Organized by Brad Bernstein
9:30 am-11:00 am
7 Cambridge Center Monadnock Room (NE30-2040)

"Inhibition of histone deacetylases for the treatment of sickle cell disease."
by Ben Ebert (Broad Institute)


"Genetics and epigenetics of Wilms tumor"
by Miguel Rivera (MGH)

Organized by David Sabatini and Michael Yaffe
11:30 am-1:00 pm
7 Cambridge Center Monadnock Room (NE30-2040)

"How T cells see antigen"
by Arup Chakraborty (MIT Dept. of Chemical Engineering)


Special Series on the Interface Between Biology & Engineering

Organized by Genome Analysis Program Leadership
1:00 pm-2:00 pm
320 Charles Street Caribbean Room (NE125-2250)

"The Long Tail of the Human Microbiome and Other Short Stories"
by Doyle Ward and Georgia Giannoukos (The Broad Institute)

Organized by Todd Golub
9:30 am-11:00 am
7 Cambridge Center Monadnock Room (NE30-2040)

"Context dependent transformation of adult pancreatic cells by oncogenic K-ras"
by Sharon Friedlander (Lab of Tyler Jacks, Ph.D.)


"Endogenous T cell responses to lung adenocarcinoma neoantigens delay malignant tumor progression"
by Michel Dupage (Lab of Tyler Jacks, Ph.D.)


Notes: CANCER PROGRAM SHUTTLE BUS - PICK UP AT 9:00 A.M.: At the Dana Farber Cancer Institute's Main Entrance located at 44 Binney Street and drop off at the main entrance to the Broad (7 Cambridge Center). RETURN PICK UP AT 11:15 a.m.: In front of the Broad (7 Cambridge Center). Will drop off at the Dana Farber Cancer Institute 44 Binney Street entrance.

8:30 am-9:30 am
7 Cambridge Center Monadnock Room (NE30-2040)

Organized by David Altshuler
9:30 am-11:00 am
7 Cambridge Center Monadnock Room (NE30-2040)

Organized by Todd Golub
9:30 am-11:00 am
7 Cambridge Center Monadnock Room (NE30-2040)

"."
by Michael Hemann (Koch Institute for Integrative Cancer Research, MIT)

Organized by Jill Mesirov
9:30 am-11:00 am
7 Cambridge Center Monadnock Room (NE30-2040)

"Beyond Transcriptome assembly: qualitative and quantitative analysis"
by Manfred Grabherr (Computational Biologist, GSAP)

Abstract: Illumina high-throughput RNA sequencing (RNA-seq) is a cost-effective vehicle to investigate the presence and prevalence of mRNA in different tissue cells. It is not always possible, however, to extrapolate this information using read-to-reference alignments, since a) an adequate reference genome might not exist, and b) especially in splice junctions, short reads are difficult to align correctly. To overcome both problems, we developed algorithms to reconstruct partial or complete transcripts through de-novo assembly, including the capture of alternatively spliced variants. Consequently, read coverage over the transcripts (rather than a reference) is used to compute a measure for expression levels, allowing us to comparatively quantify expression patterns across cells from different tissues. We show that this approach achieves good sensitivity and specificity, even in absence of a (well-annotated) reference genome.

Organized by Vamsi Mootha and Joel Hirschhorn
4:00 pm-5:30 pm
7 Cambridge Center Olympus Room (NE30-1001)

"Genetic and genomic Identification of pathways involved in fat metabolism in C. elegans."
by Alex Soukas

Organized by David Altshuler
9:30 am-11:00 am
7 Cambridge Center Monadnock Room (NE30-2040)

"Genetic Architecture of Cognitive Decline"
by David Bennett (RUSH University)

Organized by Deb Hung, Bruce Birren, Lisa Cosimi, Pardis Sabeti
9:00 am-10:00 am
7 Cambridge Center Monadnock Room (NE30-2040)

"TBD"
by Steve Carr (Broad Institute, Proteomics Platform)