SNP Copy Number and Loss of Heterozygosity Determination
Compute SNP copy number and loss of heterozygosity (LOH) based on Affymetrix SNP chip data for paired target/normal samples. In cancer genomics, copy number change is one of the hallmarks of the genetic instability common to most human cancers and LOH of tumor suppressor genes is a crucial step in the development of sporadic and hereditary cancer (Monti, 2005).
To see the complete protocol, click here.