• From mice to men: Broad researchers develop a human model for studying DNA methylation

    Angela Page, April 3rd, 2015

    It’s not every day that scientists get to offer their colleagues a model system that will enable a wave of future research. “Often you make a discovery, you describe it, and that’s the end of the story,” said Alexander Meissner, a Senior Associate Member at the Broad Institute of MIT and Harvard. “Here it’s not the end of something, it’s just the beginning.”

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  • Broad Summer Scholar wins prestigious Intel science prize

    Veronica Meade-Kelly, March 27th, 2015

    Each year, well over a thousand promising high school science students enter the Intel Science Talent Search, long considered the nation’s most prestigious science competition. When all is said and done, only three take home top honors and the accompanying $150,000 prize.

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  • Cancer drug resistance-from laundry list to paradigms

    Lisa Girard, March 20th, 2015

    Drug resistance is one of the greatest obstacles to effective cancer therapy. Research has shown that cancer cells can use any number of genes and strategies to achieve or acquire resistance to particular therapies. Until recently, scientists have taken a piecemeal approach to understanding the problem of resistance—unraveling individual mechanisms without reaching any kind of overarching theme.

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  • For drivers of Alzheimer’s disease, check the roadmap

    Leah Eisenstadt, March 13th, 2015

    Recently, the BroadMinded blog highlighted the exciting science emerging from the Roadmap Epigenomics program, resulting in the most comprehensive map of the human epigenome — the collection of chemical changes to DNA and its supporting proteins that help control how genes are turned on or off.

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  • Learning from Ebola

    Paul Goldsmith, March 9th, 2015

    In the fall of 2014, Ebola Zaire did for viral hemorrhagic fever what Jaws did for sharks in the summer of ‘75. The first Ebola diagnosis (and later death) on U.S. soil touched off a nationwide panic. Suddenly, Ebola was everywhere—dominating headlines, trending on social media, fueling the 24-hour news cycle. For a time, the fear and misinformation fueling the hysteria threatened to undermine relief efforts and overshadow the ongoing tragedy in West Africa.

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  • A partnership in the name of reproducible research

    Angela Page, February 27th, 2015

    In 1610, Galileo Galilei set a scientific precedent for the next half millennium: he published his notebooks. Sidereus Nuncius, as the publication was officially dubbed, documented Galilei’s observation of several astronomical features, including the orbit of Jupiter’s moons around the planet and the play of light and shadow on the earth&rsqu

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  • Epigenomics roadmap: where the road has led

    Veronica Meade-Kelly, February 20th, 2015

    The completion of the human reference genome over a decade ago served as a springboard for countless studies of genetic variation and its role in disease, but understanding how the body operates at the DNA sequence-level isn’t enough to resolve some of the finer points of human biology. Specifically: how can the same sequence of genetic code give rise to over 200 different cell types that perform distinct biological functions? And how might the processes that give rise to that functional variation contribute to human disease?

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  • Dynamic profiling of the protein life cycle in response to pathogens

    Lisa Girard, February 13th, 2015

    Cellular protein levels are dictated by the net balance of mRNA expression (the type of RNA that provides genetic information for proteins), protein synthesis, and protein degradation. While changes in protein levels are commonly inferred from measuring changes in mRNA levels (due to the difficulties involved in measuring protein levels), it’s not often clear whether determining RNA levels is actually a good proxy for measuring protein levels.

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  • Structural variation goes extreme

    Leah Eisenstadt, February 6th, 2015

    From person to person, the human genome varies in a number of important ways. Some of the variation is in the form of genetic misspellings – single nucleotide polymorphisms, or SNPs. Other variation takes the form of so-called “structural variation:” as genetic rearrangements, or as missing or extra segments of DNA, known as copy number variation (CNV). Scientists at the Broad Institute and elsewhere are working to locate and characterize many different types of variation and look for connections between the variants and human traits and disease.

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  • Attack, alter, evade: The immune system’s critical role in tumor destruction and adaptation

    Paul Goldsmith, January 30th, 2015

    One of the great misconceptions about cancer is that, since tumors originate from normal cells, they are able to disguise themselves from the immune system—lurking undetected and unopposed as they divide and proliferate. In reality, the immune system is no passive observer when it comes to cancer. Evidence is mounting that many tumors undergo almost constant immune attack. But just how these attacks are initiated and what their effect is on different tumor types has remained largely unexplored. Until now.

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