicrelease_HapMapCeuFreq_WCadjBMI_WOMEN_N.txt|Download WCadjBMI Women]]
 +
 
 +
*[[Media:GIANT_Randall2013PlosGenet_stage1_publicrelease_HapMapCeuFreq_WEIGHT_MEN_N.txt|Download WEIGHT Men]]
 +
*[[Media:GIANT_Randall2013PlosGenet_stage1_publicrelease_HapMapCeuFreq_WEIGHT_WOMEN_N.txt|Download WEIGHT Women]]
 +
 
 +
*[[Media:GIANT_Randall2013PlosGenet_stage1_publicrelease_HapMapCeuFreq_WHR_MEN_N.txt|Download WHR Men]]
 +
*[[Media:GIANT_Randall2013PlosGenet_stage1_publicrelease_HapMapCeuFreq_WHR_WOMEN_N.txt|Download WHR Women]]
 +
 
 +
*[[Media:GIANT_Randall2013PlosGenet_stage1_publicrelease_HapMapCeuFreq_WHRadjBMI_MEN_N.txt|Download WHRadjBMI Men]]
 +
*[[Media:GIANT_Randall2013PlosGenet_stage1_publicrelease_HapMapCeuFreq_WHRadjBMI_WOMEN_N.txt|Download WHRadjBMI Women]]
 +
 
 +
If you use these data, please cite: [http://www.ncbi.nlm.nih.gov/pubmed/23754948?dopt=Citation Randall JC, Winkler TW, Kutalik Z, Berndt SI, Jackson AU, Monda KL, Kilpeläinen TO, Esko T, Mägi R, Li S, et al.] (2013). Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits. PLoS Genet <strong>9</strong>: e1003500.
 +
 
 +
==Extremes of Anthropometric Traits==
 +
 
 +
*[[Media:GIANT_EXTREME_BMI_Stage1_Berndt2013_publicrelease_HapMapCeuFreq.txt.gz|Download Extreme BMI Stage 1 GZIP]]
  
*[[Media:GIANT_Randall2013PlosGenet_stage1_publicrelease_HapMapCeuFreq_HIP_MEN.txt.gz|Download HIP Men GZIP]]
+
*[[Media:GIANT_EXTREME_HEIGHT_Stage1_Berndt2013_publicrelease_HapMapCeuFreq.txt.gz| Download Extreme Height Stage 1 GZIP]]
*[[Media:GIANT_Randall2013PlosGenet_stage1_publicrelease_HapMapCeuFreq_HIP_WOMEN.txt.gz|Download HIP Women GZIP]]
 
  
*HIPadjBMI Men
+
*[[Media: GIANT_EXTREME_WHR_Stage1_Berndt2013_publicrelease_HapMapCeuFreq.txt.gz | Download Extreme WHR Stage 1 GZIP]]
*HIPadjBMI Women
 
  
*WAIST Men
+
*[[Media:GIANT_OBESITY_CLASS1_Stage1_Berndt2013_publicrelease_HapMapCeuFreq.txt.gz | Download Obesity Class 1 Stage 1 GZIP]]
*WAIST Women
 
  
*WC Men
+
*[[Media:GIANT_OBESITY_CLASS2_Stage1_Berndt2013_publicrelease_HapMapCeuFreq.txt.gz | Download Obesity Class 2 Stage1 GZIP]]
*WC Women
 
  
*WCadjBMI Men
+
*[[Media:GIANT_OBESITY_CLASS3_Stage1_Berndt2013_publicrelease_HapMapCeuFreq.txt.gz | Download Obesity Class 3 Stage1 GZIP]]
*WCadjBMI Women
 
  
*WEIGHT Men
+
*[[Media:GIANT_OVERWEIGHT_Stage1_Berndt2013_publicrelease_HapMapCeuFreq.txt.gz | Download Overweight Stage 1 GZIP]]
*WEIGHT Women
 
*WHR Men
 
*WHR Women
 
*WHRadjBMI Men
 
*WHRadjBMI Women
 
  
==Anthropometric Traits==
+
If you use these data, please cite: [http://www.ncbi.nlm.nih.gov/pubmed/23563607?dopt=Citation Berndt SI, Gustafsson S, Mägi R, Ganna A, Wheeler E, Feitosa MF, Justice AE, Monda KL, Croteau-Chonka DC, Day FR, et al.] (2013). Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nature Genetics <strong>45</strong>:501-512.

Revision as of 23:29, 8 March 2015

We are releasing the summary data from our 2010-2013 meta-analyses of Genome-wide Association (GWA) data, in order to enable other researchers to examine particular variants or loci for their evidence of association with anthropometric traits. The files include p-values and direction of effect at over 2 million directly genotyped or imputed single nucleotide polymorphisms (SNPs). To prevent the possibility of identification of individuals from these summary results, we are not releasing allele frequency data from our samples.

GIANT Consortium 2010 GWAS Metadata is Available Here for Download

2010 Data File Description:

Each file consists of the following information for each SNP and its association to the specified trait based on meta-analysis in the respective publication. SNPs where N < 50% of the maximum have been excluded.

  • MarkerName: The dbSNP name of the genetic marker
  • Allele1: The first allele, by definition the trait-increasing allele (hg18 + strand)
  • Allele2: The second allele (hg18 + strand)
  • Freq.Allele1.HapMapCEU: The allele frequency of Allele1 in the HapMap CEU population
  • P: P value after meta-analysis using regression coefficients (beta and standard error), and after correction for inflation of test statistics using genomic control both at the individual study level and again after meta-analysis
  • N: Number of observations

BMI (download GZIP)

MD5 (GIANT_BMI_Speliotes2010_publicrelease_HapMapCeuFreq.txt -- 79 MB; 2,471,517 lines) = 38c836542807a3830101bcf48bb34472

If you use these Body Mass Index data, please cite: Speliotes, E.K., Willer, C.J., Berndt, S.I., Monda, K.L., Thorleifsson, G., Jackson, A.U., Allen, H.L., Lindgren, C.M., Luan, J., Magi, R., et al. (2010). Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet 42, 937-948.

Height (download GZIP)

MD5 (GIANT_HEIGHT_LangoAllen2010_publicrelease_HapMapCeuFreq.txt -- 82 MB; 2,469,636 lines) = b51b4c4ff1f03bd33c4b2dfd6b10cb82

If you use these height data, please cite: Lango Allen, H., Estrada, K., Lettre, G., Berndt, S.I., Weedon, M.N., Rivadeneira, F., Willer, C.J., Jackson, A.U., Vedantam, S., Raychaudhuri, S., et al. (2010). Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature 467, 832-838.

WHRadjBMI (download GZIP)

MD5 (GIANT_WHRadjBMI_Heid2010_publicrelease_HapMapCeuFreq.txt -- 75 MB; 2,483,326 lines) = 8f7e2ca61c33a120db9e7bfe51e3c053

If you use these waist-hip ratio adjusted for BMI data, please cite: Heid, I.M., Jackson, A.U., Randall, J.C., Winkler, T.W., Qi, L., Steinthorsdottir, V., Thorleifsson, G., Zillikens, M.C., Speliotes, E.K., Magi, R., et al. (2010). Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet 42, 949-960.

GIANT consortium 2012-2015 GWAS Metadata is Available Here for Download

2012-2015 Data File Description:

Each file consists of the following information for each SNP and its association to the specified trait based on meta-analysis in the respective publication. Significant digits for the p values, betas and standard errors are limited to two digits to further limit the possibility of identifiability.

  • MarkerName: The dbSNP name of the genetic marker
  • Allele1: The first allele (hg19 + strand). Where the regression coefficients (betas) are provided, the first allele is the effect allele. Where betas are not provided (typically the 2010 data), the first allele is the trait-increasing allele.
  • Allele2: The second allele (hg19 + strand)
  • Freq.Allele1.HapMapCEU: The allele frequency of Allele1 in the HapMap CEU population
  • b: beta
  • SE: standard error
  • p: p-value after meta-analysis using regression coefficients (beta and standard error), and after correction for inflation of test statistics using genomic control both at the individual study level and again after meta-analysis
  • N: Number of observations


For the Height DEPICT Gene Set Enrichment Analysis file, the columns are as follows:

  • A: the ID of the predefined gene set (before reconstitution by DEPICT);
  • B: the name of the gene set;
  • C: the DEPICT P-value for enrichment;
  • D: the false discovery rate for enrichment;
  • E: the genes in the gene set that overlap height-associated loci


GWAS Anthropometric 2015 BMI

If you use these BMI data, please cite: Locke AE, Kahali B, Berndt SI, Justice AE, Pers TH, Day FR, Powell C, Vedantam S, Buchkovich ML, Yang J, Croteau-Chonka DC, Esko T et al. (2015). Genetic studies of body mass index yield new insights for obesity biology. Nature 518, 197-206.

GWAS Anthropometric 2015 Waist

HIP:

HIPadjBMI:

WC:

WCadjBMI:

WHR:

WHRadjBMI:

If you use these Waist data please cite: Shungin D, Winkler TW, Croteau-Chonka DC, Ferreira T, Locke AE, Magi R, Strawbridge R, Pers TH, Fischer K, Justice AE, Workalemahu T, Wu JM, et al. (2015). New genetic loci link adipose and insulin biology to body fat distribution. Nature 518: 187-196.

GWAS Anthropometric 2014 Height

If you use these Height data, please cite: Wood AR, Esko T, Yang J, Vedantam S, Pers TH, Gustafsson S et al. (2014). Defining the role of common variation in the genomic and biological architecture of adult human height. Nature Genetics 11:1173-86.

Variability in BMI and Height

If you use these Body Mass Index or Height data, please cite: Yang J, Loos RJ, Powell JE, Medland SE, Speliotes EK, Chasman DI, Rose LM, Thorleifsson G, Steinthorsdottir V, Mägi R, et al. (2012). FTO genotype is associated with phenotypic variability of body mass index. Nature 490:267-272.

Sex Stratified Anthropometrics

If you use these data, please cite: Randall JC, Winkler TW, Kutalik Z, Berndt SI, Jackson AU, Monda KL, Kilpeläinen TO, Esko T, Mägi R, Li S, et al. (2013). Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits. PLoS Genet 9: e1003500.

Extremes of Anthropometric Traits

If you use these data, please cite: Berndt SI, Gustafsson S, Mägi R, Ganna A, Wheeler E, Feitosa MF, Justice AE, Monda KL, Croteau-Chonka DC, Day FR, et al. (2013). Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nature Genetics 45:501-512.