• Structural variation goes extreme

    Leah Eisenstadt, February 6th, 2015

    From person to person, the human genome varies in a number of important ways. Some of the variation is in the form of genetic misspellings – single nucleotide polymorphisms, or SNPs. Other variation takes the form of so-called “structural variation:” as genetic rearrangements, or as missing or extra segments of DNA, known as copy number variation (CNV). Scientists at the Broad Institute and elsewhere are working to locate and characterize many different types of variation and look for connections between the variants and human traits and disease.

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  • Attack, alter, evade: The immune system’s critical role in tumor destruction and adaptation

    Paul Goldsmith, January 30th, 2015

    One of the great misconceptions about cancer is that, since tumors originate from normal cells, they are able to disguise themselves from the immune system—lurking undetected and unopposed as they divide and proliferate. In reality, the immune system is no passive observer when it comes to cancer. Evidence is mounting that many tumors undergo almost constant immune attack. But just how these attacks are initiated and what their effect is on different tumor types has remained largely unexplored. Until now.

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  • Introducing: B60

    Veronica Meade-Kelly, November 25th, 2014

    B60, a new video series appearing on the Broad Institute YouTube channel, is a window into Broad science and culture. Each 60-second video offers a glimpse into the innovative work taking place at the institute, and the spirit of collaboration and creativity that makes it possible. Watch the series to learn how the Broad is tackling some of the most ambitious challenges in biomedicine today.

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  • Cancer gene found hiding in plain sight

    Veronica Meade-Kelly, October 27th, 2014

    A mutation that may be driving as many as 20 percent of endometrial and colorectal cancers has come to light this week, thanks to a study by researchers from the Broad Institute of MIT and Harvard and Dana-Farber Cancer Institute.

    The researchers describe finding the connection between the gene RNF43 and these cancers earlier this week in Nature Genetics.

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  • Broad Paper Vids: Metabolic changes signal early development of pancreatic cancer

    Paul Goldsmith, October 3rd, 2014

    Pancreatic cancer is the tenth most common cancer in the United States, but the fourth most common cause of cancer death. This disparity is due, in part, to the disease’s elusive nature. Because the pancreas is located deep in the abdomen, symptoms often present only after cancer has spread to other places in the body. But this week, a team of researchers from the Broad, Dana-Farber Cancer Institute, MIT, and elsewhere reported the discovery of metabolic changes that indicate early development of the disease.

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  • Broad Institute, Ragon Institute aim to help “end HIV” by awarding new catalytic grants

    Leah Eisenstadt, September 25th, 2014

    Despite significant gains made by the scientific and medical communities to understand the HIV virus, an effective HIV/AIDS vaccine – the best hope for ending the epidemic – is still out of reach.

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  • Sangeeta Bhatia awarded Lemelson-MIT Prize

    Veronica Meade-Kelly, September 8th, 2014

    Broad senior associate member Sangeeta Bhatia has been named the 2014 recipient of the $500,000 Lemelson-MIT Prize. The honor, which is celebrating its 20th year, recognizes outstanding, mid-career inventors who are improving the world through technological invention, and demonstrating a commitment to mentorship in science, technology, engineering, and mathematics.

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  • The Rabbit Rift

    Paul Goldsmith, September 4th, 2014

    By all accounts, Pope Gregory I was quite the innovator. Along with his many liturgical accomplishments, he’s credited (somewhat apocryphally) with popularizing Gregorian chant, coining the phrase ‘bless you’ after someone sneezes, and perhaps, most unwittingly, creating one of the best experimental models for studying the evolution of domesticated animals. 

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  • Ebola update: New research sheds light on origin, transmission of Sierra Leone outbreak

    Haley Bridger, September 2nd, 2014 | Filed under

    Researchers from the Broad Institute have been working with a team of international collaborators to collect samples, rapidly sequence genomes, and share data in order to accelerate response efforts to the ongoing outbreak of Ebola in West Africa. The team’s efforts culminate with a paper published online in the journal Science, but the story of their research and collaboration stretches back many years.

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  • Finding the mutations that matter

    Veronica Meade-Kelly, August 7th, 2014

    A major endeavor in genomics research, at the Broad Institute and beyond, is to identify the variations in the human genetic code that may be associated with disease. Such variations can point to potential drug targets or shed light on the biological mechanisms underlying a disease.

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