Allele frequency from maf files

Hello,

I'm interested in the allele frequency and zygosity of the TCGA tumours in the Firehose maf files; is it appropriate to use the tumour allele columns to infer zygosity and frequency?

Thanks in advance,
Dave

Allele frequency from maf files

Hi Dave,

That approach won't work well. For a better approach, see our article in Cell:

Evolution and Impact of Subclonal Mutations in Chronic Lymphocytic Leukemia

http://www.cell.com/abstract/S0092-8674(13)00071-8

Thanks!
Gordon Saksena