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Table 1: Top focal regions of amplification and deletion

Cytoband*q valuePeak region* Max /Min inferred copy # # of genes *^Known proto-oncogene/ tumor suppressor gene in region *#New candidate(s)
Amplifications       
14q13.3 2.26E-2935.61-36.0913.72 NKX2-1, MBIP
12q15 1.78E-1567.48-68.029.73MDM2 
8q24.21 9.06E-13129.18-129.3410.30MYC $  
7p11.2 9.97E-1154.65-55.528.73EGFR  
8q21.131.13E-0780.66-82.5510.48  
12q14.1 1.29E-0756.23-56.5410.415CDK4  
12p12.1 2.83E-0724.99-25.7810.46KRAS  
19q12 1.60E-0634.79-35.426.75CCNE1 
17q12 2.34E-0534.80-35.1816.112ERBB2  
11q13.3 5.17E-0568.52-69.366.59CCND1  
5p15.33 0.0002790.75-1.624.210TERT 
22q11.210.00146119.06-20.136.615  
5p15.31 0.0074728.88-10.515.67  
1q21.2 0.028766143.48-149.414.686ARNT 
20q13.320.044555.52-56.304.46  
5p14.3 0.06467319.72-23.093.82  
6p21.1 0.07806143.76-44.127.72 VEGFA
Deletions      
9p21.3 3.35E-1321.80-22.190.73CDKN2A/ CDKN2B  
9p23 0.0011499.41-10.400.41 PTPRD $$
5q11.2 0.00520258.40-59.060.61 PDE4D
7q11.22 0.02555269.50-69.620.71 AUTS2
10q23.310.06500689..67-89.950.51PTEN  




* based on hg17 human genome assembly, positions in Mb;
^ RefSeq genes only;
# Known tumor suppressor genes and proto-oncogenes defined as found in either COSMIC, CGP Census or other evidence; if there is more than one known proto-oncogene in the region, only one is listed (priority for listing is, in order: known lung adenocarcinoma mutation, known lung cancer mutation, other known mutation (by COSMIC frequency), listing in CGP Census);
$ MYC is near, but not within the peak region;
$$ Single gene deletions previously seen, this study provides new mutations as well.