Blog

  • Sneak preview of 'Harnessing genomics to decipher fundamental differences'

    Elizabeth Cooney, July 31st, 2012

    Stacey Gabriel gives us a sneak peek of her upcoming Midsummer Nights’ Science lecture, which she will give on August 1. Director of the Broad's Genomics Platform, she will discuss the implications of using DNA sequencing and genotyping technologies to compare DNA from one person to another, and from humans to other animals.

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  • Building a better TAL effector toolbox

    Haley Bridger, July 26th, 2012

    To comprehend a book written in English, readers need to recognize all 26 letters of the alphabet. To probe the inner workings of the genome, researchers need tools that can recognize a much shorter alphabet: the four “letters” or bases (As, Cs, Ts, and Gs) that make up DNA. Just as frequently misreading a letter in the English alphabet can make for a bewildering read, mistaking any of the letters in the DNA alphabet can be a source of confusion too.

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  • Tethered to the genome

    Haley Bridger, July 24th, 2012

    Matthew Freedman remembers the moment as clear as day. “I was sitting in the Massachusetts General Hospital cafeteria with David Altshuler talking about human genetics, and it just hit me,” Matthew recalls. “This is what I want to do.”

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  • Sneak preview of “Regeneration of missing body parts: lessons from flatworms”

    Haley Bridger, July 19th, 2012

    Peter Reddien gives us a sneak preview of his upcoming Midsummer Nights’ Science lecture, which he will give on July 25. As Peter explains in the video below, planarians – a kind of flatworm – possess an amazing ability. They can regenerate new heads, or any other missing body part, after injury. Peter and his colleagues are trying to understand how these amazing feats of regeneration happen. Watch the video below to hear more.

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  • Sneak preview of “Dissecting the brain, one gene at a time”

    Haley Bridger, July 17th, 2012

    Last week, we spoke with core member Feng Zhang to get a sneak preview of his upcoming Midsummer Nights’ Science lecture, which he will give on July 18. His talk, titled “Dissecting the brain, one gene at a time” will introduce you to new technologies he and his colleagues are developing for genome engineering, and for manipulating the activities of different cell types, including neurons.

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  • Unpacking a complex genetic suitcase

    Haley Bridger, July 11th, 2012

    Long before Homo sapiens lived in Africa, even before Neanderthals roamed part of the world, something interesting was happening on chromosome 17. Around 2.3 million years ago, a 900-kb chunk of DNA broke off, reversed itself, and reattached on the chromosome in the opposite orientation. These kinds of genomic rearrangements (known as inversions) are not entirely uncommon, but what is unusual is that both versions of the chromosome – each with a substantial chunk of DNA pointing in a different direction – still exist in the human gene pool.

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  • Sneak preview of Miniature science - How microfluidics is powering biology

    Haley Bridger, July 5th, 2012

    Each summer, the Broad Institute holds a free, public lecture series at 7 Cambridge Center in Kendall Square in Cambridge, MA. This year, visitors will hear about the power of a tiny chip, new ways to investigate the inner-workings of the brain, the regenerative feats of flatworms, and the genomic differences that underlie our health and biology. You can find the full schedule and register for the series here.

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  • Faster, cheaper, smaller

    Leah Eisenstadt, June 26th, 2012 | Filed under

    A team of researchers at the Broad Institute recently revealed a new cell microarray capable of probing the functions of genes faster and cheaper than ever before.

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  • Two-way exchange

    Elizabeth Cooney, June 20th, 2012

    The Slim Initiative for Genomic Medicine is a two-way street, with researchers and information moving in both directions as part of an international collaboration between the Broad Institute and the National Institute of Genomic Medicine in Mexico City, known by its Spanish acronym INMEGEN.

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  • Learning the language of cancer cell metabolism

    Haley Bridger, May 29th, 2012

    When Mohit Jain joined the Broad Institute, he had no idea that the postdoc at the desk next to him would become a close collaborator and friend. Although Mo and Roland Nilsson sat only a few feet apart, they were working in different worlds.

    “I spoke the language of clinical biology, and Roland spoke the language of math,” Mo recalls. “We’d look at each other’s data, and it was as if we were speaking completely different languages. We couldn’t decipher at all what the other person did.”

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