Blog

  • A Sage partnership

    Haley Bridger, April 12th, 2012

    Even when everything is in working order, the team in the Broad’s Genome Sequencing Platform is never completely satisfied. Someone is always tinkering, inventing, or thinking about a way to strengthen one of the links in the chain of events that leads to sequenced DNA.

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  • Broad artist in residence at MassArt

    Ellen Clegg, April 4th, 2012 | Filed under

    Look around the Broad's public spaces, and you'll find that the Broad is “Unfolding.” That’s the title of an exhibition featuring the work that artist-in-residence Guhapriya Ranganathan has created during her two-year collaboration with scientists here. Tonight, Ranganathan, known as Gupi, will give a talk at the Massachusetts College of Art and Design in Boston about that collaboration.

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  • Zooming in on early embryonic development

    Elizabeth Cooney, March 30th, 2012

    If there were just one book of biology, it would be rewritten constantly with the sometimes dramatic, more often incremental advances in understanding that come with the nature of science. Constant revision can come with insight – think Darwin – or with technology – witness faster, cheaper sequencing machines – or with both.

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  • 2000 common variations and counting

    Alice McCarthy, March 27th, 2012

    Over the past five years, genome-wide association studies (GWAS) have identified about 2,000 common genetic variations that underlie human disease risk. Earlier this week, we told you about a model Broad researchers and collaborators developed to help explain how thousands of other common genetic variations with low effect size combine to contribute to disease risk in rheumatoid arthritis and three other common diseases with a known genetic link.

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  • The opening moves of HIV

    Haley Bridger, March 9th, 2012

    Picture a game of chess between the immune system and HIV. For every move the immune system makes against the virus, its opponent adapts, changing the game and shifting the advantage. But what if you could turn the clock back and watch the first few moves of the game? What could you learn about the virus from its opening moves?

    Researchers from the Broad Institute and the Ragon Institute of Massachusetts General Hospital, MIT, and Harvard set out to take a careful look at a viral population during the critical time period just after infection.

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  • Eric Lander wins Dan David Prize

    Haley Bridger, March 2nd, 2012

    The Broad Institute’s Director Eric Lander is among the recipients of the 2012 Dan David Prize – a prestigious Israeli award for achievements having an outstanding scientific, technological, cultural or social impact.

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  • Making waves at Marco Island

    Elizabeth Cooney, February 24th, 2012

    It’s been a long time since Chad Nusbaum has seen a conference room go so quiet so fast.

    A speaker from Oxford Nanopore Technologies had just described the company’s new disposable device, which will sell for less than $900. The size of a USB memory stick, it reads individual chemical bases on a strand of DNA as it passes through a tiny hole, measuring differences in electrical conductivity to reveal their identity. A larger version of the device will stack in arrays that are projected to be able to sequence a human genome in 15 minutes.

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  • Kimberly Stegmaier, MD: Physician-Scientist

    Alice McCarthy, February 17th, 2012 | Filed under

    When you speak with Kimberly Stegmaier about her work as a pediatric oncologist at Children’s Hospital Boston, it is clear that she loves treating patients, particularly children with hematological cancers like leukemia. Kim devotes her time to caring for children through the in-patient oncology service yet she also maintains long-term clinical relationships with patients she has been treating since completing her pediatric hematology oncology residency.

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  • New wind in the sails of rheumatoid arthritis research

    Haley Bridger, February 9th, 2012

    In 1987, Peter Gregersen was part of a big breakthrough in the field of rheumatoid arthritis (RA) research. By comparing versions of a particular gene in patients with RA to those without the disease, Peter and his colleagues found a telltale stretch of amino acids – the building blocks of proteins – that seemed to distinguish those who had RA from those who did not.

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  • From a quiet genome, a new cancer gene emerges

    Haley Bridger, January 12th, 2012

    Chronic lymphocytic leukemia, the most common form of blood cancer, is a strikingly heterogeneous disease. In some cases, the disease is aggressive and fatal; in others, it causes few symptoms for years or decades. From a genome analysis perspective, CLL is also unusual: it is quiet.

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