Center for Cell Circuits

Regulatory circuits in cells process signals, make appropriate decisions, and orchestrate physiological responses under diverse signals. Diseases, in turn, arise from circuit malfunctions: one or more components are missing or defective; a key module is over- or under-active. 

To understand disease and develop more effective treatments, we need a comprehensive picture of all the cellular components, the circuits in which they function, and how these integrate to form responses. We focus on a combinatorial approach: perturbing multiple components simultaneously, at a large enough scale to reliably reconstruct circuits.

The Center for Cell Circuits at the Broad Institute is a Center of Excellence in Genomic Science (CEGS), a program established by the National Human Genome Research Institute for multi-investigator, interdisciplinary research that develops novel and highly innovative genomic research projects. Our Center is now supported by its second CEGS award.