Supplementary Tables









     

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Supplementary Table 13: Additional focal regions of deletion

Cytoband* q value Peak region* Min. inferred copy # # of samples (percentage) below threshold% # of most variable samples (percentage) above threshold% # of genes*^ Region reported in lung cancer? Minimal previously defined regional boundary* Notes Known tumor suppressor gene in region*# Evidence for candidate gene(s)$ Genomic evidence in lung adenocarcinoma$ Single gene deletion previously seen in cancer New candidate gene(s)
8p23.2 1.93E-062.54-3.950.88 (2.2)8 (6.5)1Yes 0.18-2.57 Potential polymorphism   CSMD1 
4q34.3 0.025552180.14-191.410.62 (0.5)2 (1.6)31Yes 182.66-183.20 Potential polymorphism     
16q23.3 0.02898381.38-81.650.83 (0.8)2 (1.6)1No Potential polymorphism   CDH13 
12p13.310.0650066.90-10.650.93 (0.8)2 (1.6)59No Potential polymorphism     
5q23.1 0.071159115.02-118.780.93 (0.8)2 (1.6)7Yes 114.60-115.05 Potential polymorphism     
22q11.230.03022623.98-24.240.83 (0.8)2 (1.6)1No Known polymorphism   LRP5L 
15q11.2 0.0125131-20.080.94 (1.1)3 (2.4)3No Known polymorphism     


% Most variable numbers and percentages refer to the top 1/3 least stromally contaminated samples, as assayed by standard deviation measurements;
* based on hg17 human genome assembly, positions in Mb;
^ RefSeq genes only; $ Abbreviations are del. = deletion and mut. = mutation.