Blog

  • MuTect: An engine powering cancer genome analysis

    Haley Bridger, February 13th, 2013

    Over the last year, researchers at the Broad and elsewhere have analyzed genes in over 100 samples of breast cancer, identified new pathways in head and neck cancer, uncovered new subtypes of prostate cancer, and revealed significant mutations in dozens of forms of cancer. Behind all of these studies lies a central tool developed by Broad researchers: MuTect. Used to detect point mutations – single “letter” alterations in the genome that may help twist a normal cell into a cancerous one – the MuTect algorithm is one of the engines powering cancer genome analysis.

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  • Genome engineering gets CRISPR

    Haley Bridger, January 9th, 2013

    Many of the most remarkable tools in genome engineering have humble beginnings. This week, Broad core member Feng Zhang and his colleagues from MIT and Rockefeller University report on one of the newest additions to the growing list of genome editing technologies. Known as CRISPR (clustered regularly interspaced short palindromic repeats) systems,

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  • Five Questions for Mitch Guttman

    Haley Bridger, December 20th, 2012

    This week, Mitch Guttman — one of the Broad Institute’s first generation of “alumni” — was named to the Forbes "30 Under 30: Science and Healthcare" list of rising stars. This accolade comes on the heels of another prestigious honor for Guttman, who received an NIH Early Independence Award in the fall.

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  • Genetic causes of disease within reach of TALENs

    Haley Bridger, December 17th, 2012

    Most likely, German physician Robert Koch never dreamed of genomes. When he died in 1910, Koch certainly didn’t know that a century later his work would still have echoes in the research of physicians and geneticists interested in our genes’ inner workings and how the code within us leads to disease.

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  • An image of Ebola emerges

    Haley Bridger, November 15th, 2012

    In the following video, Stephen Gire, a researcher in Pardis Sabeti’s lab at the Broad Institute and Harvard University, gives us a behind-the-scenes look at a perspective piece he and his colleagues published in Science Nov. 9. In the piece, Gire and his co-authors describe the widespread prevalence and ancient origins of highly contagious viruses such as Lassa and Ebola.

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  • Connecting the genetic dots of disease

    Haley Bridger, November 8th, 2012

    When Liz Rossin began the PhD portion of the Harvard/MIT MD-PhD program in the lab of Mark Daly, a ubiquitous and critical problem in genetic research caught her attention. At the time, researchers had identified more than 150 genetic regions scattered throughout the genome tied to various diseases. Such experiments, known as genome-wide association studies (GWAS), would turn up dozens of regions likely harboring genetic changes contributing to risk of disease, but would not point to specific causal mutations.

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  • Broad awarded top honor again

    Leah Eisenstadt, November 7th, 2012

    For the third straight year, the Broad Institute has been selected by the Boston Globe as one of the “Top Places to Work” in Massachusetts. This honor is an amazing tribute to the entire Broad community and its collaborative spirit.

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  • The Broad Institute is closed on Monday, October 29, 2012

    Rose Circeo, October 28th, 2012

    The Broad Institute is expected to open for normal business hours on Tuesday, October 30, 2012.

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  • Profiling multiple sclerosis

    Veronica Meade-Kelly, October 18th, 2012

    By its very nature, multiple sclerosis (MS) is disruptive. It’s disruptive at the cellular level, where the body’s own defenses attack the nervous system, stripping the protective myelin sheath that covers the nerve cells, causing interruptions in communication between the nerve cells and a deterioration of brain tissue. It’s also disruptive at a personal level. Sufferers not only deal with debilitating symptoms that can affect movement, vision, and speech but also face an unpredictable disease path that varies from person to person.

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  • MPG series “primed” to reach a wider audience

    Haley Bridger, October 10th, 2012

    Back when Christopher Newton-Cheh was a postdoctoral fellow at the Broad, he and a group of other postdocs would get together and hold informal, journal club-like discussions. The young scientists would all read one or two recent journal articles and discuss the findings and techniques, helping them stay abreast of recent work in the ever-evolving field of genetics. Over the years, those once small and informal talks among a handful of Broadies have evolved into something open to the wider Broad community.

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