Blog

  • Arrested development: head and neck cancer

    Elizabeth Cooney, July 28th, 2011

    Two teams – including one from the Broad Institute, Dana-Farber Cancer Institute, and the University of Pittsburgh School of Medicine – report surprising discoveries about head and neck cancer biology in back-to-back papers published in Science.

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  • HapMix: A tool for finding genetic diversity

    Alice McCarthy, July 21st, 2011

    When researchers from the Broad Institute and the Department of Human Genetics at Harvard University set about the task of pinpointing ancestral diversity in African Americans, the first tool they used for the job was the HapMix software engine. HapMix is a software tool that helps researchers infer the ancestry of extremely small bits of DNA.

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  • Journey of a cancer sample, part III

    Haley Bridger, July 21st, 2011

    Today, the cancer samples we have been following will go from tangible pieces of tissue to something a bit more abstract: invisible strands of pure DNA. In the process, the samples will be whirled and spun through laboratory machinery, incubated over night, and washed repeatedly with different chemical substances. The final product of all of this will be large droplets of clear liquid at the bottom of tiny, plastic Eppendorf tubes.

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  • Getting the cover story

    Leah Eisenstadt, July 19th, 2011 | Filed under

    Back in May, we told you on the blog about Trinity, a suite of tools that assembles transcripts, or bits of RNA that have been copied from a cell’s genome, into a “transcriptome,” even without a reference genome handy.

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  • Engineering the liver

    Haley Bridger, July 14th, 2011 | Filed under

    The liver is a critical and intriguing organ, and our understanding of it continues to evolve to this day. As reported in a paper published earlier this week in Proceedings of the National Academy of Sciences, Broad and MIT researchers teamed up to put artificial liver tissue to the test (read the news story here and Project Spotlight here).

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  • Functional cancer genomics comes of age

    Alice McCarthy, July 12th, 2011

    Just yesterday, a new paper from the Project Achilles team appeared online in the Proceedings of the National Academy of Sciences. Researchers examined over 100 tumors, including 25 ovarian cancer tumors in search of genes and mutations fostering cancer growth. The team found that nearly one-fifth of the ovarian tumors harbored mutations in the PAX8 gene.

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  • Word of the day: Biomarkers

    Leah Eisenstadt, July 7th, 2011 | Filed under

    Last week on the Broad website, we told you about a new approach to detect and verify biomarkers, using the search for signals of heart attack as a test case. In this study, the team of scientists from the Broad Institute and Massachusetts General Hospital looked for proteins in the blood that are released when heart cells are injured and that can be detected quickly after the attack.

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  • The changing landscape of the cancer genome

    Alice McCarthy, July 6th, 2011

    It has been a big year in the world of sequencing cancer genomes. And if you attended the recent Keystone Symposium in Boston, “The Changing Landscape of the Cancer Genome,” it’s only getting bigger – fast. The symposium focused on discoveries coming from large-scale cancer genomic efforts.

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  • Invitation to an evening of science

    Haley Bridger, July 5th, 2011 | Filed under

    More than a hundred years ago, Austrian monk Gregor Mendel observed something astounding in flowering pea plants: a first glimpse of genetics. Today, Mendel’s observations about how physical traits pass from one generation to the next continue to inspire amazing discoveries.

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  • Mystery of the mitochondria

    Haley Bridger, June 22nd, 2011 | Filed under

    Postdoctoral scholar Fabiana Perocchi remembers her Ph.D. advisor once telling her that if you want to go from a million candidates to a few thousand, you need to find something that does not agree with the pattern.

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